Keystone Symposia

Doubletree by Hilton - Park City Floorplan

This meeting took place in 2017



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Frontiers of Serotonin Beyond the Brain (T5)


Organizer(s) Fusun Kilic, Michael D. Gershon and Luc Maroteaux
November 12—15, 2017
Doubletree by Hilton - Park City • Park City, UT USA
Discounted Abstract Deadline: Jul 11, 2017
Abstract Deadline: Aug 10, 2017
Scholarship Deadline: Jul 11, 2017
Discounted Registration Deadline: Sep 12, 2017

Supported by the Directors' Fund

Summary of Meeting:
Serotonin is a multifunctional signaling molecule that plays extra-cerebral roles, not only in adult life but in development as well. Although research concerning extra-cerebral serotonin is growing rapidly and interest in the subject is great, the physiological control and underlying molecular processes, as well as the involvement of peripheral serotonin in disease, have not been definitively established. Furthermore, the role of serotonin in peripheral tissues, has been neglected and under-represented at current meetings, which have focused on the 3-5% of the body’s serotonin that is present in the central nervous system. Therefore, this Keystone Symposia meeting aims to reveal insights into the role of serotonin in peripheral tissues, specifically in the diagnosis, prevention and treatment of many diseases, which is long overdue.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, November 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, November 15 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Thursday, November 16 in order to fully experience the meeting.

SUNDAY, NOVEMBER 12

16:00—20:00
Arrival and Registration

Main Hotel Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Vertical Lounge

MONDAY, NOVEMBER 13

07:30—08:30
Breakfast

Summit B & C
08:30—09:30
Welcome and Keynote Address

Summit A
* Fusun Kilic, Merced College, USA
Session Chair

Michael D. Gershon, Columbia University, USA
Serotonergic Regulation of Enteric Neurogenesis

09:30—12:00
Serotonin, a Major Peripheral Neurohormone

Summit A
* Fusun Kilic, Merced College, USA
Session Chair

Elaine Y. Hsiao, University of California, Los Angeles, USA
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

Coffee Break

Gary M. Mawe, University of Vermont, USA
Mucosal Serotonin Signaling in the Gut: Changes in Disease and Therapeutic Targets

Nick J. Spencer, Flinders University, Australia
Is There a Role for Mucosal Serotonin in the Generation of Neurogenic Motor Patterns in the Gut Wall?

Supriya Srinivasan, The Scripps Research Institute, USA
Short Talk: Serotonergic Orchestration of Energy Balance: Translating Insights and New Pathways from Caenorhabditis elegans

Natalia Alenina, Max Delbrück Center for Molecular Medicine, Germany
Short Talk: Reevaluation of Serotonin Synthesis Pathways: Phenylalanine Hydroxylase as an Alternative Source of Peripheral Serotonin

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

Summit B & C
13:00—22:00
Poster Viewing

Summit B & C
16:30—17:00
Coffee Available

Summit Foyer
17:00—19:00
Serotonin in a New Drug Target

Summit A
* Michael D. Gershon, Columbia University, USA
Session Chair

Gerard Karsenty, Columbia University Medical Center, USA
Serotonin in a New Drug Target

Suman Wason, Lexicon Pharmaceuticals, Inc., USA
Tryptophan Hydroxylase Inhibitors for Carcinoid Syndrome

Michael Bader, Max Delbrück Center for Molecular Medicine, Germany
Peripheral Serotonin, a New Drug Target

Mari Lilith Lund, University of Copenhagen, Denmark
Short Talk: Serotonin-Producing Enterochromaffin Cells Are a Major Target for GLP-1 in the Gastrointestinal Tract

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Summit B & C
19:30—22:00
Poster Session 1

Summit B & C

TUESDAY, NOVEMBER 14

07:30—08:30
Breakfast

Summit B & C
08:30—09:30
Keynote Address

Summit A
* Laurent Monassier, Université de Strasbourg, France
Session Chair

Stephanie Wengert Watts, Michigan State University, USA
5-HT and Blood Pressure: Knowing and Learning

09:30—11:45
Serotonin in the Circulatory System

Summit A
* Laurent Monassier, Université de Strasbourg, France
Session Chair

Francine Côté, INSERM, France
Bone Marrow-Derived Serotonin Regulates Expansion of Red Blood Cell Progenitors

Coffee Break

Harvey J. Kliman, Yale University, USA
The Serotonin Highway in the Human Placenta: Serotonin Transport from Mother to Fetus

Fusun Kilic, Merced College, USA
Serotonin Transporter in Platelets and Placenta

Yahan Liu, Peking University Health Science Center, China
Short Talk: 5-HT2BR Promoted Vascular Restenosis via β-arrestin2-mTOR/p70S6K Pathway

11:45—17:00
On Own for Lunch

13:00—22:00
Poster Viewing

Summit B & C
16:30—17:00
Coffee Available

Summit Foyer
17:00—19:00
Serotonin Receptors in Cardiovascular and Pulmonary Functions

Summit A
* Stephanie Wengert Watts, Michigan State University, USA
Session Chair

Laurent Monassier, Université de Strasbourg, France
Heart Disease and Valvulopathy

Luc Maroteaux, INSERM UMR-S 839 / Université Pierre et Marie Curie (UPMC), France
Serotonin Receptor Signaling in Development

Kevin Currie, Cooper Medical School of Rowan University, USA
Peripheral Serotonin and Control of the Sympathoadrenal Stress Response

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Summit B & C

WEDNESDAY, NOVEMBER 15

07:30—08:30
Breakfast

Summit B & C
08:30—11:30
Peripheral Serotonin in Relation to Brain Function and Development

Summit A
* Luc Maroteaux, INSERM UMR-S 839 / Université Pierre et Marie Curie (UPMC), France
Session Chair

Kara Gross Margolis, NewYork-Presbyterian Morgan Stanley Children's Hospital, USA
The Involvement of Peripheral Serotonin in Autism

Randy Blakely, Florida Atlantic University, USA
Keeping the Periphery in Mind: Peripheral Inflammatory Modulation of Behavior Mediated by CNS Serotonin

Coffee Break

Alexandre Bonnin, University of Southern California, USA
Prenatal Exposures and Placental Serotonin: a Pathway for the Fetal Programming of Mental Disorders

Hail Kim, Korea Advanced Institute of Science and Technology, South Korea
Regulation of Systemic Energy Homeostasis by Peripheral Serotonin

Jeremy M. Veenstra-VanderWeele, Columbia University and New York State Psychiatric Institute, USA
Short Talk: Maternal Whole Blood Serotonin Levels Are Associated with Cognitive Ability and Core Symptoms in Children with Autism Spectrum Disorder

11:30—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Summit Foyer
17:00—18:45
Serotonin in Diseases

Summit A
* Michael Bader, Max Delbrück Center for Molecular Medicine, Germany
Session Chair

Joanne Wang, University of Washington, USA
Serotonin Transporter Deficiency Drives Estrogen-Dependent Obesity and Glucose Intolerance

Robin L. Haynes, Children's Hospital Boston, USA
High Levels of Serum Serotonin in Sudden Infant Death Syndrome

Terence Keith Smith, University of Nevada School of Medicine, USA
Does Neuronal Serotonin Have a Role in Colonic Motor Patterns?

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Summit A
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Summit B & C
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Summit B & C

THURSDAY, NOVEMBER 16

11:00—11:00
Departure


*Session Chair †Invited, not yet responded.



We gratefully acknowledge support for this conference from:


Directors' Fund


These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.



We gratefully acknowledge additional support for this conference from:

Chroma Technology Corporation Oncotarget

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179