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This meeting took place in 2017
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Modeling Viral Infections and Immunity (E1)
Organizer(s) Alan S. Perelson, Rob J. De Boer and Phillip D. Hodgkin
May 1—4, 2017
Stanley Hotel • Estes Park, CO USA
Discounted Abstract Deadline: Jan 10, 2017
Abstract Deadline: Feb 1, 2017
Scholarship Deadline: Jan 10, 2017
Discounted Registration Deadline: Mar 1, 2017
Sponsored by Merck & Co., Inc.
Summary of Meeting:
Viral infection modeling has provided insights into the pathogenesis and treatment of HIV, HCV, HSV-2, CMV and other viruses. It has had impact in revealing the lifespan of infected cells, how rapidly virus is produced and cleared from the circulation, and the means for evaluating the effectiveness of antiviral treatments. HIV remains a global health threat and there is great interest in revealing features of the main HIV reservoir, latently infected cells and mechanisms of reducing the size of this reservoir by pharmacological means. Other important gaps in knowledge revolve around the cell-mediated and humoral immune responses to HIV, important for generating vaccines and broadly neutralizing antibodies as therapeutics, topics that will be discussed. Further, viral infections generally occur in tissues and thus the meeting will discuss imaging techniques and methods of modeling and analyzing spatial infection data, the role of tissue-resident memory cells, and important features of immune regulation, such as immune exhaustion, cytokine signaling between cells, and viral subversion of innate responses and escape from adaptive responses. The meeting will highlight what we believe are significant hurdles to curing viral infections and will bring together experimental virologists, physician scientists and modelers of various types and experience, groups that do not normally meet. It should foster new collaborations between experimentalists and theoreticians, and between theoreticians working on different viral infections or different aspects of viral infections, as well as help young scientists formulate new research directions and make connections with established senior scientists.
View Scholarships/Awards
Viral infection modeling has provided insights into the pathogenesis and treatment of HIV, HCV, HSV-2, CMV and other viruses. It has had impact in revealing the lifespan of infected cells, how rapidly virus is produced and cleared from the circulation, and the means for evaluating the effectiveness of antiviral treatments. HIV remains a global health threat and there is great interest in revealing features of the main HIV reservoir, latently infected cells and mechanisms of reducing the size of this reservoir by pharmacological means. Other important gaps in knowledge revolve around the cell-mediated and humoral immune responses to HIV, important for generating vaccines and broadly neutralizing antibodies as therapeutics, topics that will be discussed. Further, viral infections generally occur in tissues and thus the meeting will discuss imaging techniques and methods of modeling and analyzing spatial infection data, the role of tissue-resident memory cells, and important features of immune regulation, such as immune exhaustion, cytokine signaling between cells, and viral subversion of innate responses and escape from adaptive responses. The meeting will highlight what we believe are significant hurdles to curing viral infections and will bring together experimental virologists, physician scientists and modelers of various types and experience, groups that do not normally meet. It should foster new collaborations between experimentalists and theoreticians, and between theoreticians working on different viral infections or different aspects of viral infections, as well as help young scientists formulate new research directions and make connections with established senior scientists.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.
MONDAY, MAY 1
TUESDAY, MAY 2
WEDNESDAY, MAY 3
THURSDAY, MAY 4
FRIDAY, MAY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.
MONDAY, MAY 1
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
*
Alan S. Perelson,
Los Alamos National Laboratory, USA
Robert F. Siliciano,
Johns Hopkins University School of Medicine, USA
Modeling HIV Infection: Insights into Treatment and the Possibility of Cure
Modeling HIV Infection: Insights into Treatment and the Possibility of Cure
09:30—12:00
HIV - Barriers to a Cure
*
Alan S. Perelson,
Los Alamos National Laboratory, USA
Sharon R. Lewin,
University of Melbourne, Australia
Optimizing Latency Reversal to Eliminate HIV Persistence on Antiretroviral Therapy
Optimizing Latency Reversal to Eliminate HIV Persistence on Antiretroviral Therapy
Coffee Break
John Michael Murray,
University of New South Wales, Australia
Short Talk: Perturbations of the Latent Reservoir to Achieve a Functional Cure
Short Talk: Perturbations of the Latent Reservoir to Achieve a Functional Cure
Audrey Fahrny,
University Hospital Zurich, Switzerland
Short Talk: A HIV-1 Persistence Humanized Mouse Model for the Characterization of HIV-1 Reservoir Cells
Short Talk: A HIV-1 Persistence Humanized Mouse Model for the Characterization of HIV-1 Reservoir Cells
14:30—16:30
Workshop 1: Modeling HIV Infection
*
Roland R. Regoes,
Integrative Biology, ETH Zurich, Switzerland
Catherine A.A. Beauchemin,
Ryerson University, Canada
Duration of SHIV Production by Infected Cells Is Not Exponentially Distributed: Implications for Estimates of Infection Parameters and Antiviral Efficacy
Duration of SHIV Production by Infected Cells Is Not Exponentially Distributed: Implications for Estimates of Infection Parameters and Antiviral Efficacy
Erwing F. Cardozo-Ojeda,
Los Alamos National Laboratory, USA
Dynamics of HIV-1 in Chronically Infected Individuals during Therapy with Raltegravir
Dynamics of HIV-1 in Chronically Infected Individuals during Therapy with Raltegravir
Stanca M. Ciupe,
Virginia Tech, USA
The Role of Antibody during SIV Infections in Rhesus Macaques
The Role of Antibody during SIV Infections in Rhesus Macaques
Jason M. Hataye,
National Institutes of Health, USA
Rebound Establishment of HIV Dependent on Burst Size Breakthrough of a Growth Threshold
Rebound Establishment of HIV Dependent on Burst Size Breakthrough of a Growth Threshold
Vincent Madelain,
INSERM, France
Modeling Viral Kinetics Predicts a Rapid Establishment of the Cytotoxic Immune Response Targeting Distinct Infected Cell Compartments in SIV Controller Macaques
Modeling Viral Kinetics Predicts a Rapid Establishment of the Cytotoxic Immune Response Targeting Distinct Infected Cell Compartments in SIV Controller Macaques
Angie Raad,
York University, Canada
A Mathematical Model Predicting Restored T Cell Homeostasis as a Major Contributor to the Decay in HIV Persistence
A Mathematical Model Predicting Restored T Cell Homeostasis as a Major Contributor to the Decay in HIV Persistence
Daniel Reeves,
Fred Hutchinson Cancer Research Center, USA
Long-Term Antiretroviral Therapy Shifts the Mechanism of HIV Persistence toward Proliferating Latently Infected Cells
Long-Term Antiretroviral Therapy Shifts the Mechanism of HIV Persistence toward Proliferating Latently Infected Cells
Robin N. Thompson,
University of Oxford, UK
Accounting for Donor Viral Diversity Gives High Estimates of the Number of HIV Founder Virions among Recipients
Accounting for Donor Viral Diversity Gives High Estimates of the Number of HIV Founder Virions among Recipients
17:00—19:00
Modeling Cellular Immune Responses
*
Phillip D. Hodgkin,
Walter and Eliza Hall Institute of Medical Research, Australia
Andrew J. McMichael,
Oxford University, UK
Cell-Mediated Immune Responses to HIV
Cell-Mediated Immune Responses to HIV
Becca Asquith,
Imperial College London, UK
KIRs, CD8+ T Cell Dynamics and Control of Chronic Viral Infection
KIRs, CD8+ T Cell Dynamics and Control of Chronic Viral Infection
Lydie Trautmann,
US Military HIV Research Program, USA
Short Talk: Immune Cell Dynamics in Lymph Node and Blood during Acute HIV Infection
Short Talk: Immune Cell Dynamics in Lymph Node and Blood during Acute HIV Infection
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Spatial Aspects of Infection
*
Rob J. De Boer,
Utrecht University, Netherlands
Scott N. Mueller,
University of Melbourne, Australia
Dissecting the Dynamics of Antiviral Immunity and the Lymphoid Tissue Microenvironment
Dissecting the Dynamics of Antiviral Immunity and the Lymphoid Tissue Microenvironment
Joshua T. Schiffer,
Fred Hutchinson Cancer Research Center, USA
Thresholds of Protection for Tissue-Resident T-Cells
Thresholds of Protection for Tissue-Resident T-Cells
Coffee Break
Ruy M. Ribeiro,
University of Lisbon, Portugal
Spatial Aspects of Hepatitis C Virus Infection
Spatial Aspects of Hepatitis C Virus Infection
Jean-Pierre Levraud,
Institut Pasteur, France
Short Talk: From Whole-Body Imaging to Whole-Body Modeling of Viral Infection in Zebrafish
Short Talk: From Whole-Body Imaging to Whole-Body Modeling of Viral Infection in Zebrafish
Richard Beck,
Leiden Academic Centre for Drug Research, Netherlands
Short Talk: Direct T Cell-Mediated Killing of Solid Tumours Is Insufficient to Explain Tumor Regression
Short Talk: Direct T Cell-Mediated Killing of Solid Tumours Is Insufficient to Explain Tumor Regression
17:00—19:00
Modeling Viral Infection
*
Jane Heffernan,
York University, Canada
Thomas Hofer,
Deutsches Krebsforschungszentrum, Germany
Dengue Virus Spread and Innate Immune Response at the Single-Cell Level
Dengue Virus Spread and Innate Immune Response at the Single-Cell Level
Narendra M. Dixit,
Indian Institute of Science, India
Viral Infection and Subversion of the Interferon Response
Viral Infection and Subversion of the Interferon Response
Amber M. Smith,
University of Tennessee Health Science Center, USA
Modeling the Lethal Synergism of Influenza A Virus and Pneumococcal Coinfection
Modeling the Lethal Synergism of Influenza A Virus and Pneumococcal Coinfection
Frederik Graw,
Heidelberg University, Germany
Short Talk: Towards Understanding Malaria Pathogenesis and Efficient Experimental Vaccination
Short Talk: Towards Understanding Malaria Pathogenesis and Efficient Experimental Vaccination
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Using Big Data to Understand Viral Infection
*
Lars Kaderali,
University Medicine Greifswald, Germany
Thierry Mora,
École Normale Supérieure, France
Analyzing High-Throughput Sequence Data to Understand Immune Repertoire Diversity and Affinity
Analyzing High-Throughput Sequence Data to Understand Immune Repertoire Diversity and Affinity
Steven H. Kleinstein,
Yale University School of Medicine, USA
Systems Immunology of Influenza Infection and Vaccination
Systems Immunology of Influenza Infection and Vaccination
Coffee Break
Katia Koelle,
Duke University, USA
Capturing the Roles of Cellular Coinfection and Viral Complementation in the Within-Host Dynamics of Influenza
Capturing the Roles of Cellular Coinfection and Viral Complementation in the Within-Host Dynamics of Influenza
Thomas B. Kepler,
Boston University, USA
Affinity Maturation in Humans: Immunization, Analysis and Modeling
Affinity Maturation in Humans: Immunization, Analysis and Modeling
Florian Rubelt,
Stanford University, USA
Short Talk: Distinctive Differences in T Cell Receptor Repertoire and Cell Frequencies Are Evident in Individual Immune Responses
Short Talk: Distinctive Differences in T Cell Receptor Repertoire and Cell Frequencies Are Evident in Individual Immune Responses
14:30—16:30
Workshop 2: Modeling Other Virus Infectious and Immune Responses
*
Vitaly V. Ganusov,
University of Tennessee, USA
Ruian Ke,
North Carolina State University, USA
Modeling the Mechanistic Action and Predicting the Impact of an Immunotherapeutic DART® Molecule in HIV 'Shock and Kill' Strategies
Modeling the Mechanistic Action and Predicting the Impact of an Immunotherapeutic DART® Molecule in HIV 'Shock and Kill' Strategies
Wen-Han Yu,
Gates Medical Research Institute, USA
Multivariate Modeling of Immunological Profilings from HIV Vaccine Trials Cross-Predicts Vaccine Protection and Infers the Underlying Mechanisms
Multivariate Modeling of Immunological Profilings from HIV Vaccine Trials Cross-Predicts Vaccine Protection and Infers the Underlying Mechanisms
Nathanael Hoze,
ETH Zurich, Switzerland
Quantitative Delineation of Antibody Composition from Polyclonal Plasmas
Quantitative Delineation of Antibody Composition from Polyclonal Plasmas
Shingo Iwami,
Kyushu University, Japan
Optimizing Drug Combinations against Hepatitis C Virus Infection in Pre-Clinical Setting
Optimizing Drug Combinations against Hepatitis C Virus Infection in Pre-Clinical Setting
Christopher Dächert,
German Cancer Research Center - DKFZ, Germany
Understanding the Fight by Looking at the Soldiers - A Quantitative Systems Biology Approach to Analyze the Dynamic Host-Virus-Interactions by the Example of Hepatitis C Virus
Understanding the Fight by Looking at the Soldiers - A Quantitative Systems Biology Approach to Analyze the Dynamic Host-Virus-Interactions by the Example of Hepatitis C Virus
Laura Liao,
Ryerson University, Canada
Counting Defective Interfering Particles: Easy as 1, 2, 3 ...?
Counting Defective Interfering Particles: Easy as 1, 2, 3 ...?
Katharine Best,
Los Alamos National Laboratory, USA
Modeling Zika Plasma Viral Dynamics in Non-Human Primates: Insights into Viral Pathogenesis and Antiviral Strategies
Modeling Zika Plasma Viral Dynamics in Non-Human Primates: Insights into Viral Pathogenesis and Antiviral Strategies
Sanket Rane,
Columbia University, USA
Age Is Not Just A Number – Time Since Thymic Export Influences Homeostatic Fitness and Drives the Accumulation of Veteran Naïve T Cells in Mice
Age Is Not Just A Number – Time Since Thymic Export Influences Homeostatic Fitness and Drives the Accumulation of Veteran Naïve T Cells in Mice
17:00—18:45
Modeling Immune Regulation
*
Sebastian L. Bonhoeffer,
ETH-Zentrum, Switzerland
Phillip D. Hodgkin,
Walter and Eliza Hall Institute of Medical Research, Australia
Formation of Effector and Memory Cells
Formation of Effector and Memory Cells
Rustom Antia,
Emory University, USA
How Does Prior Immunity Affect the Dynamics of Immune Responses to New Strains of Influenza?
How Does Prior Immunity Affect the Dynamics of Immune Responses to New Strains of Influenza?
Alan S. Perelson,
Los Alamos National Laboratory, USA
Modeling Antibodies and HIV Cure
Modeling Antibodies and HIV Cure
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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