Granlibakken Tahoe Floorplan
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This meeting took place in 2018
Here are the related meetings in 2020:
AAA+ Proteins: From Atomic Structures to Organisms (A5)
MEETING CANCELLED: Cryo-EM for Health Science (E2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Cryo-EM from Cells to Molecules: Multi-Scale Visualization of Biological Systems (F1)
Organizer(s) Georgios Skiniotis, Elizabeth Villa and Andrew B. Ward
February 4—8, 2018
Granlibakken Tahoe • Tahoe City, CA USA
Discounted Abstract Deadline: Oct 5, 2017
Abstract Deadline: Nov 7, 2017
Scholarship Deadline: Oct 5, 2017
Discounted Registration Deadline: Dec 7, 2017
Sponsored by Pfizer Inc.
Summary of Meeting:
Fast-evolving cryo-EM visualization techniques have recently started to illuminate the inner workings of complicated and dynamic biological assemblies with a level of detail we have never seen before. Cryo-EM is now the state-of-the-art methodology for taking snapshots of biological systems from low to high resolution and with various levels of complexities, from small macromolecular complexes all the way to subcellular organizations. This symposium will showcase cryo-EM breakthroughs in addressing crucial problems in cell biology and will further highlight cryo-EM imaging as a platform for the integration of data from orthogonal approaches. With talks on a variety of biological specimens, procedures and types of biological questions, the meeting aims to attract a very diverse audience from both academia and industry with interest in the method, and beyond the traditional cryo-EM specialist. The symposium will focus on four themes: 1) Single-particle cryo-EM with attention to the characterization of the conformational ensemble adopted by macromolecular complexes and aiming to delineate their mechanism of action; 2) Cryo-electron tomography (cryo-ET) and correlative light electron microscopy (CLEM) to visualize cellular organizations and their dynamics; 3) The emergence of cryo-EM as tool for drug discovery and translational research through both high-resolution structure determination and characterization of cellular phenotypes; and 4) Recent developments in sample preparation and image acquisition. Furthermore, the symposium will include workshops in specimen preparation and evaluation of suitability for cryo-EM, modeling of structures using cryo-EM data, and how to set up a cryo-EM lab.
View Scholarships/Awards
Fast-evolving cryo-EM visualization techniques have recently started to illuminate the inner workings of complicated and dynamic biological assemblies with a level of detail we have never seen before. Cryo-EM is now the state-of-the-art methodology for taking snapshots of biological systems from low to high resolution and with various levels of complexities, from small macromolecular complexes all the way to subcellular organizations. This symposium will showcase cryo-EM breakthroughs in addressing crucial problems in cell biology and will further highlight cryo-EM imaging as a platform for the integration of data from orthogonal approaches. With talks on a variety of biological specimens, procedures and types of biological questions, the meeting aims to attract a very diverse audience from both academia and industry with interest in the method, and beyond the traditional cryo-EM specialist. The symposium will focus on four themes: 1) Single-particle cryo-EM with attention to the characterization of the conformational ensemble adopted by macromolecular complexes and aiming to delineate their mechanism of action; 2) Cryo-electron tomography (cryo-ET) and correlative light electron microscopy (CLEM) to visualize cellular organizations and their dynamics; 3) The emergence of cryo-EM as tool for drug discovery and translational research through both high-resolution structure determination and characterization of cellular phenotypes; and 4) Recent developments in sample preparation and image acquisition. Furthermore, the symposium will include workshops in specimen preparation and evaluation of suitability for cryo-EM, modeling of structures using cryo-EM data, and how to set up a cryo-EM lab.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 4 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, February 8 with a closing plenary session and keynote address from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Friday, February 9 in order to fully experience the meeting.
SUNDAY, FEBRUARY 4
MONDAY, FEBRUARY 5
TUESDAY, FEBRUARY 6
WEDNESDAY, FEBRUARY 7
THURSDAY, FEBRUARY 8
FRIDAY, FEBRUARY 9
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 4 with registration from 16:00 to 20:00 and a welcome mixer and light meal from 18:00 to 20:00. Conference events conclude on Thursday, February 8 with a closing plenary session and keynote address from 17:00 to 19:00, followed by dinner and entertainment. We recommend return travel on Friday, February 9 in order to fully experience the meeting.
SUNDAY, FEBRUARY 4
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Georgios Skiniotis,
Stanford University, USA
*
Andrew B. Ward,
The Scripps Research Institute, USA
*
Elizabeth Villa,
University of California, San Diego, USA
Patrick Cramer,
Max Planck Institute for Biophysical Chemistry, Germany
Integrated Structural Biology of Gene Transcription
Integrated Structural Biology of Gene Transcription
09:00—11:30
Visualizing Cells
*
Elizabeth Villa,
University of California, San Diego, USA
Opening Windows into the Cell: Bringing Structure to Cell Biology using Cryo-Electron Tomography
Opening Windows into the Cell: Bringing Structure to Cell Biology using Cryo-Electron Tomography
Coffee Break
Grant J. Jensen,
California Institute of Technology, USA
Structure and Function of the Bacterial Type IV Secretion System through Electron Cryotomography
Structure and Function of the Bacterial Type IV Secretion System through Electron Cryotomography
Mark H. Ellisman,
University of California, San Diego, USA
Revealing Secrets Hiding in Plain Sight
Revealing Secrets Hiding in Plain Sight
Christina Heroven,
MRC Laboratory of Molecular Biology, UK
Short Talk: In-situ Structural Studies of RPTPmu by Cryo-Electron Tomography of FIB Milled Cells
Short Talk: In-situ Structural Studies of RPTPmu by Cryo-Electron Tomography of FIB Milled Cells
Kanika Khanna,
University of California, San Diego, USA
Short Talk: Understanding Morphological Changes Accompanying Sporulation in B. subtilis using in situ Cryo-Electron Tomography
Short Talk: Understanding Morphological Changes Accompanying Sporulation in B. subtilis using in situ Cryo-Electron Tomography
17:00—19:00
Visualizing Subcellular Compartments
Daniela Nicastro,
University of Texas Southwestern Medical Center, USA
Probing the Molecular Organization of Cells and Organelles using Cryo-Electron Microscopy
Probing the Molecular Organization of Cells and Organelles using Cryo-Electron Microscopy
Jun Liu,
Yale School of Medicine, USA
High-Throughput Cryo-Electron Tomography: Visualizing Host-Pathogen Interactions at High Resolution
High-Throughput Cryo-Electron Tomography: Visualizing Host-Pathogen Interactions at High Resolution
*
Kay Grünewald,
University of Oxford, UK
Trafficking Vesicles and Enveloped Viruses
Trafficking Vesicles and Enveloped Viruses
Joshua Hutchings,
Birkbeck College, UK
Short Talk: Cryo-EM Tomography and Subtomogram Averaging of COPII Assembled on Membranes
Short Talk: Cryo-EM Tomography and Subtomogram Averaging of COPII Assembled on Membranes
08:00—11:15
Translational Cryo-EM
*
Andrew B. Ward,
The Scripps Research Institute, USA
Structure-Based Vaccine Design
Structure-Based Vaccine Design
Tom Ceska,
UCB Celltech, UK
Cryo-EM as a Tool for Structure Determination in Industry
Cryo-EM as a Tool for Structure Determination in Industry
Coffee Break
Seungil Han,
Pfizer Inc., USA
Applications of Cryo-EM in Small Molecule and Biologics Drug Design
Applications of Cryo-EM in Small Molecule and Biologics Drug Design
Christian Wiesmann,
Novartis, Switzerland
Cryo-Em: A New Tool for Drug Discovery at Novartis
Cryo-Em: A New Tool for Drug Discovery at Novartis
Gregory Martin,
Oregon Health & Science University, USA
Short Talk: Anti-Diabetic Drug Binding Site in KATP Channels Revealed by Cryo-EM
Short Talk: Anti-Diabetic Drug Binding Site in KATP Channels Revealed by Cryo-EM
Chitra Shintre,
University of Oxford, UK
Short Talk: Structure of the Polycistic Kidney Disease TRP Channel PC2
Short Talk: Structure of the Polycistic Kidney Disease TRP Channel PC2
14:30—16:30
Workshop 1: Specimen Preparation and Troubleshooting for Single-Particle Work
*
Iban Ubarretxena,
Icahn School of Medicine at Mount Sinai, USA
Structures of Key Intermediates in the Human Mitochondrial Chaperonin Reaction Cycle
Structures of Key Intermediates in the Human Mitochondrial Chaperonin Reaction Cycle
Anika L. Burrell,
University of Washington, USA
Human IMPDH1 Retinal Degeneration Mutations Promote Polymer Assembly
Human IMPDH1 Retinal Degeneration Mutations Promote Polymer Assembly
Joel Butterwick,
Rockefeller University, USA
Cryo-EM Structure of Orco: The Molecular Basis for Insect Olfaction
Cryo-EM Structure of Orco: The Molecular Basis for Insect Olfaction
Ziao Fu,
Columbia University, USA
Lipid Bilayer Structure in Native Cell Membrane Nanoparticles of Multidrug Exporter AcrB
Lipid Bilayer Structure in Native Cell Membrane Nanoparticles of Multidrug Exporter AcrB
Jonas Barandun,
Rockefeller University, USA
Structure of the Earliest Stable Precursor of the Ribosome - the Small Subunit Processome
Structure of the Earliest Stable Precursor of the Ribosome - the Small Subunit Processome
Vignesh Kasinath,
University of California, Berkeley, USA
Cryo-EM Structure of the Full Human PRC2 and Regulation by AEBP2 and JARID2
Cryo-EM Structure of the Full Human PRC2 and Regulation by AEBP2 and JARID2
Qianhui Qu,
Stanford University, USA
Structure of a Histone H3K4 Methyltransferase COMPASS
Structure of a Histone H3K4 Methyltransferase COMPASS
Julia Brasch,
Columbia University, USA
Assembly of Clustered Protocadherin Neuronal Recognition Complexes Studied by X-ray Crystallography and Cryo-electron Tomography
Assembly of Clustered Protocadherin Neuronal Recognition Complexes Studied by X-ray Crystallography and Cryo-electron Tomography
Cristina Puchades,
The Scripps Research Institute, USA
Hand-Over-Hand: How ATP Drives Protein Translocation
Hand-Over-Hand: How ATP Drives Protein Translocation
17:00—19:00
Frontiers in Cryo-EM
Andrej Sali,
University of California, San Francisco, USA
Integrative Modeling of Biomolecular Assembly Structures and Pathways
Integrative Modeling of Biomolecular Assembly Structures and Pathways
*
Sharon Grayer Wolf,
Weizmann Institute of Science, Israel
Deep Views into Vitrified Cells by Cryo-Scanning Transmission Electron Tomography
Deep Views into Vitrified Cells by Cryo-Scanning Transmission Electron Tomography
David Baker,
University of Washington, USA
De novo Design of Self-Assembling Protein Nano Materials
De novo Design of Self-Assembling Protein Nano Materials
Yuxi Liu,
University of California, Los Angeles, USA
Short Talk: Near-Atomic Resolution Cryo-EM for a Small Protein on a Symmetric Imaging Scaffold
Short Talk: Near-Atomic Resolution Cryo-EM for a Small Protein on a Symmetric Imaging Scaffold
08:00—11:00
Cryo-EM of Small Single Particles
Dmitry Lyumkis,
The Salk Institute for Biological Studies, USA
High-Resolution Cryo-EM Studies of Retroviral Intasomes
High-Resolution Cryo-EM Studies of Retroviral Intasomes
Maofu Liao,
Harvard Medical School, USA
Single Particle Cryo-EM Studies of Lipid-Protein Interactions
Single Particle Cryo-EM Studies of Lipid-Protein Interactions
Coffee Break
*
Gabriel C. Lander,
The Scripps Research Institute, USA
How Low Can You Go? Size and Resolution Limits using Conventional Cryo-EM
How Low Can You Go? Size and Resolution Limits using Conventional Cryo-EM
Moran Shalev-Benami,
Stanford University, USA
Short Talk: Cryo-EM Structure of the Synaptic Wiring Protein Teneurin
Short Talk: Cryo-EM Structure of the Synaptic Wiring Protein Teneurin
Christopher P. Hill,
University of Utah, USA
Short Talk: Structural Basis for Protein Translocation by the Vps4 AAA ATPase
Short Talk: Structural Basis for Protein Translocation by the Vps4 AAA ATPase
Daniel Southworth,
University of California, San Francisco, USA
Short Talk: Visualizing the Substrate Translocation Mechanism of the Hsp104 AAA+ Disaggregase
Short Talk: Visualizing the Substrate Translocation Mechanism of the Hsp104 AAA+ Disaggregase
14:30—16:30
Workshop 2: Modeling and Refining Structures of Macromolecules in Cryo-EM Maps
*
Gunnar Schroeder,
Forschungszentrum Julich, Germany
Fibril Structure of Amyloid-ß(1-42) by Cryo-Electron Microscopy
Fibril Structure of Amyloid-ß(1-42) by Cryo-Electron Microscopy
Jane S. Richardson,
Duke University, USA
CaBLAM - A New Tool Designed to Validate 2.5-4Å Models from CryoEM
CaBLAM - A New Tool Designed to Validate 2.5-4Å Models from CryoEM
Doo Nam Kim,
Los Alamos National Laboratory, USA
CryoFIT: Flexible Fitting of Biomolecule Structures from Cryo-EM Maps with User-Friendly Molecular Dynamics Simulation
CryoFIT: Flexible Fitting of Biomolecule Structures from Cryo-EM Maps with User-Friendly Molecular Dynamics Simulation
Jianpeng Ma,
Baylor College of Medicine, USA
Application of Parallel Continuous Simulated Tempering to Cryo-EM Structural Refinement at Near-Atomic Resolution
Application of Parallel Continuous Simulated Tempering to Cryo-EM Structural Refinement at Near-Atomic Resolution
Abhishek Singharoy,
Arizona State University, USA
Molecular Dynamics Flexible Fitting at sub-5 Å Resolution
Molecular Dynamics Flexible Fitting at sub-5 Å Resolution
Till Rudack,
Ruhr University Bochum, Germany
ModelMaker: An Interactive Integrative Modeling Tool to Build Complete Macromolecular Machines
ModelMaker: An Interactive Integrative Modeling Tool to Build Complete Macromolecular Machines
Kelly Brock,
Harvard Medical School, USA
Using Evolutionary Couplings to Help Build and Refine Cryo-EM Models
Using Evolutionary Couplings to Help Build and Refine Cryo-EM Models
17:00—19:15
Cryo-EM of Large Macromolecular Assemblies
Kiyoshi Nagai,
Medical Research Council, UK
Cryo-EM Snapshots of the Spliceosome Provide Insights into the Mechanism of pre-mRNA Splicing
Cryo-EM Snapshots of the Spliceosome Provide Insights into the Mechanism of pre-mRNA Splicing
Gira Bhabha,
New York University School of Medicine, USA
Architectures of Lipid Transport Systems in Bacteria
Architectures of Lipid Transport Systems in Bacteria
*
Adam Frost,
University of California, San Francisco, USA
Function Follows Form: Cryo-EM Insights into Cell Biology
Function Follows Form: Cryo-EM Insights into Cell Biology
Eva Nogales,
University of California, Berkeley, USA
Challenges and Progress in the Study of Large Human Complexes in Gene Expression Regulation
Challenges and Progress in the Study of Large Human Complexes in Gene Expression Regulation
08:00—11:15
Cryo-EM of Membrane Proteins
*
Georgios Skiniotis,
Stanford University, USA
Cryo-EM Visualization of G Protein-Coupled Receptors
Cryo-EM Visualization of G Protein-Coupled Receptors
Judy Hirst,
University of Cambridge, UK
CryoEM Structure of Mammalian Respiratory Complex I, an Asymmetric 1 MDa Energy-Converting Enzyme
CryoEM Structure of Mammalian Respiratory Complex I, an Asymmetric 1 MDa Energy-Converting Enzyme
Coffee Break
Doreen Matthies,
National Institutes of Health, USA
Single Particle Cryo-EM of a 200 kDa Magnesium Ion Channel
Single Particle Cryo-EM of a 200 kDa Magnesium Ion Channel
Eric Gouaux,
Oregon Health & Science University, USA
Structure and Mechanism of AMPA Receptor - Auxiliary Protein Complexes
Structure and Mechanism of AMPA Receptor - Auxiliary Protein Complexes
Kei Saotome,
The Scripps Research Institute, USA
Short Talk: Structure of the Mechanically Activated Ion Channel Piezo1
Short Talk: Structure of the Mechanically Activated Ion Channel Piezo1
Luke H. Chao,
Massachusetts General Hospital, USA
Short Talk: Single Particle Cryo-EM Studies of Mitochondrial Inner-Membrane Fusion
Short Talk: Single Particle Cryo-EM Studies of Mitochondrial Inner-Membrane Fusion
17:00—18:00
Recent Technological Advances in Cryo EM
*
Bridget Carragher,
New York Structural Biology Center, USA
Sample Vitrification Issues and Some Ideas about How to Overcome Them
Sample Vitrification Issues and Some Ideas about How to Overcome Them
18:00—18:45
Closing Keynote Address
*
Georgios Skiniotis,
Stanford University, USA
Joachim Frank,
Columbia University, USA
Story in a Sample: Multiple Ribosome Structures in a Single Cryo-EM Experiment
Story in a Sample: Multiple Ribosome Structures in a Single Cryo-EM Experiment
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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