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This meeting took place in 2019
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Mitochondrial Biology in Heart and Skeletal Muscle (J1)
Organizer(s) E. Dale Abel and Andrea L. Hevener
January 13—17, 2019
Keystone Resort • Keystone, CO USA
Discounted Abstract Deadline: Oct 9, 2018
Abstract Deadline: Oct 17, 2018
Scholarship Deadline: Oct 9, 2018
Discounted Registration Deadline: Nov 14, 2018
Supported by the Directors' Fund
Joint Meeting:
Mitochondria in Aging and Age-Related Disease (J2)
Summary of Meeting:
Mitochondria are highly dynamic and communicative organelles that regulate a variety of cellular processes including energy homeostasis, redox status, thermogenesis and cell death via apoptosis. Mitochondria collaborate with a host of intracellular organelles including endoplasmic reticulum, peroxisomes, lysosomes and nuclei to maintain metabolic homeostasis. Mitochondrial dysfunction disrupts metabolism and is thought to underlie cellular aging as well as the development of chronic diseases such as type 2 diabetes, cardiovascular disease, heart failure and aging-associated sarcopenia. Since mitochondria are enriched in cardiac and striated skeletal muscle, and since these tissues are critical in regulating whole body metabolism, insulin action and locomotion, the objective of this conference is to identify novel mechanisms controlling mitochondrial function and connect mitochondrial phenotypes with improved health and disease pathobiology. New insight into the biology and pathobiology of mitochondria will allow for the advance of therapeutic approaches that can be utilized to combat metabolic-related diseases associated with mitochondrial dysfunction. Our understanding of the precise molecular signaling that links mitochondrial function (biogenesis, fission-fusion-mitophagy dynamics, and mitochondrial genome integrity) with integrative metabolism and muscle action remains inadequate. This deficiency in our fundamental knowledge of mitochondrial biology and the implications of this knowledge gap for the treatment and clinical care of common and rare mitochondrial diseases underpin the importance of this Keystone Symposia conference. The conference will bring together investigators from diverse areas of integrative biology and metabolism who typically do not interact or attend the same meetings, sparking the development of new collaborations, novel biological concepts and innovative therapeutic strategies to harness the mitochondria for metabolic disease prevention.
View Scholarships/Awards
Mitochondria are highly dynamic and communicative organelles that regulate a variety of cellular processes including energy homeostasis, redox status, thermogenesis and cell death via apoptosis. Mitochondria collaborate with a host of intracellular organelles including endoplasmic reticulum, peroxisomes, lysosomes and nuclei to maintain metabolic homeostasis. Mitochondrial dysfunction disrupts metabolism and is thought to underlie cellular aging as well as the development of chronic diseases such as type 2 diabetes, cardiovascular disease, heart failure and aging-associated sarcopenia. Since mitochondria are enriched in cardiac and striated skeletal muscle, and since these tissues are critical in regulating whole body metabolism, insulin action and locomotion, the objective of this conference is to identify novel mechanisms controlling mitochondrial function and connect mitochondrial phenotypes with improved health and disease pathobiology. New insight into the biology and pathobiology of mitochondria will allow for the advance of therapeutic approaches that can be utilized to combat metabolic-related diseases associated with mitochondrial dysfunction. Our understanding of the precise molecular signaling that links mitochondrial function (biogenesis, fission-fusion-mitophagy dynamics, and mitochondrial genome integrity) with integrative metabolism and muscle action remains inadequate. This deficiency in our fundamental knowledge of mitochondrial biology and the implications of this knowledge gap for the treatment and clinical care of common and rare mitochondrial diseases underpin the importance of this Keystone Symposia conference. The conference will bring together investigators from diverse areas of integrative biology and metabolism who typically do not interact or attend the same meetings, sparking the development of new collaborations, novel biological concepts and innovative therapeutic strategies to harness the mitochondria for metabolic disease prevention.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.
SUNDAY, JANUARY 13
MONDAY, JANUARY 14
TUESDAY, JANUARY 15
WEDNESDAY, JANUARY 16
THURSDAY, JANUARY 17
FRIDAY, JANUARY 18
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.
SUNDAY, JANUARY 13
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session (Joint)
*
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
*
Andrea L. Hevener,
University of California, Los Angeles, USA
*
Gerald S. Shadel,
The Salk Institute for Biological Studies, USA
*
Holly Van Remmen,
Oklahoma Medical Research Foundation, USA
Andrew G. Dillin,
University of California, Berkeley, USA
Mitochondrial Regulation of Longevity
Mitochondrial Regulation of Longevity
Vamsi K. Mootha,
Massachusetts General Hospital, USA
Hypoxia as a Therapy for Mitochondrial Disease
Hypoxia as a Therapy for Mitochondrial Disease
Coffee Break
09:50—11:30
Mitochondria in Cardiovascular Aging and Disease (Joint)
*
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
*
Kenneth M. Humphries,
Oklahoma Medical Research Foundation, USA
Hesham A. Sadek,
University of Texas Southwestern Medical Center, USA
Heart Regeneration via Inhibition of Aerobic Respiration
Heart Regeneration via Inhibition of Aerobic Respiration
Zoltan P. Arany,
University of Pennsylvania, USA
New Players in Mitophagy
New Players in Mitophagy
Timothy S. Luongo,
University of Pennsylvania, USA
Short Talk: Cardiac Nicotinamide Adenine Dinucleotide Depletion Results in Myocardial Dysfunction Despite Normal or Enhanced Mitochondrial Respiratory Capacity
Short Talk: Cardiac Nicotinamide Adenine Dinucleotide Depletion Results in Myocardial Dysfunction Despite Normal or Enhanced Mitochondrial Respiratory Capacity
Pidder Jansen-Dürr,
Universität Innsbruck, Austria
Short Talk: Oxaloacetate Decarboxylase FAHD1 - A Novel Regulator of Mitochondrial Function and Cellular Senescence
Short Talk: Oxaloacetate Decarboxylase FAHD1 - A Novel Regulator of Mitochondrial Function and Cellular Senescence
14:30—16:30
Workshop
*
Veronique Lacombe,
Oklahoma State University, USA
*
Katsu Funai,
University of Utah, USA
Helena C. Kenny,
University of Iowa, USA
Inducible Deletion of OPA1 in the Heart Induces ER Stress that Precedes Mitochondrial and Contractile Dysfunction
Inducible Deletion of OPA1 in the Heart Induces ER Stress that Precedes Mitochondrial and Contractile Dysfunction
Martin Picard,
Columbia University, USA
Human Mitochondrial 3D Network Organization and Nanotunnels in mtDNA Disease
Human Mitochondrial 3D Network Organization and Nanotunnels in mtDNA Disease
Michael J. Jurczak,
University of Pittsburgh, USA
SGLT2 Inhibition Restores Mitochondrial Metabolic Flexibility in Heart and is Associated with Reduced Ischemia-Induced Cardiac Injury
SGLT2 Inhibition Restores Mitochondrial Metabolic Flexibility in Heart and is Associated with Reduced Ischemia-Induced Cardiac Injury
Brad Willingham,
NHLBI, National Institutes of Health, USA
mitoRACE: In Vivo Assessment of Mitochondrial Function using Multiphoton NADH Fluorescence
mitoRACE: In Vivo Assessment of Mitochondrial Function using Multiphoton NADH Fluorescence
Paul J. Wrighton,
Brigham and Women's Hospital, USA
Novel pH-Sensitive Biosensor Zebrafish Enable the in vivo Visualization and Interrogation of Mitophagy during Development and Metabolic Stress
Novel pH-Sensitive Biosensor Zebrafish Enable the in vivo Visualization and Interrogation of Mitophagy during Development and Metabolic Stress
Antonietta Franco,
Washington University in St. Louis, USA
Mfn-2 Shape Shifting Mutation Causes Cardiomyopathy
Mfn-2 Shape Shifting Mutation Causes Cardiomyopathy
María Concepción Jiménez Gómez,
National Center of Cardiovascular Research, Spain
Development of OMA1 Inhibitor to Protect against Heart Failure in Mice
Development of OMA1 Inhibitor to Protect against Heart Failure in Mice
Jun Wang,
Texas Heart Institute, USA
Role of SUMO-2 in Cardiac Hypertrophy Induced by G Protein–Coupled Receptor Activation
Role of SUMO-2 in Cardiac Hypertrophy Induced by G Protein–Coupled Receptor Activation
17:00—19:00
Skeletal Muscle Mitochondria and Metabolic Regulation
*
P. Darrell Neufer,
East Carolina University, USA
*
Yvan Ricardo Campos,
St. Jude Children's Research Hospital, USA
Deborah M. Muoio,
Duke University Medical Center, USA
Mitochondrial Acetylation and Skeletal Muscle Metabolism
Mitochondrial Acetylation and Skeletal Muscle Metabolism
K. Sreekumaran Nair,
Mayo Clinic, USA
Mitochondrial Protein Turnover and Metabolic Regulation
Mitochondrial Protein Turnover and Metabolic Regulation
Matthijs K. Hesselink,
Maastricht University Medical Center, Netherlands
Short Talk: Day-Night Rhythm in Mitochondrial Network Morphology in Human Skeletal Muscle
Short Talk: Day-Night Rhythm in Mitochondrial Network Morphology in Human Skeletal Muscle
Erik C. Böttger,
University of Zurich, Switzerland
Short Talk: Mitochondrial Misreading Accelerates Metabolic Aging in Skeletal Muscle
Short Talk: Mitochondrial Misreading Accelerates Metabolic Aging in Skeletal Muscle
17:00—19:00
Mitochondrial Quality Control in Aging and Longevity
*
Liza A. Pon,
Columbia University Medical Center, USA
Cole M. Haynes,
University of Massachusetts Medical School, USA
Mitochondrial UPR in Organismal Homeostasis and Aging
Mitochondrial UPR in Organismal Homeostasis and Aging
Richard J. Youle,
NINDS, National Institutes of Health, USA
Mitophagy and Inflammation during Exercise and Aging
Mitophagy and Inflammation during Exercise and Aging
Rong Li,
Johns Hopkins University School of Medicine, USA
Mitochondrial Degradation of Cytosolic Proteins by MAGIC
Mitochondrial Degradation of Cytosolic Proteins by MAGIC
Shefali Krishna,
The Salk Institute for Biological Studies, USA
Short Talk: Long-Lived Proteins in the Mitochondria and their Role in Aging
Short Talk: Long-Lived Proteins in the Mitochondria and their Role in Aging
Liam Coyne,
SUNY Upstate Medical University, USA
Short Talk: Mitochondrial Carrier Protein Overloading and Misfolding Induce Aggresomes in the Cytosol
Short Talk: Mitochondrial Carrier Protein Overloading and Misfolding Induce Aggresomes in the Cytosol
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Calcium Signaling in Muscle Mitochondria
*
Paul S. Brookes,
University of Rochester Medical Center, USA
*
Florin Despa,
University of Kentucky, USA
Anna Raffaello,
University of Padova, Italy
Role of Mitochondrial Calcium in the Maintenance of Skeletal Muscle Homeostasis
Role of Mitochondrial Calcium in the Maintenance of Skeletal Muscle Homeostasis
György Hajnóczky,
Thomas Jefferson University, USA
Mitochondrial Dynamics and Excitation Contraction Coupling
Mitochondrial Dynamics and Excitation Contraction Coupling
Coffee Break
Toren Finkel,
University of Pittsburgh, UPMC, USA
Mitochondrial Calcium Uptake Mechanisms in the Heart
Mitochondrial Calcium Uptake Mechanisms in the Heart
Stefan Feske,
New York University School of Medicine, USA
Store Operated Calcium and Mitochondrial Metabolism
Store Operated Calcium and Mitochondrial Metabolism
Denis Vecellio Reane,
University of Padova, Italy
Short Talk: A MICU1 Splice Variant Confers High Sensitivity to the Ca2+ Uptake Machinery of Skeletal Muscle
Short Talk: A MICU1 Splice Variant Confers High Sensitivity to the Ca2+ Uptake Machinery of Skeletal Muscle
Olha Koval,
University of Iowa, USA
Short Talk: Mitochondrial Ca2+ Uptake via MCU Controls Cell Proliferation through CaMKII and Drp-1
Short Talk: Mitochondrial Ca2+ Uptake via MCU Controls Cell Proliferation through CaMKII and Drp-1
Luiz H. M. Bozi,
University of São Paulo, Brazil
Short Talk: Inhibition of Mitochondrial Unfolded Protein Response (mtUPR) Mediates Doxorubicin-Induced Cardiotoxicity
Short Talk: Inhibition of Mitochondrial Unfolded Protein Response (mtUPR) Mediates Doxorubicin-Induced Cardiotoxicity
08:00—11:00
Mitochondria in Immunity and Inflammation
*
Gerald S. Shadel,
The Salk Institute for Biological Studies, USA
Judith Campisi,
Buck Institute for Research on Aging, USA
Cellular Senescence, Mitochondrial Function and Aging
Cellular Senescence, Mitochondrial Function and Aging
Anna Katharina Simon,
University of Oxford, UK
Autophagy, Mitochondria and Telomeres in Aged Lymphocytes
Autophagy, Mitochondria and Telomeres in Aged Lymphocytes
Coffee Break
Michael Karin,
University of California, San Diego, USA
Mitochondrial DNA in Macrophage Immune Signaling
Mitochondrial DNA in Macrophage Immune Signaling
Peter D. Adams,
Sanford Burnham Prebys Medical Discovery Institute, USA
Short Talk: A Mitochondria-to-Nucleus Retrograde Signal Initiates Extrusion of Chromatin into Cytoplasm and Senescence-Associated Inflammation
Short Talk: A Mitochondria-to-Nucleus Retrograde Signal Initiates Extrusion of Chromatin into Cytoplasm and Senescence-Associated Inflammation
Sweelin Chew,
University of Eastern Finland, Finland
Short Talk: Pinpointing Novel Targets of Air Pollution in Olfactory and Neural Cells
Short Talk: Pinpointing Novel Targets of Air Pollution in Olfactory and Neural Cells
Adrienne Mottis,
École Polytechnique Fédérale de Lausanne, Switzerland
Short Talk: Doxycycline-Induced Mitochondrial Stress in Germ-Free Mice Reveals an Organ-Specific Response and Engages Antiviral Immunity
Short Talk: Doxycycline-Induced Mitochondrial Stress in Germ-Free Mice Reveals an Organ-Specific Response and Engages Antiviral Immunity
17:00—19:00
Novel Regulators of Mitochondrial Metabolism
*
Liming Pei,
Children's Hospital of Philadelphia/University of Pennsylvania, USA
*
Ryan L. Boudreau,
University of Iowa, USA
Andrea L. Hevener,
University of California, Los Angeles, USA
Estrogen Regulation of Skeletal Muscle Mitochondria and Insulin Sensitivity
Estrogen Regulation of Skeletal Muscle Mitochondria and Insulin Sensitivity
Daniel P. Kelly,
University of Pennsylvania, USA
Cardiac Mitochondrial Remodeling in Health and Disease
Cardiac Mitochondrial Remodeling in Health and Disease
Karyn A. Esser,
University of Florida, USA
Circadian Regulation of Skeletal Muscle Mitochondrial Metabolism
Circadian Regulation of Skeletal Muscle Mitochondrial Metabolism
Weiwei Fan,
The Salk Institute for Biological Studies, USA
Short Talk: Estrogen-Related Receptors α and γ are Master Regulators of Innate and Adaptive Mitochondrial Energy Metabolism in Muscle
Short Talk: Estrogen-Related Receptors α and γ are Master Regulators of Innate and Adaptive Mitochondrial Energy Metabolism in Muscle
Julien Delezie,
University of Basel, Switzerland
Short Talk: PER2 is a Potent Regulator of Mitochondrial Function in Mouse Skeletal Muscle
Short Talk: PER2 is a Potent Regulator of Mitochondrial Function in Mouse Skeletal Muscle
17:00—19:00
Mitochondrial Metabolism in Aging
*
Holly Van Remmen,
Oklahoma Medical Research Foundation, USA
Noga Ron-Harel,
Technion-Israel Institute of Technology, Israel
Mitochondrial Metabolism in T Cell Activation and Aging
Mitochondrial Metabolism in T Cell Activation and Aging
Hazel H. Szeto,
Social Profit Network Research Laboratory, USA
Cardiolipin-Targeted Peptides Rejuvenate Mitochondrial Function, Remodel Mitochondria, and Promote Tissue Regeneration during Aging
Cardiolipin-Targeted Peptides Rejuvenate Mitochondrial Function, Remodel Mitochondria, and Promote Tissue Regeneration during Aging
Adam L. Hughes,
University of Utah, USA
Short Talk: Dissecting the Metabolic Connection Between Mitochondria and Lysosomes in Aging
Short Talk: Dissecting the Metabolic Connection Between Mitochondria and Lysosomes in Aging
Jennifer Baily,
University of California, Davis, USA
Short Talk: Alternating Phases of AMPK and mTORC1: A Potential Mechanism of Mitochondrial Biogenesis during Electron Transport Chain Inhibition
Short Talk: Alternating Phases of AMPK and mTORC1: A Potential Mechanism of Mitochondrial Biogenesis during Electron Transport Chain Inhibition
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:15
Mitochondria and Cell Death
*
Anton M. Bennett,
Yale University School Of Medicine, USA
Junichi Sadoshima,
Rutgers New Jersey Medical School, USA
Autophagy and Mitochondrial Dysfunction in Heart Failure
Autophagy and Mitochondrial Dysfunction in Heart Failure
Åsa B. Gustafsson,
University of California, San Diego, USA
Beclin1 as a Key Regulator of Mitochondrial Quality Control
Beclin1 as a Key Regulator of Mitochondrial Quality Control
Coffee Break
Gerald W. Dorn, II,
Washington University School of Medicine, USA
Cardiomitopathy – Novel Cardiomyopathy of Dysfunctional Mitochondria
Cardiomitopathy – Novel Cardiomyopathy of Dysfunctional Mitochondria
Hiromi Sesaki,
Johns Hopkins University School of Medicine, USA
Mitochondrial Dynamics and Mitophagy
Mitochondrial Dynamics and Mitophagy
Juyoun Beak,
University of North Carolina, USA
Short Talk: The Nuclear Receptor RORα Plays Critical Roles in Mitochondrial Quality Control
Short Talk: The Nuclear Receptor RORα Plays Critical Roles in Mitochondrial Quality Control
Payam Anthony Gammage,
University of Cambridge, UK
Short Talk: Genome Editing in Cardiac Mitochondria Corrects a Pathogenic mtDNA Mutation in vivo
Short Talk: Genome Editing in Cardiac Mitochondria Corrects a Pathogenic mtDNA Mutation in vivo
*
Joan M. Taylor,
University of North Carolina at Chapel Hill, USA
Short Talk: GRAF1 is A Novel Mediator of Parkin-Dependent Mitophagy
Short Talk: GRAF1 is A Novel Mediator of Parkin-Dependent Mitophagy
08:00—11:00
Mitochondrial Signaling in Aging
*
Carlos T. Moraes,
University of Miami, USA
Navdeep S. Chandel,
Northwestern University, USA
Mitochondria as Signaling Organelles
Mitochondria as Signaling Organelles
Tamas L. Horvath,
Yale School of Medicine, USA
Hypothalamic Mitochondrial Dynamics in Homeostatic Control and Aging
Hypothalamic Mitochondrial Dynamics in Homeostatic Control and Aging
Coffee Break
Gerald S. Shadel,
The Salk Institute for Biological Studies, USA
Adaptive, Anti-Aging Responses to Mitochondrial Stress: From Yeast to Mammals
Adaptive, Anti-Aging Responses to Mitochondrial Stress: From Yeast to Mammals
Jose M. Cuezva,
Universidad Autónoma de Madrid, Spain
ATPase Inhibitory Factor 1 (IF1), a Driver of Mitochondrial/Nuclear Genome Signaling Pathways
ATPase Inhibitory Factor 1 (IF1), a Driver of Mitochondrial/Nuclear Genome Signaling Pathways
Gavin Pharaoh,
University of Oklahoma Health Sciences Center, USA
Short Talk: Central and Peripheral Effects of IGF-1 Deficiency on Tissue Mitochondrial Function
Short Talk: Central and Peripheral Effects of IGF-1 Deficiency on Tissue Mitochondrial Function
Robert Radford,
The Salk Institute for Biological Studies, USA
Short Talk: TIN2: A Mitochondrial Effector of Telomere Status in Aging
Short Talk: TIN2: A Mitochondrial Effector of Telomere Status in Aging
14:30—16:30
Workshop: Mitochondrial Metabolic Signaling and Communication with Other Organelles in Aging
*
Dan Gottschling,
Calico, USA
Sam Katz,
Yale University School of Medicine, USA
Regulation of ER-Mitochondrial Contact Site Signaling by the BCL-2 Family Member BOK
Regulation of ER-Mitochondrial Contact Site Signaling by the BCL-2 Family Member BOK
Changhan Lee,
University of Southern California and Ajou University, USA
Intergenomic Basis of Mitonuclear Communication
Intergenomic Basis of Mitonuclear Communication
Nuno Raimundo,
University Medical Center Goettingen, Germany
Impact of Mitochondrial Function in Aging Is Mediated by Impaired Lysosomes
Impact of Mitochondrial Function in Aging Is Mediated by Impaired Lysosomes
Katharina Schlacher,
MD Anderson Cancer Center, USA
Mitochondrial DNA Replication Fork Stability by the BRCA/Fanconi Anemia Pathway Suppresses Inflammation and Disease
Mitochondrial DNA Replication Fork Stability by the BRCA/Fanconi Anemia Pathway Suppresses Inflammation and Disease
Jaroslaw Waldemar Zmijewski,
University of Alabama, USA
AMPK is a Therapeutic Target for Metabolic and Bioenergetic Maladaptation in Aging-Related Non-Resolving Lung Fibrosis
AMPK is a Therapeutic Target for Metabolic and Bioenergetic Maladaptation in Aging-Related Non-Resolving Lung Fibrosis
Ana Victoria Lechuga Vieco,
Spanish National Center for Cardiovascular Research, Spain
Mitochondrial and Nuclear DNA Matching Shapes Metabolism and Healthy Ageing
Mitochondrial and Nuclear DNA Matching Shapes Metabolism and Healthy Ageing
Kortessa Sotiropoulou,
Institute of Medical Biology, ASTAR, Singapore
The Proline Metabolic Pathway in Human Skin Ageing
The Proline Metabolic Pathway in Human Skin Ageing
Teresa Gonçalves,
University of Coimbra, Portugal
Dynamics of Adenosine A2A Receptors is Associated with Increased Susceptibility to Candida Albicans Colonization and Inflammation in the Elderly
Dynamics of Adenosine A2A Receptors is Associated with Increased Susceptibility to Candida Albicans Colonization and Inflammation in the Elderly
17:00—19:00
Mitochondrial Dynamics and Metabolism
*
John P. Kirwan,
Pennington Biomedical Research Center, USA
*
Brian Timothy O'Neill,
University of Iowa, Carver College of Medicine, USA
E. Dale Abel,
University of Iowa, Carver College of Medicine, USA
Paracrine Regulation of Metabolism by OPA1
Paracrine Regulation of Metabolism by OPA1
Robert S. Balaban,
NHLBI, National Institutes of Health, USA
The Mitochondria Reticulum of Muscle Cells
The Mitochondria Reticulum of Muscle Cells
Antonio Zorzano,
Institute for Research in Biomedicine, Spain
Mitochondrial Fusion Proteins, Metabolism and Inflammation
Mitochondrial Fusion Proteins, Metabolism and Inflammation
Brian Glancy,
NHLBI and NIAMS, National Institutes of Health, USA
Short Talk: Intra- and Inter-Organelle Interactions within the Muscle Mitochondrial Reticulum
Short Talk: Intra- and Inter-Organelle Interactions within the Muscle Mitochondrial Reticulum
Sandra S. Zinkel,
Vanderbilt University, USA
Short Talk: Bid Maintains Mitochondrial Cristae Structure and Function and Protects against Cardiac Disease in an Integrative Genomics Study
Short Talk: Bid Maintains Mitochondrial Cristae Structure and Function and Protects against Cardiac Disease in an Integrative Genomics Study
17:00—19:00
Mitochondria in Age-Related Pathology
*
Rudolf J. Wiesner,
University of Cologne, Germany
David J. Marcinek,
University of Washington, USA
The Effects of Mitochondrial Redox Stress on Energetics and the Proteome in Aged Skeletal Muscle
The Effects of Mitochondrial Redox Stress on Energetics and the Proteome in Aged Skeletal Muscle
Scott M. Plafker,
Oklahoma Medical Research Foundation, USA
Mitochondria-Associated Stress Sensing Proteins Govern Intracellular Homeostasis
Mitochondria-Associated Stress Sensing Proteins Govern Intracellular Homeostasis
James B. Stewart,
Max Planck Institute for Biology of Ageing, Germany
Mouse Models of Mitochondrial DNA Mutations in Disease Pathology
Mouse Models of Mitochondrial DNA Mutations in Disease Pathology
Douglas C. Wallace,
Children's Hospital of Philadelphia, USA
Nuclear-Mitochondrial Interactions in Age-Related Diseases
Nuclear-Mitochondrial Interactions in Age-Related Diseases
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Mitochondria in Aging Muscle (Joint)
*
In-Kyu Lee,
Kyungpook National University Hospital, South Korea
David J. Glass,
Regeneron Pharmaceuticals, Inc., USA
Mitochondria Pathways in Aging and Sarcopenia
Mitochondria Pathways in Aging and Sarcopenia
Holly Van Remmen,
Oklahoma Medical Research Foundation, USA
Is Mitochondrial Oxidative Stress a Determining Factor in Sarcopenia?
Is Mitochondrial Oxidative Stress a Determining Factor in Sarcopenia?
Coffee Break
Mike P. Murphy,
Medical Research Council, UK
Therapeutic Targeting of Mitochondria
Therapeutic Targeting of Mitochondria
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
New Insights into the Genetics of Mitochondria and Aging
New Insights into the Genetics of Mitochondria and Aging
Mitchell Allen,
Virginia Tech, USA
Short Talk: The Cardiolipin-Aggregating Peptide Elamipretide Protects Mitochondrial Structure-Function
Short Talk: The Cardiolipin-Aggregating Peptide Elamipretide Protects Mitochondrial Structure-Function
Robert V. Musci,
Colorado State University, USA
Short Talk: Nrf2 Activator Improves Mitochondrial Function and Attenuates Age-Related Musculoskeletal Dysfunction in a Novel Guinea Pig Model
Short Talk: Nrf2 Activator Improves Mitochondrial Function and Attenuates Age-Related Musculoskeletal Dysfunction in a Novel Guinea Pig Model
17:00—19:00
Mitochondria, Energy Expenditure and Insulin Sensitivity
*
Anastasia Kralli,
Johns Hopkins Medical School, USA
*
Weiwei Fan,
The Salk Institute for Biological Studies, USA
Patrick Schrauwen,
Maastricht University, Netherlands
Human Skeletal Muscle Mitochondrial function and Insulin Sensitivity
Human Skeletal Muscle Mitochondrial function and Insulin Sensitivity
Mary-Ellen Harper,
University of Ottawa, Canada
Skeletal Muscle Mitochondrial Energetics in Diet-Resistant and Diet-Sensitive Obesity
Skeletal Muscle Mitochondrial Energetics in Diet-Resistant and Diet-Sensitive Obesity
Yvan Ricardo Campos,
St. Jude Children's Research Hospital, USA
Short Talk: Mitochondrial Defects in Ozz and Alix Knockout Mouse Models
Short Talk: Mitochondrial Defects in Ozz and Alix Knockout Mouse Models
Danielle S. Murashige,
University of Pennsylvania, USA
Short Talk: Promotion of Specifically Cardiac Branched Chain Amino Acid Metabolism does not Prevent Cardiac Remodeling
Short Talk: Promotion of Specifically Cardiac Branched Chain Amino Acid Metabolism does not Prevent Cardiac Remodeling
17:00—18:45
Mitochondria Dynamics and Aging
*
Richard J. Youle,
NINDS, National Institutes of Health, USA
Liza A. Pon,
Columbia University Medical Center, USA
Inheritance of the Fittest Mitochondria and Lifespan Control in Budding Yeast
Inheritance of the Fittest Mitochondria and Lifespan Control in Budding Yeast
Monica Driscoll,
Rutgers University, USA
Throwing It Away: Neuronal Extrusion of Trashy Mitochondria as a Mito-Stasis Strategy
Throwing It Away: Neuronal Extrusion of Trashy Mitochondria as a Mito-Stasis Strategy
Lisa Norquay,
Janssen, USA
Mitochondrial Dynamics and Mitophagy in Metabolic Disease
Mitochondrial Dynamics and Mitophagy in Metabolic Disease
Sofie Hindkjaer Lautrup,
University of Oslo and Akershus University Hospital, Norway
Short Talk: NAD+ Prevents Accelerated Aging in Werner Syndrome by Induction of Mitophagy
Short Talk: NAD+ Prevents Accelerated Aging in Werner Syndrome by Induction of Mitophagy
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
We gratefully acknowledge support for this conference from:
We gratefully acknowledge additional support for this conference from:
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