Lee Shau Kee Lecture Centre, Centennial Campus University of Hong Kong Floorplan
This meeting took place in 2017
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Regenerative Biology and Applications: Cell Differentiation, Tissue Organization and Biomedical Engineering (T3)
Organizer(s) Paul K.H. Tam, Urban Lendahl and Freda D. Miller
October 15—19, 2017
Lee Shau Kee Lecture Centre, Centennial Campus University of Hong Kong • Pok Fu Lam, Hong Kong
Discounted Abstract Deadline: Jun 15, 2017
Abstract Deadline: Jul 24, 2017
Scholarship Deadline: Jun 15, 2017
Discounted Registration Deadline: Aug 15, 2017
Organized in collaboration with the Croucher Foundation and The University of Hong Kong; Held in honor of the 130th Anniversary of The University of Hong Kong Li Ka Shing Faculty of Medicine
Summary of Meeting:
This four-day Keystone Symposia conference focuses on three important aspects of the rapidly developing area of regenerative biology: 1) The biology of the stem cell, with a focus on single-cell transcriptomics, deduction of cell lineage, pluripotency control and epigenetic regulation; 2) The tissue level, including the stem cell niche, organ generation, organoids and dysregulation of these processes in disease; and 3) Biomedical engineering and various types of disease modeling. Focusing on these three particular areas will prevent the meeting from being spread too thin over the entire realm of regenerative medicine, but will at the same time provide insights into research fields where progress currently occurs at blistering speed. The overall goal of the conference is to provide both late-breaking data for the experts in the fields as well as overviews in areas that will interest a broad scientific community. Across the three main themes, the aim is to blend discussions on a range of organs, such as liver, heart, bone and skin, with talks that cover novel tissue engineering and organoid biology principles. Speakers from both academia and industry who are at the forefront in disease modeling, organs-on-chips and drug discovery will present. With this three-pronged thematic approach, the conference will be focused, yet broad enough to foster an exciting cross-disciplinary discussion among speakers and attendees, which will be highly stimulating for the regenerative medicine community in Hong Kong and the rest of the world. This is vital for training the next-generation stem cell biologists and clinicians and to accelerate the pace at which basic science discoveries can be converted into clinical applications.
View Scholarships/Awards
This four-day Keystone Symposia conference focuses on three important aspects of the rapidly developing area of regenerative biology: 1) The biology of the stem cell, with a focus on single-cell transcriptomics, deduction of cell lineage, pluripotency control and epigenetic regulation; 2) The tissue level, including the stem cell niche, organ generation, organoids and dysregulation of these processes in disease; and 3) Biomedical engineering and various types of disease modeling. Focusing on these three particular areas will prevent the meeting from being spread too thin over the entire realm of regenerative medicine, but will at the same time provide insights into research fields where progress currently occurs at blistering speed. The overall goal of the conference is to provide both late-breaking data for the experts in the fields as well as overviews in areas that will interest a broad scientific community. Across the three main themes, the aim is to blend discussions on a range of organs, such as liver, heart, bone and skin, with talks that cover novel tissue engineering and organoid biology principles. Speakers from both academia and industry who are at the forefront in disease modeling, organs-on-chips and drug discovery will present. With this three-pronged thematic approach, the conference will be focused, yet broad enough to foster an exciting cross-disciplinary discussion among speakers and attendees, which will be highly stimulating for the regenerative medicine community in Hong Kong and the rest of the world. This is vital for training the next-generation stem cell biologists and clinicians and to accelerate the pace at which basic science discoveries can be converted into clinical applications.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, October 15 with registration from 18:00 to 20:00. Conference events conclude on Thursday, October 19 with a closing plenary session from 15:30 to 19:30, followed by dinner. We recommend return travel on Friday, October 20 in order to fully experience the meeting.
SUNDAY, OCTOBER 15
MONDAY, OCTOBER 16
TUESDAY, OCTOBER 17
WEDNESDAY, OCTOBER 18
THURSDAY, OCTOBER 19
FRIDAY, OCTOBER 20
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, October 15 with registration from 18:00 to 20:00. Conference events conclude on Thursday, October 19 with a closing plenary session from 15:30 to 19:30, followed by dinner. We recommend return travel on Friday, October 20 in order to fully experience the meeting.
SUNDAY, OCTOBER 15
18:00—20:00
Arrival and Registration
Time and location changed from HKU to Hotel Jen due to weather. Registration will also be available tomorrow in the Grand Hall Foyer Monday from 7:30am.
Hotel Jen Foyer
07:30—08:00
Arrival and Registration
Grand Hall Foyer, Lee Shau Kee Lecture Centre, HKU
09:00—09:15
Welcoming Remarks
Peter Mathieson, President and Vice-Chancellor, University of Hong Kong, Hong Kong
Sophia Chan Siu-chee, Secretary for Food and Health, Hong Kong
Nicolas W. Yang, Secretary for Innovation and Technology, Hong Kong
Sophia Chan Siu-chee, Secretary for Food and Health, Hong Kong
Nicolas W. Yang, Secretary for Innovation and Technology, Hong Kong
09:15—10:15
Keynote Address
Grand Hall
*
Freda D. Miller,
Hospital for Sick Children, Canada
Session Chair
Session Chair
10:15—12:45
Pluripotency and Differentiation of Stem Cells
Grand Hall
*
Patrick P.L. Tam,
Children's Medical Research Institute, Australia
Session Chair
Session Chair
*
Elly S.W. Ngan,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Andrew Hutchins,
Southern University of Science and Technology, China
The Use of Gene Modification Technologies and the Potential Use in Humans
The Use of Gene Modification Technologies and the Potential Use in Humans
Coffee Break
Pentao Liu,
Wellcome Trust Sanger Institute, UK
Establishment of Cultures of Mammalian Expanded Potential Stem Cells
Establishment of Cultures of Mammalian Expanded Potential Stem Cells
Huck-Hui Ng,
Genome Institute of Singapore, Singapore
Systems Biology of Stem Cells
Systems Biology of Stem Cells
Michelle M.W. Chan,
University of California, San Francisco, USA
Short Talk: Assembling Cell Lineages Using an Evolvable Barcoding Strategy to Probe Mammalian Development
Short Talk: Assembling Cell Lineages Using an Evolvable Barcoding Strategy to Probe Mammalian Development
David R. Hyde,
University of Notre Dame, USA
Short Talk: Transcriptomic and Epigenomic Changes during Müller Glia Reprogramming in the Regenerating Zebrafish Retina
Short Talk: Transcriptomic and Epigenomic Changes during Müller Glia Reprogramming in the Regenerating Zebrafish Retina
12:45—14:00
Networking Lunch
Lecture Hall LG 2
14:00—16:15
Molecular Regulation of Stem Cells
Grand Hall
*
David R. Kaplan,
Hospital for Sick Children, Canada
Session Chair
Session Chair
*
Wood Yee Chan,
Chinese University of Hong Kong, Hong Kong
Session Chair
Session Chair
Urban Lendahl,
Karolinska Institutet, Sweden
Notch Signaling and Vascular Differentiation
Notch Signaling and Vascular Differentiation
Ana Martin-Villalba,
DKFZ German Cancer Research Center, Germany
Chromatin as a Hub Integrating Environmental Signals and Fate Decisions in Adult Neural Stem Cells
Chromatin as a Hub Integrating Environmental Signals and Fate Decisions in Adult Neural Stem Cells
Timm Schroeder,
ETH Zürich, Switzerland
Long-Term Single Cell Quantification: New Tools for Old Questions
Long-Term Single Cell Quantification: New Tools for Old Questions
András Simon,
Karolinska Institutet, Sweden
Short Talk: Reading and Editing a Salamander Genome Reveals Novel Features of Tetrapod Regeneration
Short Talk: Reading and Editing a Salamander Genome Reveals Novel Features of Tetrapod Regeneration
Jan Kaslin,
Australian Regenerative Medicine Institute, Australia
Short Talk: Make Do and Make New: How Zebrafish Rapidly Regenerates CNS Injury
Short Talk: Make Do and Make New: How Zebrafish Rapidly Regenerates CNS Injury
16:15—16:45
Poster Teasers for Poster Session 1
3-minute poster teaser talks
Lecture Hall LG 2
*
David R. Kaplan,
Hospital for Sick Children, Canada
Session Chair
Session Chair
*
Wood Yee Chan,
Chinese University of Hong Kong, Hong Kong
Session Chair
Session Chair
Shermaine Eng,
Agency for Science Technology and Research A-STAR, Singapore
Investigating the Human Teashirt Genes TSHZ2 and TSHZ3 in Pancreatic and Endocrine Lineage Commitment Using Genome-Modified Human Embryonic Stem Cells (hESC)
Investigating the Human Teashirt Genes TSHZ2 and TSHZ3 in Pancreatic and Endocrine Lineage Commitment Using Genome-Modified Human Embryonic Stem Cells (hESC)
Suji Kim,
Yeungnam University College of Medicine, South Korea
The Role of p90RSK in Pulmonary Fibrosis
The Role of p90RSK in Pulmonary Fibrosis
Anil Chandrashekran,
King's College London, UK
Characterizing a Liver-Organoid System for the Treatment of Acute Live Failure
Characterizing a Liver-Organoid System for the Treatment of Acute Live Failure
Paschalis Efstathopoulos,
Karolinska Institutet, Sweden
A Novel Method to Increase Reproducibility of Ventral Midbrain Organoids Derived from Human Pluripotent Stem Cells
A Novel Method to Increase Reproducibility of Ventral Midbrain Organoids Derived from Human Pluripotent Stem Cells
Wenqiang Fan,
University of Mainz, Germany
Role of Hippo Signaling in Adult Neural Stem Cell Homeostasis
Role of Hippo Signaling in Adult Neural Stem Cell Homeostasis
Jie Shi Chua,
University of Utah, USA
Manipulating GAG Biosynthesis to Guide the Fate and Growth of Neuronal Progenitors
Manipulating GAG Biosynthesis to Guide the Fate and Growth of Neuronal Progenitors
Dmitry Penkov,
Russian Cardiological Institute, Russia
Prep1 Is a New Player in Adipogenic Differentiation of Mesenchymal Progenitors
Prep1 Is a New Player in Adipogenic Differentiation of Mesenchymal Progenitors
18:00—22:00
Optional Dinner Gathering
Jumbo Kingdom
08:30—09:00
Poster Setup
Lecture Hall LG 2
09:00—19:30
Poster Viewing
Lecture Hall LG 2
09:00—12:00
Tissue Organization (The Stem Cell Niche)
Grand Hall
*
Ronald A. Li,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
*
Martin C.H. Cheung,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Yechiel Elkabetz,
Max-Planck Institute for Molecular Genetics, Germany
Neural Stem Cells/Epigenetics
Neural Stem Cells/Epigenetics
Michael Rudnicki,
Ottawa Hospital Research Institute, Canada
Molecular Regulation of Muscle Stem Cell Function
Molecular Regulation of Muscle Stem Cell Function
Coffee Break
Guo-li Ming,
University of Pennsylvania, USA
Engineering Brain-Region-Specific Organoids for Neural Development and Brain Disease Modeling
Engineering Brain-Region-Specific Organoids for Neural Development and Brain Disease Modeling
Christopher S. Chen,
Boston University, USA
Engineering 3D Culture Models of Physiology and Disease
Engineering 3D Culture Models of Physiology and Disease
12:00—13:30
Networking Lunch
Lecture Hall LG 2
12:30—15:30
Poster Session 1
Organizer judges panel will browse the posters for Poster Prize consideration.
Lecture Hall LG 2
15:00—15:30
Coffee Available
Lecture Hall LG 2
15:30—17:30
Tissue Organization (Generating Tissue-Specific Cells)
Grand Hall
*
Edwin H. Chan,
Chinese University of Hong Kong, Hong Kong
Session Chair
Session Chair
*
Stephanie K.Y. Ma,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Kristin J. Hope,
McMaster Stem Cell and Cancer Research Institute, Canada
Molecular Mechanisms that Regulate Hematopoietic Stem Cell Expansion
Molecular Mechanisms that Regulate Hematopoietic Stem Cell Expansion
David Piper,
Thermo Fisher Scientific, USA
Improvements in the Genome Engineering of iPSCs to Build Disease Models for Screening
Improvements in the Genome Engineering of iPSCs to Build Disease Models for Screening
Mahendra S. Rao,
New York Stem Cell Foundation, USA
Generation of Clinical-Grade Pluripotent Stem Cells
Generation of Clinical-Grade Pluripotent Stem Cells
17:30—19:30
Reception
No registration fees are used to fund alcohol served at this function.
Lecture Hall LG 2
09:00—12:00
Tissue Organization (Physiological and Pathophysiological Development of Organ Systems) I
Grand Hall
*
Hsiao-Yuan Lee,
Academia Sinica, Taiwan
Session Chair
Session Chair
*
Kathryn S.E. Cheah,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Berthold Göttgens,
Cambridge Institute for Medical Research, UK
Cellular States and Regulatory Networks of Normal and Leukaemic Blood Cell Development
Cellular States and Regulatory Networks of Normal and Leukaemic Blood Cell Development
Freda D. Miller,
Hospital for Sick Children, Canada
Cellular Mechanisms Underlying Adult Mammalian Digit Tip Regeneration
Cellular Mechanisms Underlying Adult Mammalian Digit Tip Regeneration
Coffee Break
Yukiko Gotoh,
University of Tokyo, Japan
Regulation of Embryonic and Adult Neural Stem Cell Fate
Regulation of Embryonic and Adult Neural Stem Cell Fate
Paul K.H. Tam,
University of Hong Kong, Hong Kong
Neural Crest Stem Cells and Hirschsprung Disease
Neural Crest Stem Cells and Hirschsprung Disease
10:20—12:00
Poster Setup
Lecture Hall LG 2
12:00—16:30
Poster Viewing
Lecture Hall LG 2
12:00—14:00
Networking Lunch
Lecture Hall LG 2
14:00—16:00
Tissue Organization (Physiological and Pathophysiological Development of Organ Systems) II
Grand Hall
*
Ola Hermanson,
Karolinska Institutet, Sweden
*
Danny Chan,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Hongkui Deng,
Peking University, China
Small Molecule-Induced Cell Fate Reprogramming
Small Molecule-Induced Cell Fate Reprogramming
Benedikt Berninger,
King's College London, UK
Unfolding of a Developmental Program during Lineage Conversion of Human Brain Pericytes into Neurons by Synergistic Ascl1 and Sox2
Unfolding of a Developmental Program during Lineage Conversion of Human Brain Pericytes into Neurons by Synergistic Ascl1 and Sox2
Jessica Lehoczky,
Brigham and Women's Hospital, Harvard Medical School, USA
Short Talk: A Role for Lgr6 in Mouse Digit Tip Regeneration
Short Talk: A Role for Lgr6 in Mouse Digit Tip Regeneration
Carmine Gentile,
University of Sydney, Australia
Short Talk: Cardiac Spheroid Co-Cultures as Novel in vitro Models to Study the Human Heart Microenvironment
Short Talk: Cardiac Spheroid Co-Cultures as Novel in vitro Models to Study the Human Heart Microenvironment
16:00—16:30
Poster Teasers for Poster Session 2
3-minute poster teaser talks
Lecture Hall LG 2
*
Hsiao-Yuan Lee,
Academia Sinica, Taiwan
Session Chair
Session Chair
*
Kathryn S.E. Cheah,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Allan Patrick Stephane Renom,
Hong Kong University of Science and Technology, Hong Kong
Investigating the Role of Ca2+ Signaling during Zebrafish Embryonic Heart Development
Investigating the Role of Ca2+ Signaling during Zebrafish Embryonic Heart Development
Marcelo J. Salierno,
University Medical Center Johannes Gutenberg University Mainz, Germany
Controlling Somal Translocation of Embryonic Cortical Neurons
Controlling Somal Translocation of Embryonic Cortical Neurons
Natalia Soshnikova,
Institute of Molecular Biology, Germany
Defining Lgr5+ Embryonic Intestinal Progenitor Niche Using Single Cell Transcriptomics
Defining Lgr5+ Embryonic Intestinal Progenitor Niche Using Single Cell Transcriptomics
Nam Myeong-Ok,
CHA University, South Korea
Effects of a Small Molecule R-Spondin-1 Substitute RS-246204 on a Mouse Intestinal Organoid Culture
Effects of a Small Molecule R-Spondin-1 Substitute RS-246204 on a Mouse Intestinal Organoid Culture
Chia-Ning Shen,
Academia Sinica, Taiwan
ABCG2 Deficiency in Hepatocytes Disrupts Mitochondrial Fusion/Fission Balance and Impairs Reprogramming-Mediated Liver Repairing
ABCG2 Deficiency in Hepatocytes Disrupts Mitochondrial Fusion/Fission Balance and Impairs Reprogramming-Mediated Liver Repairing
Sharon W.S. Tan,
National University of Singapore, Singapore
Redox Homeostasis Is Essential for the Maintenance of the Drosophila Testis Germline Stem Cells
Redox Homeostasis Is Essential for the Maintenance of the Drosophila Testis Germline Stem Cells
Hannah M. Thomas,
University of South Australia, Australia
Flightless I Regulation of Pericyte Function in Diabetic Wounds
Flightless I Regulation of Pericyte Function in Diabetic Wounds
16:30—18:30
On Own for Dinner
09:00—15:30
Poster Viewing
Lecture Hall LG 2
09:00—10:00
Keynote Address
Grand Hall
*
Urban Lendahl,
Karolinska Institutet, Sweden
Session Chair
Session Chair
Hans C. Clevers,
F. Hoffmann-La Roche Ltd, Switzerland
Lgr5 Stem Cell-Based Organoids in Human Disease
Lgr5 Stem Cell-Based Organoids in Human Disease
10:00—12:30
Stem Cells for Biomedical Engineering
Grand Hall
*
Xian-Jie Yang,
University of California, Los Angeles, USA
Session Chair
Session Chair
*
Mai Har Sham,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
Lorenz Studer,
Memorial Sloan Kettering Cancer Center, USA
Parkinson's Disease
Parkinson's Disease
Coffee Break
Himanshu Kaul,
University of Toronto, Canada
Engineering Early Human Development
Engineering Early Human Development
Molly S. Shoichet,
University of Toronto, Canada
Using Biomimetic Strategies to Design Hydrogels for 3D Cell Culture
Using Biomimetic Strategies to Design Hydrogels for 3D Cell Culture
Sunny S.K. Chan,
University of Minnesota, USA
Short Talk: Teratomas Harbor Skeletal Muscle Stem Cells with Extremely High Functional Regenerative Potency
Short Talk: Teratomas Harbor Skeletal Muscle Stem Cells with Extremely High Functional Regenerative Potency
Dhvanit I. Shah,
, USA
Short Talk: Bioreactor Simulating Mechanosensation Stimulates Hematopoietic Stem Cell Formation
Short Talk: Bioreactor Simulating Mechanosensation Stimulates Hematopoietic Stem Cell Formation
12:30—13:30
Networking Lunch
Lecture Hall LG 2
12:30—15:30
Poster Session 2
Organizer judges panel will browse the posters for Poster Prize consideration.
Lecture Hall LG 2
15:00—15:30
Coffee Available
Lecture Hall LG 2
15:30—17:30
Biomedical Engineering for Stem Cells
Grand Hall
*
Hans C. Clevers,
F. Hoffmann-La Roche Ltd, Switzerland
Session Chair
Session Chair
*
Dong Sun,
City University of Hong Kong, Hong Kong
Session Chair
Session Chair
Benjamin F. L. Lai,
, Canada
Short Talk: Perfusable Vascularized Tissues for Drug Testing and Modeling Inter-Organ Biological Events on a Microfluidic Plate
Short Talk: Perfusable Vascularized Tissues for Drug Testing and Modeling Inter-Organ Biological Events on a Microfluidic Plate
Lee L. Rubin,
Harvard University, USA
Improving Neural Function
Improving Neural Function
Paolo De Coppi,
University College London, UK
Engineering Gut Tissue: A Step-by-Step Approach
Engineering Gut Tissue: A Step-by-Step Approach
17:30—17:45
Meeting Wrap-Up: Outcomes and Future Directions
Grand Hall
*
Paul K.H. Tam,
University of Hong Kong, Hong Kong
Session Chair
Session Chair
18:30—19:30
Social Hour
No registration fees are used to fund alcohol served at this function.
Café Malacca, Hotel Jen
19:30—21:00
Buffet Dinner
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
Café Malacca
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:
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We gratefully acknowledge additional support for this conference from:
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We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:
We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:
Click here to view more of these organizations
Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:
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If your organization is interested in joining these entities in support of Keystone
Symposia, please contact: John Monson,
Director of Corporate Relations, Email: johnm@keystonesymposia.org, Phone:+1 970-262-2690 Click here for more information on Industry Support and Recognition Opportunities. If you are interested in becoming an advertising/marketing in-kind partner, please contact: Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org, Phone:+1 970-262-1179 |
