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This meeting took place in 2019
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Windows on the Brain: Formation and Function of Synapses and Circuits and their Disruption in Disease (A6)
Organizer(s) Kristin Scott, Paola Arlotta, Rui M. Costa and Yimin Zou
January 21—25, 2019
Sagebrush Inn & Suites • Taos, NM USA
Discounted Abstract Deadline: Oct 17, 2018
Abstract Deadline: Oct 25, 2018
Scholarship Deadline: Oct 17, 2018
Discounted Registration Deadline: Nov 28, 2018
Sponsored by Takeda Pharmaceutical Company Limited
Summary of Meeting:
A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and function of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity. Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same process, no small highly interactive “Keystone Symposia-style” meeting brings these three groups together in the same room. This symposium will bring together leaders working on synapse development and function, circuit structure and function, and the study of brain disease, believing with confidence that mutually beneficial insights will emerge from discussing each other’s work.
View Scholarships/Awards
A fundamental goal of neuroscience is to understand the molecular, cellular and activity-based mechanisms that control the formation and function of neural circuits and determine how these mechanisms become compromised in neurodevelopmental, psychiatric and neurodegenerative disorders. Over the past two decades, molecular neuroscientists have identified key molecules and mechanisms that underlie synapse development, activity and stability. Meanwhile, the study of neuronal circuits has been revolutionized by new methods to visualize and map circuits in living animals, as well as the development of approaches to control neuronal activity. Finally, disease researchers have identified genes associated with neurodevelopmental and psychiatric disorders and neurodegenerative diseases. Animal models of these diseases are proving useful to understand how dysfunction of affected genes and proteins contributes to disease pathology. Although these fields are working on the same process, no small highly interactive “Keystone Symposia-style” meeting brings these three groups together in the same room. This symposium will bring together leaders working on synapse development and function, circuit structure and function, and the study of brain disease, believing with confidence that mutually beneficial insights will emerge from discussing each other’s work.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Monday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, January 26 in order to fully experience the meeting.
MONDAY, JANUARY 21
TUESDAY, JANUARY 22
WEDNESDAY, JANUARY 23
THURSDAY, JANUARY 24
FRIDAY, JANUARY 25
SATURDAY, JANUARY 26
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Monday, January 21 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 25 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, January 26 in order to fully experience the meeting.
MONDAY, JANUARY 21
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address
*
Kristin Scott,
University of California, Berkeley, USA
Anirvan Ghosh,
Biogen, USA
Molecular Foundations of Neural Circuit Development
Molecular Foundations of Neural Circuit Development
09:00—11:30
Patterning and Wiring of the Nervous System
*
Tony Koleske,
Yale University, USA
Paola Arlotta,
Harvard University, USA
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex
Programming, Reprogramming and Modeling of the Mammalian Cerebral Cortex
Coffee Break
Nenad Sestan,
Yale School of Medicine, USA
Cell Fate Determination in the Cerebral Cortex
Cell Fate Determination in the Cerebral Cortex
Yimin Zou,
University of California, San Diego, USA
Polarity Proteins in Axon and Synapse Development
Polarity Proteins in Axon and Synapse Development
Franck Polleux,
Columbia University, Mortimer B. Zuckerman Mind Brain Behavior Institute, USA
Slit-Robo Signaling Links Synapse Specificity with Functional Circuit Wiring
Slit-Robo Signaling Links Synapse Specificity with Functional Circuit Wiring
17:00—19:00
Synapse Development and Function
*
Shernaz X. Bamji,
University of British Columbia, Canada
Nils Brose,
Max Planck Institute of Experimental Medicine, Germany
Synaptic Vesicle Priming and the Unique Features of Regulated Exocytosis at Nerve Cell Synapses
Synaptic Vesicle Priming and the Unique Features of Regulated Exocytosis at Nerve Cell Synapses
Tony Koleske,
Yale University, USA
Receptor-Mediated Cytoskeletal Control of Dendrite and Synapse Development and Function
Receptor-Mediated Cytoskeletal Control of Dendrite and Synapse Development and Function
Nicola J. Allen,
The Salk Institute for Biological Studies, USA
The Role of Astrocytes in Synapse Formation and Function
The Role of Astrocytes in Synapse Formation and Function
Daniel Alfonso Colón-Ramos,
Yale School of Medicine, USA
Building a Brain: Systematic Examination of the Logic of Brain Connectivity in C. elegans
Building a Brain: Systematic Examination of the Logic of Brain Connectivity in C. elegans
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
09:00—11:30
Activity-Dependent Synapse Formation and Plasticity
*
Nicola J. Allen,
The Salk Institute for Biological Studies, USA
Anne E. West,
Duke University Medical Center, USA
Chromatin Regulation of Synapse Maturation and Plasticity
Chromatin Regulation of Synapse Maturation and Plasticity
Graeme W. Davis,
University of California, San Francisco, USA
Homeostatic Mechanisms that Regulate Activity
Homeostatic Mechanisms that Regulate Activity
Coffee Break
Shernaz X. Bamji,
University of British Columbia, Canada
Post-Translational Palmitoylation and its Regulation of Synaptic Plasticity
Post-Translational Palmitoylation and its Regulation of Synaptic Plasticity
Matthew B. Dalva,
Thomas Jefferson University, USA
The Nanoscale Organization of Glutamate Receptor Subtypes Is Optimized for Synaptic Function and Plasticity
The Nanoscale Organization of Glutamate Receptor Subtypes Is Optimized for Synaptic Function and Plasticity
14:30—16:30
Workshop: Synapse Formation and Plasticity
*
Yimin Zou,
University of California, San Diego, USA
Ewoud Schmidt,
Columbia University, USA
Humanization of SRGAP2C Expression Increases Cortico-Cortical Connectivity in the Mouse Brain
Humanization of SRGAP2C Expression Increases Cortico-Cortical Connectivity in the Mouse Brain
Jaewon Ko,
Daegu Gyeongbuk Institute of Science and Technology, South Korea
IQSEC3 Controls Activity-Dependent GABAergic Synapse Development
IQSEC3 Controls Activity-Dependent GABAergic Synapse Development
Seok-Kyu Kwon,
Korea Institute of Science and Technology, South Korea
Mitochondrial Fission Regulates Presynaptic Function and Axon Branching by Limiting Axonal Mitochondrial Size
Mitochondrial Fission Regulates Presynaptic Function and Axon Branching by Limiting Axonal Mitochondrial Size
Joshua E. Mayfield,
University of California, San Diego, USA
Defining a Role for the Secretory Pathway Kinase Fam20C in the Brain
Defining a Role for the Secretory Pathway Kinase Fam20C in the Brain
Christina Chatzi,
Oregon Health & Science University, USA
Exercise-Induced Enhancement of Synaptic Function Triggered by the Inverse BAR Protein, Mtss1L
Exercise-Induced Enhancement of Synaptic Function Triggered by the Inverse BAR Protein, Mtss1L
Graziella Di Cristo,
University of Montreal, Canada
mTOR Inhibition Restricted to a Postnatal Sensitive Period Rescues the Deficits in GABAergic PV Cell Connectivity and Social Behavior Caused by Loss of Tsc1
mTOR Inhibition Restricted to a Postnatal Sensitive Period Rescues the Deficits in GABAergic PV Cell Connectivity and Social Behavior Caused by Loss of Tsc1
17:00—19:15
Connectomics
*
Rui M. Costa,
Columbia University, USA
H. Sebastian Seung,
Princeton University, USA
Models of Cortical Learning Are Constrained by Functional Connectomics
Models of Cortical Learning Are Constrained by Functional Connectomics
Anthony Zador,
Cold Spring Harbor Laboratory, USA
Sequencing the Connectome
Sequencing the Connectome
Kristin Scott,
University of California, Berkeley, USA
Tracing Gustatory Circuits in the Fly Brain
Tracing Gustatory Circuits in the Fly Brain
Fred Shen,
University of Michigan, USA
Short Talk: Multimodal Interrogation of Neuron Morphology, Connectivity, and Molecular Identity Using Novel Clearing and Expansion Technology
Short Talk: Multimodal Interrogation of Neuron Morphology, Connectivity, and Molecular Identity Using Novel Clearing and Expansion Technology
Hanqing Liu,
The Salk Institute for Biological Studies, USA
Short Talk: Single-Cell Epigenomic Profiling Uncovers Regulatory Diversity of Brain Cell Types
Short Talk: Single-Cell Epigenomic Profiling Uncovers Regulatory Diversity of Brain Cell Types
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Plasticity in Neural Circuits
*
Sandeep Robert Datta,
Harvard Medical School, USA
Di Lu,
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Short Talk: Emergence of Sequence Ensembles of Striatal D1 and D2 Neurons with Distinct Temporal Patterns during Motor Learning
Short Talk: Emergence of Sequence Ensembles of Striatal D1 and D2 Neurons with Distinct Temporal Patterns during Motor Learning
Rui M. Costa,
Columbia University, USA
Mechanisms Underlying the Generation and Learning of Novel Actions
Mechanisms Underlying the Generation and Learning of Novel Actions
Michele Pignatelli,
Massachusetts Institute of Technology, USA
Short Talk: Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Short Talk: Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Coffee Break
Jun Ding,
Stanford University School of Medicine, USA
Short Talk: Regulation of Short-Term and Long-Term Plasticity of Corticostriatal Synapses by Synucleins
Short Talk: Regulation of Short-Term and Long-Term Plasticity of Corticostriatal Synapses by Synucleins
Kaitlyn Ellis,
University of Utah, USA
Short Talk: Biased Randomness: A Connectivity Mechanism for Associative Brain Centers
Short Talk: Biased Randomness: A Connectivity Mechanism for Associative Brain Centers
Annie Handler,
Rockefeller University, USA
Short Talk: Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Synaptic Plasticity in Associative Learning
Short Talk: Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Synaptic Plasticity in Associative Learning
17:00—19:00
Neural Circuits for Sensory Processing
*
Kristin Scott,
University of California, Berkeley, USA
M. Eugenia Chiappe,
Champalimaud Neuroscience Programme, Portugal
Motor-Context Dependent Active Visual Control of Locomotion
Motor-Context Dependent Active Visual Control of Locomotion
Salil Bidaye,
University of California, Berkeley, USA
Central Neurons for Walking Control in Drosophila
Central Neurons for Walking Control in Drosophila
Sandeep Robert Datta,
Harvard Medical School, USA
A Systematic Representation of Odor Space in Cortex
A Systematic Representation of Odor Space in Cortex
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Therapeutics for Nervous System Disease
Chris Towne,
Circuit Therapeutics, USA
A Circuit-Based Approach to CNS Drug Discovery: Integrating Optogenetics and Single-Cell Genomics
A Circuit-Based Approach to CNS Drug Discovery: Integrating Optogenetics and Single-Cell Genomics
Yeri J. Song,
University of Pennsylvania, USA
Short Talk: Altered Ionotropic Receptor Maturation and Intracortical Connectivity in the Impaired Auditory Critical Periods of Fragile X Knockout Mice
Short Talk: Altered Ionotropic Receptor Maturation and Intracortical Connectivity in the Impaired Auditory Critical Periods of Fragile X Knockout Mice
Changuk Chung,
Korea Institute of Science and Technology, South Korea
Short Talk: Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice
Short Talk: Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2-/- Mice
Coffee Break
Barbara Terzic,
University of Pennsylvania, USA
Short Talk: Cell Type-Specific Dissection of CDKL5 Function in vivo Using Mouse Models
Short Talk: Cell Type-Specific Dissection of CDKL5 Function in vivo Using Mouse Models
17:00—18:45
Modeling Disorders of the Nervous System
*
Paola Arlotta,
Harvard University, USA
Ravi Jagasia,
Roche Innovation Center Basel, Switzerland
UBE3A Modulates Retrotransposon-Derived GAG Proteins Involved Extracellular Vesicle Release in a Angelman's Disease Relevant Manner
UBE3A Modulates Retrotransposon-Derived GAG Proteins Involved Extracellular Vesicle Release in a Angelman's Disease Relevant Manner
Inbal Israely,
Columbia University Medical Center, USA
Short Talk: Spine Competition during Plasticity in Health and Disease
Short Talk: Spine Competition during Plasticity in Health and Disease
Rebecca Muhle,
Yale School of Medicine, USA
Short Talk: Immunohistochemistry and Single-Cell Transcriptome Analysis Reveal Patterns of Neurodevelopmental Risk Gene Expression during Corticogenesis
Short Talk: Immunohistochemistry and Single-Cell Transcriptome Analysis Reveal Patterns of Neurodevelopmental Risk Gene Expression during Corticogenesis
Bidisha Chattopadhyaya,
Centre Hospitalier Universitaire Sainte-Justine, Canada
Short Talk: p75 Neurotrophin Receptor Regulates the Timing of Maturation of Cortical Parvalbumin Cell Connectivity and Promotes Ocular Dominance Plasticity in Adult Visual Cortex
Short Talk: p75 Neurotrophin Receptor Regulates the Timing of Maturation of Cortical Parvalbumin Cell Connectivity and Promotes Ocular Dominance Plasticity in Adult Visual Cortex
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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