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This meeting took place in 2018
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Noncoding RNAs: Form, Function, Physiology (C2)
Organizer(s) Joshua T. Mendell, Igor Ulitsky and Sohail F. Tavazoie
February 25—March 1, 2018
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 24, 2017
Abstract Deadline: Nov 21, 2017
Scholarship Deadline: Oct 24, 2017
Discounted Registration Deadline: Dec 19, 2017
Sponsored by Ionis Pharmaceuticals, Inc.
Summary of Meeting:
Recent research has revealed pervasive transcription of eukaryotic genomes outside of protein-coding genes. The resulting noncoding RNA transcripts come in many forms, perform diverse functions and play critical roles in organismal health and disease. Tens of thousands of noncoding RNAs have been identified so far, but we are still at the earliest stages of understanding their regulation and function. Such knowledge will be critical in order to harness the full potential of noncoding RNAs for the diagnosis and treatment of human diseases. To address this gap in our understanding, this conference aims to: 1) Bring together a multi-disciplinary group of scientists at all career stages to share their latest research in this field; 2) Provide a forum for the presentation of cutting-edge data on noncoding RNA structure, function and their roles in physiology and disease; and 3) Offer junior scientists outstanding mentoring and networking opportunities through close interactions with senior investigators. It is anticipated that the interactions of participants with diverse backgrounds, expertise and experimental models will spur new lines of investigation and collaborations that will lead to breakthroughs in our understanding of the noncoding transcriptome.
View Scholarships/Awards
Recent research has revealed pervasive transcription of eukaryotic genomes outside of protein-coding genes. The resulting noncoding RNA transcripts come in many forms, perform diverse functions and play critical roles in organismal health and disease. Tens of thousands of noncoding RNAs have been identified so far, but we are still at the earliest stages of understanding their regulation and function. Such knowledge will be critical in order to harness the full potential of noncoding RNAs for the diagnosis and treatment of human diseases. To address this gap in our understanding, this conference aims to: 1) Bring together a multi-disciplinary group of scientists at all career stages to share their latest research in this field; 2) Provide a forum for the presentation of cutting-edge data on noncoding RNA structure, function and their roles in physiology and disease; and 3) Offer junior scientists outstanding mentoring and networking opportunities through close interactions with senior investigators. It is anticipated that the interactions of participants with diverse backgrounds, expertise and experimental models will spur new lines of investigation and collaborations that will lead to breakthroughs in our understanding of the noncoding transcriptome.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.
SUNDAY, FEBRUARY 25
MONDAY, FEBRUARY 26
TUESDAY, FEBRUARY 27
WEDNESDAY, FEBRUARY 28
THURSDAY, MARCH 1
FRIDAY, MARCH 2
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.
SUNDAY, FEBRUARY 25
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Session Chair
Session Chair
09:00—11:15
Evolution and Structure of Noncoding RNAs
*
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Session Chair
Session Chair
Igor Ulitsky,
Weizmann Institute of Science, Israel
Sequences Enriched in Alu Repeats Drive Nuclear Localization of Long RNAs in Human Cells
Sequences Enriched in Alu Repeats Drive Nuclear Localization of Long RNAs in Human Cells
Coffee Break
Kevin Weeks,
University of North Carolina, USA
Structure-Based Discovery of New Functions in Large RNAs
Structure-Based Discovery of New Functions in Large RNAs
Yashar Niknafs,
University of Michigan, USA
Short Talk: Oncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNA
Short Talk: Oncogenic Role of THOR, a Conserved Cancer/Testis Long Noncoding RNA
17:00—19:00
Prokaryotic and Viral Noncoding RNAs
*
Howard Y. Chang,
Stanford University, USA
Session Chair
Session Chair
Jörg Vogel,
University of Würzburg, Germany
Grad-seq Discovers the Third Domain of Small RNA-mediated Gene Regulation in Bacteria
Grad-seq Discovers the Third Domain of Small RNA-mediated Gene Regulation in Bacteria
Roee Amit,
Technion - Israel Institute of Technology, Israel
Short Talk: Short CU-Rich Motifs Insulate Bacterial Genes from Transcriptional Read-Through
Short Talk: Short CU-Rich Motifs Insulate Bacterial Genes from Transcriptional Read-Through
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Noncoding RNAs in Epigenetic Regulation
*
John L. Rinn,
University of Colorado Boulder, USA
Session Chair
Session Chair
Jeannie T. Lee,
Massachusetts General Hospital / Harvard Medical School, USA
How RNA Recruits Epigenetic Complexes to the X-Chromosome
How RNA Recruits Epigenetic Complexes to the X-Chromosome
Neil Brockdorff,
University of Oxford, UK
Chromosome Silencing by Xist RNA
Chromosome Silencing by Xist RNA
Coffee Break
Roberto Bonasio,
University of Pennsylvania, USA
Regulation of Chromatin Complexes by Protein–RNA Interactions
Regulation of Chromatin Complexes by Protein–RNA Interactions
Xiaohua Shen,
Tsinghua University, China
Cis-Acting lncRNAs in Transcription and Chromatin Regulation
Cis-Acting lncRNAs in Transcription and Chromatin Regulation
Chen Davidovich,
Monash University, Australia
Short Talk: Mechanism for RNA-Mediated Regulation of the Histone Methyltransferase Polycomb Repressive Complex 2 (PRC2)
Short Talk: Mechanism for RNA-Mediated Regulation of the Histone Methyltransferase Polycomb Repressive Complex 2 (PRC2)
Amanda J. Whipple,
Harvard University, USA
Short Talk: Neuronal Functions of Imprinted, Noncoding RNAs
Short Talk: Neuronal Functions of Imprinted, Noncoding RNAs
14:30—16:30
Workshop: Highlights of Submitted Abstracts
*
Susan B. Carpenter,
University of California, Santa Cruz, USA
Session Chair
Session Chair
*
David L. Spector,
Cold Spring Harbor Laboratory, USA
Session Chair
Session Chair
Amanda Louise Gervaise,
Baylor College of Medicine, USA
Global Profiling Identifies Germline miRNAs Functioning During Oogenesis in C. elegans
Global Profiling Identifies Germline miRNAs Functioning During Oogenesis in C. elegans
Yunsun Nam,
University of Texas Southwestern Medical Center, USA
Heme Enables Proper Positioning of Drosha and DGCR8 on Primary microRNAs
Heme Enables Proper Positioning of Drosha and DGCR8 on Primary microRNAs
Yoo Jane Han,
University of Chicago, USA
Circular RNAs Expressed from the BRCA1 Pseudogene Regulates the DNA Damage Response through SERBP1 RNA-Binding Protein
Circular RNAs Expressed from the BRCA1 Pseudogene Regulates the DNA Damage Response through SERBP1 RNA-Binding Protein
Rui Zhou,
Johns Hopkins University School of Medicine, USA
The Circular RNA Edis Modulates Innate Immunity and Neurodevelopment in Drosophila
The Circular RNA Edis Modulates Innate Immunity and Neurodevelopment in Drosophila
Andre Verdel,
Institut for Advanced Biosciences, France
A New lncRNA-based Mechanism Controlling Sexual Differentiation and Heterochromatin Gene Silencing in Fission Yeast
A New lncRNA-based Mechanism Controlling Sexual Differentiation and Heterochromatin Gene Silencing in Fission Yeast
Martina Rossi,
Università degli Studi di Genova, Genoa (UNIGE), Italy
LncRNA EPR Orchestrates Epithelial Gene Expression Program in Mammary Gland Cells
LncRNA EPR Orchestrates Epithelial Gene Expression Program in Mammary Gland Cells
Musaddeque Ahmed,
Princess Margaret Cancer Centre, Canada
CRISPRi Screening of Susceptibility Regulatory Regions and Long Noncoding RNAs in Prostate Cancer
CRISPRi Screening of Susceptibility Regulatory Regions and Long Noncoding RNAs in Prostate Cancer
Joon H. Choi,
University of Texas at Austin, USA
The Triphosphatase DUSP11 Controls the Level and Immunostimulatory Activity of Alu Transcripts
The Triphosphatase DUSP11 Controls the Level and Immunostimulatory Activity of Alu Transcripts
17:00—19:00
Noncoding RNAs in Subcellular Organization
*
Jeannie T. Lee,
Massachusetts General Hospital / Harvard Medical School, USA
Session Chair
Session Chair
Tetsuro Hirose,
Osaka University, Japan
Dissection of Elements and Machinery of Architectural Noncoding RNAs
Dissection of Elements and Machinery of Architectural Noncoding RNAs
David L. Spector,
Cold Spring Harbor Laboratory, USA
Targeting Long Noncoding RNAs to Impact Breast Cancer Progression
Targeting Long Noncoding RNAs to Impact Breast Cancer Progression
John L. Rinn,
University of Colorado Boulder, USA
High-Throughput Identification of RNA Nuclear Enrichment Sequences
High-Throughput Identification of RNA Nuclear Enrichment Sequences
Miha Modic,
Helmholtz Zentrum München, Germany
Short Talk: Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
Short Talk: Cross-Regulation between TDP-43 and Paraspeckles Promotes Pluripotency-Differentiation Transition
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Transcriptional and Post-Transcriptional Regulation by Noncoding RNAs
*
Matthias W. Hentze,
European Molecular Biology Laboratory, Germany
Session Chair
Session Chair
Reuven Agami,
Netherlands Cancer Institute, Netherlands
Transcriptional Control by lncRNAs
Transcriptional Control by lncRNAs
Susan B. Carpenter,
University of California, Santa Cruz, USA
Genetic Models Reveal Cis and Trans Functions for LincRNA-Cox2
Genetic Models Reveal Cis and Trans Functions for LincRNA-Cox2
Coffee Break
Joshua T. Mendell,
University of Texas Southwestern Medical Center, USA
Noncoding RNAs in Post-Transcriptional Regulatory Circuits
Noncoding RNAs in Post-Transcriptional Regulatory Circuits
Irene Bozzoni,
University La Sapienza, Rome, Italy
Long Noncoding RNAs and Circular RNAs in the Control of Muscle Differentiation
Long Noncoding RNAs and Circular RNAs in the Control of Muscle Differentiation
Olof S. Dallner,
Rockefeller University, USA
Short Talk: Quantitative Regulation of the Leptin Gene by a Fat-Specific lncRNA
Short Talk: Quantitative Regulation of the Leptin Gene by a Fat-Specific lncRNA
Ramesh S. Pillai,
University of Geneva, Switzerland
Short Talk: Regulation of m6A Transcripts by YTHDC2 Is Essential for Meiosis in the Mammalian Germline
Short Talk: Regulation of m6A Transcripts by YTHDC2 Is Essential for Meiosis in the Mammalian Germline
17:00—19:00
Non-Canonical Roles of tRNAs, snoRNAs, and Repetitive RNAs
*
Irene Bozzoni,
University La Sapienza, Rome, Italy
Session Chair
Session Chair
Sohail F. Tavazoie,
Rockefeller University, USA
tRNA Fragments in Hypoxic Response and Cancer Progression
tRNA Fragments in Hypoxic Response and Cancer Progression
Britt Glaunsinger,
University of California, Berkeley and HHMI, USA
Repetitive Noncoding RNAs in Viral Pathogenesis
Repetitive Noncoding RNAs in Viral Pathogenesis
Matthias W. Hentze,
European Molecular Biology Laboratory, Germany
Regulation of Selective Autophagy by the Small Noncoding Vault RNA1-1
Regulation of Selective Autophagy by the Small Noncoding Vault RNA1-1
Benjamin R. Hawley,
Weill Cornell Medicine, USA
Short Talk: Drosha Drives the Formation of DNA:RNA Hybrids around DNA Break Sites to Facilitate DNA Damage Repair
Short Talk: Drosha Drives the Formation of DNA:RNA Hybrids around DNA Break Sites to Facilitate DNA Damage Repair
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Noncoding RNAs in Disease
*
Sohail F. Tavazoie,
Rockefeller University, USA
Session Chair
Session Chair
Stefanie Dimmeler,
University of Frankfurt, Germany
Noncoding RNAs in Cardiovascular Diseases
Noncoding RNAs in Cardiovascular Diseases
Coffee Break
Caroline Woo,
Translate Bio, USA
Targeting lncRNAs for Gene Upregulation Using Oligonucleotides as a Therapeutic Modality
Targeting lncRNAs for Gene Upregulation Using Oligonucleotides as a Therapeutic Modality
Stefano Gustincich,
Italian Institute of Technology, Italy
SINEUPs: A Versatile Tool to Increase Protein Synthesis
SINEUPs: A Versatile Tool to Increase Protein Synthesis
Ashish Lal,
NCI, National Institutes of Health, USA
Short Talk: Regulating the Regulator: Long Noncoding RNAs in the p53 Network in Colorectal Cancer
Short Talk: Regulating the Regulator: Long Noncoding RNAs in the p53 Network in Colorectal Cancer
Doug Hanniford,
New York University Langone Medical Center, USA
Short Talk: CDR1as Arises from a lncRNA Transcript which Is Epigenetically Silenced to Drive Melanoma Metastasis
Short Talk: CDR1as Arises from a lncRNA Transcript which Is Epigenetically Silenced to Drive Melanoma Metastasis
17:00—18:45
Unconventional RNA Form and Function
*
Igor Ulitsky,
Weizmann Institute of Science, Israel
Session Chair
Session Chair
Ling-Ling Chen,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Biogenesis of Circular RNAs
Biogenesis of Circular RNAs
Antonio J. Giraldez,
Yale University School of Medicine, USA
Noncoding RNAs and Peptides in Zebrafish Development
Noncoding RNAs and Peptides in Zebrafish Development
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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