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This meeting took place in 2019
Here are the related meetings in 2020:
MEETING CANCELLED: Tumor Metabolism (C2)
For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.
Tumor Metabolism (B5)
Organizer(s) Lewis C. Cantley, Karen H. Vousden and Jeffrey A. Engelman
February 24—28, 2019
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 27, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Jan 8, 2019
Organized in collaboration with Cancer Research UK
Sponsored by Akebia Therapeutics and Cell Research
Sponsored by Akebia Therapeutics and Cell Research
Summary of Meeting:
The fact that tumor cells have altered metabolism compared to their tissues of origin has been known for more than 90 years. Some commonly used chemotherapies, such as methotrexate, target metabolic enzymes. Over the past decade there has been a revival of interest in developing new therapies that target metabolic vulnerabilities of tumor cells. Dramatic improvements in technologies for monitoring tumor metabolism by mass spectrometry and by multiple modes of imaging have revealed that tumors evolve diverse alterations in metabolism in order to grow in the primary tissue and in metastatic sites. This conference will bring together scientists with a wide spectrum of expertise who are world leaders in this rapidly moving field. The conference includes talks from pharmaceutical scientists who are developing first-in-class drugs that target metabolic enzymes. In addition there will be presentations from academic scientists who are studying not only changes in metabolism in tumor cells, but also changes in metabolism in cells in the tumor microenvironment and in the whole body. The conference will also include poster sessions, short talks chosen from poster abstracts and plenty of time for discussion of each talk.
View Scholarships/Awards
The fact that tumor cells have altered metabolism compared to their tissues of origin has been known for more than 90 years. Some commonly used chemotherapies, such as methotrexate, target metabolic enzymes. Over the past decade there has been a revival of interest in developing new therapies that target metabolic vulnerabilities of tumor cells. Dramatic improvements in technologies for monitoring tumor metabolism by mass spectrometry and by multiple modes of imaging have revealed that tumors evolve diverse alterations in metabolism in order to grow in the primary tissue and in metastatic sites. This conference will bring together scientists with a wide spectrum of expertise who are world leaders in this rapidly moving field. The conference includes talks from pharmaceutical scientists who are developing first-in-class drugs that target metabolic enzymes. In addition there will be presentations from academic scientists who are studying not only changes in metabolism in tumor cells, but also changes in metabolism in cells in the tumor microenvironment and in the whole body. The conference will also include poster sessions, short talks chosen from poster abstracts and plenty of time for discussion of each talk.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
MONDAY, FEBRUARY 25
TUESDAY, FEBRUARY 26
WEDNESDAY, FEBRUARY 27
THURSDAY, FEBRUARY 28
FRIDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 24 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 28 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, March 1 in order to fully experience the meeting.
SUNDAY, FEBRUARY 24
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Lewis C. Cantley,
Weill Cornell Medicine, USA
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Metabolic Requirements and Vulnerabilities of Cancer Cells
Metabolic Requirements and Vulnerabilities of Cancer Cells
09:00—12:15
Cancer Cell Metabolism
*
Dafna Bar-Sagi,
New York University School of Medicine, USA
Coffee Break
Christian Metallo,
University of California, San Diego, USA
Coordinating Flux through Amino Acid and Lipid Metabolism in Cancer
Coordinating Flux through Amino Acid and Lipid Metabolism in Cancer
Jeffrey A. Engelman,
Novartis Institutes for BioMedical Research, USA
Therapeutic Interventions that Alter Metabolism
Therapeutic Interventions that Alter Metabolism
Kevin Marks,
Agios Pharmaceuticals, USA
Targeting Metabolic Vulnerabilities in Cancer
Targeting Metabolic Vulnerabilities in Cancer
Gerta Hoxhaj,
Harvard School of Public Health, USA
Short Talk: Acute Stimulation of NADP Synthesis through Akt-Mediated Phosphorylation of NAD Kinase
Short Talk: Acute Stimulation of NADP Synthesis through Akt-Mediated Phosphorylation of NAD Kinase
Won Dong Lee,
Princeton University, USA
Short Talk: SDH-Deficient Cells Increase Mitochondrial Reductive Flux through IDH2 Followed by a Reversal of CS Flux to Support Pyrimidine Biosynthesis
Short Talk: SDH-Deficient Cells Increase Mitochondrial Reductive Flux through IDH2 Followed by a Reversal of CS Flux to Support Pyrimidine Biosynthesis
Shivani K. Thaker,
University of California, Los Angeles, USA
Short Talk: Ketohexokinase Is Important for Lung Tumor Growth
Short Talk: Ketohexokinase Is Important for Lung Tumor Growth
14:30—16:30
Workshop: Nutrient Transport and Dependencies
*
Matthew G. Vander Heiden,
Massachusetts Institute of Technology, USA
Ariel Bensimon,
CeMM – Research Center for Molecular Medicine, Austria
Functional Integration of the Core Cancer Transportome
Functional Integration of the Core Cancer Transportome
Ayelet Erez,
Weizmann Institute of Science, Israel
c-MYC Induces Arginine Metabolism to Promote Cancer Survival under Glucose Starvation
c-MYC Induces Arginine Metabolism to Promote Cancer Survival under Glucose Starvation
Nora Kory,
Massachusetts Institute of Technology, USA
SFXN1 Is A Mitochondrial Serine Transporter Required for One-Carbon Metabolism
SFXN1 Is A Mitochondrial Serine Transporter Required for One-Carbon Metabolism
Alexander Muir,
Massachusetts Institute of Technology, USA
Absolute Quantification of Tumor Nutrients in Murine Models of Pancreatic and Lung Adenocarcinoma
Absolute Quantification of Tumor Nutrients in Murine Models of Pancreatic and Lung Adenocarcinoma
Pankaj Kumar Singh,
University of Nebraska Medical Center, USA
Metabolic Regulation of Therapy Outcome by Endoplasmic Reticulum Stress in Pancreatic Cancer
Metabolic Regulation of Therapy Outcome by Endoplasmic Reticulum Stress in Pancreatic Cancer
Ross Weber,
Rockefeller University, USA
Loss of Mitochondrial Transporter SFXN1 Enables Cell Proliferation under Limited Cysteine
Loss of Mitochondrial Transporter SFXN1 Enables Cell Proliferation under Limited Cysteine
17:00—19:15
Feeding the Cancer
*
Jeffrey A. Engelman,
Novartis Institutes for BioMedical Research, USA
Eileen P. White,
Rutgers University, USA
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response
Dafna Bar-Sagi,
New York University School of Medicine, USA
Function and Regulation of Protein Scavenging in Mutant Ras Tumors
Function and Regulation of Protein Scavenging in Mutant Ras Tumors
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway
Regulation of Growth by the mTOR Pathway
Sanjeethan C. Baksh,
Rockefeller University, USA
Short Talk: Extracellular Serine Dependence Restricts Differentiation in Oncogenic Stem Cells
Short Talk: Extracellular Serine Dependence Restricts Differentiation in Oncogenic Stem Cells
Jihye Yun,
Baylor College of Medicine, USA
Short Talk: High-Fructose Corn Syrup Enhances Intestinal Tumor Growth
Short Talk: High-Fructose Corn Syrup Enhances Intestinal Tumor Growth
Oliver Maddocks,
University of Glasgow, UK
Short Talk: IDO1-Driven Tryptophan Utilisation Can Augment One-Carbon Metabolism in Pancreatic Cancer and Stromal Cells
Short Talk: IDO1-Driven Tryptophan Utilisation Can Augment One-Carbon Metabolism in Pancreatic Cancer and Stromal Cells
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Metabolism, Microenvironment and Metastasis
*
Elena Piskounova,
Weill Cornell Medicine, USA
Martin O. Bergo,
Karolinska Institutet, Sweden
Antioxidant Stimulation of Lung Cancer Metastasis
Antioxidant Stimulation of Lung Cancer Metastasis
Richard White,
Memorial Sloan Kettering Cancer Center, USA
A Role for Adipocytes in the Melanoma Microenvironment
A Role for Adipocytes in the Melanoma Microenvironment
Coffee Break
Aimee L. Edinger,
University of California, Irvine, USA
Starving Cancer Cells to Death by Limiting Nutrient Access
Starving Cancer Cells to Death by Limiting Nutrient Access
Karen H. Vousden,
Francis Crick Institute, UK
Metabolic Control of ROS and Tumour Progression
Metabolic Control of ROS and Tumour Progression
Stefan M. Schieke,
University of Wisconsin-Madison, USA
Short Talk: Metabolic Dynamics Modulate Cancer Progression Through mROS/HIF-1a Axis
Short Talk: Metabolic Dynamics Modulate Cancer Progression Through mROS/HIF-1a Axis
Christopher J. Halbrook,
University of Michigan, USA
Short Talk: Macrophage-Epithelial Metabolic Crosstalk Impairs Chemotherapy in Pancreatic Cancer
Short Talk: Macrophage-Epithelial Metabolic Crosstalk Impairs Chemotherapy in Pancreatic Cancer
Xiaobo Li,
H.Lee Moffitt Cancer Center, USA
Short Talk: TAp63 Regulated lncRNA and its Downstream Effector in Human Breast Cancer Cell Metabolism
Short Talk: TAp63 Regulated lncRNA and its Downstream Effector in Human Breast Cancer Cell Metabolism
17:00—19:15
The Metabolism of ROS and Survival
*
Gina DeNicola,
Moffitt Cancer Center, USA
Navdeep S. Chandel,
Northwestern University, USA
Mitochondria Metabolism and Cancer
Mitochondria Metabolism and Cancer
Thales Papagiannakopoulos,
New York University School of Medicine, USA
Uncovering Metabolic Bottlenecks in KRAS-Driven Lung Cancer
Uncovering Metabolic Bottlenecks in KRAS-Driven Lung Cancer
Timothy Humpton,
Beatson Institute for Cancer Research, UK
ROS and Mitophagy Dependencies in Pancreatic Cancer
ROS and Mitophagy Dependencies in Pancreatic Cancer
Veerle W.L.E. Daniels,
Dana-Farber Cancer Institute, USA
Short Talk: Metabolic Perturbation Sensitizes Triple-Negative Breast Cancer Cells to BH3 Mimetics
Short Talk: Metabolic Perturbation Sensitizes Triple-Negative Breast Cancer Cells to BH3 Mimetics
Kenneth Olive,
Columbia University, USA
Short Talk: Modulation of Cystine Import Induces Pancreatic Cancer-Selective Ferroptosis
Short Talk: Modulation of Cystine Import Induces Pancreatic Cancer-Selective Ferroptosis
George Poulogiannis,
Institute of Cancer Research, UK
Short Talk: iKnife Couples Oncogenic PIK3CA with an Arachidonic Acid-Mediated Eicosanoid Storm
Short Talk: iKnife Couples Oncogenic PIK3CA with an Arachidonic Acid-Mediated Eicosanoid Storm
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Metabolism Outside the Tumor
*
Kathryn E. Wellen,
University of Pennsylvania, USA
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Metabolic Perturbations and Human Disease
Metabolic Perturbations and Human Disease
Katja A. Lamia,
The Scripps Research Institute, USA
Connecting Circadian Clocks and Cancer
Connecting Circadian Clocks and Cancer
Coffee Break
Vuk Stambolic,
University Health Network, Canada
Obesity and Cancer
Obesity and Cancer
Tak W. Mak,
Campbell Family Institute for Breast Cancer, Canada
Metabolic Adaptation in Hemopoietic Malignancies
Metabolic Adaptation in Hemopoietic Malignancies
Julian J. Lum,
British Columbia Cancer Agency, Canada
Short Talk: Autophagy Suppresses CD8+ T Cell Antitumor Responses through Glucose-Dependent Changes in Transcription
Short Talk: Autophagy Suppresses CD8+ T Cell Antitumor Responses through Glucose-Dependent Changes in Transcription
Steven Zhao,
University of Pennsylvania, USA
Short Talk: Dietary Fructose Promotes de novo Lipogenesis from Microbiome-Derived Acetate
Short Talk: Dietary Fructose Promotes de novo Lipogenesis from Microbiome-Derived Acetate
17:00—19:15
Metabolic Adaptation and the Response to Therapy
*
Ralph J. DeBerardinis,
University of Texas Southwestern Medical Center, USA
Alec Kimmelman,
New York University Langone Medical Center, USA
Identifying Metabolic Dependencies in Pancreatic Cancer
Identifying Metabolic Dependencies in Pancreatic Cancer
Lewis C. Cantley,
Weill Cornell Medicine, USA
PI 3-Kinase and Cancer Metabolism
PI 3-Kinase and Cancer Metabolism
Kathryn E. Wellen,
University of Pennsylvania, USA
Acetyl-CoA Metabolism in Chromatin Regulation and Tumorigenesis
Acetyl-CoA Metabolism in Chromatin Regulation and Tumorigenesis
Lei Shi,
Massachusetts General Hospital, USA
Short Talk: Leveraging Reprogrammed Metabolism to Define Selective Vulnerabilities of IDH1 Mutated Cholangiocarcinoma Cells
Short Talk: Leveraging Reprogrammed Metabolism to Define Selective Vulnerabilities of IDH1 Mutated Cholangiocarcinoma Cells
Sindhu Carmen Sivakumaren,
Dana-Farber Cancer Institute, USA
Short Talk: Targeting the PI5P4K Lipid Kinase Family in Cancer using Novel Covalent Inhibitors
Short Talk: Targeting the PI5P4K Lipid Kinase Family in Cancer using Novel Covalent Inhibitors
Liang Zhao,
Johns Hopkins University School of Medicine, USA
Short Talk: Inhibition Proximal Glycolysis and Disruption of Krebs Cycle by Broad-Targeting Glutamine Metabolism for Cancer Therapy
Short Talk: Inhibition Proximal Glycolysis and Disruption of Krebs Cycle by Broad-Targeting Glutamine Metabolism for Cancer Therapy
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Modeling Cancer Metabolism
*
Karen H. Vousden,
Francis Crick Institute, UK
Coffee Break
Saverio Tardito,
Beatson Institute for Cancer Research, Scotland
Reformulating Cell Culture Medium to Improve the Metabolic Fidelity of in vitro Models of Cancer
Reformulating Cell Culture Medium to Improve the Metabolic Fidelity of in vitro Models of Cancer
Jason R. Cantor,
Morgridge Institute for Research, University of Wisconsin-Madison, USA
Short Talk: Use of Physiologic Media to Explore Genetic Dependencies in Cancer
Short Talk: Use of Physiologic Media to Explore Genetic Dependencies in Cancer
Henry Däbritz,
CRUK Beatson Institute, Scotland
Short Talk: Oncogenic Hras and Loss of Succinate Dehydrogenase B Synergise to Drive Kidney Neoplasia in a Genetically Engineered Mouse Model
Short Talk: Oncogenic Hras and Loss of Succinate Dehydrogenase B Synergise to Drive Kidney Neoplasia in a Genetically Engineered Mouse Model
Ashley Solmonson,
University of Texas Southwestern Medical Center, USA
Short Talk: Inborn Errors of Metabolism: Evaluating Critical Metabolic Regulators of Mammalian Development
Short Talk: Inborn Errors of Metabolism: Evaluating Critical Metabolic Regulators of Mammalian Development
17:00—18:45
Imaging Cancer Metabolism in vitro and in vivo
*
Oliver Maddocks,
University of Glasgow, UK
Kevin M. Brindle,
University of Cambridge, UK
Imaging Tumor Metabolism with Hyperpolarized 13C-Labeled Metabolites – From Mouse to Man
Imaging Tumor Metabolism with Hyperpolarized 13C-Labeled Metabolites – From Mouse to Man
Vsevolod V. Belousov,
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS, Russia
Imaging and Manipulating Redox in Cells
Imaging and Manipulating Redox in Cells
Tamara Maric,
École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Novel Bioluminescent Probe for Non-Invasive Imaging and Quantification of Glucose Uptake in vitro and in vivo
Short Talk: Novel Bioluminescent Probe for Non-Invasive Imaging and Quantification of Glucose Uptake in vitro and in vivo
Daria Ezerina,
VIB/VUB, Belgium
Short Talk: Novel Fluorescent Biosensors for Real-Time in vivo Detection of Metabolites
Short Talk: Novel Fluorescent Biosensors for Real-Time in vivo Detection of Metabolites
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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