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This meeting took place in 2017

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Modeling Viral Infections and Immunity (E1)

Organizer(s) Alan S. Perelson, Rob J. De Boer and Phillip D. Hodgkin
May 1—4, 2017
Stanley Hotel • Estes Park, CO USA
Discounted Abstract Deadline: Jan 10, 2017
Abstract Deadline: Feb 1, 2017
Scholarship Deadline: Jan 10, 2017
Discounted Registration Deadline: Mar 1, 2017

Sponsored by Merck & Co., Inc.

Summary of Meeting:
Viral infection modeling has provided insights into the pathogenesis and treatment of HIV, HCV, HSV-2, CMV and other viruses. It has had impact in revealing the lifespan of infected cells, how rapidly virus is produced and cleared from the circulation, and the means for evaluating the effectiveness of antiviral treatments. HIV remains a global health threat and there is great interest in revealing features of the main HIV reservoir, latently infected cells and mechanisms of reducing the size of this reservoir by pharmacological means. Other important gaps in knowledge revolve around the cell-mediated and humoral immune responses to HIV, important for generating vaccines and broadly neutralizing antibodies as therapeutics, topics that will be discussed. Further, viral infections generally occur in tissues and thus the meeting will discuss imaging techniques and methods of modeling and analyzing spatial infection data, the role of tissue-resident memory cells, and important features of immune regulation, such as immune exhaustion, cytokine signaling between cells, and viral subversion of innate responses and escape from adaptive responses. The meeting will highlight what we believe are significant hurdles to curing viral infections and will bring together experimental virologists, physician scientists and modelers of various types and experience, groups that do not normally meet. It should foster new collaborations between experimentalists and theoreticians, and between theoreticians working on different viral infections or different aspects of viral infections, as well as help young scientists formulate new research directions and make connections with established senior scientists.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Monday, May 1 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.


Arrival and Registration

Hotel Lobby
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Music Room



MacGregor Ballroom
Welcome and Keynote Address

Concert Hall
* Alan S. Perelson, Los Alamos National Laboratory, USA

Robert F. Siliciano, Johns Hopkins University School of Medicine, USA
Modeling HIV Infection: Insights into Treatment and the Possibility of Cure

HIV - Barriers to a Cure

Concert Hall
* Alan S. Perelson, Los Alamos National Laboratory, USA

Sharon R. Lewin, University of Melbourne, Australia
Optimizing Latency Reversal to Eliminate HIV Persistence on Antiretroviral Therapy

Coffee Break

Alison L. Hill, Harvard University, USA
Modeling the Dynamics of HIV Latency, Rebound, and Control

Miles P. Davenport, University of New South Wales, Australia
The Dynamics of HIV / SIV Latency

John Michael Murray, University of New South Wales, Australia
Short Talk: Perturbations of the Latent Reservoir to Achieve a Functional Cure

Audrey Fahrny, University Hospital Zurich, Switzerland
Short Talk: A HIV-1 Persistence Humanized Mouse Model for the Characterization of HIV-1 Reservoir Cells

On Own for Lunch

Poster Setup

MacGregor Ballroom
Poster Viewing

MacGregor Ballroom
Workshop 1: Modeling HIV Infection

Concert Hall
* Roland R. Regoes, Integrative Biology, ETH Zurich, Switzerland

Catherine A.A. Beauchemin, Ryerson University, Canada
Duration of SHIV Production by Infected Cells Is Not Exponentially Distributed: Implications for Estimates of Infection Parameters and Antiviral Efficacy

Erwing F. Cardozo-Ojeda, Los Alamos National Laboratory, USA
Dynamics of HIV-1 in Chronically Infected Individuals during Therapy with Raltegravir

Stanca M. Ciupe, Virginia Tech, USA
The Role of Antibody during SIV Infections in Rhesus Macaques

Jason M. Hataye, National Institutes of Health, USA
Rebound Establishment of HIV Dependent on Burst Size Breakthrough of a Growth Threshold

Vincent Madelain, INSERM, France
Modeling Viral Kinetics Predicts a Rapid Establishment of the Cytotoxic Immune Response Targeting Distinct Infected Cell Compartments in SIV Controller Macaques

Angie Raad, York University, Canada
A Mathematical Model Predicting Restored T Cell Homeostasis as a Major Contributor to the Decay in HIV Persistence

Daniel Reeves, Fred Hutchinson Cancer Research Center, USA
Long-Term Antiretroviral Therapy Shifts the Mechanism of HIV Persistence toward Proliferating Latently Infected Cells

Robin N. Thompson, University of Oxford, UK
Accounting for Donor Viral Diversity Gives High Estimates of the Number of HIV Founder Virions among Recipients

Coffee Available

Concert Hall
Modeling Cellular Immune Responses

Concert Hall
* Phillip D. Hodgkin, Walter and Eliza Hall Institute of Medical Research, Australia

Andrew J. McMichael, Oxford University, UK
Cell-Mediated Immune Responses to HIV

Rob J. De Boer, Utrecht University, Netherlands
Broad CD8 Immune Responses to HIV

Becca Asquith, Imperial College London, UK
KIRs, CD8+ T Cell Dynamics and Control of Chronic Viral Infection

Lydie Trautmann, US Military HIV Research Program, USA
Short Talk: Immune Cell Dynamics in Lymph Node and Blood during Acute HIV Infection

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacGregor Ballroom
Poster Session 1

MacGregor Ballroom



MacGregor Ballroom
Spatial Aspects of Infection

Concert Hall
* Rob J. De Boer, Utrecht University, Netherlands

Scott N. Mueller, University of Melbourne, Australia
Dissecting the Dynamics of Antiviral Immunity and the Lymphoid Tissue Microenvironment

Joshua T. Schiffer, Fred Hutchinson Cancer Research Center, USA
Thresholds of Protection for Tissue-Resident T-Cells

Coffee Break

Ruy M. Ribeiro, University of Lisbon, Portugal
Spatial Aspects of Hepatitis C Virus Infection

Jean-Pierre Levraud, Institut Pasteur, France
Short Talk: From Whole-Body Imaging to Whole-Body Modeling of Viral Infection in Zebrafish

Richard Beck, Leiden Academic Centre for Drug Research, Netherlands
Short Talk: Direct T Cell-Mediated Killing of Solid Tumours Is Insufficient to Explain Tumor Regression

On Own for Lunch

Poster Setup

MacGregor Ballroom
Poster Viewing

MacGregor Ballroom
Coffee Available

Concert Hall
Modeling Viral Infection

Concert Hall
* Jane Heffernan, York University, Canada

Thomas Hofer, Deutsches Krebsforschungszentrum, Germany
Dengue Virus Spread and Innate Immune Response at the Single-Cell Level

Narendra M. Dixit, Indian Institute of Science, India
Viral Infection and Subversion of the Interferon Response

Amber M. Smith, University of Tennessee Health Science Center, USA
Modeling the Lethal Synergism of Influenza A Virus and Pneumococcal Coinfection

Frederik Graw, Heidelberg University, Germany
Short Talk: Towards Understanding Malaria Pathogenesis and Efficient Experimental Vaccination

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacGregor Ballroom
Poster Session 2

MacGregor Ballroom



MacGregor Ballroom
Using Big Data to Understand Viral Infection

Concert Hall
* Lars Kaderali, University Medicine Greifswald, Germany

Thierry Mora, École Normale Supérieure, France
Analyzing High-Throughput Sequence Data to Understand Immune Repertoire Diversity and Affinity

Steven H. Kleinstein, Yale University School of Medicine, USA
Systems Immunology of Influenza Infection and Vaccination

Coffee Break

Katia Koelle, Duke University, USA
Capturing the Roles of Cellular Coinfection and Viral Complementation in the Within-Host Dynamics of Influenza

Thomas B. Kepler, Boston University, USA
Affinity Maturation in Humans: Immunization, Analysis and Modeling

Florian Rubelt, Stanford University, USA
Short Talk: Distinctive Differences in T Cell Receptor Repertoire and Cell Frequencies Are Evident in Individual Immune Responses

On Own for Lunch

Workshop 2: Modeling Other Virus Infectious and Immune Responses

Concert Hall
* Vitaly V. Ganusov, University of Tennessee, USA

Ruian Ke, North Carolina State University, USA
Modeling the Mechanistic Action and Predicting the Impact of an Immunotherapeutic DART® Molecule in HIV 'Shock and Kill' Strategies

Wen-Han Yu, Gates Medical Research Institute, USA
Multivariate Modeling of Immunological Profilings from HIV Vaccine Trials Cross-Predicts Vaccine Protection and Infers the Underlying Mechanisms

Nathanael Hoze, ETH Zurich, Switzerland
Quantitative Delineation of Antibody Composition from Polyclonal Plasmas

Shingo Iwami, Kyushu University, Japan
Optimizing Drug Combinations against Hepatitis C Virus Infection in Pre-Clinical Setting

Christopher Dächert, German Cancer Research Center - DKFZ, Germany
Understanding the Fight by Looking at the Soldiers - A Quantitative Systems Biology Approach to Analyze the Dynamic Host-Virus-Interactions by the Example of Hepatitis C Virus

Laura Liao, Ryerson University, Canada
Counting Defective Interfering Particles: Easy as 1, 2, 3 ...?

Katharine Best, Los Alamos National Laboratory, USA
Modeling Zika Plasma Viral Dynamics in Non-Human Primates: Insights into Viral Pathogenesis and Antiviral Strategies

Sanket Rane, Columbia University, USA
Age Is Not Just A Number – Time Since Thymic Export Influences Homeostatic Fitness and Drives the Accumulation of Veteran Naïve T Cells in Mice

Coffee Available

Concert Hall
Modeling Immune Regulation

Concert Hall
* Sebastian L. Bonhoeffer, ETH-Zentrum, Switzerland

Phillip D. Hodgkin, Walter and Eliza Hall Institute of Medical Research, Australia
Formation of Effector and Memory Cells

Rustom Antia, Emory University, USA
How Does Prior Immunity Affect the Dynamics of Immune Responses to New Strains of Influenza?

Alan S. Perelson, Los Alamos National Laboratory, USA
Modeling Antibodies and HIV Cure

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Concert Hall
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacGregor Ballroom
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

MacGregor Ballroom



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Merck & Co., Inc.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI131602-01

Funding for this conference was made possible (in part) by AI 131602 - 01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Phone:+1 970-262-2690

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