Hyatt Regency Austin Floorplan
This meeting took place in 2018
Here are the related meetings in 2023:
Molecular Basis of Healthy Aging (X6)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Aging, Inflammation and Immunity (X2)
Organizer(s) Bonnie B. Blomberg and Graham Pawelec
February 25—March 1, 2018
Hyatt Regency Austin • Austin, TX USA
Discounted Abstract Deadline: Oct 26, 2017
Abstract Deadline: Nov 29, 2017
Scholarship Deadline: Oct 26, 2017
Discounted Registration Deadline: Dec 21, 2017
This activity was supported by an educational grant from Celgene Corporation
Joint Meeting:
Immunological Memory: Innate, Adaptive and Beyond (X1)
Summary of Meeting:
The world’s aging population and problems with morbidity have been increasing rapidly. Decreases in immune function and increases in chronic inflammation with age are a major contributor to age-related diseases. This Keystone Symposia conference will provide a venue for researchers from around the world to discuss current findings and fundamental research to understand the mechanisms underlying declining immune function, increasing chronic inflammation, and possible interventions. The meeting will address essential aspects of aging/longevity research, with particular emphasis on the immune system and inflammation including effects of immunosenescence on cancer, autoimmunity, vaccine response and infectious disease. Longitudinal studies on aging and immunity, frailty and effects on mortality, quality of life and survival will also be covered as well as biomarkers of the aging immune system, mechanisms for generating chronic inflammation including the SASP, telomeres and the microbiome, regulation of aging and age-related immune function, and therapeutic approaches to slow aging and/or improve the immune system. The adaptive, innate and mucosal immune systems will be covered as these systems have a significant impact on human aging. Questions to be addressed include: 1) What changes in the immune system contribute to the observed decline in immune function and increase in the chronic inflammatory state? 2) How do diseases of aging or decreased immunity develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from interdisciplinary areas on aging, inflammation and immunology and will focus first on the human and secondly the murine immune systems.
View Scholarships/Awards
The world’s aging population and problems with morbidity have been increasing rapidly. Decreases in immune function and increases in chronic inflammation with age are a major contributor to age-related diseases. This Keystone Symposia conference will provide a venue for researchers from around the world to discuss current findings and fundamental research to understand the mechanisms underlying declining immune function, increasing chronic inflammation, and possible interventions. The meeting will address essential aspects of aging/longevity research, with particular emphasis on the immune system and inflammation including effects of immunosenescence on cancer, autoimmunity, vaccine response and infectious disease. Longitudinal studies on aging and immunity, frailty and effects on mortality, quality of life and survival will also be covered as well as biomarkers of the aging immune system, mechanisms for generating chronic inflammation including the SASP, telomeres and the microbiome, regulation of aging and age-related immune function, and therapeutic approaches to slow aging and/or improve the immune system. The adaptive, innate and mucosal immune systems will be covered as these systems have a significant impact on human aging. Questions to be addressed include: 1) What changes in the immune system contribute to the observed decline in immune function and increase in the chronic inflammatory state? 2) How do diseases of aging or decreased immunity develop, and what can be done to prevent or reverse them? To address these questions, the symposium will gather investigators from interdisciplinary areas on aging, inflammation and immunology and will focus first on the human and secondly the murine immune systems.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.
SUNDAY, FEBRUARY 25
MONDAY, FEBRUARY 26
TUESDAY, FEBRUARY 27
WEDNESDAY, FEBRUARY 28
THURSDAY, MARCH 1
FRIDAY, MARCH 2
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, March 1 with a closing plenary session and keynote address from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, March 2 in order to fully experience the meeting.
SUNDAY, FEBRUARY 25
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—10:00
Welcome and Keynote Session (Joint)
*
Rafi Ahmed,
Emory University School of Medicine, USA
Session Chair
Session Chair
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Session Chair
Session Chair
Rino Rappuoli,
Fondazione Biotecnopolo di Siena, Italy
Vaccines 2018
Vaccines 2018
Vishwa Deep Dixit,
Yale University, USA
Immunometabolic Regulation of Healthspan
Immunometabolic Regulation of Healthspan
Coffee Break
10:30—12:45
Lifestyle, Epigenetics, Interventions
*
Vishwa Deep Dixit,
Yale University, USA
Session Chair
Session Chair
Nir Barzilai,
Albert Einstein College of Medicine, USA
Moving to Translational Geroscience
Moving to Translational Geroscience
Manel Esteller,
Josep Carreras Leukaemia Research Institute, Spain
Cancer Epigenetics: From Knowledge to Applications
Cancer Epigenetics: From Knowledge to Applications
Valter D. Longo,
University of Southern California, USA
Dietary Interventions
Dietary Interventions
Duygu Ucar,
The Jackson Laboratory, USA
Short Talk: The Chromatin Accessibility Signature of Human Immune Aging Stems from CD8+ T Cells
Short Talk: The Chromatin Accessibility Signature of Human Immune Aging Stems from CD8+ T Cells
Leena Bharath,
Boston University, USA
Short Talk: Effects of Metformin on Aging-Related Immune Cell Dysfunction
Short Talk: Effects of Metformin on Aging-Related Immune Cell Dysfunction
10:30—12:45
Initial Reactions: Forming Innate Memory
*
Steven L. Reiner,
Columbia University, USA
Session Chair
Session Chair
Lewis L. Lanier,
University of California, San Francisco, USA
NK Cells Remember
NK Cells Remember
Joseph C. Sun,
Memorial Sloan Kettering Cancer Center, USA
Immunological Memory in Innate Lymphocytes
Immunological Memory in Innate Lymphocytes
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Homeostatic Immunity to the Microbiota
Homeostatic Immunity to the Microbiota
Fadi G. Lakkis,
University of Pittsburgh, USA
Short Talk: Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
Short Talk: Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
Samantha B. Larsen,
NYU Langone, USA
Short Talk: Inflammatory Memory Sensitizes Skin Epithelial Stem Cells to Tissue Damage
Short Talk: Inflammatory Memory Sensitizes Skin Epithelial Stem Cells to Tissue Damage
17:00—19:00
Longitudinal Studies on Aging and Immunity
*
Daniela Frasca,
University of Miami, USA
Session Chair
Session Chair
Graham Pawelec,
University of Tübingen, Germany
Immune Parameters Associated with Mortality in the Elderly Are Context-Dependent: Lessons from Sweden, Holland and Belgium
Immune Parameters Associated with Mortality in the Elderly Are Context-Dependent: Lessons from Sweden, Holland and Belgium
Luigi Ferrucci,
NIA, National Institutes of Health, USA
Blood Inflammatory Mediators and Aging: Causes and Consequences
Blood Inflammatory Mediators and Aging: Causes and Consequences
Allison E. Aiello,
University of North Carolina at Chapel Hill, USA
Stress, Immunity, Infection and Cellular Aging in Population-Based Studies
Stress, Immunity, Infection and Cellular Aging in Population-Based Studies
Rebecca G. Reed,
University of Kentucky, USA
Short Talk: Stress, Cytomegalovirus, and Immunosenescence: A Longitudinal Study of Older Adults
Short Talk: Stress, Cytomegalovirus, and Immunosenescence: A Longitudinal Study of Older Adults
17:00—19:15
CD8 T Cell Memory
*
Rafi Ahmed,
Emory University School of Medicine, USA
Session Chair
Session Chair
Ananda W. Goldrath,
University of California, San Diego, USA
Identification of Molecules Essential for CD8+ T Cell Residency in Non-Lymphoid Tissues and Tumors
Identification of Molecules Essential for CD8+ T Cell Residency in Non-Lymphoid Tissues and Tumors
Dirk Hans Busch,
Technical University Munich, Germany
Lineage Tracing of Memory CD8 T Cell Development
Lineage Tracing of Memory CD8 T Cell Development
Steven L. Reiner,
Columbia University, USA
Metabolic Ambivalence and the Logic of Immunologic Memory
Metabolic Ambivalence and the Logic of Immunologic Memory
Scott N. Mueller,
University of Melbourne, Australia
Short Talk: Lymphoid Stromal Cells Support CD8 T Cell Priming and Memory
Short Talk: Lymphoid Stromal Cells Support CD8 T Cell Priming and Memory
Henrique Borges da Silva,
University of Minnesota, USA
Short Talk: The Extracellular ATP Receptor P2RX7 Controls Metabolic Fitness of Long-Lived Memory CD8+ T Cells
Short Talk: The Extracellular ATP Receptor P2RX7 Controls Metabolic Fitness of Long-Lived Memory CD8+ T Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Mechanisms of Inflammaging
*
Janet M. Lord,
University of Birmingham, UK
Session Chair
Session Chair
Judith Campisi,
Buck Institute for Research on Aging, USA
Cellular Senescence and Inflammaging
Cellular Senescence and Inflammaging
Margaret M. Harnett,
University of Glasgow, UK
Short Talk: Can the Parasitic Worm Product ES-62 Protect against Diet-Associated Pathologies in Aging Male and Female Mice?
Short Talk: Can the Parasitic Worm Product ES-62 Protect against Diet-Associated Pathologies in Aging Male and Female Mice?
Debbie Van Baarle,
National Institute of Public Health and Environment, Netherlands
Short Talk: Proinflammatory Microbial Profiles Associate with Respiratory Infections in Older Adults
Short Talk: Proinflammatory Microbial Profiles Associate with Respiratory Infections in Older Adults
Coffee Break
Daniela Frasca,
University of Miami, USA
Adipose Tissue, Inflammation and Aging
Adipose Tissue, Inflammation and Aging
Michael P. Cancro,
University of Pennsylvania, USA
Mechanisms that Regulate Age-Associated B Cell Formation and Survival
Mechanisms that Regulate Age-Associated B Cell Formation and Survival
Elizabeth A. Leadbetter,
University of Texas Health Science Center at San Antonio, USA
Short Talk: iNKT Cells Support Tbet+ B Cells in Adipose Tissue and Are Required to Limit Symptoms of Metabolic Disease
Short Talk: iNKT Cells Support Tbet+ B Cells in Adipose Tissue and Are Required to Limit Symptoms of Metabolic Disease
08:30—11:45
CD4 T Cell Memory
*
Marion Pepper,
University of Washington, USA
Session Chair
Session Chair
Shane Crotty,
La Jolla Institute for Immunology, USA
T Follicular Helper (Tfh) CD4 T Cells, Germinal Centers and the Generation of Memory
T Follicular Helper (Tfh) CD4 T Cells, Germinal Centers and the Generation of Memory
Marc K. Jenkins,
University of Minnesota Medical School, USA
Differentiation of CD4+ T Effector and Memory Cells during Bacterial Infection
Differentiation of CD4+ T Effector and Memory Cells during Bacterial Infection
Coffee Break
Mark R. Boothby,
Vanderbilt University Medical Center, USA
Hypoxia-Inducible Factors Regulate Metabolism and Function of B Cells and their Helpers in Antibody Responses
Hypoxia-Inducible Factors Regulate Metabolism and Function of B Cells and their Helpers in Antibody Responses
Amy Weinmann,
University of Alabama at Birmingham, USA
Role for Metabolites in T Cell Differentiation Programs
Role for Metabolites in T Cell Differentiation Programs
Lillian B. Cohn,
Chan Zuckerberg Biohub, USA
Short Talk: Clonally Expanded CD4+ T Cells Contribute to the HIV-1 Latent Reservoir and Display a Distinct Gene Signature upon Reactivation
Short Talk: Clonally Expanded CD4+ T Cells Contribute to the HIV-1 Latent Reservoir and Display a Distinct Gene Signature upon Reactivation
Raquel M. Furtado,
BioNTech US, USA
Short Talk: Expansion of Circulating CXCR3loPD-1+CXCR5+ Memory CD4+ T Helper Cells Correlates with Clinical Protection against Human Malaria
Short Talk: Expansion of Circulating CXCR3loPD-1+CXCR5+ Memory CD4+ T Helper Cells Correlates with Clinical Protection against Human Malaria
14:30—16:30
Workshop 1
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Session Chair
Session Chair
Petra Burilova,
St. Anne´s University Hospital, Czech Republic
Accelerated Aging of Monocytes in Childhood and Adolescent Cancer Survivors
Accelerated Aging of Monocytes in Childhood and Adolescent Cancer Survivors
Mati Mann,
California Institute of Technology, USA
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age
Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age
Nick P. Goplen,
Mayo Clinic, USA
Non-Resolving Influenza Response in Geriatric Lungs
Non-Resolving Influenza Response in Geriatric Lungs
Kylie Quinn,
RMIT University, Australia
Survival of Naïve CD8 T Cells During Aging Is Controlled by Homeostatic Signaling and Metabolic Remodeling
Survival of Naïve CD8 T Cells During Aging Is Controlled by Homeostatic Signaling and Metabolic Remodeling
Michelle Ratliff,
University of Okalhoma Health Sciences Center, USA
Expression of the DNA-Binding Protein ARID3a, a Mediator of Human Hematopoiesis, Is Reduced in Hematopoietic Progenitors from Aged Individuals
Expression of the DNA-Binding Protein ARID3a, a Mediator of Human Hematopoiesis, Is Reduced in Hematopoietic Progenitors from Aged Individuals
YanChun Peng,
University of Oxford, UK
Identifying Age-Associated Immune Signatures on Influenza-Specific Human Memory T Cells using Single-Cell RNASeq
Identifying Age-Associated Immune Signatures on Influenza-Specific Human Memory T Cells using Single-Cell RNASeq
Bo Ruem Yoon,
Seoul National University College of Medicine, South Korea
SLC7A5-Mediated Leucine Influx Controls IL-1β Production via Glycolytic Reprogramming in Human Monocytes/Macrophages
SLC7A5-Mediated Leucine Influx Controls IL-1β Production via Glycolytic Reprogramming in Human Monocytes/Macrophages
Juan I. Moliva,
Vaccine Research Center, USA
Natural Aging Is Associated with Decreases in Lung Fluid Innate Immune Protein Function Driving Susceptibility to Mycobacterium Tuberculosis Infection
Natural Aging Is Associated with Decreases in Lung Fluid Innate Immune Protein Function Driving Susceptibility to Mycobacterium Tuberculosis Infection
14:30—16:30
Workshop 1: Memory I
*
Joseph C. Sun,
Memorial Sloan Kettering Cancer Center, USA
Session Chair
Session Chair
Brian J. Laidlaw,
Washington University in St. Louis, USA
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells
The Eph-Related Tyrosine Kinase Ligand Ephrin-B1 Marks Germinal Center and Memory Precursor B Cells
Anoma Nellore,
University of Alabama at Birmingham, USA
T-bet Expression by Influenza-Specific Human Memory B Cells Is Differentially Regulated by Vaccine Platform and Prior Host Immunity and Correlates with Long-Lived Antibody Responses
T-bet Expression by Influenza-Specific Human Memory B Cells Is Differentially Regulated by Vaccine Platform and Prior Host Immunity and Correlates with Long-Lived Antibody Responses
Aakanksha Jain,
UT Southwestern Medical Center, USA
T Cell Intrinsic IL-1R Signaling Licenses Effector Cytokine Production by Memory CD4 T Cells
T Cell Intrinsic IL-1R Signaling Licenses Effector Cytokine Production by Memory CD4 T Cells
Robin Stephens,
University of Texas Medical Branch, USA
Mechanisms of Maintenance of Protection from Persistent Malaria Infection by CD4 Effector Memory T Cells
Mechanisms of Maintenance of Protection from Persistent Malaria Infection by CD4 Effector Memory T Cells
Thomas Ciucci,
NCI, National Institutes of Health, USA
The Development of Memory CD4 T Cells Relies on a Thpok-Dependent Circuitry-Antagonizing Exhaustion Program
The Development of Memory CD4 T Cells Relies on a Thpok-Dependent Circuitry-Antagonizing Exhaustion Program
Jenny Jiang,
University of Pennsylvania, USA
High-Throughput Single-Cell Linking of Antigen Specificities with T Cell Receptor Sequences using de novo Generated DNA-Linked MHC Tetramers
High-Throughput Single-Cell Linking of Antigen Specificities with T Cell Receptor Sequences using de novo Generated DNA-Linked MHC Tetramers
17:00—19:15
New Ways to Generate B Cell Memory
*
Shane Crotty,
La Jolla Institute for Immunology, USA
Session Chair
Session Chair
Mark J. Shlomchik,
University of Pittsburgh School of Medicine, USA
Heterogeneity of Memory B Cell Compartments
Heterogeneity of Memory B Cell Compartments
David M. Tarlinton,
Monash University, Australia
Molecular Regulation of Germinal Center Responses and B Cell Memory
Molecular Regulation of Germinal Center Responses and B Cell Memory
Scott D. Boyd,
Stanford University, USA
B Cell Memory Repertoires in Vaccination and Infection
B Cell Memory Repertoires in Vaccination and Infection
Mary F. Fontana,
University of Washington, USA
Short Talk: Expansion of an FCRL5+ B Cell Subset Resembling Atypical Memory B Cells in an Animal Model of Malaria
Short Talk: Expansion of an FCRL5+ B Cell Subset Resembling Atypical Memory B Cells in an Animal Model of Malaria
Ali H. Ellebedy,
Washington University School of Medicine, USA
Short Talk: Biphasic B Cell Responses to Adjuvanted H5N1 Influenza Virus Vaccination in Humans
Short Talk: Biphasic B Cell Responses to Adjuvanted H5N1 Influenza Virus Vaccination in Humans
17:00—19:00
Frailty, Morbidity, Mortality/Survival
*
Nir Barzilai,
Albert Einstein College of Medicine, USA
Session Chair
Session Chair
Janet M. Lord,
University of Birmingham, UK
Exercise, Frailty, Inflammation and Aging
Exercise, Frailty, Inflammation and Aging
Janet E. McElhaney,
Health Sciences North Research Institute, Canada
Frailty, Inflammation and Immunosenescence
Frailty, Inflammation and Immunosenescence
Daniel Belsky,
Duke University, USA
Quantification of Biological Aging: Implications for Clinical Trials and Extension of Healthspan
Quantification of Biological Aging: Implications for Clinical Trials and Extension of Healthspan
Leonard Daniël Samson,
National Institute for Public Health and the Environment/ RIVM, Netherlands
Short Talk: The Relationship between Frailty, Disease and the Development of Immunosenescence over a Time Span of More than 20 Years
Short Talk: The Relationship between Frailty, Disease and the Development of Immunosenescence over a Time Span of More than 20 Years
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Immunosenescence and Diseases
*
Judith Campisi,
Buck Institute for Research on Aging, USA
Session Chair
Session Chair
*
Michael P. Cancro,
University of Pennsylvania, USA
Session Chair
Session Chair
Janko Nikolich-Zugich,
University of Arizona College of Medicine, USA
T Cell Rejuvenation Requires Multiple Steps to Restore Immune Function with Aging
T Cell Rejuvenation Requires Multiple Steps to Restore Immune Function with Aging
Coffee Break
Laura Haynes,
UConn Health, USA
The Impact of Aging on Response to Influenza Infection
The Impact of Aging on Response to Influenza Infection
Russell C. Ault,
Texas Biomedical Research Institute, USA
Short Talk: Age-Related Differences in Peripheral Immunity at Tuberculosis Diagnosis in Humans
Short Talk: Age-Related Differences in Peripheral Immunity at Tuberculosis Diagnosis in Humans
Patricia J. Gearhart,
NIA, National Institutes of Health, USA
Short Talk: Role of B Cells in Atherosclerosis
Short Talk: Role of B Cells in Atherosclerosis
08:30—11:45
Immunoregulation
*
Ananda W. Goldrath,
University of California, San Diego, USA
Session Chair
Session Chair
Ronald N. Germain,
NIAID, National Institutes of Health, USA
Using Multiplex Histocytometry to Relate Tissue Microanatomy to Immune Activation and Regulation
Using Multiplex Histocytometry to Relate Tissue Microanatomy to Immune Activation and Regulation
Coffee Break
Ellen A. Robey,
University of California, Berkeley, USA
What Makes a Protective Anti-Toxoplasma T Cell Response?
What Makes a Protective Anti-Toxoplasma T Cell Response?
Susan M. Kaech,
The Salk Institute, USA
Metabolic Control of Memory T Cell Lifespan
Metabolic Control of Memory T Cell Lifespan
John R. Teijaro,
The Scripps Research Institute, USA
Short Talk: Cytokine-Mediated Expansion of Follicular Cytotoxic T Cells
Short Talk: Cytokine-Mediated Expansion of Follicular Cytotoxic T Cells
Kimberly S. Schluns,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Upregulating IL-15 in the Tumor Microenvironment Promotes Anti-Tumor Responses
Short Talk: Upregulating IL-15 in the Tumor Microenvironment Promotes Anti-Tumor Responses
17:00—19:30
Inflammation, Biomarkers of the Aging Immune System and Possible Treatments
*
Arne N. Akbar,
University College London, UK
Session Chair
Session Chair
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
B Cells, Inflammation and Aging in Vaccine Response
B Cells, Inflammation and Aging in Vaccine Response
Susan L. Swain,
University of Massachusetts Medical School, USA
Optimum Ag Presentation Can Counteract Age-Related Defects in CD4 T Cell Immunity and Lead to Better CD4 T and B Cell Effector and Memory Responses
Optimum Ag Presentation Can Counteract Age-Related Defects in CD4 T Cell Immunity and Lead to Better CD4 T and B Cell Effector and Memory Responses
Luca Pangrazzi,
University of Innsbruck, Austria
Adaptive Immunity in the Bone Marrow in Old Age
Adaptive Immunity in the Bone Marrow in Old Age
Joan Mannick,
Tornado Therapeutics, USA
TORC1 Inhibition as a Potential Immunotherapy to Decrease Infections in the Elderly
TORC1 Inhibition as a Potential Immunotherapy to Decrease Infections in the Elderly
Suresh Pallikkuth,
University of Miami, USA
Short Talk: Frequency and Function of Antigen-Specific Peripheral T Follicular Helper Cells Are Impaired by Basal Immune Activation and Impact Flu Vaccine Response in Biologic Aging with and without HIV In
Short Talk: Frequency and Function of Antigen-Specific Peripheral T Follicular Helper Cells Are Impaired by Basal Immune Activation and Impact Flu Vaccine Response in Biologic Aging with and without HIV In
17:00—19:15
Imprinting Memory in Tissues
*
Linda S. Cauley,
University of Connecticut Health Center, USA
Session Chair
Session Chair
David B. Masopust,
University of Minnesota, USA
Functions of Trm Cells
Functions of Trm Cells
Donna L. Farber,
Columbia University Medical Center, USA
Tissue Specialization and Maintenance of Human Memory T Cells
Tissue Specialization and Maintenance of Human Memory T Cells
Laura K. Mackay,
University of Melbourne, Australia
Short Talk: Local Maintenance of a Proliferating Tissue-Resident Memory T Cell Pool following Antiviral Recall Responses
Short Talk: Local Maintenance of a Proliferating Tissue-Resident Memory T Cell Pool following Antiviral Recall Responses
Angela Pizzolla,
Peter Doherty Institute for Infection and Immunity, University of Melbourne, Australia
Short Talk: Nasal Tissue-Resident Memory CD8+ T Cells Prevent Pulmonary Influenza A Virus Infection
Short Talk: Nasal Tissue-Resident Memory CD8+ T Cells Prevent Pulmonary Influenza A Virus Infection
19:30—20:30
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Therapeutic Approaches to Vaccines and Aging (Joint)
*
Donna L. Farber,
Columbia University Medical Center, USA
Session Chair
Session Chair
Antonio Lanzavecchia,
Vir Biotechnology, Inc., USA
Lessons from the Analysis of the Immune Response to P. falciparum
Lessons from the Analysis of the Immune Response to P. falciparum
Bali Pulendran,
Stanford University School of Medicine, USA
Lessons from Successful Human Vaccines
Lessons from Successful Human Vaccines
Coffee Break
Tyler J. Curiel,
Dartmouth College, USA
Challenges in Successful Immunotherapy of Cancer in Aged Individuals
Challenges in Successful Immunotherapy of Cancer in Aged Individuals
Arne N. Akbar,
University College London, UK
Targeting MAP Kinase Signaling to Enhance Immunity during Aging
Targeting MAP Kinase Signaling to Enhance Immunity during Aging
Katherine Kedzierska,
University of Melbourne, Australia
Short Talk: Dynamics of CD8+ T Cell Memory Repertoires across Human Life-Span and Tissue Compartments
Short Talk: Dynamics of CD8+ T Cell Memory Repertoires across Human Life-Span and Tissue Compartments
Sara Van Den Berg,
National Institute of Public Health and Environment, Netherlands
Short Talk: T Cell Responses to Influenza Infection in Elderly Are Impaired by Latent Cytomegalovirus (CMV) Infection
Short Talk: T Cell Responses to Influenza Infection in Elderly Are Impaired by Latent Cytomegalovirus (CMV) Infection
14:30—16:30
Workshop 2
*
Graham Pawelec,
University of Tübingen, Germany
Session Chair
Session Chair
Christina Camell,
University of Minnesota, USA
NLRP3 Inflammasome Controls Adipose Tissue B Cell Accumulation during Aging
NLRP3 Inflammasome Controls Adipose Tissue B Cell Accumulation during Aging
Claire Gustafson,
Stanford University, USA
Differentiation- and Age-Related MicroRNA Profiling Reveals Two Dimensions of CD8 T Cell Aging
Differentiation- and Age-Related MicroRNA Profiling Reveals Two Dimensions of CD8 T Cell Aging
Abhijit Kale,
Buck Institute for Research on Aging, USA
Elimination of Senescent Cells by Innate Immune System
Elimination of Senescent Cells by Innate Immune System
Mladen Jergovic,
University of Arizona, USA
Expression of Ly6C Defines a Subpopulation of Naïve CD8 T Cells with a Rapid Effector Function which Is Expanded Under "non-SPF" Conditions
Expression of Ly6C Defines a Subpopulation of Naïve CD8 T Cells with a Rapid Effector Function which Is Expanded Under "non-SPF" Conditions
Susan Baldwin,
Seattle Children's Research Institute, USA
Adjuvanted H1N1 Vaccines Improve Immune Responses in Young and Aged Mice
Adjuvanted H1N1 Vaccines Improve Immune Responses in Young and Aged Mice
Andy Schile,
The Jackson Laboratory, USA
Lessons Learned From Managing Aged Colonies of C57BL/6J Mice
Lessons Learned From Managing Aged Colonies of C57BL/6J Mice
14:30—16:30
Workshop 2: Memory II
*
Susan M. Kaech,
The Salk Institute, USA
Session Chair
Session Chair
Allan J. Zajac,
University of Alabama, Birmingham, USA
The Production of IL-2 by CD8 T Cells Shapes Their Fate Decisions and Protective Efficacy
The Production of IL-2 by CD8 T Cells Shapes Their Fate Decisions and Protective Efficacy
Enrico Lugli,
Humanitas Clinical and Research Center, Italy
High-Dimensional Single Cell Analysis of the Tumor CD8+ T Cell Infiltrate Identifies Long-Lived Memory CD8+ T Cells with Enhanced Stemness
High-Dimensional Single Cell Analysis of the Tumor CD8+ T Cell Infiltrate Identifies Long-Lived Memory CD8+ T Cells with Enhanced Stemness
Philip Ansumana Hull,
Bristol-Myers Squibb, USA
Metabolic Reprogramming of Human CD8+ Memory T Cells through Loss of SIRT1
Metabolic Reprogramming of Human CD8+ Memory T Cells through Loss of SIRT1
Vandana Kalia,
University of Washington and Seattle Children’s Research Institute, USA
Anatomic and Cellular Regulators of Metabolic Remodeling during Effector CTL to Memory Conversion
Anatomic and Cellular Regulators of Metabolic Remodeling during Effector CTL to Memory Conversion
Dietmar Herndler-Brandstetter,
Medical University of Vienna, Austria
Developmental Plasticity of KLRG1+ Effector CD8+ T Cells Promotes Protective Immunity
Developmental Plasticity of KLRG1+ Effector CD8+ T Cells Promotes Protective Immunity
Paul Richard Dunbar,
SQZ Biotech, USA
Pulmonary Monocytes Promote the Establishment of Lung Tissue-Resident CD8 T Cell Memory following Influenza Infection
Pulmonary Monocytes Promote the Establishment of Lung Tissue-Resident CD8 T Cell Memory following Influenza Infection
Linda S. Cauley,
University of Connecticut Health Center, USA
Innate Cytokine Stimulation Plays a Decisive Role in Late Differentiation of Activated CTLs
Innate Cytokine Stimulation Plays a Decisive Role in Late Differentiation of Activated CTLs
Peter Cockerill,
University of Birmingham, UK
Immunological Memory in T Cells is Established via T Cell Receptor Signaling which Creates Stably Maintained Active Chromatin Domains at Immune Response Genes
Immunological Memory in T Cells is Established via T Cell Receptor Signaling which Creates Stably Maintained Active Chromatin Domains at Immune Response Genes
17:00—18:15
Genetic, Epigenetic, Transcriptomic Regulation of Aging and Age-Related Diseases
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Session Chair
Session Chair
*
Graham Pawelec,
University of Tübingen, Germany
Session Chair
Session Chair
Albert C. Shaw,
Yale School of Medicine, USA
Consequences of Aging on Signatures of Influenza Vaccine Response
Consequences of Aging on Signatures of Influenza Vaccine Response
Ruth R. Montgomery,
Yale University School of Medicine, USA
Short Talk: Expression and Signaling of TAM Receptor Inflammatory Regulators in Aging
Short Talk: Expression and Signaling of TAM Receptor Inflammatory Regulators in Aging
17:00—18:00
The Wear and Tear on T Cells in Chronic Infection and Tumors
*
Susan M. Kaech,
The Salk Institute, USA
Session Chair
Session Chair
E. John Wherry,
University of Pennsylvania, USA
T Cell Exhaustion
T Cell Exhaustion
Rafi Ahmed,
Emory University School of Medicine, USA
Human CD8 T Cell Memory
Human CD8 T Cell Memory
18:15—19:00
Closing Keynote Address
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Session Chair
Session Chair
*
Graham Pawelec,
University of Tübingen, Germany
Session Chair
Session Chair
Claudio Franceschi,
University of Bologna, Italy
Aging, Inflammation and Immunity
Aging, Inflammation and Immunity
18:00—18:45
Closing Keynote Address
*
Susan M. Kaech,
The Salk Institute, USA
Session Chair
Session Chair
Federica Sallusto,
Università della Svizzera Italiana & ETH Zurich, Switzerland
Human Memory T Cell Subsets: from Phenotype to Function
Human Memory T Cell Subsets: from Phenotype to Function
19:00—19:15
Discussion of Meeting, Summary, Conclusion and Mouse-Human Connections
*
Bonnie B. Blomberg,
University of Miami School of Medicine, USA
Session Chair
Session Chair
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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