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This meeting took place in 2017
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Genomic Instability and DNA Repair (Z1)
Organizer(s) Julia Promisel Cooper, Marco F. Foiani and Geneviève Almouzni
April 2—6, 2017
Santa Fe Community Convention Center • Santa Fe, NM USA
Discounted Abstract Deadline: Dec 5, 2016
Abstract Deadline: Jan 12, 2017
Scholarship Deadline: Dec 5, 2016
Discounted Registration Deadline: Feb 2, 2017
Sponsored by AstraZeneca, Bayer HealthCare Pharmaceuticals, Editas Medicine, Inc., EMD Serono Research and Development Institute, Inc., Journal of Molecular Cell Biology (JMCB) and TESARO, Inc.
Joint Meeting:
DNA Replication and Recombination (Z2)
Summary of Meeting:
Genome stability is the foundation upon which all cellular and organismal processes depend. This conference will grapple with the intricate array of biochemical reactions orchestrated by the cell to replicate, repair and segregate chromosomes accurately despite constant threats from spontaneous and environmentally-induced damage. Defects in these reactions lead to genomic instability, a confirmed driver of cancer and degenerative diseases. Fascinating and therapeutically crucial questions remain about the mechanisms underlying chromosome stability, and cross-disciplinary approaches are required to address them. How do epigenetic chromatin marks influence repair of underlying DNA sequences, and how can we predict the effects of chemotherapeutic agents that alter such marks? To what extent is the nucleus organized into subdomains with distinct functions; how are these subdomains altered when cells move or differentiate? How are the myriad helicases, nucleases and polymerases coordinated to safeguard genome stability, why are these molecules often mutated in human disease, and how can we ameliorate the effects of such mutations? What is the array of strategies available to cancer cells as they achieve unlimited proliferation? This conference has a history of bringing together investigators from diverse subfields who otherwise rarely meet. Cutting-edge concepts in translational, genomic, cellular, molecular, RNA and structural biology will be dissected to take the conversation to unprecedented levels of depth and breadth. The concurrent conference on “DNA Replication and Recombination” will provide additional opportunities for cross-talk. Both conferences are committed to nurturing interactions among longtime experts in the field with students, postdocs and investigators new to the field.
View Scholarships/Awards
Genome stability is the foundation upon which all cellular and organismal processes depend. This conference will grapple with the intricate array of biochemical reactions orchestrated by the cell to replicate, repair and segregate chromosomes accurately despite constant threats from spontaneous and environmentally-induced damage. Defects in these reactions lead to genomic instability, a confirmed driver of cancer and degenerative diseases. Fascinating and therapeutically crucial questions remain about the mechanisms underlying chromosome stability, and cross-disciplinary approaches are required to address them. How do epigenetic chromatin marks influence repair of underlying DNA sequences, and how can we predict the effects of chemotherapeutic agents that alter such marks? To what extent is the nucleus organized into subdomains with distinct functions; how are these subdomains altered when cells move or differentiate? How are the myriad helicases, nucleases and polymerases coordinated to safeguard genome stability, why are these molecules often mutated in human disease, and how can we ameliorate the effects of such mutations? What is the array of strategies available to cancer cells as they achieve unlimited proliferation? This conference has a history of bringing together investigators from diverse subfields who otherwise rarely meet. Cutting-edge concepts in translational, genomic, cellular, molecular, RNA and structural biology will be dissected to take the conversation to unprecedented levels of depth and breadth. The concurrent conference on “DNA Replication and Recombination” will provide additional opportunities for cross-talk. Both conferences are committed to nurturing interactions among longtime experts in the field with students, postdocs and investigators new to the field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 2 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 6 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 2
MONDAY, APRIL 3
TUESDAY, APRIL 4
WEDNESDAY, APRIL 5
THURSDAY, APRIL 6
FRIDAY, APRIL 7
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 2 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 6 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 7 in order to fully experience the meeting.
SUNDAY, APRIL 2
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
*
Julia Promisel Cooper,
NCI, National Institutes of Health, USA
*
Scott Keeney,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Johannes C. Walter,
Harvard Medical School, USA
Mechanisms of Replication-Coupled Repair
Mechanisms of Replication-Coupled Repair
Coffee Break
09:50—12:00
Mechanisms of DNA Repair
*
Timothy C. Humphrey,
University of Oxford, UK
Wei Yang,
NIDDK, National Institutes of Health, USA
Structural Insights into Translesion DNA Polymerases
Structural Insights into Translesion DNA Polymerases
James E. Haber,
Brandeis University, USA
Short Talk: Rad51-Mediated Double-Strand Break Repair and Mismatch Correction of Highly Diverged Substrates
Short Talk: Rad51-Mediated Double-Strand Break Repair and Mismatch Correction of Highly Diverged Substrates
Joseph J. Loparo,
Harvard Medical School, USA
Short Talk: Single-Molecule Imaging of Non-Homologous End Joining
Short Talk: Single-Molecule Imaging of Non-Homologous End Joining
Michael D. Stone,
University of California, Santa Cruz, USA
Mechanical Transitions in Long Duplex Telomere DNA Molecules
Mechanical Transitions in Long Duplex Telomere DNA Molecules
Fena Ochs,
University of Copenhagen, Denmark
Short Talk: Dynamic Chromatin Superstructures Safeguard Integrity of Nuclear Compartments Challenged by DNA Breakage
Short Talk: Dynamic Chromatin Superstructures Safeguard Integrity of Nuclear Compartments Challenged by DNA Breakage
09:50—12:00
Replication/Repair Structure and Function
*
John F.X. Diffley,
Francis Crick Institute, UK
Michael E. O'Donnell,
Rockefeller University, USA
Structure and Function of the Eukaryotic Replisome
Structure and Function of the Eukaryotic Replisome
Tyler H. Stanage,
University of Wisconsin-Madison, USA
Short Talk: The Escherichia coli RarA Protein is Involved in the Switch between DNA Replication and Translesion Synthesis in vivo
Short Talk: The Escherichia coli RarA Protein is Involved in the Switch between DNA Replication and Translesion Synthesis in vivo
Karlene A. Cimprich,
Stanford University, USA
When RNA Meets DNA: Dangerous Liaisons in the Genome
When RNA Meets DNA: Dangerous Liaisons in the Genome
Alessandro Costa,
Francis Crick Institute, UK
Cryo-EM Approaches to Understanding the Eukaryotic Replisome
Cryo-EM Approaches to Understanding the Eukaryotic Replisome
Matthew L. Bochman,
Indiana University, USA
Short Talk: Hrq1, The Yeast Homolog of RecQ4, Inhibits Telomerase Activity on Long Telomeres
Short Talk: Hrq1, The Yeast Homolog of RecQ4, Inhibits Telomerase Activity on Long Telomeres
14:30—16:30
Workshop 1: Genome Instability and DNA Repair I
*
James E. Haber,
Brandeis University, USA
Elena Balkanska-Sinclair,
Duke University, USA
The BRD4-NUT Fusion Protein from Nut-Midline Carcinoma modulates DNA Damage Signaling and Ionizing Radiation Response
The BRD4-NUT Fusion Protein from Nut-Midline Carcinoma modulates DNA Damage Signaling and Ionizing Radiation Response
Michael M. Cox,
University of Wisconsin-Madison, USA
Ionizing Radiation Resistance in Experimentally Evolved Escherichia coli Populations
Ionizing Radiation Resistance in Experimentally Evolved Escherichia coli Populations
Nitika Taneja,
NCI, National Institutes of Health, USA
SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication
SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication
Ryan M. Baxley,
University of Minnesota, USA
Progressive Genomic Instability and Telomere Erosion in Human Cells following Inactivation of a Single MCM10 Allele
Progressive Genomic Instability and Telomere Erosion in Human Cells following Inactivation of a Single MCM10 Allele
Michael H. Hauer,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates
Histone Degradation in Response to DNA Damage Enhances Chromatin Dynamics and Recombination Rates
Mariano Labrador-San Jose,
University of Tennessee, USA
Components of the DNA Damage Response Pathway, ATR and ATM, Modulate Chromatin Insulator Activity through Phosphorylation of Histone H2Av at Insulator Sites
Components of the DNA Damage Response Pathway, ATR and ATM, Modulate Chromatin Insulator Activity through Phosphorylation of Histone H2Av at Insulator Sites
Mitch McVey,
Tufts University, USA
Coordination of ATPase and Polymerase Activities of Drosophila DNA Polymerase Theta during Interstrand Crosslink and Alternative End-Joining Repair of Double-Strand Breaks
Coordination of ATPase and Polymerase Activities of Drosophila DNA Polymerase Theta during Interstrand Crosslink and Alternative End-Joining Repair of Double-Strand Breaks
Hilda A. Pickett,
Children's Medical Research Institute, Australia
BLM and SLX4 Play Opposing Roles in Recombination-Dependent Replication at Human Telomeres
BLM and SLX4 Play Opposing Roles in Recombination-Dependent Replication at Human Telomeres
14:30—16:30
Workshop 1: Recombination and Repair
Tracey E. Beyer,
Biotech Research and Innovation Centre, Denmark
Ontogeny of Genome Rearrangements in Budding Yeast
Ontogeny of Genome Rearrangements in Budding Yeast
*
Simon N. Powell,
Memorial Sloan Kettering Cancer Center, USA
Replication Fork Cleavage Occurs within 100bp from Local ATM Signaling of Site-Specific DNA Replication Block in Human Cells
Replication Fork Cleavage Occurs within 100bp from Local ATM Signaling of Site-Specific DNA Replication Block in Human Cells
Erin Hannah Sybouts,
University of Texas Health Science Center at San Antonio, USA
Recombination and BLM Helicase Compensate for Replication Fork Defects in the Absence of 53BP1 Protein
Recombination and BLM Helicase Compensate for Replication Fork Defects in the Absence of 53BP1 Protein
Shane McDevitt,
Temple University Lewis Katz School of Medicine, USA
Mechanisms of RNA-Transcript Templated DNA Recombinational Repair Promoted by RAD52
Mechanisms of RNA-Transcript Templated DNA Recombinational Repair Promoted by RAD52
Susanne S. C. Bantele,
Max Planck Institute of Biochemistry, Germany
Regulation of the Conserved Chromatin Remodeler Fun30SMARCAD1 at DNA Double-Strand Breaks
Regulation of the Conserved Chromatin Remodeler Fun30SMARCAD1 at DNA Double-Strand Breaks
Walter J. Chazin,
Vanderbilt University, USA
Mechanisms for Counting and Handoff by Human DNA Primase- A Role for the 4Fe-4S Cluster?
Mechanisms for Counting and Handoff by Human DNA Primase- A Role for the 4Fe-4S Cluster?
Holger Puchta,
Karlsruhe Institute of Technology, Germany
The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana
The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana
Christian Biertuempfel,
Max Planck Institute of Biochemistry, Germany
DNA Recognition Features of Human Holliday Junction Resolvase GEN1
DNA Recognition Features of Human Holliday Junction Resolvase GEN1
17:00—19:00
RNA Metabolism and Genome Stability
*
Hengyao Niu,
Indiana University Bloomington, USA
Vihandha Wickramasinghe,
Peter MacCallum Cancer Centre, Australia
Effects of Altered RNA Processing on Genome Stability and the Proteome
Effects of Altered RNA Processing on Genome Stability and the Proteome
Frédéric L. Chedin,
University of California, Davis, USA
Short Talk: R-Loop Formation is a Hallmark of Active Early Replication Origins in Mammalian Genomes
Short Talk: R-Loop Formation is a Hallmark of Active Early Replication Origins in Mammalian Genomes
Julius Brennecke,
IMBA - Institut für Molekulare Biotechnologie GmbH, Austria
An RNA-Based Genome Immune System Safeguards Genome Stability
An RNA-Based Genome Immune System Safeguards Genome Stability
Eric A. Hunt,
New England Biolabs, USA
Short Talk: Prokaryotic Argonautes and their Potential as New Molecular Tools
Short Talk: Prokaryotic Argonautes and their Potential as New Molecular Tools
Alice Meroni,
University of Milan, Italy
Short Talk: DNA Polymerase eta Sensitizes Cells to Nucleotide Pool Deprivation in Absence of RNase H
Short Talk: DNA Polymerase eta Sensitizes Cells to Nucleotide Pool Deprivation in Absence of RNase H
Francesca Storici,
Georgia Institute of Technology, USA
Short Talk: Double-Strand Break Repair by Transcript RNA Is Stimulated by Rad52 and Requires Limited End Resection
Short Talk: Double-Strand Break Repair by Transcript RNA Is Stimulated by Rad52 and Requires Limited End Resection
17:00—19:00
Starting Recombination
Covering meiotic initiation, somatic lesion formation, DSB processing.
*
Bernard de Massy,
Institut de Génétique Humaine, France
Scott Keeney,
HHMI/Memorial Sloan Kettering Cancer Center, USA
Breaking and Chewing DNA during Meiosis
Breaking and Chewing DNA during Meiosis
Florencia M. Pratto,
NIDDK, National Institutes of Health, USA
Linking Replication and Meiotic Recombination Initiation in Mammals
Linking Replication and Meiotic Recombination Initiation in Mammals
Kara A. Bernstein,
University of Pittsburgh School of Medicine, USA
Short Talk: The Function of the Shu Complex and the Rad51 Paralogs in Repair of Replication Intermediate by Promotion of Rad51 Presynaptic Filament Assembly
Short Talk: The Function of the Shu Complex and the Rad51 Paralogs in Repair of Replication Intermediate by Promotion of Rad51 Presynaptic Filament Assembly
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Protecting the Genome by Homologous Recombination
Protecting the Genome by Homologous Recombination
Sofija Mijic,
Linköping University, Sweden
Short Talk: Replication Fork Reversal Triggers Fork Degradation in BRCA2-Defective Cells
Short Talk: Replication Fork Reversal Triggers Fork Degradation in BRCA2-Defective Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Interplay between Chromatin Structure and DNA Replication/Repair (Joint)
*
Jennifer A. Cobb,
University of Calgary, Canada
*
Anja Groth,
University of Copenhagen, Denmark
Geneviève Almouzni,
Centre National de la Recherche Scientifique, France
Shaping Chromatin in the Nucleus, the Bricks and the Architects
Shaping Chromatin in the Nucleus, the Bricks and the Architects
Gary Karpen,
University of California, Berkeley, USA
Regulation of DNA Repair in Heterochromatin and Euchromatin
Regulation of DNA Repair in Heterochromatin and Euchromatin
Francesca Mattiroli,
HHMI/Colorado University Boulder, USA
Short Talk: DNA-Mediated Association of Two Histone-Bound CAF-1 Complexes Drives Tetrasome Assembly in the Wake of DNA Replication
Short Talk: DNA-Mediated Association of Two Histone-Bound CAF-1 Complexes Drives Tetrasome Assembly in the Wake of DNA Replication
Coffee Break
Robert A. Martienssen,
Cold Spring Harbor Laboratory, USA
RNAi Promotes Heterochromatic Silencing through Replication-Coupled Release of RNA Polymerase II
RNAi Promotes Heterochromatic Silencing through Replication-Coupled Release of RNA Polymerase II
Bernard de Massy,
Institut de Génétique Humaine, France
The Control of Initiation of Meiotic Recombination by PRDM9
The Control of Initiation of Meiotic Recombination by PRDM9
Philipp Oberdoerffer,
NCI, National Institutes of Health, USA
Short Talk: Replication Stress Shapes a Protective Chromatin Environment Across Fragile Genomic Regions
Short Talk: Replication Stress Shapes a Protective Chromatin Environment Across Fragile Genomic Regions
17:00—19:00
Cell Cycle Regulation of DNA Damage Response
*
Frédéric L. Chedin,
University of California, Davis, USA
Tanya T. Paull,
University of Texas at Austin, USA
Double-Strand Break Repair Factors and R-Loop-Mediated Genomic Instability
Double-Strand Break Repair Factors and R-Loop-Mediated Genomic Instability
David Cortez,
Vanderbilt University School of Medicine, USA
Regulation of Replication Fork Stability by Single-Stranded DNA Binding Proteins
Regulation of Replication Fork Stability by Single-Stranded DNA Binding Proteins
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
Short Talk: DNA Damage Causes¬ Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM
Short Talk: DNA Damage Causes¬ Rapid Accumulation of Phosphoinositides to Recruit ATR but not ATM
Linda J. Kenney,
National University of Singapore, Singapore
Short Talk: Salmonella Typhimurium forms Biofilms on Solid Tumors
Short Talk: Salmonella Typhimurium forms Biofilms on Solid Tumors
17:00—19:00
Regulating Recombination
Cell cycle, site choice, partner choice, pathway choice.
*
Xiaolan Zhao,
Memorial Sloan Kettering Cancer Center, USA
Jennifer A. Cobb,
University of Calgary, Canada
Nej1 Regulates Repair Pathway Choice by Inhibiting Dna2-Sgs1 Mediated Resection
Nej1 Regulates Repair Pathway Choice by Inhibiting Dna2-Sgs1 Mediated Resection
Aurele Piazza,
Ecole Normale Superieure de Lyon, France
Short Talk: Multi-Invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements
Short Talk: Multi-Invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements
Eric C. Greene,
Columbia University, USA
Single-Molecule Studies of Recombination Pathways
Single-Molecule Studies of Recombination Pathways
Sneha Saxena,
Indian Institute of Science, India
Short Talk: RAD51 Paralog XRCC2 Suppresses Pathological Replication Fork Progression
Short Talk: RAD51 Paralog XRCC2 Suppresses Pathological Replication Fork Progression
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Nuclear Dynamics and Genome Stability
*
Arnab Ray Chaudhuri,
Erasmus University Medical Center, Netherlands
Marco F. Foiani,
Instituto FIRC di Oncologia Molecolare, Italy
An Integrated ATR, ATM and mTOR-Mechanical Network Controlling Nuclear Plasticity and Cell Migration
An Integrated ATR, ATM and mTOR-Mechanical Network Controlling Nuclear Plasticity and Cell Migration
Angela Taddei,
Institut Curie, France
Nuclear Organization and Chromatin Status Modulate Homologous Recombination Efficiency and Outcome
Nuclear Organization and Chromatin Status Modulate Homologous Recombination Efficiency and Outcome
Irene Chiolo,
University of Southern California, USA
Short Talk: Highways for Repair: Nuclear Myosins and Actin Filaments Relocalize Heterochromatic DNA Breaks to the Nuclear Periphery
Short Talk: Highways for Repair: Nuclear Myosins and Actin Filaments Relocalize Heterochromatic DNA Breaks to the Nuclear Periphery
Coffee Break
Martin W. Hetzer,
The Salk Institute for Biological Studies, USA
How the Nuclear Membrane Controls Genome Function
How the Nuclear Membrane Controls Genome Function
Emmanuelle Fabre,
Hopital St Louis, France
Short Talk: DNA Damage Increases Chromatin Stiffening in Budding Yeast
Short Talk: DNA Damage Increases Chromatin Stiffening in Budding Yeast
Neil T. Umbreit,
Dana-Farber Cancer Institute, USA
Short Talk: Chromosome Bridge Resolution Requires Mechanical Forces from Actin-Based Contractility
Short Talk: Chromosome Bridge Resolution Requires Mechanical Forces from Actin-Based Contractility
Peter Ly,
University of California San Diego, USA
Short Talk: Mitotic Errors Promote Chromosome Shattering and DNA Break Repair by Non-Homologous End Joining
Short Talk: Mitotic Errors Promote Chromosome Shattering and DNA Break Repair by Non-Homologous End Joining
08:00—11:00
Replication Fork Progression and Restart
*
Anne D. Donaldson,
University of Aberdeen, UK
Kenneth J. Marians,
Memorial Sloan Kettering Cancer Center, USA
Imaging Individual Replisomes Reveals Independence and Decoupling of Polymerases During Replication
Imaging Individual Replisomes Reveals Independence and Decoupling of Polymerases During Replication
Anja Groth,
University of Copenhagen, Denmark
Chromatin Replication and Epigenome Maintenance
Chromatin Replication and Epigenome Maintenance
Alberto Ciccia,
Columbia University, USA
Short Talk: Restoration of Fork Stability in BRCA1- and BRCA2-Deficient Cells
Short Talk: Restoration of Fork Stability in BRCA1- and BRCA2-Deficient Cells
Coffee Break
Xiaolan Zhao,
Memorial Sloan Kettering Cancer Center, USA
Smc5/6-Mediated Control of Recombinational Repair is Critical for Genome Duplication
Smc5/6-Mediated Control of Recombinational Repair is Critical for Genome Duplication
Advaitha Madireddy,
Albert Einstein Collge of Medicine, USA
Short Talk: FANCD2 Facilitates DNA Replication through Common Fragile Sites
Short Talk: FANCD2 Facilitates DNA Replication through Common Fragile Sites
Joseph L. Stodola,
Washington University School of Medicine, USA
Short Talk: Kinetic Analysis of Lagging Strand Replication and Okazaki Fragment Maturation
Short Talk: Kinetic Analysis of Lagging Strand Replication and Okazaki Fragment Maturation
Joseph Yeeles,
MRC Laboratory of Molecular Biology, UK
Short Talk: How the Eukaryotic Replisome Responds to DNA Damage in the Leading- and Lagging-Strand Templates
Short Talk: How the Eukaryotic Replisome Responds to DNA Damage in the Leading- and Lagging-Strand Templates
17:00—19:00
DNA Repair and Human Diseases
*
Hilda A. Pickett,
Children's Medical Research Institute, Australia
Agnel Sfeir,
New York University School of Medicine, USA
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion
Cecilia Cotta-Ramusino,
Tessera Therapeutic, USA
Short Talk: Characterization of the Interplay between DNA Repair and CRISPR/Cas9-Induced DNA Lesions at an Endogenous Locus
Short Talk: Characterization of the Interplay between DNA Repair and CRISPR/Cas9-Induced DNA Lesions at an Endogenous Locus
Simon J. Boulton,
Francis Crick Institute, UK
Mechanistic Insights into Telomere Dysfunction Disorders
Mechanistic Insights into Telomere Dysfunction Disorders
Madalena Tarsounas,
University of Oxford, UK
Short Talk: MUS81 Nuclease Activity Is Essential for Replication Stress Tolerance and Chromosome Segregation in BRCA2-Deficient Cells
Short Talk: MUS81 Nuclease Activity Is Essential for Replication Stress Tolerance and Chromosome Segregation in BRCA2-Deficient Cells
Janet Partridge,
St Jude Children's Research Hospital, USA
Short Talk: Histone H3G34R Mutation Causes Replicative Stress, Defective Homologous Recombination and Genomic Instability in Fission Yeast
Short Talk: Histone H3G34R Mutation Causes Replicative Stress, Defective Homologous Recombination and Genomic Instability in Fission Yeast
17:00—19:00
Replication Initiation Mechanisms
*
Kenneth J. Marians,
Memorial Sloan Kettering Cancer Center, USA
Stephen P. Bell,
Massachusetts Institute of Technology, USA
Mechanism and Timing of Mcm2-7 Ring Closure During Origin Licensing
Mechanism and Timing of Mcm2-7 Ring Closure During Origin Licensing
Heath Murray,
Newcastle University, UK
Short Talk: A New Bacterial Replication Origin Element Specifies Single-Strand Initiator Binding
Short Talk: A New Bacterial Replication Origin Element Specifies Single-Strand Initiator Binding
Anne D. Donaldson,
University of Aberdeen, UK
The Conserved Role of Rif1 as a Substrate-Targeting Subunit of Protein Phosphatase 1
The Conserved Role of Rif1 as a Substrate-Targeting Subunit of Protein Phosphatase 1
Dominik Boos,
University of Duisburg-Essen, Germany
Short Talk: MTBP Is an Essential Replication Initiation Factor with Vertebrate-Specific and Sld7-Like Features
Short Talk: MTBP Is an Essential Replication Initiation Factor with Vertebrate-Specific and Sld7-Like Features
08:00—11:00
Replication Fork Establishment and Replication-Coupled Repair (Joint)
*
Jeannine Gerhardt,
Weill Cornell Medicine, USA
*
Karlene A. Cimprich,
Stanford University, USA
James M. Berger,
Johns Hopkins University School of Medicine, USA
Physical Mechanisms for Initiating DNA Replication in Cells
Physical Mechanisms for Initiating DNA Replication in Cells
Eric J. Brown,
Perelman School of Medicine, University of Pennsylvania, USA
Short Talk: Characterizing Replisome Ubiquitination upon Fork Stalling
Short Talk: Characterizing Replisome Ubiquitination upon Fork Stalling
Coffee Break
André Nussenzweig,
NCI, National Institutes of Health, USA
DNA Breaks and End-Resection Measured Genome-Wide by End Sequencing (END-seq)
DNA Breaks and End-Resection Measured Genome-Wide by End Sequencing (END-seq)
Helle D. Ulrich,
Institute of Molecular Biology, Germany
Coordination of DNA Damage Bypass with Genome Replication and Checkpoint Signaling
Coordination of DNA Damage Bypass with Genome Replication and Checkpoint Signaling
Stephane Koundrioukoff,
Institute Gustave Roussy, France
Short Talk: DNA Replication Compensation: A Two Steps Mechanism
Short Talk: DNA Replication Compensation: A Two Steps Mechanism
14:30—16:30
Workshop 2: Genome Instability and DNA Repair II
*
Michael P. Sheetz,
Mechanobiology Institute, National University of Singapore, Singapore
Katharina Schlacher,
MD Anderson Cancer Center, USA
Epigenetics-Enabled MRE11 Replication Restart by p53 Promotes Replication Pathway Homeostasis to Suppress Opportunistic Transcription Reprogramming
Epigenetics-Enabled MRE11 Replication Restart by p53 Promotes Replication Pathway Homeostasis to Suppress Opportunistic Transcription Reprogramming
Kristijan Ramadan,
University of Oxford, UK
SPRTN Is a Novel Mammalian Protease with the Central Role in DNA Replication-Coupled DNA-Protein Crosslink Repair
SPRTN Is a Novel Mammalian Protease with the Central Role in DNA Replication-Coupled DNA-Protein Crosslink Repair
Jason Sheltzer,
Cold Spring Harbor Laboratory, USA
Single-Chromosome Aneuploidy Commonly Functions as a Tumor Suppressor but Can Drive Genome Evolution
Single-Chromosome Aneuploidy Commonly Functions as a Tumor Suppressor but Can Drive Genome Evolution
Manuel Stucki,
University of Zurich, Switzerland
TOPBP1 Cooperate with TCOF1/Treacle in the Nucleolar Response to DNA Double-Strand Breaks
TOPBP1 Cooperate with TCOF1/Treacle in the Nucleolar Response to DNA Double-Strand Breaks
Maria Teresa Teixeira,
CNRS – UMR 8226, France
Telomere Replication in the Absence of Telomerase: Failure, Repair and Adaptation
Telomere Replication in the Absence of Telomerase: Failure, Repair and Adaptation
Johannes van den Boom,
University of Duisburg-Essen, Germany
The AAA-ATPase VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
The AAA-ATPase VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
Catherine H. Freudenreich,
Tufts University, USA
Cytosine Deamination Mediates R-Loop Dependent CAG Repeat Fragility and Instability
Cytosine Deamination Mediates R-Loop Dependent CAG Repeat Fragility and Instability
Muwen Kong,
University of Pittsburgh, USA
Auto-PARylation Switches PARP1 Search Mechanism from Three-Dimensional Diffusion to Anomalous One-Dimensional Sliding
Auto-PARylation Switches PARP1 Search Mechanism from Three-Dimensional Diffusion to Anomalous One-Dimensional Sliding
14:30—16:30
Workshop 2: Replication
*
Linda B. Bloom,
University of Florida, USA
Active Sliding Clamp Opening in Three Steps
Active Sliding Clamp Opening in Three Steps
Christopher Sansam,
Oklahoma Medical Research Foundation, USA
DNA Replication Timing during Development Anticipates Transcriptional Programs and Parallels Enhancer Activation
DNA Replication Timing during Development Anticipates Transcriptional Programs and Parallels Enhancer Activation
Boris Pfander,
Max Planck Institute of Biochemistry, Germany
Robust Replication Control by Temporal Gaps between Licensing and Firing Phases
Robust Replication Control by Temporal Gaps between Licensing and Firing Phases
Hasan Yardimci,
Francis Crick Institute, UK
Super-Resolution Fluorescence Imaging of DNA Replication Intermediates
Super-Resolution Fluorescence Imaging of DNA Replication Intermediates
Jon Baxter,
University of Sussex, UK
Transcription Promotes Replication Fork Rotation and Double-Stranded DNA Intertwining via a Cohesin-Dependent Pathway
Transcription Promotes Replication Fork Rotation and Double-Stranded DNA Intertwining via a Cohesin-Dependent Pathway
Ivan Psakhye,
IFOM, FIRC Institute of Molecular Oncology, Italy
DDK-Mediated Regulation of the deSUMOylating Enzyme Ulp2 Facilitates DNA Replication Initiation
DDK-Mediated Regulation of the deSUMOylating Enzyme Ulp2 Facilitates DNA Replication Initiation
17:00—18:45
Telomeres and Centromeres
*
Maria Teresa Teixeira,
CNRS – UMR 8226, France
Titia de Lange,
Rockefeller University, USA
How Shelterin Solves the Telomere End-Protection Problem
How Shelterin Solves the Telomere End-Protection Problem
Kerry S. Bloom,
University of North Carolina at Chapel Hill, USA
The Molecular Basis for the Centromere Spring
The Molecular Basis for the Centromere Spring
Nausica Arnoult,
The Salk Institute for Biological Studies, USA
Short Talk: Regulation of DNA Repair Pathway Choice in S/G2 by the NHEJ Inhibitor CYREN
Short Talk: Regulation of DNA Repair Pathway Choice in S/G2 by the NHEJ Inhibitor CYREN
Julia Promisel Cooper,
NCI, National Institutes of Health, USA
Telomeric Control of Kinetochore Assembly and Nuclear Envelope Breakdown
Telomeric Control of Kinetochore Assembly and Nuclear Envelope Breakdown
17:00—18:45
Finishing Recombination
Homology search, strand exchange, dealing with DNA joint molecules.
*
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Stephen C. Kowalczykowski,
University of California, Davis, USA
Molecular Functions and Single Molecule Studies of BRCA1, BRCA2, and RAD51 Paralogs
Molecular Functions and Single Molecule Studies of BRCA1, BRCA2, and RAD51 Paralogs
Petr Cejka,
University of Zurich, Switzerland
Processing of DNA Double-Strand Breaks for Repair by Homologous Recombination
Processing of DNA Double-Strand Breaks for Repair by Homologous Recombination
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Short Talk: Microhomology-Mediated Tandem Duplications form at Tus/Ter-Stalled Replication Forks in BRCA1 Mutant Cells
Short Talk: Microhomology-Mediated Tandem Duplications form at Tus/Ter-Stalled Replication Forks in BRCA1 Mutant Cells
Stephen C. West,
Francis Crick Institute, UK
Unresolved Recombination Intermediates as a Source of DNA Breaks and Chromosome Aberration
Unresolved Recombination Intermediates as a Source of DNA Breaks and Chromosome Aberration
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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