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This meeting took place in 2019
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Myeloid Cells (B7)
Organizer(s) Tiffany Horng, Gregory M. Barton and Ajay Chawla
February 24—28, 2019
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 24, 2018
Abstract Deadline: Nov 28, 2018
Scholarship Deadline: Oct 24, 2018
Discounted Registration Deadline: Jan 9, 2019
Sponsored by Bayer AG, Boehringer Ingelheim Pharmaceuticals, Inc., Compass Therapeutics and Genentech, Inc.
This activity is also supported by an educational grant from Celgene Corporation
This activity is also supported by an educational grant from Celgene Corporation
Summary of Meeting:
Myeloid cells regulate tissue homeostasis, immunity, and inflammation, whereas their dysregulation contributes to cancer, metabolic, inflammatory diseases, and degenerative diseases. This Keystone Meeting will cover areas of long-standing interest as well as topical areas in the field of myeloid cell biology, including ontogeny and tissue specification, myeloid cell activation, immunometabolism, immunity and infection, mucosal immunity, and cancer immunology. Multiple myeloid cell populations will be discussed, including tissue resident macrophages, monocytes, dendritic cells, and neutrophils. The meeting will highlight the diverse approaches being used to study myeloid cell biology, including genomic analyses, single cell profiling, imaging, and metabolic profiling. Both basic and translational aspects of myeloid cell research will be covered. The goals of the meeting are to share recent advances in this rapidly evolving field, stimulate interactions between interdisciplinary groups of scientists, and define future areas of investigation in myeloid cell research.
View Scholarships/Awards
Myeloid cells regulate tissue homeostasis, immunity, and inflammation, whereas their dysregulation contributes to cancer, metabolic, inflammatory diseases, and degenerative diseases. This Keystone Meeting will cover areas of long-standing interest as well as topical areas in the field of myeloid cell biology, including ontogeny and tissue specification, myeloid cell activation, immunometabolism, immunity and infection, mucosal immunity, and cancer immunology. Multiple myeloid cell populations will be discussed, including tissue resident macrophages, monocytes, dendritic cells, and neutrophils. The meeting will highlight the diverse approaches being used to study myeloid cell biology, including genomic analyses, single cell profiling, imaging, and metabolic profiling. Both basic and translational aspects of myeloid cell research will be covered. The goals of the meeting are to share recent advances in this rapidly evolving field, stimulate interactions between interdisciplinary groups of scientists, and define future areas of investigation in myeloid cell research.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
MONDAY, FEBRUARY 25
TUESDAY, FEBRUARY 26
WEDNESDAY, FEBRUARY 27
THURSDAY, FEBRUARY 28
FRIDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Tiffany Horng,
ShanghaiTech University, China
Ruslan Medzhitov,
HHMI/Yale University School of Medicine, USA
Myeloid Cells in Control of Homeostasis, Inflammation, and Disease
Myeloid Cells in Control of Homeostasis, Inflammation, and Disease
09:00—11:15
Innate Immune Receptors and Myeloid Cell Activation
*
Gregory M. Barton,
University of California, Berkeley, USA
Vishva M. Dixit,
Genentech, Inc., USA
Gasdermin-D Mediates Inflammasome Signaling
Gasdermin-D Mediates Inflammasome Signaling
Coffee Break
Thirumala-Devi Kanneganti,
St. Jude Children's Research Hospital, USA
Molecular Targets for the Treatment of Inflammatory and Infectious Diseases.
Molecular Targets for the Treatment of Inflammatory and Infectious Diseases.
Tanya Freedman,
University of Minnesota, Twin Cities, USA
Short Talk: LynA Signaling and the Macrophage Response Threshold
Short Talk: LynA Signaling and the Macrophage Response Threshold
14:30—16:30
Workshop 1: Myeloid Cell Activation
*
Kaoru Saijo,
University of California, Berkeley, USA
*
Tanya Freedman,
University of Minnesota, Twin Cities, USA
Jose M. Adrover,
Centro Nacional de Investigaciones Cardiovasculares, Spain
Spontaneous Degranulation of Neutrophils Ensures Diurnal Protection of Tissues
Spontaneous Degranulation of Neutrophils Ensures Diurnal Protection of Tissues
Mallar Bhattacharya,
University of California, San Francisco, USA
Transitional Macrophages Identified by Single Cell Sequencing Drive Mesenchymal Expansion in Lung Fibrosis
Transitional Macrophages Identified by Single Cell Sequencing Drive Mesenchymal Expansion in Lung Fibrosis
Yajing Gao,
University of Texas Southwestern Medical Center, USA
Enteropathogenic Bacteria-Induced Unfolded Protein Response in Dendritic Cells Is Critical for Effective Th17 Differentiation
Enteropathogenic Bacteria-Induced Unfolded Protein Response in Dendritic Cells Is Critical for Effective Th17 Differentiation
Scott M. Gordon,
Children's Hospital of Philadelphia, USA
Novel CD122+ Macrophages Develop Under Direction of Type I Interferon
Novel CD122+ Macrophages Develop Under Direction of Type I Interferon
Jennifer Guerriero,
Dana-Farber Cancer Institute, USA
Harnessing Macrophages in Triple-Negative Breast Cancer (TNBC) to Overcome PARP-Inhibitor Resistance
Harnessing Macrophages in Triple-Negative Breast Cancer (TNBC) to Overcome PARP-Inhibitor Resistance
Michael Hickey,
Monash University, Australia
Patrolling Monocytes Initiate T Cell-Dependent Glomerular Inflammation via Presentation of Intravascular Antigen to Effector CD4+ T Cells
Patrolling Monocytes Initiate T Cell-Dependent Glomerular Inflammation via Presentation of Intravascular Antigen to Effector CD4+ T Cells
Jacob Hopkins,
Tufts University, USA
Cytosolic DNA-sensing Shapes the Tissue Macrophage Niche with Age
Cytosolic DNA-sensing Shapes the Tissue Macrophage Niche with Age
17:00—19:00
Myeloid Cells in Metabolism
*
Kathryn J. Moore,
New York University Medical Center, USA
Tiffany Horng,
ShanghaiTech University, China
Mitochondrial Glycerol 3-Phosphate Dehydrogenase GPD2 Drives Glucose Oxidation to Regulate Macrophage Inflammatory Responses
Mitochondrial Glycerol 3-Phosphate Dehydrogenase GPD2 Drives Glucose Oxidation to Regulate Macrophage Inflammatory Responses
Amira Klip,
Hospital for Sick Children, Canada
Influence of Bone Marrow Adipocytes on Monocyte Lineage during Obesity
Influence of Bone Marrow Adipocytes on Monocyte Lineage during Obesity
Mithilesh Kumar Jha,
Johns Hopkins University, USA
Short Talk: Monocarboxylate Transporter 1 (MCT1) Is Critical for Recovery from Peripheral Nerve Injury by Shifting Macrophages to a Pro-Regenerative Phenotype
Short Talk: Monocarboxylate Transporter 1 (MCT1) Is Critical for Recovery from Peripheral Nerve Injury by Shifting Macrophages to a Pro-Regenerative Phenotype
Ajay Chawla,
Merck and University of California, San Francisco, USA
Macrophages in Systemic Metabolism
Macrophages in Systemic Metabolism
08:00—11:00
Myeloid Cells in Metabolic and Inflammatory Diseases
*
Ajay Chawla,
Merck and University of California, San Francisco, USA
Peter Tontonoz,
University of California, Los Angeles, USA
Anti-Inflammatory Signaling Pathways and the Control of Adipose Thermogenesis
Anti-Inflammatory Signaling Pathways and the Control of Adipose Thermogenesis
Itzhak Mendel,
VBL Therapeutics, Israel
Short Talk: MOSPD2: Key Regulator of Myeloid Cell Migration and a Novel Target for Treatment of Inflammatory Diseases
Short Talk: MOSPD2: Key Regulator of Myeloid Cell Migration and a Novel Target for Treatment of Inflammatory Diseases
Catherine Hedrick,
La Jolla Institute for Immunology, USA
Myeloid Cells in Cancer
Myeloid Cells in Cancer
Coffee Break
Andrés Hidalgo,
Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain
Strategies of Neutrophils during Vascular Inflammation
Strategies of Neutrophils during Vascular Inflammation
Ty D. Troutman,
University of California, San Diego, USA
Short Talk: Exploiting Altered Enhancer Landscapes to Decode Pathogenic Changes in Gene Expression of Diverse Hepatic Macrophages
Short Talk: Exploiting Altered Enhancer Landscapes to Decode Pathogenic Changes in Gene Expression of Diverse Hepatic Macrophages
Kathryn J. Moore,
New York University Medical Center, USA
Macrophages in Metabolic and Inflammatory Diseases
Macrophages in Metabolic and Inflammatory Diseases
17:00—19:00
Macrophage Specification in the Tissue Environment
*
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
Frederic Geissmann,
Memorial Sloan Kettering Cancer Center, USA
Ontogeny of Tissue-Resident Macrophages
Ontogeny of Tissue-Resident Macrophages
Ruth A. Franklin,
Yale School of Medicine, USA
Short Talk: Macrophage-Fibroblast Cell Circuitry in Tissue Homeostasis and Inflammation
Short Talk: Macrophage-Fibroblast Cell Circuitry in Tissue Homeostasis and Inflammation
Stephen T. Smale,
University of California, Los Angeles, USA
Selective Transcriptional Responses of Macrophages to Environmental Stimuli
Selective Transcriptional Responses of Macrophages to Environmental Stimuli
Chinwen Lai,
Washington University in St. Louis, USA
Short Talk: Mesothelial Niche Imprints Peritoneal Macrophage Differentiation
Short Talk: Mesothelial Niche Imprints Peritoneal Macrophage Differentiation
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Myeloid Cells in Immunity and Infection
*
Jonathan C. Kagan,
Boston Children's Hospital, USA
Bas Surewaard,
University of Calgary, Canada
Myeloid Cell Dynamics in vivo
Myeloid Cell Dynamics in vivo
Nan Zhang,
Washington University in St. Louis, USA
Short Talk: Expression of Factor V by Resident Macrophages Boosts Host Defense in the Peritoneal Cavity
Short Talk: Expression of Factor V by Resident Macrophages Boosts Host Defense in the Peritoneal Cavity
Jenny P.Y. Ting,
University of North Carolina at Chapel Hill, USA
Intracellular Innate Immune Receptors: Molecular and Biologic Roles in Myeloid Cells
Intracellular Innate Immune Receptors: Molecular and Biologic Roles in Myeloid Cells
Coffee Break
Chandrashekhar Pasare,
Cincinnati Children's Hospital Medical Center, USA
Myeloid Cells in Control of Adaptive Immunity
Myeloid Cells in Control of Adaptive Immunity
Timothy J. Nice,
Oregon Health & Science University, USA
Short Talk: Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells
Short Talk: Persistence of Systemic Murine Norovirus Is Maintained by Inflammatory Recruitment of Susceptible Myeloid Cells
Denise M. Monack,
Stanford University, USA
Myeloid Cells and Bacterial Pathogenesis
Myeloid Cells and Bacterial Pathogenesis
17:00—19:00
Myeloid Cells in Mucosal Immunity
*
Denise M. Monack,
Stanford University, USA
Gregory M. Barton,
University of California, Berkeley, USA
Determinants of CD4 T Cell Responses to the Microbiota
Determinants of CD4 T Cell Responses to the Microbiota
Daniel Mucida,
Rockefeller University, USA
Tissue Adaptation: Implications for Gut Immunity and Tolerance
Tissue Adaptation: Implications for Gut Immunity and Tolerance
Balázs Koscsó,
Pennsylvania State University, USA
Short Talk: Gut-Resident IL10+CX3CR1hi Macrophages Induce Tertiary Lymphoid Tissue and IgA Response in situ
Short Talk: Gut-Resident IL10+CX3CR1hi Macrophages Induce Tertiary Lymphoid Tissue and IgA Response in situ
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Myeloid Cells in Control of Mucosal Immunity
Myeloid Cells in Control of Mucosal Immunity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Myeloid Cells in Cancer
*
Catherine Hedrick,
La Jolla Institute for Immunology, USA
Matthew L. Meizlish,
Yale University, USA
Short Talk: Macrophages Sense Extracellular Matrix Mechanics to Regulate Tissue Repair
Short Talk: Macrophages Sense Extracellular Matrix Mechanics to Regulate Tissue Repair
Steven F. Ziegler,
Benaroya Research Institute, USA
Regulation of Breast Cancer Progression by Myeloid Cell-Derived TSLP
Regulation of Breast Cancer Progression by Myeloid Cell-Derived TSLP
Coffee Break
Judith A. Varner,
University of California, San Diego, USA
Tissue-Resident and Bone Marrow-Derived Macrophage Contributions to Cancer Progression
Tissue-Resident and Bone Marrow-Derived Macrophage Contributions to Cancer Progression
Peiwen Chen,
MD Anderson Cancer Center, USA
Short Talk: Symbiotic Macrophage-Glioma Cell Interactions in the Tumor Microenvironment Reveals GBM Vulnerabilities
Short Talk: Symbiotic Macrophage-Glioma Cell Interactions in the Tumor Microenvironment Reveals GBM Vulnerabilities
Matthew F. Krummel,
University of California, San Francisco, USA
A Myeloid-Based Cellular Mancala for Tumor Antigen Presentation
A Myeloid-Based Cellular Mancala for Tumor Antigen Presentation
14:30—16:30
Workshop 2: Myeloid Cells in Health and Disease
*
Jennifer Guerriero,
Dana-Farber Cancer Institute, USA
*
Timothy J. Nice,
Oregon Health & Science University, USA
Nicholas N. Jarjour,
University of Minnesota, USA
Bhlhe40 Mediates Tissue-Specific Control of Macrophage Proliferation in Homeostasis and Type 2 Immunity
Bhlhe40 Mediates Tissue-Specific Control of Macrophage Proliferation in Homeostasis and Type 2 Immunity
Americo Lopez-Yglesias,
University of Rochester, USA
ILC1s Maintain Dendritic Cells via IFN-γ during Acute Intracellular Infection
ILC1s Maintain Dendritic Cells via IFN-γ during Acute Intracellular Infection
Gianluca Matteoli,
KU Leuven, Belgium
Phagocytosis of Dying Enteric Glial Cells Induces Neurosupportive Phenotype in Monocyte-Derived Macrophages, Limiting Enteric Neuronal Damage during Intestinal Inflammation
Phagocytosis of Dying Enteric Glial Cells Induces Neurosupportive Phenotype in Monocyte-Derived Macrophages, Limiting Enteric Neuronal Damage during Intestinal Inflammation
Michael Nash,
University of Colorado, Anschutz Medical Campus, USA
Maternal Western-Style Diet Persistently Alters Bone and Liver Myeloid Cell Development and Function in a Non-Human Primate Model
Maternal Western-Style Diet Persistently Alters Bone and Liver Myeloid Cell Development and Function in a Non-Human Primate Model
Giang T. Nguyen,
Tufts University School of Medicine, USA
SKAP-2 Is Required for Protection Against Klebsiella Pneumoniae Infection and for C-Type Lectin-Mediated ROS Production in PMNs
SKAP-2 Is Required for Protection Against Klebsiella Pneumoniae Infection and for C-Type Lectin-Mediated ROS Production in PMNs
Eva Kristine Nichols,
University of California, Berkeley, USA
Microglial Inflammasome Regulates Normal Brain Development and Prevents ADHD-Like Behavior
Microglial Inflammasome Regulates Normal Brain Development and Prevents ADHD-Like Behavior
Anh V. Vo,
University of Tsukuba, Japan
Involvement of DNAM-1 (CD226) Expressed on Small Peritoneal Macrophages in CD4+ T Cell Priming
Involvement of DNAM-1 (CD226) Expressed on Small Peritoneal Macrophages in CD4+ T Cell Priming
17:00—18:45
Tissue-Resident Macrophages
*
Frederic Geissmann,
Memorial Sloan Kettering Cancer Center, USA
Marco Colonna,
Washington University School of Medicine, USA
Microglia
Microglia
Kaoru Saijo,
University of California, Berkeley, USA
Microglia in Early Brain Development
Microglia in Early Brain Development
Nehemiah Cox,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Developmental Control of Adipose Tissue by Resident Macrophages
Short Talk: Developmental Control of Adipose Tissue by Resident Macrophages
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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