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This meeting took place in 2019
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DNA Replication and Genome Instability: From Mechanism to Disease (A1)
Organizer(s) Karlene A. Cimprich, Mark J. O'Connor and Johannes C. Walter
January 13—17, 2019
Snowbird Resort • Snowbird, UT USA
Discounted Abstract Deadline: Oct 4, 2018
Abstract Deadline: Oct 16, 2018
Scholarship Deadline: Oct 4, 2018
Discounted Registration Deadline: Nov 13, 2018
Organized in collaboration with Cancer Research UK
This activity is supported by an educational grant from Celgene Corporation
Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.
This activity is supported by an educational grant from Celgene Corporation
Sponsored by Editas Medicine, EMD Serono Research and Development Institute, Inc. and TESARO, Inc.
Summary of Meeting:
This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.
View Scholarships/Awards
This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.
SUNDAY, JANUARY 13
MONDAY, JANUARY 14
TUESDAY, JANUARY 15
WEDNESDAY, JANUARY 16
THURSDAY, JANUARY 17
FRIDAY, JANUARY 18
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, January 13 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 17 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 18 in order to fully experience the meeting.
SUNDAY, JANUARY 13
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:30
Welcome and Keynote Session
*
Karlene A. Cimprich,
Stanford University, USA
Session Chair
Session Chair
*
Johannes C. Walter,
Harvard Medical School, USA
Session Chair
Session Chair
David Cortez,
Vanderbilt University School of Medicine, USA
Replication Fork Proteomes: How Many Proteins Are Needed?
Replication Fork Proteomes: How Many Proteins Are Needed?
Coffee Break
09:50—11:30
The Influence of Chromatin on Replication and Repair
*
Karlene A. Cimprich,
Stanford University, USA
Session Chair
Session Chair
*
Johannes C. Walter,
Harvard Medical School, USA
Session Chair
Session Chair
Iestyn Whitehouse,
Memorial Sloan Kettering Cancer Center, USA
Coordination of Transcription and DNA Replication during Embryogenesis
Coordination of Transcription and DNA Replication during Embryogenesis
Gaëlle Legube,
Univsersité Paul Sabatier, France
Chromatin and Chromosome Dynamics during DNA Double-Strand Break Repair
Chromatin and Chromosome Dynamics during DNA Double-Strand Break Repair
Andrew N. Blackford,
University of Oxford, UK
Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis
Short Talk: How Cells Respond to DNA Double-Strand Breaks in Mitosis
Philipp Oberdoerffer,
Johns Hopkins University, USA
Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome
Short Talk: Epigenetic Control of Genome Stability at the Inactive X Chromosome
14:30—16:30
Workshop 1: Basic Mechanisms of Replication
*
Joseph Yeeles,
MRC Laboratory of Molecular Biology, UK
Session Chair
Session Chair
Bik Kwoon Tye,
Hong Kong University of Science and Technology, Hong Kong
Selectivity for Replication Origins by the Origin Recognition Complex
Selectivity for Replication Origins by the Origin Recognition Complex
Nynke H. Dekker,
Delft University of Technology, Netherlands
In vitro Single-Molecule Fluorescence Studies of Yeast Replication
In vitro Single-Molecule Fluorescence Studies of Yeast Replication
Neha Puri,
Johns Hopkins University School of Medicine, USA
Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation
Structural and Functional Coupling of ATP Turnover to Replicative Helicase Loading and Activation
Conrad A. Nieduszynski,
University of Oxford, UK
Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads
Capturing the Dynamics of DNA Replication on Individual Ultra-Long Nanopore Sequencing Reads
Marko Lõoke,
Massachusetts Institute of Technology, USA
Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function
Life without Mcm10: Identification and Characterization of Mcm2-7 Mutations that Fully Bypass Mcm10 Function
Nicholas E. Dixon,
University of Wollongong, Australia
A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome
A Primase-Induced Conformational Switch Controls Polymerase Exchange in the Bacterial Replisome
Tatiana Moiseeva,
University of Pittsburgh, USA
ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells
ATR/Chk1-Dependent Replication Initiation Control in Undamaged Cells
14:30—16:30
Workshop 2: Basic Mechanisms of Recombination
*
Sharon B. Cantor,
University of Massachusetts Medical School, USA
Session Chair
Session Chair
Wolf-Dietrich Heyer,
University of California, Davis, USA
Mechanisms of Recombination: D-loop Reversal and Pathway Control
Mechanisms of Recombination: D-loop Reversal and Pathway Control
Akira Shinohara,
Osaka University, Japan
Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase
Human RAD51 Paralog, SWSAP1, Promotes RAD51 Assembly by Regulating the Anti-Recombinase, FIGNL1 AAA+ATPase
Yizhou Joseph He,
Dana-Farber Cancer Institute, USA
DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells
DYNLL1 Binds MRE11 to Limit DNA End Resection in BRCA1-Deficient Cells
Jordan Becker,
University of Oxford, UK
The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End-Joining and PARP Inhibitor Sensitivity
The ASCIZ-DYNLL1 Axis Promotes 53BP1-Dependent Non-Homologous End-Joining and PARP Inhibitor Sensitivity
Yang Yu,
Baylor College of Medicine, USA
Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks
Dna2 Nuclease Deficiency Results in Large and Complex DNA Insertions at Chromosomal Breaks
Dongyi Xu,
Peking University, China
NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis
NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis
Abigail Shea,
CRUK Cambridge Institute, UK
A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models
A Co-Clinical Trial Investigating Targeted Agents in Breast Cancer Using Patient-Derived Tumour Xenograft Models
17:00—19:00
Mechanisms of DNA Replication
*
Bik Kwoon Tye,
Hong Kong University of Science and Technology, Hong Kong
Session Chair
Session Chair
John F.X. Diffley,
Francis Crick Institute, UK
Chromosome Replication: From Mechanism to Misregulation in Cancer
Chromosome Replication: From Mechanism to Misregulation in Cancer
Joseph Yeeles,
MRC Laboratory of Molecular Biology, UK
Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex
Short Talk: Cryo-EM Structures of a 1.4 MDa Eukaryotic Replisome Progression Complex
James M. Dewar,
Vanderbilt University, USA
Short Talk: Multiple Roles for Topoisomerase IIα during Termination of Vertebrate DNA Replication
Short Talk: Multiple Roles for Topoisomerase IIα during Termination of Vertebrate DNA Replication
Johannes C. Walter,
Harvard Medical School, USA
TRAIP: Master Regulator of ICL Repair and CMG Unloading
TRAIP: Master Regulator of ICL Repair and CMG Unloading
Kathleen Collins,
University of California, Berkeley, USA
Telomerase Assembly and Action at Telomeres
Telomerase Assembly and Action at Telomeres
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Mechanisms of Recombination and Repair
*
Wolf-Dietrich Heyer,
University of California, Davis, USA
Session Chair
Session Chair
Stephen C. West,
Francis Crick Institute, UK
MutSβ Stimulates Holliday Junction Resolution by the SMX Tri-Nuclease
MutSβ Stimulates Holliday Junction Resolution by the SMX Tri-Nuclease
Anna Malkova,
University of Iowa, USA
In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion
In Search for the Link between Alternative Lengthening of Telomeres and the Mode of Telomere Erosion
Aparna Gorthi,
University of Texas Health at San Antonio, USA
Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair
Short Talk: Role of STAG2 in R-Loop Processing, Replication and Recombinational Repair
Coffee Break
Agnel Sfeir,
Memorial Sloan Kettering Cancer Center, USA
Mechanism of Alternative End-Joining
Mechanism of Alternative End-Joining
Chao Dong,
University of Hong Kong, China
Short Talk: Fine-Tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases
Short Talk: Fine-Tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases
17:00—19:00
Understanding and Exploiting Replication Stress
*
David Cortez,
Vanderbilt University School of Medicine, USA
Session Chair
Session Chair
Massimo Lopes,
University of Zürich, Switzerland
Replication Fork Remodeling upon Cancer-Relevant Replication Stress
Replication Fork Remodeling upon Cancer-Relevant Replication Stress
Sharon B. Cantor,
University of Massachusetts Medical School, USA
Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer
Short Talk: Defining Mechanisms that Subvert the Replication Stress Response in Cancer
Mark J. O'Connor,
AstraZeneca, UK
Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response
Reversing PARP Inhibitor Resistance by Targeting the Replication Stress Response
Giorgia Federico,
University of Naples Federico II, Italy
Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication
Short Talk: NCOA4 Protein Couples Iron Availability to DNA Replication
Sarah A.E. Lambert,
Institute Curie, France
Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast
Nuclear Spatial Organization of Replication Fork Processing in Fission Yeast
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Overcoming Replication Fork Obstacles
*
Catherine H. Freudenreich,
Tufts University, USA
Session Chair
Session Chair
Ralph Scully,
Beth Israel Deaconess Medical Center, USA
Recombination and Repair at Stalled Mammalian Replication Forks
Recombination and Repair at Stalled Mammalian Replication Forks
Boris Pfander,
Max Planck Institute of Biochemistry, Germany
Short Talk: Cell Cycle Phase-Specific Recognition and Processing of DNA Over-Replication Forks
Short Talk: Cell Cycle Phase-Specific Recognition and Processing of DNA Over-Replication Forks
Coffee Break
David Gallo,
University of Toronto, Canada
Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Short Talk: Rad5 Recruits Error-Prone DNA Polymerases for Mutagenic Repair of ssDNA Gaps on Undamaged Templates
Alessandro Vindigni,
Washington University, USA
PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors
PrimPol-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA1-Deficient Tumors
Wojciech Niedzwiedz,
Institute of Cancer Research, UK
Short Talk: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
Short Talk: EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2
Sriram Sridharan,
Center for Cancer Research, USA
Short Talk: Landscape of Replication Stress Induced DNA Damage Sites
Short Talk: Landscape of Replication Stress Induced DNA Damage Sites
14:30—16:30
Workshop/Panel Discussion 3: Translating Basic Science to the Clinic
*
Mark J. O'Connor,
AstraZeneca, UK
Session Chair
Session Chair
*
Daniel Durocher,
Lunenfeld-Tanenbaum Research Institute, Canada
Session Chair
Session Chair
Yves G. Pommier,
NCI, National Institutes of Health, USA
Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic
Schlafen 11 (SLFN11), Replication Stress Executioner and its Potential Translation to the Clinic
Alan D. D'Andrea,
Dana-Farber Cancer Institute, USA
PARP Inhibitor Resistance and Acquired Vulnerability
PARP Inhibitor Resistance and Acquired Vulnerability
Lauren A. Byers,
MD Anderson Cancer Center, USA
Targeting DNA Damage Response (DDR) in Lung Cancer
Targeting DNA Damage Response (DDR) in Lung Cancer
17:00—19:00
RNA-Induced Genome Instability
*
Gaëlle Legube,
Univsersité Paul Sabatier, France
Session Chair
Session Chair
Andrew Jackson,
University of Edinburgh, UK
The Fifth Element: Genomic Consequences of Embedded Ribonucleotides
The Fifth Element: Genomic Consequences of Embedded Ribonucleotides
Peter C. Stirling,
University of British Columbia, Canada
Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance
Short Talk: Nuclease-Independent Functions of Mre11-Rad50-Nbs1 Coordinate Cellular R-Loop Tolerance
Jan-Gert Brüning,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Investigation of Replication-Transcription Collisions in vitro
Short Talk: Investigation of Replication-Transcription Collisions in vitro
Houra Merrikh,
Vanderbilt University, USA
The Impact of DNA Topology on Replication-Transcription Conflicts
The Impact of DNA Topology on Replication-Transcription Conflicts
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Genomic Drivers of Tumorigenesis and Drug Resistance
*
Agnel Sfeir,
Memorial Sloan Kettering Cancer Center, USA
Session Chair
Session Chair
Daniel Durocher,
Lunenfeld-Tanenbaum Research Institute, Canada
Mapping DNA Damage Networks with CRISPR-Based Genetic Screens
Mapping DNA Damage Networks with CRISPR-Based Genetic Screens
Christopher Lord,
Institute of Cancer Research, UK
Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors
Using Genetics to Understand Synthetic Lethal Sensitivity and Resistance to DDR Inhibitors
Violeta Serra,
Vall d'Hebron Institute of Oncology, Spain
Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR)-Deficient,PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation
Short Talk: Lack of RAD51 Nuclear Foci Formation Identifies Homologous Recombination Repair (HRR)-Deficient,PARPi-Sensitive Tumors Beyond Germline BRCA1/BRCA2 Mutation
Coffee Break
Lee Zou,
Harvard Medical School, USA
Roles of ATR in Countering APOBECs in Cancer Cells
Roles of ATR in Countering APOBECs in Cancer Cells
Domenic Pilger,
Sidney Sussex College, UK
Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks
Short Talk: ATM Orchestrates the DNA-Damage Response to Counter Toxic Non-Homologous End-Joining at Broken Replication Forks
Zachary K. Mirman,
Rockefeller University, USA
53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol Alpha-Dependent Fill-in
53BP1/Rif1/Shieldin Counteract DSB Resection through CST/Pol Alpha-Dependent Fill-in
14:30—16:30
Workshop 4: Chromatin, Replication and Repair
*
Evi Soutoglou,
University of Sussex, UK
Double-Strand Break Relocation Correlates with Heterochromatic Repeat Clustering
Double-Strand Break Relocation Correlates with Heterochromatic Repeat Clustering
Dominika T. Gruszka,
Francis Crick Institute, UK
Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level
Replication-Coupled Parental Histone Dynamics Probed at Single Molecule Level
John K. Barrows,
Medical University of South Carolina, USA
Establishing an in vitro System for Regulated Transcription and mRNA Processing
Establishing an in vitro System for Regulated Transcription and mRNA Processing
Caitlin Purman,
Washington University in St. Louis, USA
Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase
Determining the Local Transcriptional Response to DNA Double-Strand Breaks in G1 Phase
Nataliia Serbyn,
University of Geneva, Switzerland
The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast
The Aspartic Protease Ddi1 Contributes to DPC Repair in Yeast
Diana E. Libuda,
University of Oregon, USA
Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes
Temperature Increases Cause Transposon-Associated DNA Damage Specific to Spermatocytes and Not Oocytes
Mihaela Todorova Peycheva,
IMP - Research Institute of Molecular Pathology, Austria
DNA Replication Is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells
DNA Replication Is Critical for the Genesis of AID-Dependent Chromosomal Translocations in B Cells
14:30—16:30
Workshop 5: Replication Stress and DNA Damage Signaling
*
Niels Mailand,
University of Copenhagen, Denmark
Profiling Cellular Signaling Responses to DNA-Protein Crosslinks
Profiling Cellular Signaling Responses to DNA-Protein Crosslinks
Kristijan Ramadan,
University of Oxford, UK
SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication
SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication
Ya-Chu Chang,
University of Minnesota, USA
Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics
Uncovering the Molecular Dynamics Upon Replication Fork Stalling using Proteomics
Claus Storgaard Sørensen,
University of Copenhagen, Denmark
CtIP Variants Associated with Early-Onset Breast Cancer Compromise Replication Fork Stability
CtIP Variants Associated with Early-Onset Breast Cancer Compromise Replication Fork Stability
Sarem Hailemariam,
Washington University, USA
Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase
Rif2 Inhibits the MRX-Dependent Activation of Tel1 Kinase
Robin van Schendel,
Leiden University Medical Center, Netherlands
Okazaki Fragment Deposition Dictates Deletion Mutagenesis at Persistent Replication Fork Barriers
Okazaki Fragment Deposition Dictates Deletion Mutagenesis at Persistent Replication Fork Barriers
Catherine H. Freudenreich,
Tufts University, USA
Collapsed Forks Caused by Expanded CAG Repeats Relocate to the Nuclear Pore in a Manner Dependent on SUMOylation of Repair Proteins
Collapsed Forks Caused by Expanded CAG Repeats Relocate to the Nuclear Pore in a Manner Dependent on SUMOylation of Repair Proteins
17:00—18:45
Linking DNA Damage Response to the Immune Response
*
Andrew Jackson,
University of Edinburgh, UK
Session Chair
Session Chair
Alberto Bardelli,
University of Torino, Italy
Inactivation of DNA Repair to Improve Immune Surveillance
Inactivation of DNA Repair to Improve Immune Surveillance
Sophie Postel-Vinay,
Gustave Roussy Cancer Campus, France
Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?
Combining DNA Damage Response (DDR) Inhibitors with Immunotherapy: The Next Step Change in Cancer Therapy?
Timo Reislander,
University of Oxford, UK
Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation
Short Talk: PARP Inhibitors Potentiate Cell-Intrinsic Immune Responses Triggered by BRCA2 Inactivation
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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