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This meeting took place in 2018
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Myeloid Cells (D2)
Organizer(s) Edward J. Pearce, Florent Ginhoux and Ana-Maria Lennon-Duménil
April 8—12, 2018
Beaver Run Resort • Breckenridge, CO USA
Discounted Abstract Deadline: Dec 7, 2017
Abstract Deadline: Jan 9, 2018
Scholarship Deadline: Dec 7, 2017
Discounted Registration Deadline: Feb 7, 2018
Sponsored by Boehringer Ingelheim Pharmaceuticals, Inc.
Summary of Meeting:
This Keystone Symposia conference is the eighth in a series of related Keystone Symposia conferences that have played a pivotal role in emphasizing and focusing myeloid cell research. High-throughput approaches are revealing previously unappreciated complexity in myeloid cell development and function. This ninth meeting focuses on addressing these issues at the basic levels of ontogeny and cellular activation, in the areas of niche specialization, cell/cell interactions, tissue repair, regeneration and development, and infectious and neoplastic disease. The goals of the meeting are to bring together interdisciplinary groups of researchers to attempt to reveal areas of research synergy in a rapidly evolving field, and to generate a vision of critical areas of future research on myeloid cells. The meeting includes a focus on disease that will serve to emphasize the medical relevance of myeloid cell research. Emphasis on the application of cutting-edge immunological approaches in omics, imaging and cell biology makes the conference of general interest to scientists working in these areas of basic and clinical research.
View Scholarships/Awards
This Keystone Symposia conference is the eighth in a series of related Keystone Symposia conferences that have played a pivotal role in emphasizing and focusing myeloid cell research. High-throughput approaches are revealing previously unappreciated complexity in myeloid cell development and function. This ninth meeting focuses on addressing these issues at the basic levels of ontogeny and cellular activation, in the areas of niche specialization, cell/cell interactions, tissue repair, regeneration and development, and infectious and neoplastic disease. The goals of the meeting are to bring together interdisciplinary groups of researchers to attempt to reveal areas of research synergy in a rapidly evolving field, and to generate a vision of critical areas of future research on myeloid cells. The meeting includes a focus on disease that will serve to emphasize the medical relevance of myeloid cell research. Emphasis on the application of cutting-edge immunological approaches in omics, imaging and cell biology makes the conference of general interest to scientists working in these areas of basic and clinical research.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 13 in order to fully experience the meeting.
SUNDAY, APRIL 8
MONDAY, APRIL 9
TUESDAY, APRIL 10
WEDNESDAY, APRIL 11
THURSDAY, APRIL 12
FRIDAY, APRIL 13
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 12 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, April 13 in order to fully experience the meeting.
SUNDAY, APRIL 8
08:00—09:00
Welcome and Keynote Address
*
Edward J. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
Development and Function of Dendritic Cell Subsets
Development and Function of Dendritic Cell Subsets
09:00—11:30
Ontogeny and Differentiation
*
Caetano Reis e Sousa,
Francis Crick Institute, UK
*
Florent Ginhoux,
Singapore Immunology Network, Singapore
Human Dendritic Cells: From Development to Functions
Human Dendritic Cells: From Development to Functions
Coffee Break
Joachim L. Schultze,
LIMES Institute, University of Bonn, Germany
Human Monocytes, Monocyte-Derived Cells, Dendritic Cells and Tissue Macrophages Revisited
Human Monocytes, Monocyte-Derived Cells, Dendritic Cells and Tissue Macrophages Revisited
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
Venetia Bigley,
Newcastle University, UK
Short Talk: Differential IRF8 Requirement Defines Two Pathways of Human Dendritic Cell Development in vivo
Short Talk: Differential IRF8 Requirement Defines Two Pathways of Human Dendritic Cell Development in vivo
Lai Guan Ng,
Singapore Immunology Network, Singapore
Short Talk: Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking and Effector Functions
Short Talk: Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking and Effector Functions
14:30—16:30
Workshop 1: Infection
*
David L. Sacks,
NIAID, National Institutes of Health, USA
*
Molly Ingersoll,
Institut Pasteur, France
Lu Huang,
Cornell University, USA
Different Macrophage Lineages Exhibit Distinct Metabolic States and Support Differential Growth of Mycobacterium tuberculosis in vivo
Different Macrophage Lineages Exhibit Distinct Metabolic States and Support Differential Growth of Mycobacterium tuberculosis in vivo
Livia Lacerda,
Institut Pasteur, France
Novel Macrophage Subsets Differentially Impact Bladder Immunity to Uropathogen Infection
Novel Macrophage Subsets Differentially Impact Bladder Immunity to Uropathogen Infection
Sang Hun Lee,
NIAID, National Institutes of Health, USA
Mannose Receptor (MRhi), M2 Dermal Macrophages Mediate Non-Healing Leishmania Major Infection in a TH1 Immune Environment
Mannose Receptor (MRhi), M2 Dermal Macrophages Mediate Non-Healing Leishmania Major Infection in a TH1 Immune Environment
Rejane Rua,
NINDS, National Institutes of Health, USA
Infection and Natural Inflammatory Aging Drive Monocyte Engraftment into the Meninges that Impairs CNS Immunity
Infection and Natural Inflammatory Aging Drive Monocyte Engraftment into the Meninges that Impairs CNS Immunity
Nan Zhang,
Washington University in St. Louis, USA
Clotting Initiated by Factor V+ Resident Peritoneal Macrophages Rapidly Limits Systemic Microbial Dissemination and Accounts for the “Macrophage Disappearance Reaction"
Clotting Initiated by Factor V+ Resident Peritoneal Macrophages Rapidly Limits Systemic Microbial Dissemination and Accounts for the “Macrophage Disappearance Reaction"
Bibo Zhu,
Mayo Clinic, USA
Reciprocal Regulation of Lung-Resident Alveolar Macrophage Function and Repopulation by β-Catenin and PPAR-γ Dictates Host Morbidity and Tissue Recovery from Respiratory Viral Infection
Reciprocal Regulation of Lung-Resident Alveolar Macrophage Function and Repopulation by β-Catenin and PPAR-γ Dictates Host Morbidity and Tissue Recovery from Respiratory Viral Infection
17:00—19:00
Priming and Tolerance
*
Kenneth M. Murphy,
HHMI/Washington University School of Medicine, USA
*
Andrey S. Shaw,
Genentech, Inc., USA
Martin Guilliams,
Ghent University - VIB, Belgium
Transcriptional Control of Macrophage Identity
Transcriptional Control of Macrophage Identity
Jordi C. Ochando,
Mount Sinai School of Medicine, USA
Preventing Trained Immunity Promotes Immunological Tolerance
Preventing Trained Immunity Promotes Immunological Tolerance
Anders Etzerodt,
Aarhus University, Denmark
Short Talk: Tissue-Resident Macrophages in Omentum Play a Key Role in Development of Metastatic Ovarian Cancer
Short Talk: Tissue-Resident Macrophages in Omentum Play a Key Role in Development of Metastatic Ovarian Cancer
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
Inflammation
*
David L. Sacks,
NIAID, National Institutes of Health, USA
*
Tim Lämmermann,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Andrés Hidalgo,
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
Rhythms of Neutrophils in Homeostasis
Rhythms of Neutrophils in Homeostasis
Coffee Break
Mihai G. Netea,
Radboud University, Netherlands
Innate Immunity in Sepsis
Innate Immunity in Sepsis
William C. Gause,
Rutgers New Jersey Medical School, USA
Macrophage and Neutrophil Interactions during Pulmonary Inflammation
Macrophage and Neutrophil Interactions during Pulmonary Inflammation
Andreas Schlitzer,
University of Bonn, Germany
Short Talk: Lung-Specific Innate Immune Memory Controls Reactivity of Mononuclear Phagocytes to Acute and Chronic Inflammation
Short Talk: Lung-Specific Innate Immune Memory Controls Reactivity of Mononuclear Phagocytes to Acute and Chronic Inflammation
Honami Naora,
University of Texas MD Anderson Cancer Center, USA
Short Talk: Tumor-Induced Neutrophil Extracellular Traps Promote Formation of the Pre-Metastatic Niche in Ovarian Cancer
Short Talk: Tumor-Induced Neutrophil Extracellular Traps Promote Formation of the Pre-Metastatic Niche in Ovarian Cancer
Pierre Guermonprez,
Kings College London, UK
Short Talk: Ontogeny of Human Inflammatory Dendritic Cells
Short Talk: Ontogeny of Human Inflammatory Dendritic Cells
17:00—19:00
Regeneration/Repair/Development
*
Gwendalyn J. Randolph,
Washington University, USA
*
Andrés Hidalgo,
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
Limin Shang,
Light Chain Bioscience, Switzerland
Selective CD47 Targeting to Harness Macrophage Activity to Control Tumor Growth
Selective CD47 Targeting to Harness Macrophage Activity to Control Tumor Growth
Guillaume Dumenil,
Institut Pasteur, France
Short Talk: Neisseria Meningitidis Detection by Perivascular Macrophages Fails to Recruit Neutrophils Sufficiently Early to Control Vascular Damages
Short Talk: Neisseria Meningitidis Detection by Perivascular Macrophages Fails to Recruit Neutrophils Sufficiently Early to Control Vascular Damages
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Activation
*
Mihai G. Netea,
Radboud University, Netherlands
*
Ana-Maria Lennon-Duménil,
Curie Institute, France
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Krebs Cycle Repurposed for Cytokines in Macrophages
Krebs Cycle Repurposed for Cytokines in Macrophages
Edward J. Pearce,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Metabolic Control of Alternative Macrophage Activation
Metabolic Control of Alternative Macrophage Activation
Coffee Break
Ana-Maria Lennon-Duménil,
Curie Institute, France
A Unique Population of Intra-Epithelial Dendritic Cells Restricted to the Upper Region of the Small Intestine
A Unique Population of Intra-Epithelial Dendritic Cells Restricted to the Upper Region of the Small Intestine
Rab K. Prinjha,
GlaxoSmithKline, UK
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction
Drugging Transcription: Progress and Potential for Treating Human Immune Dysfunction
Philippe J. Benaroch,
Institut Curie, INSERM, France
Short Talk: Siglec-1 Expression by Human Dendritic Cell Precursors Enables HIV-1 Replication and Dissemination to CD4+ T Cells
Short Talk: Siglec-1 Expression by Human Dendritic Cell Precursors Enables HIV-1 Replication and Dissemination to CD4+ T Cells
Brian T. Edelson,
Washington University School of Medicine, USA
Short Talk: The Transcription Factor Bhlhe40 Regulates Large Peritoneal Macrophages and Type 2 Immunity
Short Talk: The Transcription Factor Bhlhe40 Regulates Large Peritoneal Macrophages and Type 2 Immunity
14:30—16:30
Workshop 2: Cancer
*
Jie Sun,
Mayo Clinic, USA
Faezzah Baharom,
National Institutes of Health, USA
Targeting Dendritic Cells and Monocytes with a Nanoparticle Neoantigen-TLR7/8 Agonist Vaccine Induces Anti-Tumor CD8 T Cell Immunity
Targeting Dendritic Cells and Monocytes with a Nanoparticle Neoantigen-TLR7/8 Agonist Vaccine Induces Anti-Tumor CD8 T Cell Immunity
Katherine Brempelis,
Seattle Children's Research Institute, USA
Genetically Engineered Macrophages as an Immunotherapy for Solid Tumors
Genetically Engineered Macrophages as an Immunotherapy for Solid Tumors
Mytrang Do,
Weill Cornell Medical College, USA
mTORC1- Dependent Regulation of Macrophage Response in Cancer
mTORC1- Dependent Regulation of Macrophage Response in Cancer
Hiroki Ishii,
NCI, National Institutes of Health, USA
miR-130a and -145 Reprogram Myeloid-Derived Suppressor Cells and Inhibit Tumor Metastasis through Improved Anti-Tumor Immunity
miR-130a and -145 Reprogram Myeloid-Derived Suppressor Cells and Inhibit Tumor Metastasis through Improved Anti-Tumor Immunity
Sarah E. Corcoran,
Trinity College Dublin, Ireland
The Small Molecule NLRP3 Inhibitor MCC950 Potently Inhibits the Production of the Mature Forms of Caspase 1, IL-1b and IL-18 ex Vivo in PBMCs from Familial Cold Autoinflammatory Syndrome (FCAS) Patients
The Small Molecule NLRP3 Inhibitor MCC950 Potently Inhibits the Production of the Mature Forms of Caspase 1, IL-1b and IL-18 ex Vivo in PBMCs from Familial Cold Autoinflammatory Syndrome (FCAS) Patients
Karen Olivia Dixon,
Harvard Medical School/Brigham and Women's Hospital, USA
The Co-Inhibitory Molecule TIGIT Contributes to Suppressor Function of Dendritic Cells
The Co-Inhibitory Molecule TIGIT Contributes to Suppressor Function of Dendritic Cells
Hai Huang,
Ohio State University, USA
Neutrophil Extracellular Traps Promote Inflammation and Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis
Neutrophil Extracellular Traps Promote Inflammation and Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis
17:00—19:00
Cancer
*
Luke A. J. O'Neill,
Trinity Biomedical Sciences Institute, Ireland
Romina S. Goldszmid,
NCI, National Institutes of Health, USA
Microbiota: Key Modulator of the Tumor Microenvironment
Microbiota: Key Modulator of the Tumor Microenvironment
Hélène Salmon,
Institut Curie and Mount Sinai School of Medicine, France
Modulating the Myeloid and Stromal Cell Compartments to Promote Anti-Tumor Immunity
Modulating the Myeloid and Stromal Cell Compartments to Promote Anti-Tumor Immunity
Matthew F. Krummel,
University of California, San Francisco, USA
Imaging and Manipulating Myeloid Biology in Cancer
Imaging and Manipulating Myeloid Biology in Cancer
Julie Helft,
Institut Curie, France
Short Talk: High-Dimensional Analysis of the Myeloid Cell Landscape in Human Breast Cancer Metastatic Lymph Nodes
Short Talk: High-Dimensional Analysis of the Myeloid Cell Landscape in Human Breast Cancer Metastatic Lymph Nodes
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Niche Specialization
*
Paul Martin,
University of Bristol, UK
*
Florent Ginhoux,
Singapore Immunology Network, Singapore
Alison Clare Lloyd,
University College London, UK
The Role of Macrophages in Peripheral Nerve Homeostasis and Regeneration
The Role of Macrophages in Peripheral Nerve Homeostasis and Regeneration
Gwendalyn J. Randolph,
Washington University, USA
Serosal Macrophages
Serosal Macrophages
Coffee Break
Steffen Jung,
Weizmann Institute of Science, Israel
Studying Microglia and BM Graft-derived CNS Macrophages - Transcriptomes, Epigenomes and Responsiveness to Challenge
Studying Microglia and BM Graft-derived CNS Macrophages - Transcriptomes, Epigenomes and Responsiveness to Challenge
Daniel R. Saban,
Duke University School of Medicine, USA
Short Talk: A Novel Microglia-Restricted Microniche in the Retina Is Associated with Neuroprotection
Short Talk: A Novel Microglia-Restricted Microniche in the Retina Is Associated with Neuroprotection
Sebastiaan De Schepper,
KU Leuven, Belgium
Short Talk: Self-Maintaining Embryonic Gut Macrophages Are Essential for Intestinal Homeostasis
Short Talk: Self-Maintaining Embryonic Gut Macrophages Are Essential for Intestinal Homeostasis
14:30—16:30
Workshop 3: Ontogeny/Different Tissue Populations
*
Slava Epelman,
University of Toronto, Canada
*
Andreas Schlitzer,
University of Bonn, Germany
Anna E. Beaudin,
University of California, Merced, USA
Regulation of Tissue-Resident Macrophage Development by IL7R
Regulation of Tissue-Resident Macrophage Development by IL7R
Sarah A. Dick,
University Health Network, Canada
Using Single Cell Genomics and Genetic Fate Mapping to Define Cardiac Macrophage Heterogeneity and Cardioprotective Functions
Using Single Cell Genomics and Genetic Fate Mapping to Define Cardiac Macrophage Heterogeneity and Cardioprotective Functions
Laufey Geirsdottir,
Uniklinik Freiburg, Germany
What Makes a Microglia? Comparing Relatives in the Molecular Age
What Makes a Microglia? Comparing Relatives in the Molecular Age
Rebecca Gentek,
Centre d'Immunologie de Marseille-Luminy CIML, France
Tissue-Resident Mast Cells Are of Dual Hematopoietic Origin
Tissue-Resident Mast Cells Are of Dual Hematopoietic Origin
Chang Liu,
NHLBI, National Institutes of Health, USA
Distribution and Functions of Embryonic Microglial Cells in the Immunoprivileged Central Nervous System
Distribution and Functions of Embryonic Microglial Cells in the Immunoprivileged Central Nervous System
Zhaoyuan Liu,
Shanghai Jiao Tong University, China
A Universal Fate Mapper Mouse Model of Blood-Circulating Monocytes
A Universal Fate Mapper Mouse Model of Blood-Circulating Monocytes
17:00—18:45
Myeloid Crosstalk
*
Steffen Jung,
Weizmann Institute of Science, Israel
*
William C. Gause,
Rutgers New Jersey Medical School, USA
Venizelos Papayannopoulos,
Francis Crick Institute, UK
Neutrophils in the Regulation of Inflammation
Neutrophils in the Regulation of Inflammation
Daniel Robert Engel,
Institute of Experimental Immunology and Imaging, Germany
Crosstalk of Myeloid Cells at Mucosal Sites
Crosstalk of Myeloid Cells at Mucosal Sites
Tim Lämmermann,
Max Planck Institute of Immunobiology and Epigenetics, Germany
Myeloid Cell Dynamics at Local Sites of Inflammation, Infection and Anaphylaxis
Myeloid Cell Dynamics at Local Sites of Inflammation, Infection and Anaphylaxis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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