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This meeting took place in 2018
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Heart Failure: Crossing the Translational Divide (A1)
Organizer(s) Yibin Wang, Joseph A. Hill and Carolyn Lam
January 14—18, 2018
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Sep 21, 2017
Abstract Deadline: Oct 19, 2017
Scholarship Deadline: Sep 21, 2017
Discounted Registration Deadline: Nov 20, 2017
Sponsored by Amgen Inc.
Summary of Meeting:
Heart failure is a major human disease that afflicts millions of people worldwide. Intensive research in the past decade has yielded many exciting new mechanistic insights into the pathogenesis of heart failure, but progress toward successful therapies to prevent, halt and reverse heart failure has been painfully slow. The overall goal of this Keystone Symposia conference is to focus on heart failure and highlight the scientific advances in basic discovery and early-phase therapeutic development in this fast-moving field. The symposium will provide the field with an opportunity for robust discussion about the major issues crossing the translational divide from basic discovery to therapies.
View Scholarships/Awards
Heart failure is a major human disease that afflicts millions of people worldwide. Intensive research in the past decade has yielded many exciting new mechanistic insights into the pathogenesis of heart failure, but progress toward successful therapies to prevent, halt and reverse heart failure has been painfully slow. The overall goal of this Keystone Symposia conference is to focus on heart failure and highlight the scientific advances in basic discovery and early-phase therapeutic development in this fast-moving field. The symposium will provide the field with an opportunity for robust discussion about the major issues crossing the translational divide from basic discovery to therapies.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 18 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, January 19 in order to fully experience the meeting.
SUNDAY, JANUARY 14
MONDAY, JANUARY 15
TUESDAY, JANUARY 16
WEDNESDAY, JANUARY 17
THURSDAY, JANUARY 18
FRIDAY, JANUARY 19
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 14 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 18 with a closing plenary session from 17:00 to 19:30, followed by a social hour and entertainment. We recommend return travel on Friday, January 19 in order to fully experience the meeting.
SUNDAY, JANUARY 14
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Yibin Wang,
University of California, Los Angeles, David Geffen School of Medicine, USA
*
Joseph A. Hill,
University of Texas Southwestern Medical Center, USA
David C. Page,
Whitehead Institute for Biomedical Research, USA
Sex and Disease: Do Males and Females Read their Genomes Differently?
Sex and Disease: Do Males and Females Read their Genomes Differently?
09:00—11:30
HFrEF: Ischemic Heart Disease (I/R Injury and Cell Death)
*
Issei Komuro,
Tokyo University Graduate School, Japan
*
Zhao Wang,
University of Texas Southwestern Medical Center, USA
Laura Mauri,
Brigham and Women's Hospital, USA
What Ischemic HFrEF Looks like Clinically and What I Wish I Had in My Toolbox
What Ischemic HFrEF Looks like Clinically and What I Wish I Had in My Toolbox
Coffee Break
Richard N. Kitsis,
Albert Einstein College of Medicine, USA
Understanding and Therapeutically Manipulating Cell Death in the Heart
Understanding and Therapeutically Manipulating Cell Death in the Heart
Junichi Sadoshima,
Rutgers New Jersey Medical School, USA
Autosis Mediates Myocardial Cell Death During Ischemia/Reperfusion
Autosis Mediates Myocardial Cell Death During Ischemia/Reperfusion
Yusuke Morita,
Kyoto University, Japan
Short Talk: Spatiotemporal and Integrative Analysis of the Transcriptome and Metabolome Response to Systemic Energetic Starvation with Cardiac Dysfunction
Short Talk: Spatiotemporal and Integrative Analysis of the Transcriptome and Metabolome Response to Systemic Energetic Starvation with Cardiac Dysfunction
Dipayan Chaudhuri,
University of Utah, USA
Short Talk: Mitochondrial Cardiomyopathies Feature Compensatory Increases in Mitochondrial Calcium
Short Talk: Mitochondrial Cardiomyopathies Feature Compensatory Increases in Mitochondrial Calcium
14:30—16:30
Workshop and Panel 1: Does an X or Y Make a Difference for the Heart?
*
Joseph A. Hill,
University of Texas Southwestern Medical Center, USA
Does XX or XY Make the Heart Grow Fonder?
Does XX or XY Make the Heart Grow Fonder?
Leslie A. Leinwand,
University of Colorado Boulder, USA
A Woman is Not a Small Man: Sex Differences in the Heart
A Woman is Not a Small Man: Sex Differences in the Heart
David C. Page,
Whitehead Institute for Biomedical Research, USA
Translate Mechanism to Practice: For Sex Differences in HF
Translate Mechanism to Practice: For Sex Differences in HF
*
Vera Regitz-Zagrosek,
Charité - University Medicine Berlin, Germany
Translational Aspects of Sex Differences in Myocardial Ischemia and Hypertrophy
Translational Aspects of Sex Differences in Myocardial Ischemia and Hypertrophy
Carolyn Lam,
Duke-NUS Medical School, Singapore
Sex Differences in HF-Clinical Trial
Sex Differences in HF-Clinical Trial
17:00—19:00
Inflammation (Non-Ischemic) HFrEF
*
Donald R. Menick,
Medical University of South Carolina, USA
*
Merry L. Lindsey,
University of Nebraska Medical Center., USA
Douglas L. Mann,
Washington University School of Medicine, USA
What Inflammatory Cardiomyopathy Looks like Clinically and What I Wish I Had in My Toolbox
What Inflammatory Cardiomyopathy Looks like Clinically and What I Wish I Had in My Toolbox
Peter Liu,
University of Ottawa Heart Institute, Canada
Immune System as Sensor/Mediator for Progression in Heart Failure – Translational Considerations
Immune System as Sensor/Mediator for Progression in Heart Failure – Translational Considerations
Georg Daniel Duerr,
University of Bonn, Germany
Short Talk: Post-Conditioning with CpG-Containing TLR9 Ligand 1668-thioate Attenuates Inflammatory Response and Remodeling Leading to Less Fibrosis and Better Left Ventricular Function in Murine Myocardial Infarction
Short Talk: Post-Conditioning with CpG-Containing TLR9 Ligand 1668-thioate Attenuates Inflammatory Response and Remodeling Leading to Less Fibrosis and Better Left Ventricular Function in Murine Myocardial Infarction
Dian Cao,
University of Texas Southwestern Medical Center, USA
Short Talk: Cytosolic DNA Sensing Governs Myocardial Ischemic Injury by Promoting Macrophage Transformation
Short Talk: Cytosolic DNA Sensing Governs Myocardial Ischemic Injury by Promoting Macrophage Transformation
Shey-Shing Sheu,
Thomas Jefferson University, USA
Short Talk: Mitochondrial Fission Protein Drp1 Clustered at the Sarcoplasmic Reticulum-Mitochondria Junctions to Regulate Cardiac Excitation-Contraction-Energetics Coupling
Short Talk: Mitochondrial Fission Protein Drp1 Clustered at the Sarcoplasmic Reticulum-Mitochondria Junctions to Regulate Cardiac Excitation-Contraction-Energetics Coupling
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
HFrEF: Hypertensive Heart Disease (Hypertrophy, Fibrosis)
*
Hina Chaudhry,
Mount Sinai School of Medicine, USA
*
Dan Tong,
University of Texas Southwestern Medical Center, USA
Joseph A. Hill,
University of Texas Southwestern Medical Center, USA
What Hypertensive HFrEF Looks Like and What I Wish I Had in my Toolbox
What Hypertensive HFrEF Looks Like and What I Wish I Had in my Toolbox
Jeffery D. Molkentin,
Cincinnati Children's Hospital Medical Center, USA
Fibroblast Dynamics in the MI-Injured Heart
Fibroblast Dynamics in the MI-Injured Heart
Coffee Break
Mark E. Anderson,
Johns Hopkins University School of Medicine, USA
CaMKII as a Therapeutic Target in Heart Failure and Arrhythmias
CaMKII as a Therapeutic Target in Heart Failure and Arrhythmias
Toshiyuki Ko,
University of Tokyo, Japan
Short Talk: Single-Cell Analysis of Non-Cardiomyocytes Reveals a Critical Regulator of Cardiac Homeostasis
Short Talk: Single-Cell Analysis of Non-Cardiomyocytes Reveals a Critical Regulator of Cardiac Homeostasis
Rajan Jain,
University of Pennsylvania, School of Medicine, USA
Short Talk: The Role of Nuclear Architecture in Myocyte Determination and Genetic Cardiomyopathy
Short Talk: The Role of Nuclear Architecture in Myocyte Determination and Genetic Cardiomyopathy
14:30—16:30
Workshop and Panel 2: Big Data and Precision Medicine for Heart Failure
-Precision medicine: What does it mean?
-Conceptual foundation of precision medicine
-Precision medicine in HF clinical practice
-Precision medicine in drug discovery and clinical trials
*
Thomas Vondriska,
University of California, Los Angeles, USA
Peipei Ping,
University of California, Los Angeles, USA
Data Science in CV Biology and Medicine
Data Science in CV Biology and Medicine
Elizabeth M. McNally,
Northwestern University, USA
Genomic Solutions to Precision Medicine
Genomic Solutions to Precision Medicine
Daniel P. Kelly,
University of Pennsylvania, USA
Integrated Profiling Approaches to Delineating the Metabolic Origins of Heart Failure
Integrated Profiling Approaches to Delineating the Metabolic Origins of Heart Failure
17:00—19:15
PH and RV Failure
*
Kristina Lorenz,
Leibniz Institute for Analytical Sciences- ISAS, Germany
Wai Hong Wilson Tang,
Cleveland Clinic, USA
What Pulmonary Hypertension and Right Heart Failure Looks like Clinically and What I Wish I Had in My Toolbox
What Pulmonary Hypertension and Right Heart Failure Looks like Clinically and What I Wish I Had in My Toolbox
Stephan Rosenkranz,
Klinik III für Innere Medizin, Germany
Novel Targets in Pulmonary Vascular Disease and RV Dysfunction
Novel Targets in Pulmonary Vascular Disease and RV Dysfunction
Yibin Wang,
University of California, Los Angeles, David Geffen School of Medicine, USA
Role of Stress-Signaling in Post-Natal RV Development and Maturation
Role of Stress-Signaling in Post-Natal RV Development and Maturation
Yingjie Chen,
University of Minnesota, USA
Short Talk: Harnessing the T Cell Function as a New Direction in Attenuating the Transition from Left Heart Failure to Right Heart Failure through Modulating Lung Inflammation
Short Talk: Harnessing the T Cell Function as a New Direction in Attenuating the Transition from Left Heart Failure to Right Heart Failure through Modulating Lung Inflammation
*
Edda Spiekerkoetter,
Stanford University, USA
Short Talk: Increasing BMPR2 Signaling with FK506 (Tacrolimus) Reduces Cardiac Fibrosis and Improves Right Ventricular Adaptation in Pulmonary Hypertension
Short Talk: Increasing BMPR2 Signaling with FK506 (Tacrolimus) Reduces Cardiac Fibrosis and Improves Right Ventricular Adaptation in Pulmonary Hypertension
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
HFrEF and Metabolism
*
Chen Gao,
University of California, Los Angeles, USA
*
Gemma Figtree,
Kolling Institute, University of Sydney, Australia
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Mitochondrial Metabolism and Signaling Mechanisms in Heart Failure
Mitochondrial Metabolism and Signaling Mechanisms in Heart Failure
Peipei Ping,
University of California, Los Angeles, USA
The O-PTM Fingerprints of Mitochondrial Proteome: Molecular Signature and Functional Phenotype
The O-PTM Fingerprints of Mitochondrial Proteome: Molecular Signature and Functional Phenotype
Coffee Break
Daniel P. Kelly,
University of Pennsylvania, USA
Mitochondrial Remodeling in Heart Failure
Mitochondrial Remodeling in Heart Failure
Jiandong Liu,
University of North Carolina at Chapel Hill, USA
Short Talk: Lin28a Regulates Pathological Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis
Short Talk: Lin28a Regulates Pathological Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis
Gregory Aubert,
Loyola University, USA
Short Talk: SUR2 as a Regulator of Cardiac Metabolism Plasticity
Short Talk: SUR2 as a Regulator of Cardiac Metabolism Plasticity
14:30—16:30
Workshop and Panel 3: Pharma for HF, How NOT to Get Lost in Translation
*
Christine E. Seidman,
Harvard Medical School, USA
*
Daria Mochly-Rosen,
Stanford University, USA
Russell A. Miller,
Pfizer Inc., USA
Anthony J. Muslin,
Tectonic Therapeutic, Inc., USA
Robert N. Willette,
GlaxoSmithKline, USA
Aarif Y. Khakoo,
Amgen, USA
Yan G. Ni,
Regeneron, USA
17:00—19:15
HFrEF: Genetics and Epigenetics
*
Lisa Wilsbacher,
Northwestern University, USA
*
Ferhaan Ahmad,
University of Iowa, USA
Elizabeth M. McNally,
Northwestern University, USA
How Genetics Informs the Care of HF
How Genetics Informs the Care of HF
Christine E. Seidman,
Harvard Medical School, USA
Genetics of Cardiomyopathy: Insights into Cardiac Physiology and Disease
Genetics of Cardiomyopathy: Insights into Cardiac Physiology and Disease
Thomas Thum,
Medical School Hannover, Germany
Noncoding RNAs and Other Therapeutic Approaches in Cardiac Remodeling
Noncoding RNAs and Other Therapeutic Approaches in Cardiac Remodeling
Manuel Rosa-Garrido,
University of California, Los Angeles, USA
Short Talk: Elucidation of Gene Regulation Paradigms by Integrating Chromatin Architecture, Histone Marks and DNA Methylation in Failing Hearts
Short Talk: Elucidation of Gene Regulation Paradigms by Integrating Chromatin Architecture, Histone Marks and DNA Methylation in Failing Hearts
Anant Chopra,
Boston University, USA
Short Talk: From Tissues to Cells: Dissecting the Mechanisms of Genetic Cardiomyopathy using in vitro Engineered Disease Models
Short Talk: From Tissues to Cells: Dissecting the Mechanisms of Genetic Cardiomyopathy using in vitro Engineered Disease Models
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Keynote Address
*
Carolyn Lam,
Duke-NUS Medical School, Singapore
Daria Mochly-Rosen,
Stanford University, USA
Cardiac Disease: Crossing the Translational Divide
Cardiac Disease: Crossing the Translational Divide
09:00—11:30
HFpEF (Mechanisms and Therapy)
*
Robert S. Danziger,
University of Illinois at Chicago, USA
Coffee Break
Carolyn Lam,
Duke-NUS Medical School, Singapore
HFpEF Exists -- We Just Don’t Know What to Call It
HFpEF Exists -- We Just Don’t Know What to Call It
Wolfgang A. Linke,
University of Munster, Germany
Targeting Cardiomyocyte Structure and Function in HFpEF
Targeting Cardiomyocyte Structure and Function in HFpEF
Gabriele G. Schiattarella,
University of Texas Southwestern Medical Center, USA
Short Talk: XBP1s-FoxO1 Axis Regulates Lipid Metabolism and Cardiac Performance in Heart Failure with Preserved Ejection Fraction
Short Talk: XBP1s-FoxO1 Axis Regulates Lipid Metabolism and Cardiac Performance in Heart Failure with Preserved Ejection Fraction
Florin Despa,
University of Kentucky, USA
Short Talk: Diabetic HFpEF in a Rat Model of Systemic Amylin Dyshomeostasis
Short Talk: Diabetic HFpEF in a Rat Model of Systemic Amylin Dyshomeostasis
17:00—19:15
HFrEF (Cellular and Molecular Therapy)
*
Lior Zangi,
Icahn School of Medicine at Mount Sinai, USA
*
Lina A. Shehadeh,
University of Miami Miller School of Medicine, USA
Roger J. Hajjar,
Mount Sinai School of Medicine, USA
Gene Therapy for Heart Failure & Pulmonary Hypertension
Gene Therapy for Heart Failure & Pulmonary Hypertension
Hesham A. Sadek,
University of Texas Southwestern Medical Center, USA
Rethinking the Effect of Hypoxia on Cardiomyocytes
Rethinking the Effect of Hypoxia on Cardiomyocytes
Joseph C. Wu,
Stanford University School of Medicine, USA
Genomics and Stem Cells for Precision Cardiovascular Medicine
Genomics and Stem Cells for Precision Cardiovascular Medicine
Erik A. Blackwood,
San Diego State University, USA
Short Talk: Pharmacologic ATF6 Activation Reprograms Cellular Proteostasis to Mitigate Pathology in a Heart Disease Model
Short Talk: Pharmacologic ATF6 Activation Reprograms Cellular Proteostasis to Mitigate Pathology in a Heart Disease Model
Carmine Gentile,
University of Sydney, Australia
Short Talk: Cardiac Spheroid-Based Therapy for Heart Failure Patients
Short Talk: Cardiac Spheroid-Based Therapy for Heart Failure Patients
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
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