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This meeting took place in 2018
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Translational Systems Immunology (A9)
Organizer(s) Sally John, Soumya Raychaudhuri, Michael Vincent and Mark M. Davis
January 28—February 1, 2018
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Oct 2, 2017
Abstract Deadline: Oct 31, 2017
Scholarship Deadline: Oct 2, 2017
Discounted Registration Deadline: Dec 1, 2017
Sponsored by AbbVie Inc., Biogen, Bioverativ Therapeutics, Merck & Co., Inc. and Theravance Biopharma
Summary of Meeting:
Advances in large-scale data acquisition, immune phenotyping and computational biology are transforming immunology research and allowing unprecedented insights into the networks, pathways and systems that influence human health and disease. This conference will cover the exciting technology advances that are enhancing our ability to elucidate human immune function and networks as well as practical applications in drug and biomarker discovery and patient stratification. The meeting begins with a look at progress in human genetics and the use of sequencing to assign functional mutations to rare human immune phenotypes. The impact of common variants on immune function requires larger sample sizes, and speakers will cover how genome-wide high-throughput genomics in combination with detailed phenotyping and physiologically relevant perturbations are providing foundational data sets that allow an unbiased view of immune function in cells and tissues. Also discussed will be emerging computational and analytical methods that enable integration and interpretation of high-content molecular data. The meeting will then move on to look at the application of these technological advances, expanding investigation to study the immune response in tissues and organs to enable a deeper understanding of interaction between immune and non-immune cells and their respective roles in disease states. Critical to clinical progress is the translation of systems immunology research into novel therapies and diagnostic or prognostic tests. Sessions themed around infectious disease and vaccine development advances in immune-oncology and patient stratification in complex disease and treatment response aim to provide depth from foundational science to clinical translation. Finally, a key goal is fostering collaboration across disciplines and the development of novel ideas. The meeting will be relevant for immunologists, computational biologists and clinicians with an interest in molecular characterization of the immune system.
View Scholarships/Awards
Advances in large-scale data acquisition, immune phenotyping and computational biology are transforming immunology research and allowing unprecedented insights into the networks, pathways and systems that influence human health and disease. This conference will cover the exciting technology advances that are enhancing our ability to elucidate human immune function and networks as well as practical applications in drug and biomarker discovery and patient stratification. The meeting begins with a look at progress in human genetics and the use of sequencing to assign functional mutations to rare human immune phenotypes. The impact of common variants on immune function requires larger sample sizes, and speakers will cover how genome-wide high-throughput genomics in combination with detailed phenotyping and physiologically relevant perturbations are providing foundational data sets that allow an unbiased view of immune function in cells and tissues. Also discussed will be emerging computational and analytical methods that enable integration and interpretation of high-content molecular data. The meeting will then move on to look at the application of these technological advances, expanding investigation to study the immune response in tissues and organs to enable a deeper understanding of interaction between immune and non-immune cells and their respective roles in disease states. Critical to clinical progress is the translation of systems immunology research into novel therapies and diagnostic or prognostic tests. Sessions themed around infectious disease and vaccine development advances in immune-oncology and patient stratification in complex disease and treatment response aim to provide depth from foundational science to clinical translation. Finally, a key goal is fostering collaboration across disciplines and the development of novel ideas. The meeting will be relevant for immunologists, computational biologists and clinicians with an interest in molecular characterization of the immune system.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.
SUNDAY, JANUARY 28
MONDAY, JANUARY 29
TUESDAY, JANUARY 30
WEDNESDAY, JANUARY 31
THURSDAY, FEBRUARY 1
FRIDAY, FEBRUARY 2
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 28 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 1 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 2 in order to fully experience the meeting.
SUNDAY, JANUARY 28
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Sally John,
Biogen, USA
Sarah Teichmann,
Wellcome Sanger Institute, UK
Immunogenomics One Cell at a Time
Immunogenomics One Cell at a Time
09:00—11:30
Human Phenotypic Validation via Rare Genetic Mutations
Unbiased exome sequencing in Mendelian phenotypes followed by functional annotation of variants are providing unique and direct insights into the function of human immune genes.
*
Sally John,
Biogen, USA
Danish Saleheen,
University of Pennsylvania, USA
Human Knockout Program
Human Knockout Program
Coffee Break
Helen C. Su,
NIAID, National Institutes of Health, USA
Elucidating Molecular Mechanisms of a Novel Inherited Immunodeficiency-Immunodysregulation Disorder
Elucidating Molecular Mechanisms of a Novel Inherited Immunodeficiency-Immunodysregulation Disorder
Hakon Hakonarson,
Children's Hospital of Philadelphia, USA
Exome Sequencing to Diagnosis and Treat Pediatric Immune Disease
Exome Sequencing to Diagnosis and Treat Pediatric Immune Disease
Cecilia Dominguez Conde,
CeMM/LBI-RUD, Austria
Short Talk: Insights into DOCK2 Deficiency through the Analysis of Protein Interactions
Short Talk: Insights into DOCK2 Deficiency through the Analysis of Protein Interactions
Michael P. O'Connell,
NIAID, National Institutes of Health, USA
Short Talk: EXTL1- and NDST2-mediated Regulation of Allergic Disease
Short Talk: EXTL1- and NDST2-mediated Regulation of Allergic Disease
14:30—16:30
Workshop 1: Translation from Mice to Man: Friendly Debate
How can we optimize our ability to translate observations between rodent and human immunology? Advances in human immune-profiling, and genetics now provides us with greater insight into the human immune system. In addition, several failures of therapeutic approaches in humans that had compelling pre-clinical evidence suggests we may have an opportunity to better understand the relationship between the mice and man immunology. The aim of this workshop will be to compare and contrast our knowledge of rodent and human immunology with a view to applying research methods to achieve optimally translatability between species. Selected short talks will highlight research approaches and the moderators will facilitate discussion that focuses us on an end goal of testing novel immunomodulatory mechanisms in humans.
*
Michael Vincent,
Pfizer Inc., USA
*
Mark M. Davis,
Stanford University School of Medicine, USA
Jeffrey Barrett,
Genomics plc, UK
Using Human Genetics for Target Discovery in Inflammatory Bowel Disease
Using Human Genetics for Target Discovery in Inflammatory Bowel Disease
Richard M. Siegel,
NIAMS, National Institutes of Health, USA
A Systems Approach to Defining Contributions of TNF-Family Cytokines to Autoimmune Disease Susceptibility Reveals a Protective Role for TL1A/TNFSF15 in IBD
A Systems Approach to Defining Contributions of TNF-Family Cytokines to Autoimmune Disease Susceptibility Reveals a Protective Role for TL1A/TNFSF15 in IBD
Adam Laing,
King's College London, UK
Immune Parameters Are Constrained within a Multidimensional Shape that Describes Immune Competence
Immune Parameters Are Constrained within a Multidimensional Shape that Describes Immune Competence
17:00—19:00
Genetics and Epigenetics Variation in Human Immune Traits
Understanding natural genetic variability as a foundation for investigation for the immune system networks and pathways.
*
Sally John,
Biogen, USA
Julian C. Knight,
University of Oxford, UK
Genetic and Epigenetic Modulators of Monocyte Activation in Health and Disease
Genetic and Epigenetic Modulators of Monocyte Activation in Health and Disease
Anjana Rao,
La Jolla Institute for Allergy and Immunology, USA
Transcriptional and Epigenetic Regulation in Cancer and Cancer Immunotherapy
Transcriptional and Epigenetic Regulation in Cancer and Cancer Immunotherapy
Nicole Soranzo,
Wellcome Trust Sanger Institute, UK
Human Genetic Variation of Hematological Parameters
Human Genetic Variation of Hematological Parameters
Dafni Glinos,
Wellcome Trust Sanger Institute, UK
Short Talk: Genetic Effects on Transcriptional Variation of Human T Regulatory Cells
Short Talk: Genetic Effects on Transcriptional Variation of Human T Regulatory Cells
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Advancing our Understanding of Immune Cell Repertoires
Progress in understanding the natural variation in immune receptor repertoires and explore potential diagnostic and therapeutic applications.
*
Michael Vincent,
Pfizer Inc., USA
Aleksandra Walczak,
École Normale Supérieure, France
Diversity of Immune Receptor Repertoires
Diversity of Immune Receptor Repertoires
Mark M. Davis,
Stanford University School of Medicine, USA
T-Cell Repertoires and How to Read Them
T-Cell Repertoires and How to Read Them
Coffee Break
Harlan Robins,
Adaptive Biotechnologies, USA
Reading the Cellular Adaptive Immune System to Diagnose Disease
Reading the Cellular Adaptive Immune System to Diagnose Disease
George Georgiou,
University of Texas at Austin, USA
The Human Serological and BCR Antibody Repertoires in Cancer, Autoimmunity or following Vaccination
The Human Serological and BCR Antibody Repertoires in Cancer, Autoimmunity or following Vaccination
Nathaniel D. Chu,
Massachusetts Institute of Technology, USA
Short Talk: Longitudinal Immunosequencing in Healthy Individuals Reveals Persistent T Cell Receptors Rich in Public Receptors
Short Talk: Longitudinal Immunosequencing in Healthy Individuals Reveals Persistent T Cell Receptors Rich in Public Receptors
Scott Nicholas Furlan,
Seattle Children's Research Institute, USA
Short Talk: Dissecting the Mechanics of T Cell Alloproliferation
Short Talk: Dissecting the Mechanics of T Cell Alloproliferation
17:00—19:00
Integrative Analysis, Dynamic Networks and Systems Immunology
In this session we focus on different methodological approaches to build networks and models of systems.
*
Soumya Raychaudhuri,
Brigham and Women's Hospital, Harvard Medical School, USA
Kasper Lage,
Massachusetts General Hospital, USA
Human Gene and Protein Networks Perturbed by Genetics to Identify Therapeutics
Human Gene and Protein Networks Perturbed by Genetics to Identify Therapeutics
Manolis Kellis,
Massachusetts Institute of Technology, Broad Institute, USA
Talk Title to be Announced
Talk Title to be Announced
Jiyang Yu,
St. Jude Children's Research Hospital, USA
Short Talk: NetBID, a Novel Systems Biology Approach, Identifies Hippo Signaling as a “Hidden” Driver Selectively Programming CD8α+ Dendritic Cell Activity
Short Talk: NetBID, a Novel Systems Biology Approach, Identifies Hippo Signaling as a “Hidden” Driver Selectively Programming CD8α+ Dendritic Cell Activity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Systems Immunology at the Tissue Level
*
Nicole Soranzo,
Wellcome Trust Sanger Institute, UK
Betty Diamond,
Feinstein Institute for Medical Research, USA
Deconstructing Lupus Nephritis through a Single Analysis of Immune Cells in the Kidney
Deconstructing Lupus Nephritis through a Single Analysis of Immune Cells in the Kidney
Soumya Raychaudhuri,
Brigham and Women's Hospital, Harvard Medical School, USA
Single Cell Sequencing in Rheumatoid Synovial Tissue
Single Cell Sequencing in Rheumatoid Synovial Tissue
Coffee Break
Carolyn B. Coyne,
University of Pittsburgh, USA
Immunology of the Human Placenta
Immunology of the Human Placenta
Elham Azizi,
Memorial Sloan Kettering Cancer Center, USA
Computational Approaches to Understanding Cellular Heterogeneity in the Tumor-Immune Microenvironment
Computational Approaches to Understanding Cellular Heterogeneity in the Tumor-Immune Microenvironment
Zoltan Maliga,
Harvard Medical School, USA
Short Talk: Deep Immunophenotyping of Idiopathic and ICI-Induced Skin Disease with Cyclic Immunofluorescence Microscopy
Short Talk: Deep Immunophenotyping of Idiopathic and ICI-Induced Skin Disease with Cyclic Immunofluorescence Microscopy
Michelle Miron,
Columbia University, USA
Short Talk: Human Lymph Nodes Maintain Resident Memory T Cells with High Proliferative Capacity and Clonal Diversity
Short Talk: Human Lymph Nodes Maintain Resident Memory T Cells with High Proliferative Capacity and Clonal Diversity
17:00—19:00
Human Immune Response to Infectious Disease
*
Mark M. Davis,
Stanford University School of Medicine, USA
Bali Pulendran,
Stanford University School of Medicine, USA
Microbiome and B Cell Responses
Microbiome and B Cell Responses
Purvesh Khatri,
Stanford University, USA
Adventures of a "Data Parasite": Translational Medicine using Heterogeneous Public Data
Adventures of a "Data Parasite": Translational Medicine using Heterogeneous Public Data
Máté Manczinger,
MTA Szegedi Biológiai Kutatóközpont, Hungary
Short Talk: Pathogen Diversity Drives the Evolution of Promiscuous Peptide Binding of Human MHC-II Alleles
Short Talk: Pathogen Diversity Drives the Evolution of Promiscuous Peptide Binding of Human MHC-II Alleles
Susanna S. Ng,
QIMR Berghofer Medical Research Institute, Australia
Short Talk: Identifying Novel Immune Checkpoint Molecules that can be Targeted to Improve CD4+ T Helper Cell Function during Chronic Infection
Short Talk: Identifying Novel Immune Checkpoint Molecules that can be Targeted to Improve CD4+ T Helper Cell Function during Chronic Infection
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:30
Immuno-Oncology from Basic Science to Clinical Practice
The next generation of oncology drugs relies upon a deeper knowledge of the interaction between host immune system and tumour biology.
*
Kasper Lage,
Massachusetts General Hospital, USA
Shannon J. Turley,
Genentech, Inc., USA
Leukocyte Function and Positioning in Diverse Stromal Niches
Leukocyte Function and Positioning in Diverse Stromal Niches
Alexandra Snyder,
Merck, USA
T Cell Receptor Sequencing (TCR) in Immuno-Oncology: Systemic, Intratumoral and Antigen-Specific Immunity
T Cell Receptor Sequencing (TCR) in Immuno-Oncology: Systemic, Intratumoral and Antigen-Specific Immunity
Coffee Break
Cassian Yee,
University of Texas MD Anderson Cancer Center, USA
Terminators: No Fate but What You Make
Terminators: No Fate but What You Make
Wendy Broom,
Genocea Biosciences, USA
Neoantigen Identification using ATLAS Across Multiple Tumor Types Highlights Limitations of Prediction Algorithms
Neoantigen Identification using ATLAS Across Multiple Tumor Types Highlights Limitations of Prediction Algorithms
Pauline L. Gonnord,
INSERM UMR1043, France
Short Talk: High-Dimensional Immunophenotyping of Chronic Lymphocytic Leukemia (CLL) Patients Reveals Remodeling of the CD8+ T Cell Compartment by Tumor Progression and Predicts Need for Therapy
Short Talk: High-Dimensional Immunophenotyping of Chronic Lymphocytic Leukemia (CLL) Patients Reveals Remodeling of the CD8+ T Cell Compartment by Tumor Progression and Predicts Need for Therapy
Daniel Wells,
Parker Institute for Cancer Immunotherapy, USA
Short Talk: Genetic Mechanisms of Immune Evasion in Colorectal Cancer
Short Talk: Genetic Mechanisms of Immune Evasion in Colorectal Cancer
Mazlina Ismail,
University College London, UK
Short Talk: Characterising the T Cell Receptor Repertoire of Patients with Non-small-cell Lung Cancer (NSCLC) within the Lung TRACERx Study
Short Talk: Characterising the T Cell Receptor Repertoire of Patients with Non-small-cell Lung Cancer (NSCLC) within the Lung TRACERx Study
14:30—16:30
Workshop 2: CyTOF Change to Human Immunoprofiling
*
Soumya Raychaudhuri,
Brigham and Women's Hospital, Harvard Medical School, USA
Petter Brodin,
Karolinska Institutet, Sweden
Convergence of Immune Systems in Diverse Newborn Children during the First Months of Life
Convergence of Immune Systems in Diverse Newborn Children during the First Months of Life
Jean-Louis Palgen,
CEA, France
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response
Prime and Boost Vaccination Elicit a Distinct Innate Myeloid Cell Immune Response
Luis Miguel Franco,
National Institutes of Health, USA
Immune Regulation by Glucocorticoids Can Be Linked to Cell-Lineage-Specific Transcriptional Responses
Immune Regulation by Glucocorticoids Can Be Linked to Cell-Lineage-Specific Transcriptional Responses
Oisin Huhn,
University of Cambridge, UK
Characterizing the Architecture of the Decidual Natural Killer Cell Niche using Time of Flight Mass Cytometry
Characterizing the Architecture of the Decidual Natural Killer Cell Niche using Time of Flight Mass Cytometry
Ainhoa Perez-Diez,
NIAID, National Institutes of Health, USA
Antibody Profiling Identifies a Strong and Widespread Auto-Immune Response in Idiopathic CD4 Lymphopenic Patients
Antibody Profiling Identifies a Strong and Widespread Auto-Immune Response in Idiopathic CD4 Lymphopenic Patients
Arnon Arazi,
Broad Institute, USA
Beyond Clustering: Using scRNA-seq Data to Generate Quantitative, Testable Models of Human Disease
Beyond Clustering: Using scRNA-seq Data to Generate Quantitative, Testable Models of Human Disease
Ning Jenny Jiang,
University of Texas at Austin, USA
High-Throughput Detection of T Cell Antigen Reactivity at Single T Cell Level using de novo Generated DNA-Linked MHC Tetramers
High-Throughput Detection of T Cell Antigen Reactivity at Single T Cell Level using de novo Generated DNA-Linked MHC Tetramers
17:00—19:00
Clinical Immunoprofiling and Patient Stratification
*
David M. Sansom,
University College London Medical School, UK
Holden T. Maecker,
Stanford School of Medicine, USA
Comprehensive Immune Profiling and Functional Analysis of Human Aging / Response to Therapy
Comprehensive Immune Profiling and Functional Analysis of Human Aging / Response to Therapy
Sally John,
Biogen, USA
A Network Approach to Understanding the Role of the Immune System in Neurodegenerative Disease
A Network Approach to Understanding the Role of the Immune System in Neurodegenerative Disease
Sathya Baarathi Shanthi Ravichandran,
Indian Institute of Science, India
Short Talk: Identification of a Robust Blood-Based Biomarker Signature for Chronic Systemic Inflammation through a Meta-Analysis of Disease Networks
Short Talk: Identification of a Robust Blood-Based Biomarker Signature for Chronic Systemic Inflammation through a Meta-Analysis of Disease Networks
Maria Gutierrez-Arcelus,
Harvard Medical School, USA
Short Talk: Cis Regulatory Variation Determines Time Dependent Allelic Expression of HLA-DQB1 during T Cell Activation
Short Talk: Cis Regulatory Variation Determines Time Dependent Allelic Expression of HLA-DQB1 during T Cell Activation
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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