Keystone Symposia

Herrenhausen Palace Floorplan

This meeting took place in 2019

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Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk (D4)

Organizer(s) Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis
April 8—11, 2019
Herrenhausen Palace • Hannover, Germany
Discounted Abstract Deadline: Dec 12, 2018
Abstract Deadline: Jan 10, 2019
Scholarship Deadline: Jan 10, 2019
Discounted Registration Deadline: Feb 7, 2019

Organized in collaboration with Volkswagen Foundation

Summary of Meeting:
The skin is the largest human organ and the primary interface between the body and the environment. It provides the first line of defense against invading pathogens and trauma via its physical barrier properties but also via active defense mechanisms orchestrated by a coordinated interplay between epithelial and immune cells. Recently, the skin microbiota has emerged as an important third player that critically influences skin homeostasis and inflammation by interacting with epithelial and immune cells. This conference highlights these reciprocal interactions and describes their impact on skin physiology and pathophysiology. A central focus is to discuss how the composition of the skin microbiota regulates homeostasis and determines susceptibility to inflammatory, allergic and neoplastic diseases of the skin and other epithelial tissues. Emerging concepts regarding the mechanisms influencing the epithelial-immune-microbiota crosstalk and opportunities for therapeutic interventions will be discussed. The conference provides a unique setting for in-depth, cross-disciplinary discussions between basic skin scientists and biologists studying immune responses in other barrier organs, as well as dermatologists, cancer biologists, immunologists and many researchers from disparate fields who normally do not have opportunities to meet. This conference will also foster interaction with potential industry partners, who increasingly see the skin as a major focus for gaining insights into immune mechanisms and for development of targeted therapies for patients with chronic inflammatory diseases, allergic diseases and cancer. Finally, the conference will promote the scientific and professional development of all attendees, with a special emphasis on trainees and early-career scientists.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Monday, April 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, April 11 with a closing plenary session from 13:00 to 15:30, followed by a social hour. We recommend return travel on Friday, April 12 in order to fully experience the meeting.


Arrival and Registration

Grand Mussmann Hotel, Tivoli Room
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Central-Hotel Kaiserhof


Welcome and Keynote Address
Welcome Remarks by Michel Gilliet, Emma Guttman, Anthony Oro and Manolis Pasparakis.
Welcome from local academic institution, Thomas Werfel, Hannover Medical School
Welcome Remarks by Henrike Hartmann, VolkswagenStiftung

* Michel Gilliet, University Hospital of Lausanne, Switzerland
Session Chair

Richard L. Gallo, University of California, San Diego, USA
Skin Microbiome in Health and Disease – The Holobiome Perspective

Epithelial-Microbiome Interactions in the Skin

* Julie A. Segre, National Institutes of Health, USA
Human Skin Microbiome: Trans-Kingdom, Host-Immune Interactions

Coffee Break

Yasmine Belkaid, NIAID, National Institutes of Health, USA
The Skin Microbiota in the Control of Skin Immunity

Elizabeth A. Grice, University of Pennsylvania, USA
Microbial Roles in Skin Barrier Function and Repair

Jan Claesen, Cleveland Clinic, USA
Short Talk: Cutibacterium Acnes Antibiotic Production Shapes Niche Competition in the Human Skin Microbiome at the Level of Individual Follicles

Mercedes Gomez de Aguero, University of Würzburg, Germany
Short Talk: Neonatal Skin Barrier Is Shaped by Embryonic Exposure to Maternal Microbiota


Poster Setup

Poster Viewing

Workshop 1

* Angela M. Christiano, Columbia University, USA
Session Chair

Jacob S. Baker, Massachusetts Institute of Technology, USA
Transmission and Evolution of Cutibacterium Acnes during Human Development

Roland Jourdain, L'Oreal, France
Malassezia restricta-Mediated Lipoperoxidation: A New Player in Dandruff Origin

Emmi Wachsmuth, University Hospital Cologne, Germany
Cell Autonomous Functions of Insulin/IGF-1 Signaling in Skin Barrier Function and Diabetes-Induced Skin Disease

Snehlata Kumari, CECAD Research Center, University of Cologne, Germany
Immunomodulatory Role of Epithelial IKK/NF-κB Signaling in Necroptosis -Mediated Skin Inflammation

Stephen Murtough, Queen Mary University of London, UK
iRhom2-mediated Immune Dysregulation: Impact on the Skin and Oesophagus

Edgar A.E. Serfling, Institute of Pathology, Germany
The Osmosensitive Transcription Factor NFAT5 Controls the Integrity of Skin

Zsolt Dajnoki, University of Debrecen, Hungary
Prominent Permeability Barrier Alterations in Rosacea Skin

Gudrun F. Debes, Thomas Jefferson University, USA
IgM Plasma Cells Reside in Healthy Skin and Accumulate with Chronic Inflammation

Coffee Available

Epithelial-Immune Interactions in the Skin

* Amy S. Paller, Northwestern University, USA
Genetic Barrier Disorders with Inflammation and Microbiome Abnormalities

Angela M. Christiano, Columbia University, USA
Immune Control of Hair Follicles

Sabine Eming, University of Cologne, Germany
Metabolic Control of Skin Inflammation

Anand Kumar Andiappan, Singapore Immunology Network, Singapore
Short Talk: Genome-Wide Gene Expression Identifies Strong Proinflammatory Signatures Associated with Skin-Relevant FLG Mutants with Potential as Non-Invasive Biomarkers for Skin Disease

Tom Hayday, King's College London, UK
Short Talk: EGFR Regulates Cell Autonomous Pro-Inflammatory Signaling in Keratinocytes

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 1



Microbiota-Immune Interactions in Skin and other Epithelial Surfaces

* Michel Gilliet, University Hospital of Lausanne, Switzerland
Role of Microbiota in Innate Immune Responses of the Skin

Daniel H. Kaplan, University of Pittsburgh, USA
Cutaneous Nociceptors Trigger Protective Innate Type-17 Anticipatory Immunity

Coffee Break

* Manolis Pasparakis, University of Cologne, Germany
Microbiota-Immune Interactions in Intestinal Inflammation

John Common, Skin Research Institute of Singapore, Singapore
Skin Microbiome Signatures in Atopic Dermatitis Are Linked to Host Immunity and Microbial Virulence

Yiyin Erin Chen, Stanford University, USA
Short Talk: Understanding Commensal-Host Communication through Genetic Engineering of Staphylococcus epidermidis

Annika Krueger, University of Queensland, Diamantina Institute, Australia
Short Talk: Secreted Bacterial Proteins from Staphylococcus aureus as Local Regulators of Epithelial Inflammation in Photo-Damaged Skin


Poster Setup

Poster Viewing

Workshop 2

* Yasmine Belkaid, NIAID, National Institutes of Health, USA
Session Chair

Karmella Naidoo, Malaghan Institute of Medical Research, New Zealand
Mucosal-Associated Invariant T (MAIT) Cells as A Novel Therapeutic Target against Atopic Dermatitis

Lennart M. Rösner, Dpt of Dermatology and Allergy, Hannover Medical School, Germany
T Cell Receptor Sequencing Underlines the Pivotal Role of Skin-Homing T Cells in Atopic Dermatitis

Travis M. Whitfill, Azitra Inc., USA
Engineering the Microbiome to Treat Netherton Syndrome, a Rare Skin Disease

David Isaac Weiss, University of California, Los Angeles, USA
IL-1β Stimulates Rapid Release of the Antimicrobial Protein IL-26 from Th17 Cells

Anissa Fries, University Hospital of Lausanne, Switzerland
Pathogenic Role of Interleukin (IL)-26-Producing Th17 Cells in the Acute Forms of Psoriasis

Lucie Loyal, BCRT/Charite, Germany
Circulating CD8+ Helper-Type T Cell Memory Subsets Represent CD4+ Helper-Alike Cells with a Skin-Resident Memory T Cell Signature

Franziska Herster, University of Tübingen, Germany
Platelet-Neutrophil Aggregates Promote Skin Pathology in Psoriasis

Anne Müller, University of Tuebingen, Germany
IκBζ Is a Key Mediator of IL-36 Signaling in Psoriasis

Coffee Available

Skin Dysbiosis and Allergic Inflammation

* Emma Guttman-Yassky, Mount Sinai Hospital, USA
Atopic Dermatitis: A Th2 and Th22 Driven Disease & Therapeutic Implications

Heidi H. Kong, National Institutes of Health, USA
Skin Microbiota and Development of Atopic Dermatitis

Brian Kim, Mount Sinai, USA
The Skin Neuro-Immune Axis, Dysbiosis and Itch

Bernhard Homey, University of Duesseldorf, Germany
Short Talk: Microbe-Host Interplay in Atopic Dermatitis and Psoriasis

Jennifer Wing-Ki Yau, Chinese University of Hong Kong, Hong Kong
Short Talk: Taxonomic and Functional Profiling of Skin Metagenomes Associated with Childhood Atopic Dermatitis

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Poster Session 2



Epithelial-Microbiota-Immune Interactions in Tumorigenesis and Systemic Diseases

* Anthony Oro, Stanford University, USA
Microenvironment Signaling in Skin Tumor Development and Resistance

Gian Paolo Dotto, University of Lausanne, Switzerland
Genetic and Epigenetic Determinants of Cancer-Associated Fibroblast Activation in Field Cancerization

Coffee Break

Tiffany C. Scharschmidt, University of California, San Francisco, USA
Early-Life Immune-Microbe Crosstalk in Skin

Sandra Iden, University of Cologne, Germany
Epidermal Polarity Networks in Non-Cell Autonomous Control of Skin Immunity and Melanoma

Esther Hoste, VIB-Ugent, Belgium
Short Talk: Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils to NETosis

Giel Tanghe, Ghent University, Belgium
Short Talk: RIPK4 Maintains Epidermal Homeostasis and Prevents Skin Cancer

Niki Ubags, University of Lausanne, Switzerland
Short Talk: The Skin Microbiome Drives Immune Maturation and Exacerbation of Both Skin and Airway Inflammation


Emerging Therapeutic Concepts

Kari Nadeau, Harvard T.H. Chan School of Public Health, USA
Novel Therapies and Immune Regulation of Food Allergies

* James G. Krueger, Rockefeller University, USA
Therapeutic Targeting Epithelial/Immune Pathways in Inflammatory Skin Diseases

George D. Yancopoulos, Regeneron Pharmaceuticals, Inc., USA
Regeneron's Efforts in Atopic and Allergic Conditions: From "BiSpecs" that Kill Long-Lived IgE Plasma Cells

Bernhard Paetzold, S-Biomedic, Belgium
Short Talk: Direct Modulation of the Skin Microbiome as Potential Therapy for Acne Vulgaris: A Pilot Study

Miao-Tzu Huang, National Taiwan University Hospital, Taiwan
Short Talk: Short-Chain Fatty Acids Ameliorate Allergic Inflammation via Induction of Immune-Regulatory Microbiome and Metabolic Pathways

Aisleen Diaz, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Changes in Skin Biomarkers Following Crisaborole Treatment Correlate With Clinical Improvement in Atopic Dermatitis

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Closing Reception and Lite Bites
No registration fees are used to fund alcohol served at this function.




*Session Chair †Invited, not yet responded.

Keystone Symposia thanks the Volkswagen Foundation for hosting this conference:

in Cooperation with Volkswagen Foundation

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AR075401-01

Funding for this conference was made possible (in part) by 1R13AR075401-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

Zymo Research Corporation

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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