Herrenhausen Palace Floorplan
This meeting took place in 2019
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Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk (D4)
Organizer(s) Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis
April 8—11, 2019
Herrenhausen Palace • Hannover, Germany
Discounted Abstract Deadline: Dec 12, 2018
Abstract Deadline: Jan 10, 2019
Scholarship Deadline: Jan 10, 2019
Discounted Registration Deadline: Feb 7, 2019
Organized in collaboration with Volkswagen Foundation
Summary of Meeting:
The skin is the largest human organ and the primary interface between the body and the environment. It provides the first line of defense against invading pathogens and trauma via its physical barrier properties but also via active defense mechanisms orchestrated by a coordinated interplay between epithelial and immune cells. Recently, the skin microbiota has emerged as an important third player that critically influences skin homeostasis and inflammation by interacting with epithelial and immune cells. This conference highlights these reciprocal interactions and describes their impact on skin physiology and pathophysiology. A central focus is to discuss how the composition of the skin microbiota regulates homeostasis and determines susceptibility to inflammatory, allergic and neoplastic diseases of the skin and other epithelial tissues. Emerging concepts regarding the mechanisms influencing the epithelial-immune-microbiota crosstalk and opportunities for therapeutic interventions will be discussed. The conference provides a unique setting for in-depth, cross-disciplinary discussions between basic skin scientists and biologists studying immune responses in other barrier organs, as well as dermatologists, cancer biologists, immunologists and many researchers from disparate fields who normally do not have opportunities to meet. This conference will also foster interaction with potential industry partners, who increasingly see the skin as a major focus for gaining insights into immune mechanisms and for development of targeted therapies for patients with chronic inflammatory diseases, allergic diseases and cancer. Finally, the conference will promote the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.
View Scholarships/Awards
The skin is the largest human organ and the primary interface between the body and the environment. It provides the first line of defense against invading pathogens and trauma via its physical barrier properties but also via active defense mechanisms orchestrated by a coordinated interplay between epithelial and immune cells. Recently, the skin microbiota has emerged as an important third player that critically influences skin homeostasis and inflammation by interacting with epithelial and immune cells. This conference highlights these reciprocal interactions and describes their impact on skin physiology and pathophysiology. A central focus is to discuss how the composition of the skin microbiota regulates homeostasis and determines susceptibility to inflammatory, allergic and neoplastic diseases of the skin and other epithelial tissues. Emerging concepts regarding the mechanisms influencing the epithelial-immune-microbiota crosstalk and opportunities for therapeutic interventions will be discussed. The conference provides a unique setting for in-depth, cross-disciplinary discussions between basic skin scientists and biologists studying immune responses in other barrier organs, as well as dermatologists, cancer biologists, immunologists and many researchers from disparate fields who normally do not have opportunities to meet. This conference will also foster interaction with potential industry partners, who increasingly see the skin as a major focus for gaining insights into immune mechanisms and for development of targeted therapies for patients with chronic inflammatory diseases, allergic diseases and cancer. Finally, the conference will promote the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 11 with a closing plenary session from 13:00 to 15:30, followed by a social hour. We recommend return travel on Friday, April 12 in order to fully experience the meeting.
MONDAY, APRIL 8
TUESDAY, APRIL 9
WEDNESDAY, APRIL 10
THURSDAY, APRIL 11
FRIDAY, APRIL 12
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 11 with a closing plenary session from 13:00 to 15:30, followed by a social hour. We recommend return travel on Friday, April 12 in order to fully experience the meeting.
MONDAY, APRIL 8
16:00—20:00
Arrival and Registration
Grand Mussmann Hotel, Tivoli Room
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Central-Hotel Kaiserhof
08:30—09:45
Welcome and Keynote Address
Welcome Remarks by Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis.
Welcome from local academic institution, Thomas Werfel, Hannover Medical School
Welcome Remarks by Henrike Hartmann, VolkswagenStiftung
Welcome from local academic institution, Thomas Werfel, Hannover Medical School
Welcome Remarks by Henrike Hartmann, VolkswagenStiftung
Auditorium
*
Michel Gilliet,
University Hospital of Lausanne, Switzerland
Session Chair
Session Chair
Richard L. Gallo,
University of California, San Diego, USA
Skin Microbiome in Health and Disease – The Holobiome Perspective
Skin Microbiome in Health and Disease – The Holobiome Perspective
09:45—12:15
Epithelial-Microbiome Interactions in the Skin
Auditorium
*
Julie A. Segre,
National Institutes of Health, USA
Human Skin Microbiome: Trans-Kingdom, Host-Immune Interactions
Human Skin Microbiome: Trans-Kingdom, Host-Immune Interactions
Coffee Break
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
The Skin Microbiota in the Control of Skin Immunity
The Skin Microbiota in the Control of Skin Immunity
Elizabeth A. Grice,
University of Pennsylvania, USA
Microbial Roles in Skin Barrier Function and Repair
Microbial Roles in Skin Barrier Function and Repair
Jan Claesen,
Cleveland Clinic, USA
Short Talk: Cutibacterium Acnes Antibiotic Production Shapes Niche Competition in the Human Skin Microbiome at the Level of Individual Follicles
Short Talk: Cutibacterium Acnes Antibiotic Production Shapes Niche Competition in the Human Skin Microbiome at the Level of Individual Follicles
Mercedes Gomez de Aguero,
University of Würzburg, Germany
Short Talk: Neonatal Skin Barrier Is Shaped by Embryonic Exposure to Maternal Microbiota
Short Talk: Neonatal Skin Barrier Is Shaped by Embryonic Exposure to Maternal Microbiota
12:15—13:00
Lunch
Ballroom
12:15—12:30
Poster Setup
Ballroom
13:00—20:30
Poster Viewing
Ballroom
13:00—15:00
Workshop 1
Auditorium
*
Angela M. Christiano,
Columbia University, USA
Session Chair
Session Chair
Jacob S. Baker,
Massachusetts Institute of Technology, USA
Transmission and Evolution of Cutibacterium Acnes during Human Development
Transmission and Evolution of Cutibacterium Acnes during Human Development
Roland Jourdain,
L'Oreal, France
Malassezia restricta-Mediated Lipoperoxidation: A New Player in Dandruff Origin
Malassezia restricta-Mediated Lipoperoxidation: A New Player in Dandruff Origin
Emmi Wachsmuth,
University Hospital Cologne, Germany
Cell Autonomous Functions of Insulin/IGF-1 Signaling in Skin Barrier Function and Diabetes-Induced Skin Disease
Cell Autonomous Functions of Insulin/IGF-1 Signaling in Skin Barrier Function and Diabetes-Induced Skin Disease
Snehlata Kumari,
CECAD Research Center, University of Cologne, Germany
Immunomodulatory Role of Epithelial IKK/NF-κB Signaling in Necroptosis -Mediated Skin Inflammation
Immunomodulatory Role of Epithelial IKK/NF-κB Signaling in Necroptosis -Mediated Skin Inflammation
Stephen Murtough,
Queen Mary University of London, UK
iRhom2-mediated Immune Dysregulation: Impact on the Skin and Oesophagus
iRhom2-mediated Immune Dysregulation: Impact on the Skin and Oesophagus
Edgar A.E. Serfling,
Institute of Pathology, Germany
The Osmosensitive Transcription Factor NFAT5 Controls the Integrity of Skin
The Osmosensitive Transcription Factor NFAT5 Controls the Integrity of Skin
Zsolt Dajnoki,
University of Debrecen, Hungary
Prominent Permeability Barrier Alterations in Rosacea Skin
Prominent Permeability Barrier Alterations in Rosacea Skin
Gudrun F. Debes,
Thomas Jefferson University, USA
IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation
IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation
15:00—15:30
Coffee Available
Foyer
15:30—17:30
Epithelial-Immune Interactions in the Skin
Auditorium
*
Amy S. Paller,
Northwestern University, USA
Genetic Barrier Disorders with Inflammation and Microbiome Abnormalities
Genetic Barrier Disorders with Inflammation and Microbiome Abnormalities
Angela M. Christiano,
Columbia University, USA
Immune Control of Hair Follicles
Immune Control of Hair Follicles
Sabine Eming,
University of Cologne, Germany
Metabolic Control of Skin Inflammation
Metabolic Control of Skin Inflammation
Anand Kumar Andiappan,
Singapore Immunology Network, Singapore
Short Talk: Genome-Wide Gene Expression Identifies Strong Proinflammatory Signatures Associated with Skin-Relevant FLG Mutants with Potential as Non-Invasive Biomarkers for Skin Disease
Short Talk: Genome-Wide Gene Expression Identifies Strong Proinflammatory Signatures Associated with Skin-Relevant FLG Mutants with Potential as Non-Invasive Biomarkers for Skin Disease
Tom Hayday,
King's College London, UK
Short Talk: EGFR Regulates Cell Autonomous Pro-Inflammatory Signaling in Keratinocytes
Short Talk: EGFR Regulates Cell Autonomous Pro-Inflammatory Signaling in Keratinocytes
17:30—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
18:00—20:30
Poster Session 1
Ballroom
08:30—11:30
Microbiota-Immune Interactions in Skin and other Epithelial Surfaces
Auditorium
*
Michel Gilliet,
University Hospital of Lausanne, Switzerland
Role of Microbiota in Innate Immune Responses of the Skin
Role of Microbiota in Innate Immune Responses of the Skin
Daniel H. Kaplan,
University of Pittsburgh, USA
Cutaneous Nociceptors Trigger Protective Innate Type-17 Anticipatory Immunity
Cutaneous Nociceptors Trigger Protective Innate Type-17 Anticipatory Immunity
Coffee Break
*
Manolis Pasparakis,
University of Cologne, Germany
Microbiota-Immune Interactions in Intestinal Inflammation
Microbiota-Immune Interactions in Intestinal Inflammation
John Common,
Skin Research Institute of Singapore, Singapore
Skin Microbiome Signatures in Atopic Dermatitis Are Linked to Host Immunity and Microbial Virulence
Skin Microbiome Signatures in Atopic Dermatitis Are Linked to Host Immunity and Microbial Virulence
Yiyin Erin Chen,
Stanford University, USA
Short Talk: Understanding Commensal-Host Communication through Genetic Engineering of Staphylococcus epidermidis
Short Talk: Understanding Commensal-Host Communication through Genetic Engineering of Staphylococcus epidermidis
Annika Krueger,
University of Queensland, Diamantina Institute, Australia
Short Talk: Secreted Bacterial Proteins from Staphylococcus aureus as Local Regulators of Epithelial Inflammation in Photo-Damaged Skin
Short Talk: Secreted Bacterial Proteins from Staphylococcus aureus as Local Regulators of Epithelial Inflammation in Photo-Damaged Skin
11:30—13:00
Lunch
Ballroom
11:30—12:30
Poster Setup
Ballroom
13:00—20:30
Poster Viewing
Ballroom
13:00—15:00
Workshop 2
Auditorium
*
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Session Chair
Session Chair
Karmella Naidoo,
Malaghan Institute of Medical Research, New Zealand
Mucosal-Associated Invariant T (MAIT) Cells as A Novel Therapeutic Target against Atopic Dermatitis
Mucosal-Associated Invariant T (MAIT) Cells as A Novel Therapeutic Target against Atopic Dermatitis
Lennart M. Rösner,
Dpt of Dermatology and Allergy, Hannover Medical School, Germany
T Cell Receptor Sequencing Underlines the Pivotal Role of Skin-Homing T Cells in Atopic Dermatitis
T Cell Receptor Sequencing Underlines the Pivotal Role of Skin-Homing T Cells in Atopic Dermatitis
Travis M. Whitfill,
Azitra Inc., USA
Engineering the Microbiome to Treat Netherton Syndrome, a Rare Skin Disease
Engineering the Microbiome to Treat Netherton Syndrome, a Rare Skin Disease
David Isaac Weiss,
University of California, Los Angeles, USA
IL-1β Stimulates Rapid Release of the Antimicrobial Protein IL-26 from Th17 Cells
IL-1β Stimulates Rapid Release of the Antimicrobial Protein IL-26 from Th17 Cells
Anissa Fries,
University Hospital of Lausanne, Switzerland
Pathogenic Role of Interleukin (IL)-26-Producing Th17 Cells in the Acute Forms of Psoriasis
Pathogenic Role of Interleukin (IL)-26-Producing Th17 Cells in the Acute Forms of Psoriasis
Lucie Loyal,
BCRT/Charite, Germany
Circulating CD8+ Helper-Type T Cell Memory Subsets Represent CD4+ Helper-Alike Cells with a Skin-Resident Memory T Cell Signature
Circulating CD8+ Helper-Type T Cell Memory Subsets Represent CD4+ Helper-Alike Cells with a Skin-Resident Memory T Cell Signature
Franziska Herster,
University of Tübingen, Germany
Platelet-Neutrophil Aggregates Promote Skin Pathology in Psoriasis
Platelet-Neutrophil Aggregates Promote Skin Pathology in Psoriasis
Anne Müller,
University of Tuebingen, Germany
IκBζ Is a Key Mediator of IL-36 Signaling in Psoriasis
IκBζ Is a Key Mediator of IL-36 Signaling in Psoriasis
15:00—15:30
Coffee Available
Foyer
15:30—17:30
Skin Dysbiosis and Allergic Inflammation
Auditorium
*
Emma Guttman-Yassky,
Mount Sinai Hospital, USA
Atopic Dermatitis: A Th2 and Th22 Driven Disease & Therapeutic Implications
Atopic Dermatitis: A Th2 and Th22 Driven Disease & Therapeutic Implications
Heidi H. Kong,
National Institutes of Health, USA
Skin Microbiota and Development of Atopic Dermatitis
Skin Microbiota and Development of Atopic Dermatitis
Bernhard Homey,
University of Duesseldorf, Germany
Short Talk: Microbe-Host Interplay in Atopic Dermatitis and Psoriasis
Short Talk: Microbe-Host Interplay in Atopic Dermatitis and Psoriasis
Jennifer Wing-Ki Yau,
Chinese University of Hong Kong, Hong Kong
Short Talk: Taxonomic and Functional Profiling of Skin Metagenomes Associated with Childhood Atopic Dermatitis
Short Talk: Taxonomic and Functional Profiling of Skin Metagenomes Associated with Childhood Atopic Dermatitis
17:30—19:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
18:00—20:30
Poster Session 2
Ballroom
08:30—11:45
Epithelial-Microbiota-Immune Interactions in Tumorigenesis and Systemic Diseases
Auditorium
*
Anthony Oro,
Stanford University, USA
Microenvironment Signaling in Skin Tumor Development and Resistance
Microenvironment Signaling in Skin Tumor Development and Resistance
Gian Paolo Dotto,
University of Lausanne, Switzerland
Genetic and Epigenetic Determinants of Cancer-Associated Fibroblast Activation in Field Cancerization
Genetic and Epigenetic Determinants of Cancer-Associated Fibroblast Activation in Field Cancerization
Coffee Break
Tiffany C. Scharschmidt,
University of California, San Francisco, USA
Early-Life Immune-Microbe Crosstalk in Skin
Early-Life Immune-Microbe Crosstalk in Skin
Sandra Iden,
University of Cologne, Germany
Epidermal Polarity Networks in Non-Cell Autonomous Control of Skin Immunity and Melanoma
Epidermal Polarity Networks in Non-Cell Autonomous Control of Skin Immunity and Melanoma
Esther Hoste,
VIB-Ugent, Belgium
Short Talk: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis
Short Talk: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis
Giel Tanghe,
Ghent University, Belgium
Short Talk: RIPK4 Maintains Epidermal Homeostasis and Prevents Skin Cancer
Short Talk: RIPK4 Maintains Epidermal Homeostasis and Prevents Skin Cancer
Niki Ubags,
University of Lausanne, Switzerland
Short Talk: The Skin Microbiome Drives Immune Maturation and Exacerbation of Both Skin and Airway Inflammation
Short Talk: The Skin Microbiome Drives Immune Maturation and Exacerbation of Both Skin and Airway Inflammation
11:45—13:00
Lunch
Ballroom
13:00—15:15
Emerging Therapeutic Concepts
Auditorium
Kari Nadeau,
Harvard T.H. Chan School of Public Health, USA
Novel Therapies and Immune Regulation of Food Allergies
Novel Therapies and Immune Regulation of Food Allergies
*
James G. Krueger,
Rockefeller University, USA
Therapeutic Targeting Epithelial/Immune Pathways in Inflammatory Skin Diseases
Therapeutic Targeting Epithelial/Immune Pathways in Inflammatory Skin Diseases
George D. Yancopoulos,
Regeneron Pharmaceuticals, Inc., USA
Regeneron's Efforts in Atopic and Allergic Conditions: From Dupilumab...to "BiSpecs" that Kill Long-Lived IgE Plasma Cells
Regeneron's Efforts in Atopic and Allergic Conditions: From Dupilumab...to "BiSpecs" that Kill Long-Lived IgE Plasma Cells
Bernhard Paetzold,
S-Biomedic, Belgium
Short Talk: Direct Modulation of the Skin Microbiome as Potential Therapy for Acne Vulgaris: A Pilot Study
Short Talk: Direct Modulation of the Skin Microbiome as Potential Therapy for Acne Vulgaris: A Pilot Study
Miao-Tzu Huang,
National Taiwan University Hospital, Taiwan
Short Talk: Short-Chain Fatty Acids Ameliorate Allergic Inflammation via Induction of Immune-Regulatory Microbiome and Metabolic Pathways
Short Talk: Short-Chain Fatty Acids Ameliorate Allergic Inflammation via Induction of Immune-Regulatory Microbiome and Metabolic Pathways
Aisleen Diaz,
Icahn School of Medicine at Mount Sinai, USA
Short Talk: Changes in Skin Biomarkers Following Crisaborole Treatment Correlate With Clinical Improvement in Atopic Dermatitis
Short Talk: Changes in Skin Biomarkers Following Crisaborole Treatment Correlate With Clinical Improvement in Atopic Dermatitis
15:15—15:30
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
Auditorium
15:30—17:00
Closing Reception and Lite Bites
No registration fees are used to fund alcohol served at this function.
Ballroom
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
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