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This meeting took place in 2019
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Autophagy: From Model Systems to Therapeutic Opportunities (B2)
Organizer(s) Vojo Deretic, Li Yu and Leon O. Murphy
February 17—21, 2019
Eldorado Hotel & Spa • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 23, 2018
Abstract Deadline: Nov 15, 2018
Scholarship Deadline: Oct 23, 2018
Discounted Registration Deadline: Dec 13, 2018
This activity is supported by an educational grant from Celgene Corporation
Summary of Meeting:
Autophagy is a homeostatic process strategically positioned at the intersection of metabolism and intracellular quality control, with broad physiological and medical manifestations ranging from metabolic imbalance to neurodegeneration, infections, immune disorders, cancer and aging. In yeast, the formation and organization of the autophagosomal apparatus follows a highly prescribed sequence, starting with the pre-autophagosomal structure and ending in autophagosomal fusion with the yeast vacuole. However, in other model organisms, as well as in mammals, the autophagy machinery and its regulators show both similarities and notable differences relative to yeast. The goals/aims of the conference are: 1) Compare and contrast autophagy in yeast and higher organisms with a focus on both the shared regulators and on those factors that have no counterparts in yeast. 2) Cover the intersection of autophagy with energy metabolism, innate immune signaling and endomembrane damage. 3) Cover how signaling cascades regulate the process of selective autophagy whereby substrates are recruited to forming autophagosomes by receptors and molecular tags such as ubiquitin, galectins, or through other modalities. The conference will cover fundamental principles as outlined above and how they apply to basic and translational aspects of human disease. Intersections with several other stress response processes will be addressed.
View Scholarships/Awards
Autophagy is a homeostatic process strategically positioned at the intersection of metabolism and intracellular quality control, with broad physiological and medical manifestations ranging from metabolic imbalance to neurodegeneration, infections, immune disorders, cancer and aging. In yeast, the formation and organization of the autophagosomal apparatus follows a highly prescribed sequence, starting with the pre-autophagosomal structure and ending in autophagosomal fusion with the yeast vacuole. However, in other model organisms, as well as in mammals, the autophagy machinery and its regulators show both similarities and notable differences relative to yeast. The goals/aims of the conference are: 1) Compare and contrast autophagy in yeast and higher organisms with a focus on both the shared regulators and on those factors that have no counterparts in yeast. 2) Cover the intersection of autophagy with energy metabolism, innate immune signaling and endomembrane damage. 3) Cover how signaling cascades regulate the process of selective autophagy whereby substrates are recruited to forming autophagosomes by receptors and molecular tags such as ubiquitin, galectins, or through other modalities. The conference will cover fundamental principles as outlined above and how they apply to basic and translational aspects of human disease. Intersections with several other stress response processes will be addressed.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, February 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 22 in order to fully experience the meeting.
SUNDAY, FEBRUARY 17
MONDAY, FEBRUARY 18
TUESDAY, FEBRUARY 19
WEDNESDAY, FEBRUARY 20
THURSDAY, FEBRUARY 21
FRIDAY, FEBRUARY 22
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, February 17 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 21 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, February 22 in order to fully experience the meeting.
SUNDAY, FEBRUARY 17
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Beth Levine,
University of Texas Southwestern Medical Center, USA
Autophagy – A View from Mammalian and Metazoan Studies
Autophagy – A View from Mammalian and Metazoan Studies
09:00—11:15
Autophagy Fundamentals
*
Anne Simonsen,
University of Oslo, Norway
*
Patrice Codogno,
INSERM, France
Coffee Break
Terje Johansen,
Institute of Medical Biology, Norway
Selective Autophagy Mediated by Both Sequestosome 1/p62-Like Receptors and Mitophagy Receptors
Selective Autophagy Mediated by Both Sequestosome 1/p62-Like Receptors and Mitophagy Receptors
Chiara De Leonibus,
Telethon Institute of Genetics and Medicine, Italy
Short Talk: A Selective ER-Phagy Exerts Procollagen Quality Control via a CALNEXIN-FAM134B Complex
Short Talk: A Selective ER-Phagy Exerts Procollagen Quality Control via a CALNEXIN-FAM134B Complex
J. Wade Harper,
Harvard Medical School, USA
Exploring Proteome Homeostasis Mechanisms using Quantitative Proteomics
Exploring Proteome Homeostasis Mechanisms using Quantitative Proteomics
14:30—16:30
Workshop 1: Structural Biology and Proteomics and Autophagy
*
Christian Behrends,
Ludwig Maximilians University München, Germany
Proteomics Studies of Autophagy Systems
Proteomics Studies of Autophagy Systems
Sharan Swarup,
Harvard Medical School, USA
Profiling the Lysophagy Pathway through Quantitative Proteomics
Profiling the Lysophagy Pathway through Quantitative Proteomics
*
James H. Hurley,
University of California, Berkeley, USA
Structural Studies of Autophagy Systems
Structural Studies of Autophagy Systems
Takanori Otomo,
The Scripps Research Institute, USA
Insights into Phagophore Expansion from Structural and Biochemical Analyses of the ATG2A-WIPI4 Complex
Insights into Phagophore Expansion from Structural and Biochemical Analyses of the ATG2A-WIPI4 Complex
Carsten Sachse,
Forschungszentrum Jülich, Germany
Structural Basis and in situ Visualization of p62/SQSTM1 Polymers by Electron Microscopy
Structural Basis and in situ Visualization of p62/SQSTM1 Polymers by Electron Microscopy
17:00—19:00
mTOR, AMPK, TFEB – Relationship to Autophagy and Other Pathways
*
Patricia Boya,
Centro de Investigaciones Biológicas, CSIC, Spain
Roberto Zoncu,
University of California, Berkeley, USA
Molecular Mechanisms of Lysosomal mTORC1 Regulation by Cellular Lipids
Molecular Mechanisms of Lysosomal mTORC1 Regulation by Cellular Lipids
Wei Liu,
Zhejiang University, China
Signal Regulation of Autophagy Initiation
Signal Regulation of Autophagy Initiation
Nuno Raimundo,
University Medical Center Goettingen, Germany
Short Talk: Mitochondrial Malfunction Impairs Lysosomal Hydrolysis via AMPK-PtdIns(3,5)P2
Short Talk: Mitochondrial Malfunction Impairs Lysosomal Hydrolysis via AMPK-PtdIns(3,5)P2
Reuben J. Shaw,
The Salk Institute for Biological Studies, USA
AMPK and ULK1: Two Critical Kinases in Autophagy Initiation
AMPK and ULK1: Two Critical Kinases in Autophagy Initiation
08:00—11:00
Membrane Trafficking and its Role in Autophagy
*
Fulvio Reggiori,
University Medical Centre Groningen, Netherlands
Ivan Dikic,
Goethe University Medical School, Germany
Multiplex CRISPR/Cas Library Screens Targeting Autophagy Networks
Multiplex CRISPR/Cas Library Screens Targeting Autophagy Networks
Jin-Mi Heo,
Harvard Medical School, USA
Short Talk: RAB7A Phosphorylation by TBK1 Promotes Mitophagy via the PINK-Parkin Pathway
Short Talk: RAB7A Phosphorylation by TBK1 Promotes Mitophagy via the PINK-Parkin Pathway
Noboru Mizushima,
University of Tokyo, Japan
Evolution of the ATG12 Conjugation System
Evolution of the ATG12 Conjugation System
Coffee Break
Cheng-Wei Hsieh,
Institute of Biological Chemistry, Taiwan
Short Talk: Omegasome-Proximal PtdIns(4,5)P2 Couples F-Actin Mediated Mitoaggregate Disassembly with Autophagosome Formation during Mitophagy
Short Talk: Omegasome-Proximal PtdIns(4,5)P2 Couples F-Actin Mediated Mitoaggregate Disassembly with Autophagosome Formation during Mitophagy
Felix Randow,
Medical Research Council, UK
Autophagy in Cell-Autonomous Immunity
Autophagy in Cell-Autonomous Immunity
Li Yu,
Tsinghua University, China
p62 Phase Separation in Autophagy
p62 Phase Separation in Autophagy
17:00—19:00
Autophagy Regulation and Processes
*
Maria Ines Vaccaro,
University of Buenos Aires, Argentina
*
Qing Zhong,
Shanghai Jiao Tong University School of Medicine, China
Elizabeth A. Allen,
University of Massachusetts Medical School, USA
Short Talk: A Myotubularin-Related Phosphatase that Regulates Autophagic Flux
Short Talk: A Myotubularin-Related Phosphatase that Regulates Autophagic Flux
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
Depletion of Acetyl-Coenzyme A by Starvation Inhibits mTORC1 Pathway via EP300
Depletion of Acetyl-Coenzyme A by Starvation Inhibits mTORC1 Pathway via EP300
Qiming Sun,
Zhejiang University, China
Short Talk: FAM134B Oligomerization Drives ER Membrane Scission for ER-Phagy
Short Talk: FAM134B Oligomerization Drives ER Membrane Scission for ER-Phagy
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Autophagy Regulation by Galectins during Membrane Damage Homeostasis
Autophagy Regulation by Galectins during Membrane Damage Homeostasis
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Autophagy, Proteostasis and Organellar Homeostasis
*
Eeva-Liisa Eskelinen,
University of Turku, Finland
Kevin M. Ryan,
Beatson Institute for Cancer Research, UK
Autophagy in Tissue Growth and Tumor Development
Autophagy in Tissue Growth and Tumor Development
Jennifer A. Lippincott-Schwartz,
Howard Hughes Medical Institute - Janelia Farm, USA
Cross-Talk between Lipid Droplets, Autophagy and Mitochondria Drives Cell Survival Under Starvation
Cross-Talk between Lipid Droplets, Autophagy and Mitochondria Drives Cell Survival Under Starvation
Martin Graef,
Max Planck Institute for Biology of Aging, Germany
Short Talk: System-Wide Profiling of Mitotic Aging Reveals Pro-Aging Functions of the Autophagy Machinery
Short Talk: System-Wide Profiling of Mitotic Aging Reveals Pro-Aging Functions of the Autophagy Machinery
Coffee Break
Tamotsu Yoshimori,
Osaka University, Japan
Suppression of Autophagic Activity by Rubicon is a Signature of Aging
Suppression of Autophagic Activity by Rubicon is a Signature of Aging
Meagan J. McGrath,
Monash University, Australia
Short Talk: Defective Lysosome Homeostasis during Autophagy Causes Skeletal Muscle Disease
Short Talk: Defective Lysosome Homeostasis during Autophagy Causes Skeletal Muscle Disease
Anastasia Henry,
Denali Therapeutics, USA
The Role of Leucine-Rich Repeat Kinase 2 (LRRK2) in Regulating Endo-Lysosomal Function
The Role of Leucine-Rich Repeat Kinase 2 (LRRK2) in Regulating Endo-Lysosomal Function
14:30—16:30
Panel: Women in Science at All Career Stages
*
Anne Simonsen,
University of Oslo, Norway
*
Malene Hansen,
Sanford Burnham Prebys Medical Discovery Institute, USA
Magdalene Moran,
Rheostat Therapeutics, USA
Helin Vakifahmetoglu-Norberg,
Karolinska Institutet, Sweden
Aurore L. Claude-Taupin,
University of New Mexico, USA
Eun-Kyeong Jo,
Chungnam National University, South Korea
Marie Bao,
Cell Press, USA
17:00—19:00
Autophagy in Aging, Degenerative, and Inflammatory Disease
*
Jennifer Martinez,
NIEHS, National Institutes of Health, USA
*
Phyllis I. Hanson,
University of Michigan, USA
Malene Hansen,
Sanford Burnham Prebys Medical Discovery Institute, USA
Regulation of Autophagy in Aging and Disease
Regulation of Autophagy in Aging and Disease
Franck Oury,
Institut Necker Enfants-Malades, France
Short Talk: Autophagy Induction is Required to Enhance Cognition and Integrate the Effects of Youthful Systemic Factors in the Aged Brain
Short Talk: Autophagy Induction is Required to Enhance Cognition and Integrate the Effects of Youthful Systemic Factors in the Aged Brain
Rupert Beale,
University of Cambridge, UK
Short Talk: Influenza A Virus Triggers a Pathway that Resembles Autophagy but Has a Distinct Molecular Basis
Short Talk: Influenza A Virus Triggers a Pathway that Resembles Autophagy but Has a Distinct Molecular Basis
Herbert (Skip) W. Virgin,
Vir Biotechnology, USA
Role of Autophagy and Autophagy Genes in Infection, Inflammation and Immunity
Role of Autophagy and Autophagy Genes in Infection, Inflammation and Immunity
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Autophagy in Metabolism, Growth Control and Cancer
*
Devrim Gozuacik,
Sabanci University, Turkey
*
Leon O. Murphy,
Casma Therapeutics, USA
Eileen P. White,
Rutgers University, USA
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response
Autophagy Maintains Host and Tumor Metabolism and an Anti-Cancer Immune Response
Rushika M. Perera,
University of California, San Francisco, USA
Short Talk: Lysosome Mediated Remodeling of the Cancer Proteome
Short Talk: Lysosome Mediated Remodeling of the Cancer Proteome
Coffee Break
Beat Nyfeler,
Novartis Institutes for BioMedical Research, Switzerland
VPS34 and Autolysosomal Regulation
VPS34 and Autolysosomal Regulation
Nunzia Pastore,
Baylor College of Medicine, USA
Short Talk: MiT-TFE Transcription Factors Couple Autophagy and Metabolism to the Peripheral Clock
Short Talk: MiT-TFE Transcription Factors Couple Autophagy and Metabolism to the Peripheral Clock
Jayanta Debnath,
University of California, San Francisco, USA
Autophagy and Metastatic Colonization
Autophagy and Metastatic Colonization
14:30—16:30
Workshop 2: Current Controversies
*
Michael Lazarou,
Monash University, Australia
Function of Mammalian Atg8s (LC3s and GABARAPs) in Autophagy: New Insights and Controversies
Function of Mammalian Atg8s (LC3s and GABARAPs) in Autophagy: New Insights and Controversies
Shigeomi Shimizu,
Tokyo Medical and Dental University, Japan
New Insights into the Mechanism and Biological Roles of Atg5-Independent Macroautophagy
New Insights into the Mechanism and Biological Roles of Atg5-Independent Macroautophagy
Shenliang Yu,
Yale University, USA
ATG2 Is a Lipid Transporter at ER-Autophagosome Contacts during Autophagosome Biogenesis
ATG2 Is a Lipid Transporter at ER-Autophagosome Contacts during Autophagosome Biogenesis
Richard I. Odle,
Babraham Institute, UK
Repression of Autophagy and Phosphorylation of Autophagy Regulators during Mitosis Is Independent of mTORC1
Repression of Autophagy and Phosphorylation of Autophagy Regulators during Mitosis Is Independent of mTORC1
Helin Vakifahmetoglu-Norberg,
Karolinska Institutet, Sweden
Targetome Analysis of Chaperone-Mediated Autophagy in Cancer Cells
Targetome Analysis of Chaperone-Mediated Autophagy in Cancer Cells
17:00—19:00
Autophagy from Model Systems to Humans – Closing the Circle
*
Quan Chen,
Nankai University, China
*
Zvulun Elazar,
Weizmann Institute of Science, Israel
Angela Ianniciello,
University of Glasgow, UK
Short Talk: ULK1 Regulates Central Carbon Metabolism and Drug-Sensitivity in Leukemic Stem Cells in Autophagy-Independent and Autophagy-Dependent Manner
Short Talk: ULK1 Regulates Central Carbon Metabolism and Drug-Sensitivity in Leukemic Stem Cells in Autophagy-Independent and Autophagy-Dependent Manner
Hong Zhang,
Chinese Academy of Sciences, China
Ciliated Sensory Neurons Detect Cuticle Damage in C. elegans and Activate Autophagy in Multiple Tissues via a TGFbeta-AMPK Axis
Ciliated Sensory Neurons Detect Cuticle Damage in C. elegans and Activate Autophagy in Multiple Tissues via a TGFbeta-AMPK Axis
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Discovery of Novel Regulators of Autophagy in Animals
Discovery of Novel Regulators of Autophagy in Animals
Ai Yamamoto,
Columbia University, USA
Short Talk: The Physiologic Cargoes of Macroautophagy in Aging and Disease
Short Talk: The Physiologic Cargoes of Macroautophagy in Aging and Disease
Andrew M. Thorburn,
University of Colorado AMC, USA
Targeting Autophagy in Cancer Treatment
Targeting Autophagy in Cancer Treatment
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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