Keystone Resort Floorplan
This meeting took place in 2018
Here are the related meetings in 2024:
Neurodegenerative Diseases (Z3)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Advances in Neurodegenerative Disease Research and Therapy (Z3)
Organizer(s) Li Gan, Leonard Petrucelli and Morgan H. Sheng
June 17—21, 2018
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Feb 15, 2018
Abstract Deadline: Mar 15, 2018
Scholarship Deadline: Feb 15, 2018
Discounted Registration Deadline: Apr 18, 2018
Sponsored by Ionis Pharmaceuticals, Inc., Merck & Co., Inc., Nestlé Institute of Health Sciences, Roche and Takeda Pharmaceutical Company Limited
Summary of Meeting:
As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
View Scholarships/Awards
As the world population ages, neurodegenerative diseases are becoming the new epidemic in both developed and developing countries. Progress made in human genetics has revealed increasingly more disease-associated genes for Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemoral dementia (FTD), amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. These discoveries have linked neurodegenerative diseases with several common key biological processes that have so far been under-studied, including RNA metabolism, protein trafficking and innate immune responses. By focusing on these emerging areas in neurodegenerative disease research, this conference seeks to challenge the current research paradigms and to inspire in-depth discussion and exploration. The program assembles leaders from various fields to facilitate interactions between groups using diverse approaches, by providing a platform to cross-fertilize ideas and to encourage new collaborations that could lead to novel mechanisms and therapeutic targets against neurodegenerative diseases.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, June 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 22 in order to fully experience the meeting.
SUNDAY, JUNE 17
MONDAY, JUNE 18
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
TUESDAY, JUNE 19
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
WEDNESDAY, JUNE 20
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
THURSDAY, JUNE 21
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
FRIDAY, JUNE 22
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, June 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, June 22 in order to fully experience the meeting.
SUNDAY, JUNE 17
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:30—09:30
Welcome and Keynote Address
*
Li Gan,
Weill Cornell Medicine, USA
Session Chair
Session Chair
Huda Y. Zoghbi,
Baylor College of Medicine, USA
Insights From Rare Disorders Shed Light on Common Neurodegenerative Diseases
Insights From Rare Disorders Shed Light on Common Neurodegenerative Diseases
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
08:30—09:30
Welcome and Keynote Address
*
Marco Prinz,
University of Freiburg, Germany
Session Chair
Session Chair
09:30—12:00
Genetics to Epigenetics in Neurodegenerative Diseases
*
Leonard Petrucelli,
Mayo Clinic Jacksonville, USA
Session Chair
Session Chair
John Hardy,
University College London, Institute of Neurology, UK
Genomics and Pathways to Neurodegeneration
Genomics and Pathways to Neurodegeneration
Coffee Break
Catherine Marquer,
Columbia University, USA
Short Talk: Excess Synaptojanin 1 Drives Age-Dependent Cognitive Deficits, a Unifying Mechanism for Individuals at High Risk of Alzheimer's Disease
Short Talk: Excess Synaptojanin 1 Drives Age-Dependent Cognitive Deficits, a Unifying Mechanism for Individuals at High Risk of Alzheimer's Disease
Alison Goate,
Icahn School of Medicine at Mount Sinai, USA
Genetic Studies Implicate Microglial Function in Alzheimer's Disease Risk
Genetic Studies Implicate Microglial Function in Alzheimer's Disease Risk
Li-Huei Tsai,
Massachusetts Institute of Technology, USA
Transcriptomic Analysis at Single Cell Resolution in Neurodegeneration
Transcriptomic Analysis at Single Cell Resolution in Neurodegeneration
John D. Fryer,
Mayo Clinic, USA
Short Talk: Translational Profiling of Microglia Reveals a Shared apoE Pathway Common to Aging, Amyloid and Tau Pathology
Short Talk: Translational Profiling of Microglia Reveals a Shared apoE Pathway Common to Aging, Amyloid and Tau Pathology
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
09:30—12:00
Immune Privilege, Blood-Brain Barrier and Microglia I
*
Knut Biber,
AbbVie Deutschland GmbH & Co. KG, Germany
Session Chair
Session Chair
Josef Priller,
Charité – Universitätsmedizin Berlin, Germany
From Bone Marrow to Brain: How Myeloid Cells Can Enter the CNS
From Bone Marrow to Brain: How Myeloid Cells Can Enter the CNS
Coffee Break
Jonathan Kipnis,
Washington University School of Medicine, USA
Lymphatics in the CNS and Their Role in Neurological Diseases
Lymphatics in the CNS and Their Role in Neurological Diseases
Richard Daneman,
University of California, San Diego, USA
Regulation of the Blood-Brain Barrier in Health and Disease
Regulation of the Blood-Brain Barrier in Health and Disease
Karen De Vlaminck,
Vrije Universiteit Brussel, Belgium
Short Talk: The Fate and Dynamics of Microglia, Border Macrophages and Infiltrating Monocytes during the Onset and Resolution of Infectious Neuroinflammation
Short Talk: The Fate and Dynamics of Microglia, Border Macrophages and Infiltrating Monocytes during the Onset and Resolution of Infectious Neuroinflammation
Cayce Dorrier,
University of California, San Diego, USA
Short Talk: The Role of the Fibrotic Scar in Repair following Neuroinflammation
Short Talk: The Role of the Fibrotic Scar in Repair following Neuroinflammation
17:00—19:00
Aging in Health and Disease
*
Morgan H. Sheng,
Broad Institute of MIT and Harvard, USA
Session Chair
Session Chair
Andrew G. Dillin,
University of California, Berkeley, USA
Aging in Protein, Homeostasis and Stress
Aging in Protein, Homeostasis and Stress
Ana Maria Cuervo,
Albert Einstein College of Medicine, USA
Contribution of Aging of Selective Autophagy to Neurodegeneration
Contribution of Aging of Selective Autophagy to Neurodegeneration
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Dissecting the Role of Cerebrovascular Dysfunction in Brain Aging
Dissecting the Role of Cerebrovascular Dysfunction in Brain Aging
Edward Giniger,
NINDS, National Institutes of Health, USA
Short Talk: Separating the Roles of Autophagy, Immunity and Aging in Neurodegeneration
Short Talk: Separating the Roles of Autophagy, Immunity and Aging in Neurodegeneration
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
17:00—19:00
Immune Privilege, Blood-Brain Barrier and Microglia II
*
Bart J.L. Eggen,
University Medical Center Groningen, Netherlands
Session Chair
Session Chair
Doron Merkler,
University of Geneva, Switzerland
Interaction between Neurons, Phagocytes and T Cells in Neuroinflammation
Interaction between Neurons, Phagocytes and T Cells in Neuroinflammation
Michal Schwartz,
Weizmann Institute of Science, Israel
Fighting Alzheimer's Disease by Unleashing the Innate and Adaptive Immune Cells
Fighting Alzheimer's Disease by Unleashing the Innate and Adaptive Immune Cells
Zhen Xu,
Shenzhen University, China
Short Talk: Repopulated Microglia Are Solely Derived from the Proliferation of Residual Microglia after Acute Depletion
Short Talk: Repopulated Microglia Are Solely Derived from the Proliferation of Residual Microglia after Acute Depletion
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Innate Immunity
*
David M. Holtzman,
Washington University, USA
Session Chair
Session Chair
Adriano M. Aguzzi,
University Hospital of Zürich, Switzerland
Protein Aggregation and Pathways of Toxicity
Protein Aggregation and Pathways of Toxicity
Christian Haass,
Ludwig-Maximilians University Munich, Germany
Loss of TREM2 Function Increases Amyloid Seeding but Reduces Plaque-Associated ApoE
Loss of TREM2 Function Increases Amyloid Seeding but Reduces Plaque-Associated ApoE
Matthew A. Cooper,
University of Queensland, Australia
Short Talk: Pharmacological Inhibition of the NLRP3 Inflammasome Prevents Synuclein Pathology and Dopaminergic Degeneration in Parkinson's Disease
Short Talk: Pharmacological Inhibition of the NLRP3 Inflammasome Prevents Synuclein Pathology and Dopaminergic Degeneration in Parkinson's Disease
Coffee Break
Christopher K. Glass,
University of California, San Diego, USA
Genomic Approaches to Dissect Innate Immunity in Neurodegeneration
Genomic Approaches to Dissect Innate Immunity in Neurodegeneration
Andrew B. West,
University of Alabama at Birmingham, USA
Short Talk: LRRK2 Mediates the Recruitment of Monocyte-Derived Macrophages to the Brain in Neurodegeneration
Short Talk: LRRK2 Mediates the Recruitment of Monocyte-Derived Macrophages to the Brain in Neurodegeneration
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
08:30—11:45
Cross-Talk of Microglia with Other CNS Cells
*
Katrin Kierdorf,
Uniklinik Freiburg, Germany
Mikael Simons,
Technische Universität München, Germany
Cholesterol Metabolisms as Key Regulator of Phagocyte Function during Remyelination
Cholesterol Metabolisms as Key Regulator of Phagocyte Function during Remyelination
Francisco J. Quintana,
Harvard Medical School and the Broad Institute of MIT and Harvard, USA
Astrocytes and Microglia
Astrocytes and Microglia
Coffee Break
Anna Victoria Molofsky,
University of California, San Francisco, USA
Astrocyte-Microglial Communication in Developmental Synapse Remodeling
Astrocyte-Microglial Communication in Developmental Synapse Remodeling
Burkhard Becher,
University of Zürich, Switzerland
T Cell Entry into the CNS: How Myelin Is Presented
T Cell Entry into the CNS: How Myelin Is Presented
Courtney Malo,
NIAID, National Institutes of Health, USA
Short Talk: MHC Class I Expression by Microglia Is Required for Generating a Complete Antigen-Specific CD8 T Cell Response in the CNS
Short Talk: MHC Class I Expression by Microglia Is Required for Generating a Complete Antigen-Specific CD8 T Cell Response in the CNS
Phi T. Nguyen,
University of California, San Francisco, USA
Short Talk: The IL-33-IL1RL1 Signaling Axis Coordinates Remodeling and Integration of Adult-Born Neurons in the Hippocampus
Short Talk: The IL-33-IL1RL1 Signaling Axis Coordinates Remodeling and Integration of Adult-Born Neurons in the Hippocampus
17:00—19:00
Neuronal and Network Dysfunction in Neurodegeneration
*
Li-Huei Tsai,
Massachusetts Institute of Technology, USA
Session Chair
Session Chair
Huaxi Xu,
Sanford Burnham Prebys Medical Discovery Institute, USA
A Novel Mechanism for Memory/Synaptic Dysfunction in Tauopathy
A Novel Mechanism for Memory/Synaptic Dysfunction in Tauopathy
Zayd M. Khaliq,
NINDS, National Institutes of Health, USA
Dendritic Ca2+ Signaling in Substantia Nigra Dopamine Neuron Subpopulations
Dendritic Ca2+ Signaling in Substantia Nigra Dopamine Neuron Subpopulations
Morgan H. Sheng,
Broad Institute of MIT and Harvard, USA
Mechanisms of Synapse Loss Revealed by Proteomic Analysis of Post-Synaptic Density in Tauopathy Mouse Model
Mechanisms of Synapse Loss Revealed by Proteomic Analysis of Post-Synaptic Density in Tauopathy Mouse Model
Keran Ma,
University of California, San Francisco, USA
Short Talk: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease
Short Talk: Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
17:00—19:00
Myeloid Cells and Neuroinflammation
*
Erik H.W.G.M. Boddeke,
University of Groningen, Netherlands
Session Chair
Session Chair
Masaaki Murakami,
Hokkaido University, Japan
Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS
Neural Stimulations Modulate the Formation of Immune Cell Gateways into the CNS
Akihiko Yoshimura,
Keio University, Japan
Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells
Regulation of Inflammation after Stroke by Macrophages and Regulatory T Cells
Robyn S. Klein,
Washington University School of Medicine, USA
Trm-Derived IFNg Causes Microglial-Mediated Spatial Learning Defects during Recovery from Differentially Neurotropic Flaviviruses
Trm-Derived IFNg Causes Microglial-Mediated Spatial Learning Defects during Recovery from Differentially Neurotropic Flaviviruses
Kevin G. Burfeind,
Oregon Health & Science University, USA
Short Talk: Infiltrating Myeloid Cells in the Central Nervous System Mediate Cancer Cachexia
Short Talk: Infiltrating Myeloid Cells in the Central Nervous System Mediate Cancer Cachexia
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
Protein Trafficking and Degradation
*
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Session Chair
Session Chair
Baris Bingol,
Genentech, Inc., USA
Lysosomal Degradation in Parkinson's Disease
Lysosomal Degradation in Parkinson's Disease
Michael E. Ward,
NINDS, National Institutes of Health, USA
Short Talk: Progranulin Mediates Endolysosomal Recruitment of the RNP-Associated Protein ANXA11
Short Talk: Progranulin Mediates Endolysosomal Recruitment of the RNP-Associated Protein ANXA11
Coffee Break
Jaehong Suh,
Massachusetts General Hospital / Harvard Medical School, USA
Short Talk: Role of Ataxin-1 in BACE1 Expression and Axonal Targeting in the Cerebrum
Short Talk: Role of Ataxin-1 in BACE1 Expression and Axonal Targeting in the Cerebrum
R. Jeremy Nichols,
Parkinson's Institute, USA
Short Talk: SQSTM1/p62 Is a Novel Substrate of the Parkinson's Disease Kinase LRRK2 that Activates its Kinase Domain and Enhances Neuronal Toxicity
Short Talk: SQSTM1/p62 Is a Novel Substrate of the Parkinson's Disease Kinase LRRK2 that Activates its Kinase Domain and Enhances Neuronal Toxicity
Naruhiko Sahara,
National Institute of Radiological Sciences, Japan
Short Talk: Neuroinflammatory Process during Pathogenesis of Tauopathy in rTg4510 Mice
Short Talk: Neuroinflammatory Process during Pathogenesis of Tauopathy in rTg4510 Mice
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
08:30—11:45
Imaging of the Healthy and Diseased CNS
*
Sophia Bardehle,
Merck, USA
Session Chair
Session Chair
Wenbiao Gan,
Skirball Institute Program of Molecular Neurobiology, USA
The Role of Microglia in Learning-Dependent Synaptic Plasticity
The Role of Microglia in Learning-Dependent Synaptic Plasticity
Martin Kerschensteiner,
Ludwig Maximilians University Munich, Germany
In vivo Analysis of Phagocyte Phenotypes and Effector Function
In vivo Analysis of Phagocyte Phenotypes and Effector Function
Coffee Break
Melanie Meyer-Luehmann,
University of Freiburg, Germany
Microglia Contribution to the Propagation of Abeta Pathology
Microglia Contribution to the Propagation of Abeta Pathology
Francesca Peri,
European Molecular Biology Laboratory, Germany
Microglia and Neuronal Interactions
Microglia and Neuronal Interactions
Anna Mechling,
Roche Innovation Center Basel, Hoffmann-La Roche Ltd., Switzerland
Short Talk: Pivotal Role of Microglial TREM2 in Remyelination as Revealed by Multiparametric Magnetic Resonance Imaging in the Cuprizone Mouse Model
Short Talk: Pivotal Role of Microglial TREM2 in Remyelination as Revealed by Multiparametric Magnetic Resonance Imaging in the Cuprizone Mouse Model
Vijayasree V. Giridharan,
University of Texas Health Science Center, USA
Short Talk: Imaging of Microglial Activation in Experimental Bacterial Meningitis using PET/CT
Short Talk: Imaging of Microglial Activation in Experimental Bacterial Meningitis using PET/CT
17:00—19:00
Disease Modeling
*
Jeffrey D. Rothstein,
Johns Hopkins University, USA
Session Chair
Session Chair
Leslie M. Thompson,
University of California, Irvine, USA
A Systems Biology Approach to Understanding ALS Pathogenesis in iPSC-Derived Motor Neurons
A Systems Biology Approach to Understanding ALS Pathogenesis in iPSC-Derived Motor Neurons
Albert R. La Spada,
Duke University, USA
Deconstructing Polyglutamine Neurodegeneration: From Pathways of Neuron Demise to Therapeutic Intervention
Deconstructing Polyglutamine Neurodegeneration: From Pathways of Neuron Demise to Therapeutic Intervention
Yadong Huang,
Gladstone Institutes/UCSF, USA
Modeling and Drug Screening of AD Using Patients-Derived iPSCs
Modeling and Drug Screening of AD Using Patients-Derived iPSCs
Michael Lee,
University of Minnesota, USA
Short Talk: Dissociation of Amyloid Dependent Cognitive Deficits and Neurodegeneration
Short Talk: Dissociation of Amyloid Dependent Cognitive Deficits and Neurodegeneration
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
17:00—19:00
Myeloid Cells as Targets of Drug Discovery and Biomarkers
*
Andrea Crotti,
Astellas Pharma, USA
Session Chair
Session Chair
Irene Knuesel,
Roche Innovation Center Basel, Switzerland
Therapeutic Effects of Anti-Amyloid-Beta Immunotherapy on Myeloid Cell Transcriptome
Therapeutic Effects of Anti-Amyloid-Beta Immunotherapy on Myeloid Cell Transcriptome
Paul R. Ormel,
University Medical Center Utrecht, Netherlands
Short Talk: Comparison of Three Human Microglia Models to Study Schizophrenia
Short Talk: Comparison of Three Human Microglia Models to Study Schizophrenia
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:30—11:45
RNA Metabolisms and New Mechanisms of Toxicity
*
Yadong Huang,
Gladstone Institutes/UCSF, USA
Session Chair
Session Chair
Wolfdieter Springer,
Mayo Clinic, USA
Short Talk: Relevance of PINK1-Parkin Mitophagy in Stress, Aging and Disease
Short Talk: Relevance of PINK1-Parkin Mitophagy in Stress, Aging and Disease
Christopher D. Link,
University of Colorado, USA
Short Talk: Knockdown of TDP-43 in Astrocytes Induces Immune Activation
Short Talk: Knockdown of TDP-43 in Astrocytes Induces Immune Activation
Jeffrey D. Rothstein,
Johns Hopkins University, USA
Nuclear Transport as an Unexpected Fundamental Defect in Familial and Sporadic Neurodegeneration
Nuclear Transport as an Unexpected Fundamental Defect in Familial and Sporadic Neurodegeneration
Zevik Melamed,
University of California, San Diego, USA
Short Talk: RNA Processing Alteration and the Link to Neurodegeneration in ALS/FTD
Short Talk: RNA Processing Alteration and the Link to Neurodegeneration in ALS/FTD
Coffee Break
Leonard Petrucelli,
Mayo Clinic Jacksonville, USA
C9 Biology and Biomarkers
C9 Biology and Biomarkers
Bess Frost,
Barshop Institute for Longevity and Aging Studies, USA
Jump Around, Jump Around: Transposable Element Activation in Tauopathy
Jump Around, Jump Around: Transposable Element Activation in Tauopathy
Xin Qi,
Case Western Reserve University, USA
Short Talk: ATAD3A Oligomerization Causes Neurodegeneration by Coupling Mitochondrial Fragmentation and Bioenergetics Defects
Short Talk: ATAD3A Oligomerization Causes Neurodegeneration by Coupling Mitochondrial Fragmentation and Bioenergetics Defects
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
08:30—11:45
Myeloid Gene Regulation
*
Inge R. Holtman,
University of California, San Diego, USA
Session Chair
Session Chair
Oleg Butovsky,
Harvard Medical School, USA
Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot "Hyde"
Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot "Hyde"
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
Coffee Break
Marco Colonna,
Washington University School of Medicine, USA
TREM2, Microglia and Neurodegeneration
TREM2, Microglia and Neurodegeneration
Bahareh Ajami,
Stanford University School of Medicine, USA
Single-Cell Mass Cytometry Reveals Molecular Signatures of Inflammation in Contrasting Models of Neuroinflammation versus Neurodegeneration
Single-Cell Mass Cytometry Reveals Molecular Signatures of Inflammation in Contrasting Models of Neuroinflammation versus Neurodegeneration
Kendra Lechtenberg,
Stanford University, USA
Short Talk: Profiling Microglia-Specific Transcriptional Changes after Ischemic Stroke
Short Talk: Profiling Microglia-Specific Transcriptional Changes after Ischemic Stroke
Carole Lara Veiga Sousa,
Luxembourg Institute of Health, Luxembourg
Short Talk: Molecular Profiling of Microglia in Steady State and Under Inflammatory Conditions at Single-Cell Level
Short Talk: Molecular Profiling of Microglia in Steady State and Under Inflammatory Conditions at Single-Cell Level
14:30—16:30
Workshop: Systems Approach and Functional Genomics
*
Martin Kampmann,
University of California, San Francisco, USA
Elucidating Cellular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases with CRISPRi and CRISPRa
Elucidating Cellular Mechanisms and Therapeutic Strategies for Neurodegenerative Diseases with CRISPRi and CRISPRa
Taisuke Kato,
Niigata University, Japan
Phenotypic Suppression of DRPLA Model Mice using CRISPR / Cas9 System
Phenotypic Suppression of DRPLA Model Mice using CRISPR / Cas9 System
Jiyoen Kim,
Baylor College of Medicine, USA
Identifying Therapeutic Targets for Alzheimer's Disease: A Cross-Species Genetic Screen for Molecules that Lower Tau Levels
Identifying Therapeutic Targets for Alzheimer's Disease: A Cross-Species Genetic Screen for Molecules that Lower Tau Levels
Alan E. Renton,
Icahn School of Medicine at Mount Sinai, USA
Alzheimer's Disease Sequencing Project: Age Extremes x APOE Genotype Sampling for Genetic Discovery
Alzheimer's Disease Sequencing Project: Age Extremes x APOE Genotype Sampling for Genetic Discovery
Tara E. Tracy,
University of California, San Francisco, USA
Spatiotemporal Mapping of the Tau Interactome in Human iPSC-Derived Neurons
Spatiotemporal Mapping of the Tau Interactome in Human iPSC-Derived Neurons
Tal Nuriel,
Columbia University Medical Center, USA
Utilizing Systems Biology Approaches to Elucidate the Effects of APOE4 Expression in an AD-Vulnerable Brain Region
Utilizing Systems Biology Approaches to Elucidate the Effects of APOE4 Expression in an AD-Vulnerable Brain Region
Rakshita A. Charan,
University of Pennsylvania, USA
Identification and Characterization of Frontotemporal Dementia Risk Factor TMEM106B Interacting Proteins
Identification and Characterization of Frontotemporal Dementia Risk Factor TMEM106B Interacting Proteins
17:00—19:00
Biomarker and Therapeutics
*
Li Gan,
Weill Cornell Medicine, USA
Session Chair
Session Chair
David V. Hansen,
Brigham Young University, USA
Short Talk: Assessing and Modulating Microglial Activation States in Alzheimer's Disease Tissues and Models
Short Talk: Assessing and Modulating Microglial Activation States in Alzheimer's Disease Tissues and Models
Xu Chen,
Gladstone Institute of Neurological Disease, USA
Short Talk: Tau Secretion and Propagation is Regulated by p300/CBP via Autophagy-Lysosomal Pathway
Short Talk: Tau Secretion and Propagation is Regulated by p300/CBP via Autophagy-Lysosomal Pathway
C. Frank Bennett,
Ionis Pharmaceuticals, Inc., USA
Antisense Oligonucleotide-Based Therapies for Neurological Diseases
Antisense Oligonucleotide-Based Therapies for Neurological Diseases
Rita Balice-Gordon,
Muna Therapeutics, Denmark
Translational Challenges in Neuroscience Drug Development
Translational Challenges in Neuroscience Drug Development
Tracy Cole,
Ionis Pharmaceuticals, Inc., USA
Short Talk: Human SNCA Antisense Oligonucleotides Reduce CNS and CSF Alpha-Synuclein Levels in a Non-Human Primate Model, Supporting their Use for Treatment of Synucleinopathies
Short Talk: Human SNCA Antisense Oligonucleotides Reduce CNS and CSF Alpha-Synuclein Levels in a Non-Human Primate Model, Supporting their Use for Treatment of Synucleinopathies
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
17:00—18:45
Microglia and CNS Diseases
*
Annett Halle,
German Center for Neurodegenerative Diseases, Germany
Session Chair
Session Chair
Shane Antony Liddelow,
New York University Langone Medical Center, USA
What Do Reactive Astrocytes Do?
What Do Reactive Astrocytes Do?
Florent Ginhoux,
Singapore Immunology Network, Singapore
Microglia Heterogeneity
Microglia Heterogeneity
Philip L. De Jager,
Columbia University Medical Center, USA
The Genetic and Population Architecture of Aged Human Microglia: Role in Accelerating Tau Pathology and Cognitive Decline
The Genetic and Population Architecture of Aged Human Microglia: Role in Accelerating Tau Pathology and Cognitive Decline
Following Session is for New Frontiers in Neuroinflammation: What Happens When CNS and Periphery Meet? (Z4)
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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