Keystone Symposia

Hyatt Regency Monterey Floorplan

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This meeting took place in 2018

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Cells vs. Pathogens: Intrinsic Defenses and Counterdefenses (C4)

Organizer(s) Sara R. Cherry, Craig R. Roy and Harmit S. Malik
March 23—26, 2018
Hyatt Regency Monterey • Monterey, CA USA
Discounted Abstract Deadline: Nov 21, 2017
Abstract Deadline: Dec 19, 2017
Scholarship Deadline: Nov 21, 2017
Discounted Registration Deadline: Jan 16, 2018

Supported by the Directors' Fund

Summary of Meeting:
Cells have evolved complex mechanisms to detect and respond to infection. We are only beginning to uncover the cellular mechanisms that engage invading pathogens to restrict infection. While bacteria, viruses and parasites are seemingly different, emerging data suggests that there is a convergence of cellular pathways that target these invading pathogens, which these pathogens have developed subversive strategies to evade. This conference will focus on host processes at the forefront of this battle and how pathogens are targeted. From the initial stages of non-self-recognition to the effector pathways engaged, these diverse pathogens are both manipulated and manipulating the system. Cutting-edge technologies are driving our deeper understanding of how core biological processes can be regulated in the favor of the host, or pathogen, and how these new mechanisms might be harnessed to treat diverse diseases. This meeting focuses on intrinsic mechanisms of defense across pathogens, bringing together diverse areas of expertise showcasing the convergence of pathways engaged.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Friday, March 23 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Monday, March 26 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Tuesday, March 27 in order to fully experience the meeting.


Arrival and Registration

Regency Foyer Terrace
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Regency Foyer Terrace



Regency Grand IV-VI
Poster Setup

Regency Grand IV-VI
Poster Viewing

Regency Grand IV-VI
Welcome and Keynote Address

Regency Grand I-III
* Sara R. Cherry, University of Pennsylvania, USA

Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Intrinsic Antiviral Defenses

Cellular Barriers to Infection

Regency Grand I-III
* Vera Tarakanova, Medical College of Wisconsin, USA

Carolyn B. Coyne, University of Pittsburgh, USA
Breaking Barriers – Virus Infection of Polarized Host Cells

Coffee Break

Emily Troemel, University of California, San Diego, USA
C. elegans Barriers to Microsporidia

Andreas J. Bäumler, University of California, Davis, USA
Healthy Guts Exclude Oxygen

Molly A. Matty, Duke University, USA
Short Talk: Whole Animal Chemical and Genetic Screens Identify P2RX7 Modulation as a Host-Directed Strategy for Control of Mycobacterial Infection


Regency Grand IV-VI
Poster Session 1

Regency Grand IV-VI

Regency Grand I-III
* Sara R. Cherry, University of Pennsylvania, USA

Kim Davis, Johns Hopkins University, Bloomberg School of Public Health, USA
Subpopulations of Stressed Y. Pseudotuberculosis Have Reduced Antibiotic Susceptibility

Aaron E. Lin, Princeton University, USA
Improving Detection of ADAR-Mediated A-to-I Viral RNA Editing using ICE-MaP

Stephanie Ragland, University of Virginia, USA
Neisseria Gonorrhoeae Employs Two Protein Inhibitors to Evade Killing by Human Lysozyme

Laughing Bear Torrez, Stanford University, USA
CD47 Blockade Reduces Cellular Sequestration and Promotes Survival of Cerebral Malaria

Melissa Kane, Rockefeller University, USA
Nuclear Pore Heterogeneity Affects HIV-1 Infection and the Antiviral Activity of Mx2

Blake Richardson, University of Texas Southwestern Medical Center, USA
IFI6 is an ER-Localized Antiviral Effector that Requires HSPA5 to Inhibit Flavivirus Replication

Emily A. Madden, University of North Carolina at Chapel Hill, USA
RNA Structural Analysis of Chikungunya Virus Identifies 3'UTR Isoforms that Impact Viral Host Range and Replication

Michal P. Wandel, MRC Laboratory of Molecular Biology, UK
Interferon-Induced GTPases (GBPs) Attack Shigella flexneri Unless Degraded by the Bacterial Ubiquitin Ligase IpaH9.8

Coffee Available

Regency Foyer Terrace
Pattern Recognition and Evasion

Regency Grand I-III
* John W. Schoggins, University of Texas Southwestern Medical Center, USA

Sun Hur, Harvard Medical School, USA
MDA5 – Self vs. Non-Self dsRNA Discrimination

John C. Boothroyd, Stanford University School of Medicine, USA
The Challenge of Life in a Bubble: How the Intracellular Parasite, Toxoplasma gondii, Manipulates its Host from Inside a Parasitophorous Vacuole

Luciano A. Marraffini, Rockefeller University, USA
Generation of Memory during the CRISPR-Cas Immune Response

Holly Ramage, University of Pennsylvania, USA
Short Talk: Using Proteomics Tools to Discover New Mechanisms in Flaviviral Infection

On Own for Dinner



Regency Grand IV-VI
Metabolic Control as a Defense

Regency Grand I-III
* Jörn Coers, Duke University, USA

Nihal Altan-Bonnet, NHLBI, National Institutes of Health, USA
Vesicular Transmission of Viral Populations: Strength in Numbers

Maayan Levy, University of Pennsylvania, USA
Metabolic Control of Intestinal Epithelial Cell Function

Coffee Break

Ken H. Cadwell, New York University School of Medicine, USA
Autophagy in Resistance versus Tolerance during Infectious Disease

Russell E. Vance, University of California, Berkeley, USA
Cytosolic Sensing of Bacterial Pathogens

Ram Savan, University of Washington, USA
Short Talk: Infiltrating Enemy Territory: Host RNA Binding Proteins Localized to Viral Factories

On Own for Lunch

Poster Setup

Regency Grand IV-VI
Poster Viewing

Regency Grand IV-VI
Coffee Available

Regency Foyer Terrace
Cell Biological Control of Infection through Capture

Regency Grand I-III
* Jeffery S. Cox, University of California, Berkeley, USA

Craig R. Roy, Yale University School of Medicine, USA
Manipulation of Autophagy by Intracellular Pathogens

Ivan Dikic, Goethe University Medical School, Germany
Phosphoribosyl-Dependent Ubiquitination in Regulation of Host-Pathogen Interface

Julie Magarian Blander, Weill Cornell Medicine, Cornell University, USA
A Cell Autonomous Stress Response to Bacterial Viability

Scott D. Pegan, University of Georgia, USA
Short Talk: Impact of ISG15 Species-Species Variation on ISG15 Structure and Viral-Host Interactions

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Regency Grand IV-VI
Poster Session 2

Regency Grand IV-VI



Regency Grand IV-VI
Evolution and Co-Evolution of Intrinsic Defenses

Regency Grand I-III
Harmit S. Malik, Fred Hutchinson Cancer Research Center, USA
Using Rapid Evolution to Dissect and Enhance Antiviral Specificity

Jörn Coers, Duke University, USA
Antibacterial Host Defense by IFN-Inducible Guanylate Binding Proteins

Coffee Break

Alan G. Goodman, Washington State University, USA
Conservation of Host-Pathogen Interactions and Innate Immunity in Insects and Mammals

Paul E. Turner, Yale University, USA
Using Phage to Select for Evolution of Reduced Virulence in Pathogenic Bacteria

* Tamara O'Connor, Johns Hopkins School of Medicine, USA
Short Talk: The Evolution of a Human Bacterial Pathogen from the Combined Selective Pressures of Multiple Environmental Hosts

On Own for Lunch

Coffee Available

Regency Foyer Terrace
Systems Approaches to Discover Intrinsic Effectors

Regency Grand I-III
* Holly Ramage, University of Pennsylvania, USA

Sara R. Cherry, University of Pennsylvania, USA
Using Functional Genomics to Explore Arbovirus-Host Interactions

Nels C. Elde, University of Utah, USA
Interim Immune Functions

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Regency Grand I-III
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Regency Grand IV-VI
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Regency Grand IV-VI



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 AI136565-01

Funding for this conference was made possible (in part) by 1 R13 AI136565-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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