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This meeting took place in 2017
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Mononuclear Phagocytes in Health, Immune Defense and Disease (D3)
Organizer(s) Steffen Jung and Miriam Merad
April 30—May 4, 2017
Hyatt Regency Austin • Austin, TX USA
Discounted Abstract Deadline: Jan 9, 2017
Abstract Deadline: Jan 31, 2017
Scholarship Deadline: Jan 9, 2017
Discounted Registration Deadline: Feb 28, 2017
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.
Summary of Meeting:
Mononuclear phagocytes (MNP) are immune cells that are uniquely equipped to sense and respond to environmental cues by promoting tissue homeostasis or initiating tissue repair and immunity. MNP also contribute significantly to tissue pathologies, and their manipulation holds considerable therapeutic potential. MNP display major functional specializations. Most macrophages are established before birth and perform tissue-specific functions in organ development and homeostasis. Short-lived classical dendritic cells (DC) are specialized in triggering adaptive T cell immunity. Monocytes complement macrophages and DC as highly plastic cells, in particular during inflammation. While MNP subsets have been identified, individual contributions to health and disease are not well-defined. Breathtaking technological advance in genomic profiling of populations and single cells is revealing the breadth of MNP functions and identifying molecular checkpoints for targeted therapeutic intervention. These molecular efforts are paralleled by astounding progress in imaging capabilities, enabling the study of the cells in their physiological context. This meeting therefore aims to: 1) Cover recent progress in the field, revealing novel and differential contributions of MNP in physiological processes, and identify critical knowledge gaps; 2) Stimulate scientific exchange, in particular between clinicians and researchers, to better translate findings from animal models into human settings and brainstorm regarding novel therapeutic intervention; and 3) Develop novel conceptual frameworks for future studies of MNP in health and disease.
View Scholarships/Awards
Mononuclear phagocytes (MNP) are immune cells that are uniquely equipped to sense and respond to environmental cues by promoting tissue homeostasis or initiating tissue repair and immunity. MNP also contribute significantly to tissue pathologies, and their manipulation holds considerable therapeutic potential. MNP display major functional specializations. Most macrophages are established before birth and perform tissue-specific functions in organ development and homeostasis. Short-lived classical dendritic cells (DC) are specialized in triggering adaptive T cell immunity. Monocytes complement macrophages and DC as highly plastic cells, in particular during inflammation. While MNP subsets have been identified, individual contributions to health and disease are not well-defined. Breathtaking technological advance in genomic profiling of populations and single cells is revealing the breadth of MNP functions and identifying molecular checkpoints for targeted therapeutic intervention. These molecular efforts are paralleled by astounding progress in imaging capabilities, enabling the study of the cells in their physiological context. This meeting therefore aims to: 1) Cover recent progress in the field, revealing novel and differential contributions of MNP in physiological processes, and identify critical knowledge gaps; 2) Stimulate scientific exchange, in particular between clinicians and researchers, to better translate findings from animal models into human settings and brainstorm regarding novel therapeutic intervention; and 3) Develop novel conceptual frameworks for future studies of MNP in health and disease.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 30 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.
SUNDAY, APRIL 30
MONDAY, MAY 1
TUESDAY, MAY 2
WEDNESDAY, MAY 3
THURSDAY, MAY 4
FRIDAY, MAY 5
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 30 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 4 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, May 5 in order to fully experience the meeting.
SUNDAY, APRIL 30
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
*
Steffen Jung,
Weizmann Institute of Science, Israel
*
Miriam Merad,
Mount Sinai School of Medicine, USA
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Mononuclear Phagocytes in Homeostasis and Inflammation
Mononuclear Phagocytes in Homeostasis and Inflammation
09:30—11:45
Mononuclear Phagocyte Development
*
Steffen Jung,
Weizmann Institute of Science, Israel
Florent Ginhoux,
Singapore Immunology Network, Singapore
EMBO Young Investigator Lecture: Ontogeny of Mononuclear Phagocytes
EMBO Young Investigator Lecture: Ontogeny of Mononuclear Phagocytes
Coffee Break
Frederic Geissmann,
Memorial Sloan Kettering Cancer Center, USA
Monocytes (and Macrophages)
Monocytes (and Macrophages)
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
Deborah R. Winter,
Northwestern University, USA
Short Talk: The Transcriptional Program of Synovial Macrophages in Rheumatoid Arthritis
Short Talk: The Transcriptional Program of Synovial Macrophages in Rheumatoid Arthritis
14:30—16:30
Workshop 1: Monocytes, DC and Macrophages
Recent technical advances in profiling and imaging of MNP in healthy tissue and disease context.
*
Chen Varol,
Sourasky Medical Center and Tel-Aviv University, Israel
Helen S. Goodridge,
Cedars-Sinai Medical Center, USA
Independent Monocyte Production by Granulocyte-Monocyte Progenitors (GMPs) and Monocyte-Dendritic Cell Progenitors (MDPs)
Independent Monocyte Production by Granulocyte-Monocyte Progenitors (GMPs) and Monocyte-Dendritic Cell Progenitors (MDPs)
Pierre Guermonprez,
Kings College London, UK
The Heterogeneity of Ly6Chi Monocytes Controls their Differentiation into iNOS+ Macrophagesor Monocyte-Derived Dendritic Cells
The Heterogeneity of Ly6Chi Monocytes Controls their Differentiation into iNOS+ Macrophagesor Monocyte-Derived Dendritic Cells
Alexander Mildner,
Max-Delbrueck Center Berlin, Germany
Genomic Characterization of Murine Monocytes Reveals C/EBP-Beta Dependence of Ly6C-Cells
Genomic Characterization of Murine Monocytes Reveals C/EBP-Beta Dependence of Ly6C-Cells
Stefan Uderhardt,
National Institutes of Health, USA
Tissue-Resident Macrophages Cloak Tissue Microlesions to Control Neutrophil-Driven Inflammatory Damage
Tissue-Resident Macrophages Cloak Tissue Microlesions to Control Neutrophil-Driven Inflammatory Damage
Brian T. Edelson,
Washington University School of Medicine, USA
Regulation of Mononuclear Phagocyte IL-10 Production by Bhlhe40 Is Required to Resist Pulmonary Mtb Infection
Regulation of Mononuclear Phagocyte IL-10 Production by Bhlhe40 Is Required to Resist Pulmonary Mtb Infection
Roxane Tussiwand,
University of Basel, Switzerland
The Expression of IRF8 Defines Plasmacytoid Dendritic Cell Commitment
The Expression of IRF8 Defines Plasmacytoid Dendritic Cell Commitment
17:00—19:00
Mononuclear Phagocyte Maintenance
*
Deborah R. Winter,
Northwestern University, USA
Christopher K. Glass,
University of California, San Diego, USA
Exploiting Natural Genetic Variation to Understand Macrophage Identity and Function
Exploiting Natural Genetic Variation to Understand Macrophage Identity and Function
Michael H. Sieweke,
Technische Universitaet Dresden, Germany
Transcriptional Control of Macrophage Proliferation
Transcriptional Control of Macrophage Proliferation
Sarah A. Dick,
University Health Network, Canada
Short Talk: Embryonic Macrophages Are Maintained in the Aged Heart and Are Required for Repair
Short Talk: Embryonic Macrophages Are Maintained in the Aged Heart and Are Required for Repair
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Mononuclear Phagocytes at the Tissue Site
*
Florent Ginhoux,
Singapore Immunology Network, Singapore
Martin Guilliams,
Ghent University - VIB, Belgium
Development and Functional Specialization of Liver-Resident Kupffer Cells
Development and Functional Specialization of Liver-Resident Kupffer Cells
Gwendalyn J. Randolph,
Washington University, USA
Macrophages in the Serosal Cavity
Macrophages in the Serosal Cavity
Coffee Break
Wolfgang Kastenmüller,
University of Bonn, Germany
Intranodal T Cell - DC Interactions during Viral Infection
Intranodal T Cell - DC Interactions during Viral Infection
Sheau Yng Lim,
National University of Singapore, Singapore
Short Talk: The Origin and Maintenance of LYVE-1-Expressing Macrophages
Short Talk: The Origin and Maintenance of LYVE-1-Expressing Macrophages
17:00—19:00
Mononuclear Phagocytes in Gut Homeostasis and Inflammation
*
Miriam Merad,
Mount Sinai School of Medicine, USA
Carla V. Rothlin,
Yale University, USA
TAM Receptor Signaling in Resolution of Inflammation
TAM Receptor Signaling in Resolution of Inflammation
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Homostatic Immunity and the Microbiota
Homostatic Immunity and the Microbiota
Michael F. Goldberg,
University of Minnesota, USA
Short Talk: Colonization of Different Phagocyte Subsets Underlies the Pathogenesis of a Persistent Phagosomal Infection
Short Talk: Colonization of Different Phagocyte Subsets Underlies the Pathogenesis of a Persistent Phagosomal Infection
Ivaylo I. Ivanov,
Columbia University, USA
Short Talk: Innate Immune Cells in Regulation of Commensal Th17 Responses
Short Talk: Innate Immune Cells in Regulation of Commensal Th17 Responses
Milena Bogunovic,
UMass Medical School, USA
Short Talk: Macrophages as Regulators of Intestinal Neuroplasticity
Short Talk: Macrophages as Regulators of Intestinal Neuroplasticity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Mononuclear Phagocyte Interactions with the Central and Peripheral Nervous System
Marco Colonna,
Washington University School of Medicine, USA
Microglia-Driven Pathology, Trem2
Microglia-Driven Pathology, Trem2
Coffee Break
*
Burkhard Becher,
University of Zurich, Switzerland
The T Cell-Myeloid Connection in Chronic Inflammation
The T Cell-Myeloid Connection in Chronic Inflammation
Shoutang Wang,
Institut Gustave Roussy, France
Short Talk: Lyl-1 Controls Primitive Macrophages and Microglia Development
Short Talk: Lyl-1 Controls Primitive Macrophages and Microglia Development
14:30—16:30
Workshop 2: Regulation of DC and Macrophage Function in Health and Disease
*
Brian T. Edelson,
Washington University School of Medicine, USA
Carl Allen,
Baylor College of Medicine, USA
Braf-V600e in Blood and Brain and Response to Braf Inhibition Suggest Hematopoietic Origin of Neurodegeneration in Lch
Braf-V600e in Blood and Brain and Response to Braf Inhibition Suggest Hematopoietic Origin of Neurodegeneration in Lch
Caroline Hutter,
St. Anna Kinderspital, Austria
Notch Signaling Induces a Langerhans Cell Histiocytosis Gene Expression Signature in Human Monocytes
Notch Signaling Induces a Langerhans Cell Histiocytosis Gene Expression Signature in Human Monocytes
Margaret E. Warren,
Columbia University, USA
Notch Signaling Confers Optimal Phenotype and Function on in vitro-Generated Classical Dendritic Cells
Notch Signaling Confers Optimal Phenotype and Function on in vitro-Generated Classical Dendritic Cells
Briana Nixon,
Memorial Sloan Kettering Cancer Center, USA
The Role of the Notch Pathway in Tumor-Associated Macrophage Differentiation
The Role of the Notch Pathway in Tumor-Associated Macrophage Differentiation
Ashley Steed,
Washington University in St. Louis, USA
The Role of Type I Interferon during Influenza A Infection
The Role of Type I Interferon during Influenza A Infection
Lucie Van Emmenis,
University College London, UK
Characterization of Macrophages in Peripheral Nerve Regeneration
Characterization of Macrophages in Peripheral Nerve Regeneration
Richard E. Zigmond,
Case Western Reserve University, USA
The Role of Mononuclear Phagocytes in Peripheral Nerve Degeneration and Regeneration: A New Perspective
The Role of Mononuclear Phagocytes in Peripheral Nerve Degeneration and Regeneration: A New Perspective
17:00—19:00
Mononuclear Phagocytes, Inflammation and Therapy
*
Gwendalyn J. Randolph,
Washington University, USA
Gabriel D. Victora,
Rockefeller University, USA
Monitoring T Cell-APC Interactions in vivo
Monitoring T Cell-APC Interactions in vivo
Catherine Hedrick,
La Jolla Institute for Immunology, USA
Monocyte Heterogeneity: Implications for Cancer
Monocyte Heterogeneity: Implications for Cancer
Michele De Palma,
École Polytechnique Fédérale de Lausanne, Switzerland
Macrophage Reprogramming for Anti-Cancer Therapy
Macrophage Reprogramming for Anti-Cancer Therapy
Irit Sagi,
Weizmann Institute of Science, Israel
Short Talk: Macrophages Are Context- Dependent Builders or Destroyers of Collagenous Matrix
Short Talk: Macrophages Are Context- Dependent Builders or Destroyers of Collagenous Matrix
08:30—11:30
Molecular Control of Mononuclear Phagocytes
*
Brian D. Brown,
Mount Sinai School of Medicine, USA
Jorge Henao-Mejia,
University of Pennsylvania and Children's Hospital of Philadelphia, USA
Long Non-Coding RNAs and the Homeostasis Mononuclear Phagocytes
Long Non-Coding RNAs and the Homeostasis Mononuclear Phagocytes
Coffee Break
Boris Reizis,
New York University Langone Medical Center, USA
Transcriptional Control of Dendritic Cell Functionality
Transcriptional Control of Dendritic Cell Functionality
Adriana M. Mujal,
University of California, San Francisco, USA
Short Talk: Characterizing the Role of CD11b+ Dendritic Cell Subsets in Priming Anti-Tumor CD4 T Cell Responses
Short Talk: Characterizing the Role of CD11b+ Dendritic Cell Subsets in Priming Anti-Tumor CD4 T Cell Responses
17:00—18:45
Mononuclear Phagocytes and Cancer Treatment
Nina Bhardwaj,
Icahn School of Medicine at Mount Sinai, USA
Cancer-Induced Innate Immune Modulation
Cancer-Induced Innate Immune Modulation
*
Laurence Zitvogel,
Institut Gustave Roussy, France
Gut Microbiota Connects Mucosal and Tumoral Immune Responses
Gut Microbiota Connects Mucosal and Tumoral Immune Responses
Miriam Merad,
Mount Sinai School of Medicine, USA
Harnessing the Tumor Myeloid Micro-Environment to Enhance Cancer Treatment
Harnessing the Tumor Myeloid Micro-Environment to Enhance Cancer Treatment
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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