Herrenhausen Palace Floorplan
This meeting took place in 2018
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Pushing the Limits of Healthspan and Longevity (D3)
Organizer(s) Rochelle Buffenstein, Holly Brown-Borg and Colin Selman
April 15—19, 2018
Herrenhausen Palace • Hannover, Germany
Discounted Abstract Deadline: Dec 12, 2017
Abstract Deadline: Jan 10, 2018
Scholarship Deadline: Dec 12, 2017
Discounted Registration Deadline: Feb 13, 2018
Local Co-Organizer: Martin S. Denzel, Max Planck Institute for Biology of Aging.
Organized in collaboration with Volkswagen Foundation
Organized in collaboration with Volkswagen Foundation
Summary of Meeting:
This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans.
View Scholarships/Awards
This conference addresses factors that may contribute to healthier lifestyles and outcomes, thereby delaying the onset of age-associated diseases and extending longevity. The focus is to highlight cutting-edge advances in aging research, novel technologies and potential therapeutic interventions. Included are talks on mechanisms of aging in a wide range of established and non-traditional animal models with the key objective to enhance understanding of the basic biology behind experimental and lifestyle manipulations thought to have direct translational application to human aging. The conference will focus on topics not covered at previous Keystone Symposia meetings on aging biology and will specifically examine both the fundamental mechanisms involved in the aging process as well as interventions and potential therapeutics that may delay aging and the onset of age-associated diseases to forge a deeper understanding of the complex, multifactorial aging process. The discussions of novel interventions and/or therapeutics that appear to slow aging processes will, in turn, guide the field toward facilitating extended periods of good health and prolonging lifespan in humans.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 19 with a closing plenary session from 16:00 to 18:00, followed by dinner and entertainment. We recommend return travel on Friday, April 20 in order to fully experience the meeting.
SUNDAY, APRIL 15
MONDAY, APRIL 16
TUESDAY, APRIL 17
WEDNESDAY, APRIL 18
THURSDAY, APRIL 19
FRIDAY, APRIL 20
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 15 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 19 with a closing plenary session from 16:00 to 18:00, followed by dinner and entertainment. We recommend return travel on Friday, April 20 in order to fully experience the meeting.
SUNDAY, APRIL 15
16:00—20:00
Arrival and Registration
Grand Mussmann Hotel, Tivoli Room
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Central-Hotel Kaiserhof
08:30—09:30
Welcome and Keynote Address
Auditorium
*
Rochelle Buffenstein,
Calico Life Sciences LLC, USA
Session Chair
Session Chair
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Controlling Metabolism during Aging, Role of Insulin and Adipose Depots
Controlling Metabolism during Aging, Role of Insulin and Adipose Depots
09:30—12:00
Communicating to Save Thyself: Is a Single Signaling Path the Answer?
Auditorium
*
Rochelle Buffenstein,
Calico Life Sciences LLC, USA
Session Chair
Session Chair
Holly M. Brown-Borg,
University of North Dakota School of Medicine, USA
Growth Hormone Signaling and Longevity
Growth Hormone Signaling and Longevity
Coffee Break
Dana L. Miller,
University of Washington, USA
Fasting Protects against Hypoxia-Induced Protein Aggregation by Inducing Non-Canonical Insulin Signaling
Fasting Protects against Hypoxia-Induced Protein Aggregation by Inducing Non-Canonical Insulin Signaling
Reinhold G. Erben,
University of Veterinary Medicine Vienna, Austria
Role of the Klotho/FGF23 Signaling Axis in Aging
Role of the Klotho/FGF23 Signaling Axis in Aging
Paul L. Fox,
Lerner Research Institute, USA
Short Talk: Glutamyl-Prolyl tRNA Synthetase Is a Critical mTORC1-S6K1 Target Determining Adiposity and Lifespan in Mice
Short Talk: Glutamyl-Prolyl tRNA Synthetase Is a Critical mTORC1-S6K1 Target Determining Adiposity and Lifespan in Mice
Christopher G. Proud,
South Australian Health & Medical Research Institute, Australia
Short Talk: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Lifespan
Short Talk: Regulation of the Elongation Phase of Protein Synthesis Enhances Translation Accuracy and Lifespan
12:00—13:00
Lunch
Ballroom
12:30—13:00
Poster Setup
Ballroom
13:00—19:30
Poster Viewing
Ballroom
13:00—15:30
Poster Session 1
Ballroom
15:30—16:00
Coffee Available
Foyer
16:00—18:15
Good Fat, Bad Fat, Brown Fat, White Fat . . .
Auditorium
*
Colin Selman,
University of Glasgow, UK
Session Chair
Session Chair
Elisabetta Mueller,
New York University, USA
Transcriptional Control of Adipocyte Function in Aging
Transcriptional Control of Adipocyte Function in Aging
Barbara Cannon,
Stockholm University, Sweden
Environmental Temperature and Longevity
Environmental Temperature and Longevity
John Speakman,
Institute of Genetics and Developmental Biology, CAS, China
Does Dietary Protein Content Leverage Total Food Intake and Hence Drive Obesity?
Does Dietary Protein Content Leverage Total Food Intake and Hence Drive Obesity?
Susanne Klaus,
German Institute of Human Nutrition, Germany
Mitochondrial Uncoupling, Diet, and Aging in Mice
Mitochondrial Uncoupling, Diet, and Aging in Mice
18:15—19:30
Dinner
No registration fees are used to fund alcohol served at this function.
Ballroom
08:30—11:45
Trash Removal: Is Enhanced Proteostasis the Way Forward in Aging
Auditorium
*
David Gems,
University College London, UK
Session Chair
Session Chair
Rochelle Buffenstein,
Calico Life Sciences LLC, USA
Extreme Longevity in Naked Mole-Rats Is Associated with Upregulated Proteostasis
Extreme Longevity in Naked Mole-Rats Is Associated with Upregulated Proteostasis
Martin S. Denzel,
Max Planck Institute for Biology of Aging, Germany
Forward Genetic Approaches Reveal Multi-Layered Regulation of the Hexosamine Pathway that Modulates Protein Quality Control
Forward Genetic Approaches Reveal Multi-Layered Regulation of the Hexosamine Pathway that Modulates Protein Quality Control
Coffee Break
Karyn L. Hamilton,
Colorado State University, USA
Contribution of Changes in Cell Proliferation to Proteostasis in Long-Lived Models
Contribution of Changes in Cell Proliferation to Proteostasis in Long-Lived Models
Louis R. Lapierre,
Brown University, USA
A Novel and Druggable Modulator of HLH-30/TFEB, Autophagy and Lifespan
A Novel and Druggable Modulator of HLH-30/TFEB, Autophagy and Lifespan
Fabian Finger,
University of Cologne, Germany
Short Talk: Food Perception through a Pair of Olfactory Neurons Triggers Rewiring of Organismal Proteostasis
Short Talk: Food Perception through a Pair of Olfactory Neurons Triggers Rewiring of Organismal Proteostasis
Mario Ost,
German Institute of Human Nutrition, Germany
Short Talk: Elevated FGF21 during Aging Is Required to Preserve Hepatic Proteostasis and Metabolic Health
Short Talk: Elevated FGF21 during Aging Is Required to Preserve Hepatic Proteostasis and Metabolic Health
11:45—13:00
Lunch
Ballroom
12:30—13:00
Poster Setup
Ballroom
13:00—19:30
Poster Viewing
Ballroom
13:00—15:30
Poster Session 2
Ballroom
15:30—16:00
Coffee Available
Foyer
16:00—18:00
Powerhouse of the Cell: Manipulating Energy in Aging
Auditorium
*
Barbara Cannon,
Stockholm University, Sweden
Session Chair
Session Chair
William B. Mair,
Harvard School of Public Health, USA
Mitochondrial Dynamics and Healthy Aging
Mitochondrial Dynamics and Healthy Aging
Hazel H. Szeto,
Social Profit Network Research Laboratory, USA
Novel Peptides Target Cellular Powerhouses to Delay Aging and Mitigate Age-Related Chronic Conditions
Novel Peptides Target Cellular Powerhouses to Delay Aging and Mitigate Age-Related Chronic Conditions
Fernanda Marques da Cunha,
Federal University of São Paulo, Brazil
Short Talk: Mitochondrial Effects of Lifespan-Extending Interventions in Caenorhabditis elegans
Short Talk: Mitochondrial Effects of Lifespan-Extending Interventions in Caenorhabditis elegans
Jan Nedergaard,
Stockholm University, Sweden
Short Talk: Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice
Short Talk: Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice
18:00—19:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
08:30—11:30
Changing What and How We Eat and its Impact upon Healthspan
Auditorium
*
Holly M. Brown-Borg,
University of North Dakota School of Medicine, USA
Session Chair
Session Chair
Colin Selman,
University of Glasgow, UK
The Influence of Genetic Background on the Metabolic Responsiveness to Dietary Restriction in Mice
The Influence of Genetic Background on the Metabolic Responsiveness to Dietary Restriction in Mice
Matthew Piper,
Monash University, Australia
The Role of Amino Acid Balance in Lifespan and Health in Drosophila
The Role of Amino Acid Balance in Lifespan and Health in Drosophila
Coffee Break
Samantha Marie Biet,
University of Sydney, Australia
Extending Healthspan and Lifespan: Insights From Nutritional Geometry
Extending Healthspan and Lifespan: Insights From Nutritional Geometry
Olga Spadaro,
Yale University, USA
Short Talk: Caloric Restriction in Humans Inhibits Inflammation: Insights from CALERIE-II
Short Talk: Caloric Restriction in Humans Inhibits Inflammation: Insights from CALERIE-II
YongTian Liang,
Free University of Berlin & Charité, Germany
Short Talk: Spermidine and Dietary Restriction Converging on Mitochondrial Metabolism in a Model of Cognitive Aging
Short Talk: Spermidine and Dietary Restriction Converging on Mitochondrial Metabolism in a Model of Cognitive Aging
11:30—13:00
Lunch
Ballroom
12:30—13:00
Poster Setup
Ballroom
13:00—19:30
Poster Viewing
Ballroom
13:00—15:30
Poster Session 3
Ballroom
15:30—16:00
Coffee Available
Foyer
16:00—18:00
Swords, Targets and Cell Death: Combatting Senescence
Auditorium
*
Martin S. Denzel,
Max Planck Institute for Biology of Aging, Germany
Session Chair
Session Chair
Judith Campisi,
Buck Institute for Research on Aging, USA
Cellular Senescence: A Double-Edged Sword
Cellular Senescence: A Double-Edged Sword
Manlio Vinciguerra,
International Clinical Research Center, Czech Republic
Epigenetic Links between Senescence and Cancer Stemness
Epigenetic Links between Senescence and Cancer Stemness
Nathan K. LeBrasseur,
Mayo Clinic, USA
Senolytic Mechanism to Extend Healthspan
Senolytic Mechanism to Extend Healthspan
Anil Bhushan,
University of California, San Francisco, USA
Short Talk: Eliminating Senescent Beta Cells Prevents Type 1 Diabetes
Short Talk: Eliminating Senescent Beta Cells Prevents Type 1 Diabetes
18:00—19:30
Dinner
No registration fees are used to fund alcohol served at this function.
Ballroom
08:30—11:45
A View from Above: Aging at the Top of the Food Chain
Auditorium
*
Susanne Klaus,
German Institute of Human Nutrition, Germany
Session Chair
Session Chair
Riikka Hamalainen,
University of Eastern Finland, Finland
Mitochondrial DNA Mutagenesis and Aging
Mitochondrial DNA Mutagenesis and Aging
P. Eline Slagboom,
Leiden University, Netherlands
Three Generations of Human Top Survivors: What Have We Learned
Three Generations of Human Top Survivors: What Have We Learned
Coffee Break
Alexander Bürkle,
University of Konstanz, Germany
Biomarkers of Human Aging – The EU FP7 MARK-AGE Project and Beyond
Biomarkers of Human Aging – The EU FP7 MARK-AGE Project and Beyond
Pénélope Andreux,
Amazentis, Switzerland
Short Talk: Orally Administered Urolithin A Is Safe and Modulates Muscle and Mitochondrial Biomarkers in Elderly
Short Talk: Orally Administered Urolithin A Is Safe and Modulates Muscle and Mitochondrial Biomarkers in Elderly
Ian R. Lanza,
Mayo Clinic College of Medicine, USA
Short Talk: Therapeutic Potential of Dietary Omega-3 Fatty Acids in Aging Skeletal Muscle
Short Talk: Therapeutic Potential of Dietary Omega-3 Fatty Acids in Aging Skeletal Muscle
11:45—13:30
Lunch
Ballroom
13:30—15:30
Workshop
Auditorium
*
Karyn L. Hamilton,
Colorado State University, USA
Session Chair
Session Chair
David A. Ferenbach,
University of Edinburgh, UK
The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice
The Impact of a Young Circulation on Renal Injury and Fibrosis in Aged Mice
Zoe E. Gillespie,
University of Saskatchewan, Canada
Metformin Treatment and Amino Acid Restriction Induce Progerin Degradation in Hutchinson-Gilford Progeria Syndrome Fibroblasts
Metformin Treatment and Amino Acid Restriction Induce Progerin Degradation in Hutchinson-Gilford Progeria Syndrome Fibroblasts
Samir Morsli,
University of Sheffield, UK
Establishing a Model of Stress-Induced Senescence in Zebrafish Larvae
Establishing a Model of Stress-Induced Senescence in Zebrafish Larvae
Teresa G. Valencak,
University of Veterinary Medicine, Vienna, Austria
Becoming Obese and Hyperthermic en Miniature in Ames Dwarf Mice (Prop1 df/df)
Becoming Obese and Hyperthermic en Miniature in Ames Dwarf Mice (Prop1 df/df)
Reza Esmaillie,
University of Cologne, Germany
Dissecting the Role of Hypoxia-Signaling in Extracellular Matrix Formation of the Nematode
Dissecting the Role of Hypoxia-Signaling in Extracellular Matrix Formation of the Nematode
Johannes Grillari,
BOKU - University of Natural Resources and Applied Life Sciences Vienna, Austria
Extracellular Vesicles and their miRNA Cargo in Aging and Age-Associated Diseases
Extracellular Vesicles and their miRNA Cargo in Aging and Age-Associated Diseases
Irina G. Shabalina,
Stockholm University, Sweden
Upregulated Cytochrome b5 May Rescue Normal Androgen Production in Mitochondrial Respiratory Chain Deficient Leydig Cells from Prematurely Aging Mice
Upregulated Cytochrome b5 May Rescue Normal Androgen Production in Mitochondrial Respiratory Chain Deficient Leydig Cells from Prematurely Aging Mice
Asael Roichman,
Princeton University, USA
SIRT6 Controls Energy Metabolism to Regulate Lifespan and Healthspan
SIRT6 Controls Energy Metabolism to Regulate Lifespan and Healthspan
15:30—16:00
Coffee Available
Foyer
16:00—17:45
Drugging Aging - Interventions to Extend Human Health and Lifespan
Auditorium
*
Nathan K. LeBrasseur,
Mayo Clinic, USA
Session Chair
Session Chair
Andrew Phillips,
C4 Therapeutics, USA
Targeted Protein Degradation
Targeted Protein Degradation
David Gems,
University College London, UK
What Is an Anti-Aging Drug?
What Is an Anti-Aging Drug?
Pedro J. Beltran,
UNITY Biotechnology, USA
Senolytic Drugs: From Mutant Mice to Human Clinical Trials
Senolytic Drugs: From Mutant Mice to Human Clinical Trials
17:45—18:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Ballroom
18:00—19:30
Dinner
No registration fees are used to fund alcohol served at this function.
Ballroom
19:00—22:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Ballroom
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:
|
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support for this conference from:
|
|
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
Click here to view more of these organizations
|
If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |
