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This meeting took place in 2018
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Regulation and Dysregulation of Innate Immunity in Disease (B9)
Organizer(s) Lynda M. Stuart, Kathryn J. Moore and Kate L. Jeffrey
February 18—22, 2018
Fairmont Hotel Vancouver • Vancouver, BC Canada
Discounted Abstract Deadline: Oct 18, 2017
Abstract Deadline: Nov 16, 2017
Scholarship Deadline: Oct 18, 2017
Discounted Registration Deadline: Dec 18, 2017
Supported by the Directors' Fund
Summary of Meeting:
The innate immune system is fundamental to protect us from pathogens. Although the core components were first elucidated in model organisms such as Drosophila and mice, exactly how they are regulated in human health and contribute to disease remains to be fully defined. Over the past several years, our ability to study the innate immune response has been enabled by a number of transformative tools that can be used to assess gene expression, cellular physiology and gene function. Such technological advances have begun to reveal new components of the innate immune system and have led to a better understanding of its regulation and dysregulation. Importantly, these new insights have allowed us to better understand the pathophysiological basis of certain human diseases and to identify new therapeutic targets to alleviate them. This conference aims to gather different viewpoints in the field of innate immunity to discuss advances in signaling and regulatory networks and to understand how their dysregulation contributes to immunopathologies and auto-inflammatory conditions.
View Scholarships/Awards
The innate immune system is fundamental to protect us from pathogens. Although the core components were first elucidated in model organisms such as Drosophila and mice, exactly how they are regulated in human health and contribute to disease remains to be fully defined. Over the past several years, our ability to study the innate immune response has been enabled by a number of transformative tools that can be used to assess gene expression, cellular physiology and gene function. Such technological advances have begun to reveal new components of the innate immune system and have led to a better understanding of its regulation and dysregulation. Importantly, these new insights have allowed us to better understand the pathophysiological basis of certain human diseases and to identify new therapeutic targets to alleviate them. This conference aims to gather different viewpoints in the field of innate immunity to discuss advances in signaling and regulatory networks and to understand how their dysregulation contributes to immunopathologies and auto-inflammatory conditions.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 23 in order to fully experience the meeting.
SUNDAY, FEBRUARY 18
MONDAY, FEBRUARY 19
TUESDAY, FEBRUARY 20
WEDNESDAY, FEBRUARY 21
THURSDAY, FEBRUARY 22
FRIDAY, FEBRUARY 23
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 18 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 22 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, February 23 in order to fully experience the meeting.
SUNDAY, FEBRUARY 18
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
*
Lynda M. Stuart,
Bill & Melinda Gates Foundation, USA
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
Regulation of Inflammation by Noncoding RNAs and Nucleic Acid Binding Proteins
Regulation of Inflammation by Noncoding RNAs and Nucleic Acid Binding Proteins
09:30—11:45
Looking for More: Screening in the Innate Immune System
*
Kathryn J. Moore,
New York University Medical Center, USA
*
Kate L. Jeffrey,
Harvard Medical School, USA
Carl L. Hansen,
University of British Columbia, Canada
Single-Cell Analysis for Deep Screening of Human Antibody Responses
Single-Cell Analysis for Deep Screening of Human Antibody Responses
Coffee Break
Lynda M. Stuart,
Bill & Melinda Gates Foundation, USA
Transposon Mutagenesis Screens for Host Resistance
Transposon Mutagenesis Screens for Host Resistance
Michael Bassik,
Stanford University, USA
Systematic Exploration of Endocytosis and Phagocytosis Pathways Using Genome-Wide CRISPR/Cas9 Screens and Genetic Interaction Maps
Systematic Exploration of Endocytosis and Phagocytosis Pathways Using Genome-Wide CRISPR/Cas9 Screens and Genetic Interaction Maps
Iain D.C. Fraser,
NIAID, National Institutes of Health, USA
Short Talk: Genome-Wide Screening Combined with an Iterative Bioinformatic Analysis Model Identifies Critical Roles for Protein Degradation and Alternative Splicing in TLR-Induced Macrophage Activation
Short Talk: Genome-Wide Screening Combined with an Iterative Bioinformatic Analysis Model Identifies Critical Roles for Protein Degradation and Alternative Splicing in TLR-Induced Macrophage Activation
17:00—19:00
Gene Regulatory Networks in Innate Immunity
*
Kate A. Fitzgerald,
University of Massachusetts Medical School, USA
*
Jose Ordovas-Montanes,
Boston Children's Hospital and Harvard Medical School, USA
Julian C. Knight,
University of Oxford, UK
Insights into Regulation of Innate Immune Responses Leveraging Human Genetic Variation
Insights into Regulation of Innate Immune Responses Leveraging Human Genetic Variation
Alex K. Shalek,
Massachusetts Institute of Technology, USA
Learning More by Looking at Less – Single Cell Analyses of Pathogen Responses
Learning More by Looking at Less – Single Cell Analyses of Pathogen Responses
Matthew L. Albert,
Genentech, Inc., USA
Geographical Variations in the Human Innate Immune Response to Pathogens
Geographical Variations in the Human Innate Immune Response to Pathogens
Hiroyuki Oshiumi,
Kumamoto University, Japan
Short Talk: miR-451a in Blood-Circulating Extracellular Vesicles Controls the Innate Immune Response of Macrophages
Short Talk: miR-451a in Blood-Circulating Extracellular Vesicles Controls the Innate Immune Response of Macrophages
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Epigenetic Regulation of Host Defense
*
Eicke Latz,
University of Bonn, Germany
Kate L. Jeffrey,
Harvard Medical School, USA
Loss of Epigenome Reader SP140 Disrupts Macrophage Transcriptional Programs and Contributes to Crohn’s Disease
Loss of Epigenome Reader SP140 Disrupts Macrophage Transcriptional Programs and Contributes to Crohn’s Disease
Gioacchino Natoli,
Humanitas University, Italy
Genomic Landscapes in Inflammation
Genomic Landscapes in Inflammation
Coffee Break
Stephen T. Smale,
University of California, Los Angeles, USA
Molecular Mechanisms Regulating Stimulus-Specific Transcriptional Cascades
Molecular Mechanisms Regulating Stimulus-Specific Transcriptional Cascades
Steven Z. Josefowicz,
Rockefeller University, USA
Short Talk: Signaling to Chromatin for a Rapid and Robust Inflammatory Response
Short Talk: Signaling to Chromatin for a Rapid and Robust Inflammatory Response
Annette E. Neele,
University of Amsterdam, Netherlands
Short Talk: Fine-Tuning of DNA Methylation during the Differentiation and Activation of Human Macrophages
Short Talk: Fine-Tuning of DNA Methylation during the Differentiation and Activation of Human Macrophages
15:00—16:30
Workshop 1
*
Daniel Mucida,
Rockefeller University, USA
*
Mélanie Hamon,
Institut Pasteur, France
Aditya Murthy,
Genentech, Inc., USA
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling
Selective Autophagy of the Innate Adaptor TRIF Regulates Inflammatory Signaling
Travis K. Hughes,
Harvard Medical School and MIT, USA
Understanding the Multi-Cellular Ecosystem of M. tuberculosis granulomas using High-Throughput Single-Cell mRNA Sequencing
Understanding the Multi-Cellular Ecosystem of M. tuberculosis granulomas using High-Throughput Single-Cell mRNA Sequencing
Jin Billy Li,
Stanford University, USA
ADAR1 RNA editing mediated dsRNA sensing by MDA5
ADAR1 RNA editing mediated dsRNA sensing by MDA5
Hans-Christian Reinecker,
Massachusetts General Hospital, USA
The GEF-H1 Innate Immune Pathway Controls Anti-Tumor Immunity by Signaling Microtubule Depolymerization in Dendritic Cells
The GEF-H1 Innate Immune Pathway Controls Anti-Tumor Immunity by Signaling Microtubule Depolymerization in Dendritic Cells
Jose Ordovas-Montanes,
Boston Children's Hospital and Harvard Medical School, USA
Barrier Dysfunction in Human Type 2 Immunity Arises from an Altered Basal Progenitor Cell State and Reduced Epithelial Cellular Diversity
Barrier Dysfunction in Human Type 2 Immunity Arises from an Altered Basal Progenitor Cell State and Reduced Epithelial Cellular Diversity
17:00—19:00
Innate Defense at the Mucosa
*
Javier E. Irazoqui,
University of Massachusetts Medical School, USA
*
Julie Magarian Blander,
Weill Cornell Medicine, Cornell University, USA
Ramnik Xavier,
Massachusetts General Hospital, USA
Microbiome and Mucosal Immunity
Microbiome and Mucosal Immunity
P'ng Loke,
New York University School of Medicine, USA
Alternatively Activated Macrophages of Tissue or Monocyte Origin
Alternatively Activated Macrophages of Tissue or Monocyte Origin
Daniel Mucida,
Rockefeller University, USA
Tissue Adaptation of Intestinal Macrophages
Tissue Adaptation of Intestinal Macrophages
Le Son Tran,
Monash University, Australia
Short Talk: NOD1 Sensing of Helicobacter Pylori Infection Mediates Processing of Pro-Interleukin-18 in Gastric Epithelial Cells to Maintain Tissue Homeostasis
Short Talk: NOD1 Sensing of Helicobacter Pylori Infection Mediates Processing of Pro-Interleukin-18 in Gastric Epithelial Cells to Maintain Tissue Homeostasis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:30
Entraining Immunity
*
Kate L. Jeffrey,
Harvard Medical School, USA
*
Steven Z. Josefowicz,
Rockefeller University, USA
Mihai G. Netea,
Radboud University, Netherlands
Trained Immunity: A Memory for Innate Host Defense
Trained Immunity: A Memory for Innate Host Defense
Coffee Break
Musa M. Mhlanga,
Radboud Institute for Molecular Life Sciences, Netherlands
Immune Genes Are Primed for Rapid Transcription by Proximal lncRNAs Located in Preformed Nuclear Compartments
Immune Genes Are Primed for Rapid Transcription by Proximal lncRNAs Located in Preformed Nuclear Compartments
Vanessa Frodermann,
Massachusetts General Hospital, USA
Short Talk: Voluntary Exercise Reduces Hematopoiesis
Short Talk: Voluntary Exercise Reduces Hematopoiesis
17:00—19:00
Metabolic Control of Innate Immune Cells
*
Fred Sheedy,
Trinity College Dublin, Ireland
Kathryn J. Moore,
New York University Medical Center, USA
Noncoding RNAs Coordinate the Physiology of Innate Immune Cells
Noncoding RNAs Coordinate the Physiology of Innate Immune Cells
Edward J. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of Myeloid Responses
Metabolic Control of Myeloid Responses
Javier E. Irazoqui,
University of Massachusetts Medical School, USA
TFEB: From Lysosome Storage to Innate Defense
TFEB: From Lysosome Storage to Innate Defense
Sonia Sharma,
La Jolla Institute for Allergy & Immunology, USA
Short Talk: Metabolic-Epigenetic Dysregulation of Cell-Intrinsic Innate Immunity in a Disease of Systemic Inflammation
Short Talk: Metabolic-Epigenetic Dysregulation of Cell-Intrinsic Innate Immunity in a Disease of Systemic Inflammation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
In the Balance: Immunodeficiencies and Auto-Inflammation
*
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
*
Adam Lacy-Hulbert,
Benaroya Research Institute, USA
Fred Sheedy,
Trinity College Dublin, Ireland
Defective Immunity Against TB via the Modulation of Macrophage Metabolism by Anti-Inflammatory MiR-21
Defective Immunity Against TB via the Modulation of Macrophage Metabolism by Anti-Inflammatory MiR-21
Andrew Oberst,
University of Washington, USA
The RIP Kinases as Modulators of Inflammation and Immunity
The RIP Kinases as Modulators of Inflammation and Immunity
Coffee Break
Kim Newton,
Genentech, Inc., USA
Cell Death as a Driver of Inflammation
Cell Death as a Driver of Inflammation
Virginia Pascual,
Cornell University, USA
Adding New Pieces to the Human SLE Puzzle
Adding New Pieces to the Human SLE Puzzle
Hachung Chung,
Rockefeller University, USA
Short Talk: Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown during the IFN Response
Short Talk: Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown during the IFN Response
Liudmila Andreeva,
Gene Center Munich, LMU Munich, Germany
Short Talk: GAS Forms DNA-Protein Ladders for Cooperative Sensing of Long and TFAM/HMGB-Bound DNA
Short Talk: GAS Forms DNA-Protein Ladders for Cooperative Sensing of Long and TFAM/HMGB-Bound DNA
15:00—16:30
Workshop 2
*
Edward J. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
*
Kim Newton,
Genentech, Inc., USA
Zack Grimmett,
University of California, San Francisco, USA
Changes in Expression of Gasdermin-Family Proteins during Monocyte to Macrophage Differentiation May Confer Susceptibility to Inflammatory Cell Death
Changes in Expression of Gasdermin-Family Proteins during Monocyte to Macrophage Differentiation May Confer Susceptibility to Inflammatory Cell Death
Rosario Luque Martin,
University of Amsterdam, Netherlands
A Screening Approach to Identify Epigenetic Compounds that Modulate Macrophage Activation
A Screening Approach to Identify Epigenetic Compounds that Modulate Macrophage Activation
Cole M. Dovey,
Colorado College, USA
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis Downstream of RIPK3
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis Downstream of RIPK3
Chris Cox,
Genentech, Inc., USA
Interleukin 1 Controls Susceptibility to Intestinal Pathogens by Directing a Stromal-Stem Cell Axis Required for Epithelial Regeneration
Interleukin 1 Controls Susceptibility to Intestinal Pathogens by Directing a Stromal-Stem Cell Axis Required for Epithelial Regeneration
Sophie Elisabeth Zahalka,
Medical University of Vienna, Austria
Exploring Trained Immunity in Lung Infection
Exploring Trained Immunity in Lung Infection
Hao-Sen Chiang,
National Taiwan University, Taiwan
DNase I Treatment Suppresses Experimental Colitis in Mice by Reducing Colonic Neutrophil Extracellular Trap Formation
DNase I Treatment Suppresses Experimental Colitis in Mice by Reducing Colonic Neutrophil Extracellular Trap Formation
17:00—18:45
Pyroptosis, Necroptosis and Inflammatory Death
*
Kathryn J. Moore,
New York University Medical Center, USA
*
Judith E. Allen,
University of Manchester, UK
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Regulation of Inflammasome Activation and Cell Death
Regulation of Inflammasome Activation and Cell Death
Julie Magarian Blander,
Weill Cornell Medicine, Cornell University, USA
Phagocyte Responses to Dying Cells
Phagocyte Responses to Dying Cells
Vishva M. Dixit,
Genentech, Inc., USA
Gasdermin-D: How to Punch Holes in a Dying Cell
Gasdermin-D: How to Punch Holes in a Dying Cell
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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