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This meeting took place in 2018
Here are the related meetings in 2021:
Precision Engineering of the Genome, Epigenome and Transcriptome (EK24)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Precision Genome Editing with Programmable Nucleases (B1)
Organizer(s) Jin-Soo Kim, Feng Zhang and Daniel F. Voytas
January 28—February 1, 2018
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 3, 2017
Abstract Deadline: Nov 1, 2017
Scholarship Deadline: Oct 3, 2017
Discounted Registration Deadline: Dec 5, 2017
Sponsored by Editas Medicine, Regeneron Pharmaceuticals, Inc., Sangamo Therapeutics, Inc. and Vertex Pharmaceuticals Incorporated
Summary of Meeting:
Genome editing refers to the use of programmable DNA-targeting platforms to manipulate genetic and epigenetic information in living cells and organisms. Genome editing has been recently democratized by the development of RNA-guided endonucleases repurposed from CRISPR-Cas microbial defense systems against viruses or plasmids. Whereas novel tools such as Cpf1 and RNA-guided deaminases are being developed to expand the scope of genome editing, old tools such as ZFNs and TALENs are likely to undergo innovations as well. These tools enable genome-wide genetic screens in cell lines and genetic studies in both model and non-model organisms. Furthermore, genome editing holds great promise for broad applications in medicine and biotechnology, raising public interest and concerns. Yet genome editing is still limited by many factors such as inefficient delivery in vivo, off-target effects, and unwanted, alternative DNA repair. This conference offers opportunities to learn about new developments, advancements and applications in the field.
View Scholarships/Awards
Genome editing refers to the use of programmable DNA-targeting platforms to manipulate genetic and epigenetic information in living cells and organisms. Genome editing has been recently democratized by the development of RNA-guided endonucleases repurposed from CRISPR-Cas microbial defense systems against viruses or plasmids. Whereas novel tools such as Cpf1 and RNA-guided deaminases are being developed to expand the scope of genome editing, old tools such as ZFNs and TALENs are likely to undergo innovations as well. These tools enable genome-wide genetic screens in cell lines and genetic studies in both model and non-model organisms. Furthermore, genome editing holds great promise for broad applications in medicine and biotechnology, raising public interest and concerns. Yet genome editing is still limited by many factors such as inefficient delivery in vivo, off-target effects, and unwanted, alternative DNA repair. This conference offers opportunities to learn about new developments, advancements and applications in the field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.
SUNDAY, JANUARY 28
MONDAY, JANUARY 29
TUESDAY, JANUARY 30
WEDNESDAY, JANUARY 31
THURSDAY, FEBRUARY 1
FRIDAY, FEBRUARY 2
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.
SUNDAY, JANUARY 28
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Jin-Soo Kim,
Institute for Basic Science, South Korea
Jennifer A. Doudna,
HHMI/University of California, Berkeley, USA
CRISPR Systems: Nature’s Toolkit for Genome Editing
CRISPR Systems: Nature’s Toolkit for Genome Editing
09:00—11:30
DNA Repair and Genome Editing
*
Jacob E. Corn,
ETH Zürich, Switzerland
Maria Jasin,
Memorial Sloan Kettering Cancer Center, USA
Protecting the Genome by Homologous Recombination
Protecting the Genome by Homologous Recombination
Coffee Break
Eric A. Hendrickson,
University of Minnesota Medical School, USA
The Mechanisms of Precise Genome Editing Using Oligonucleotide Donors
The Mechanisms of Precise Genome Editing Using Oligonucleotide Donors
Eugene V. Koonin,
National Institutes of Health, USA
CRISPRICITY: A Metric for Measuring CRISPR Association and a Comprehensive Census of Cas Proteins
CRISPRICITY: A Metric for Measuring CRISPR Association and a Comprehensive Census of Cas Proteins
Chance Meers,
Georgia Institute of Technology, USA
Short Talk: Transcript-RNA from an Actively Transcribed Gene Accurately Repairs a DNA Double-Strand Break via a Homology- Driven Mechanism
Short Talk: Transcript-RNA from an Actively Transcribed Gene Accurately Repairs a DNA Double-Strand Break via a Homology- Driven Mechanism
Anastasia Lomova,
University of California, Los Angeles, USA
Short Talk: Improving Gene Editing by Temporal Control of DNA Repair
Short Talk: Improving Gene Editing by Temporal Control of DNA Repair
11:30—11:45
NIH Somatic Cell Genome Editing Program: Overview
*
Elizabeth Wilder,
National Institutes of Health, USA
14:30—16:30
Workshop: Easi-CRISPR: CRISPRing Made Easier
The workshop is based on Easi (Efficient additions with ssDNA inserts)-CRISPR, a recently developed method at the laboratories of Drs. Masato Ohtsuka (Tokai Univeristy, Japan) and C.B. Gurumurthy, which is now becoming a widely used approach for achieving higher knock-in efficiencies via homology directed repair. The workshop will cover: 1) General introduction to animal model generation; 2) Overview of animal model generation methods during pre- and post-CRISPR era; 3) Introduction to Easi-CRISPR and its applications; 4) Examples (case studies) of Easi-CRISPR animal model designs; 5) Hands-on workshop on Easi-CRISPR animal model designs; and 6) Demonstration of animal model designing using participant’s projects (time permitting).
Relevant publications on Easi-CRISPR: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1220-4 https://www.nature.com/articles/nprot.2017.153
Pre-prints of Easi-CRISPR: https://www.biorxiv.org/content/early/2017/05/23/141424 https://www.biorxiv.org/content/early/2016/08/17/069963
Relevant publications on Easi-CRISPR: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-017-1220-4 https://www.nature.com/articles/nprot.2017.153
Pre-prints of Easi-CRISPR: https://www.biorxiv.org/content/early/2017/05/23/141424 https://www.biorxiv.org/content/early/2016/08/17/069963
*
Gurumurthy B. Channabasavaiah,
University of Nebraska Omaha, USA
17:00—19:00
Genome Editing Methods and Novel Tools I
Jonathan Samuel Gootenberg,
Harvard University, USA
Expanding the Genome Editing Toolbox by Harnessing Microbial Diversity
Expanding the Genome Editing Toolbox by Harnessing Microbial Diversity
David R. Liu,
Broad Institute, HHMI, and Harvard University, USA
Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells
Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells
J. Keith Joung,
Massachusetts General Hospital, USA
Efficient Gene Editing and Gene Regulation Using CRISPR-Cpf1 Nuclease Technology
Efficient Gene Editing and Gene Regulation Using CRISPR-Cpf1 Nuclease Technology
Evan August Boyle,
Stanford University, USA
Short Talk: High-Throughput Biochemical Profiling of dCas9 Association and Dissociation Kinetics Uncovers New Rules for Off-Target Binding
Short Talk: High-Throughput Biochemical Profiling of dCas9 Association and Dissociation Kinetics Uncovers New Rules for Off-Target Binding
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Genome Editing Methods and Novel Tools II
*
Charles Gersbach,
Duke University, USA
Scot A. Wolfe,
University of Massachusetts Medical School, USA
Orthogonal Cas9-Cas9 Fusions Provide a Versatile Platform for Precise Genome Editing
Orthogonal Cas9-Cas9 Fusions Provide a Versatile Platform for Precise Genome Editing
Jin-Soo Kim,
Institute for Basic Science, South Korea
Genome-Wide Target Specificities of CRISPR Nucleases and Deaminases
Genome-Wide Target Specificities of CRISPR Nucleases and Deaminases
Coffee Break
Jacob E. Corn,
ETH Zürich, Switzerland
Discovery of Stimulation-Responsive Immune Enhancers with CRISPR Activation
Discovery of Stimulation-Responsive Immune Enhancers with CRISPR Activation
Keiji Nishida,
Kobe University, Japan
Genome Editing with Non-Nuclease Editors from Bacteria to Plants
Genome Editing with Non-Nuclease Editors from Bacteria to Plants
Alister Funnell,
Altius Institute for Biomedical Sciences, USA
Short Talk: High-Scale in situ Functional Mapping and Quantitative Engineering of Regulatory DNA
Short Talk: High-Scale in situ Functional Mapping and Quantitative Engineering of Regulatory DNA
Omar Abudayyeh,
Massachusetts Institute of Technology, USA
Short Talk: Harnessing RNA Targeting CRISPR Systems for Transcriptome Engineering and Human Health
Short Talk: Harnessing RNA Targeting CRISPR Systems for Transcriptome Engineering and Human Health
17:00—19:00
Epigenome Editing and Gene Regulation
*
Scot A. Wolfe,
University of Massachusetts Medical School, USA
Charles Gersbach,
Duke University, USA
Epigenome Editing for Gene Therapy, Cell Programming and Functional Epigenomics
Epigenome Editing for Gene Therapy, Cell Programming and Functional Epigenomics
Jennifer Mitchell,
University of Toronto, Canada
Uncovering Distal Regulatory Element Function Using CRISPR Genome Engineering
Uncovering Distal Regulatory Element Function Using CRISPR Genome Engineering
Joseph M. Miano,
University of Rochester, USA
Short Talk: CRISPR Interrogation of Regulatory Sequence Function in Mice
Short Talk: CRISPR Interrogation of Regulatory Sequence Function in Mice
Chris Richardson,
University of California, Berkeley, USA
Short Talk: The Fanconi Anemia Pathway Plays a Key Role in Templated Repair at CRISPR-Cas9 Cut Sites
Short Talk: The Fanconi Anemia Pathway Plays a Key Role in Templated Repair at CRISPR-Cas9 Cut Sites
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Genetic Screening via CRISPR
*
Edward J. Rebar,
Sangamo Therapeutics, Inc., USA
Reuven Agami,
Netherlands Cancer Institute, Netherlands
Functional Genetic Screens of Regulatory DNA Elements
Functional Genetic Screens of Regulatory DNA Elements
Coffee Break
Neville Sanjana,
New York Genome Center & NYU, USA
New Frontiers for Pooled Screens: Finding Regulatory Elements in the Noncoding Genome and Capturing Multi-Cell Interactions
New Frontiers for Pooled Screens: Finding Regulatory Elements in the Noncoding Genome and Capturing Multi-Cell Interactions
Danwei Huangfu,
Memorial Sloan Kettering Cancer Institute, USA
Human Development and Disease through the Lens of Pluripotent Stem Cells
Human Development and Disease through the Lens of Pluripotent Stem Cells
Bushra Raj,
Harvard University, USA
Short Talk: Single-Cell Transcriptional Profiling Coupled with Lineage Tracing via Mutable Barcodes in the Vertebrate Brain
Short Talk: Single-Cell Transcriptional Profiling Coupled with Lineage Tracing via Mutable Barcodes in the Vertebrate Brain
Jason D. Arroyo,
Pfizer, USA
Short Talk: Using Human Genetics and Functional Genomics for a Locus-to-Gene Approach to Drug Target Validation
Short Talk: Using Human Genetics and Functional Genomics for a Locus-to-Gene Approach to Drug Target Validation
11:15—12:15
Panel: Somatic Cell Genome Editing Program: Discussion with NIH
*
Timothy LaVaute,
NINDS, National Institutes of Health, USA
17:00—19:00
Therapeutic Genome Editing
*
Randall J. Platt,
ETH Zurich, Switzerland
Edward J. Rebar,
Sangamo Therapeutics, Inc., USA
Therapeutic Genome Editing and Gene Regulation Using Designed Zinc Finger Proteins
Therapeutic Genome Editing and Gene Regulation Using Designed Zinc Finger Proteins
Charles F. Albright,
Editas Medicine, USA
Development of a Subretinally-Delivered, CEP290-Specific CRISPR Medicine for the Treatment of Leber Congenital Amaurosis 10 (LCA10)
Development of a Subretinally-Delivered, CEP290-Specific CRISPR Medicine for the Treatment of Leber Congenital Amaurosis 10 (LCA10)
Pavitra Roychoudhury,
University of Washington, USA
Short Talk: Rational Design and Evaluation of CRISPR/Cas9 Strategies for HIV Cure
Short Talk: Rational Design and Evaluation of CRISPR/Cas9 Strategies for HIV Cure
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Plant and Animal Biotechnology
*
Daniel F. Voytas,
University of Minnesota, USA
Caixia Gao,
Chinese Academy of Sciences, China
Genome Editing with Programmable Nucleases in Crop Plants
Genome Editing with Programmable Nucleases in Crop Plants
Coffee Break
Daniel F. Voytas,
University of Minnesota, USA
Editing the Plant Genome
Editing the Plant Genome
Weizhi Ji,
Kunming University of Science and Technology, China
Primate Gene Editing and Human Complex Disease Study
Primate Gene Editing and Human Complex Disease Study
Mariette Andersson,
Swedish University of Agricultural Sciences, Sweden
Short Talk: CRISPR-Cas9 Takes Several Bites in the Potato Genome- Efficient Targeted Multiallelic Mutagenesis in Tetraploid Solanum tuberosum
Short Talk: CRISPR-Cas9 Takes Several Bites in the Potato Genome- Efficient Targeted Multiallelic Mutagenesis in Tetraploid Solanum tuberosum
Asim Ahmad Beg,
University of Michigan, USA
Short Talk: A Rapid and Facile C. elegans Genome Engineering Pipeline Using CRISPR/Cas9 Ribonucleoproteins
Short Talk: A Rapid and Facile C. elegans Genome Engineering Pipeline Using CRISPR/Cas9 Ribonucleoproteins
17:00—18:45
Human Germline Editing and ELSI
*
Jin-Soo Kim,
Institute for Basic Science, South Korea
Kathy K. Niakan,
Francis Crick Institute, UK
Genome Editing Reveals a Role for OCT4 in Human Embryogenesis
Genome Editing Reveals a Role for OCT4 in Human Embryogenesis
Shoukrat Mitalipov,
Oregon Health & Science University, USA
Human Germline Gene Correction
Human Germline Gene Correction
Tetsuya Ishii,
Hokkaido University, Japan
The Potential Guidelines for Germline Genome Editing in Clinics
The Potential Guidelines for Germline Genome Editing in Clinics
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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