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This meeting took place in 2019

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Delivering Therapeutics Across Biological Barriers (E1)

Organizer(s) David Brayden, Claus-Michael Lehr and Kathryn Whitehead
May 6—9, 2019
Royal Dublin Society • Dublin 4, Ireland
Discounted Abstract Deadline: Jan 8, 2019
Abstract Deadline: Feb 6, 2019
Scholarship Deadline: Jan 8, 2019
Discounted Registration Deadline: Mar 6, 2019

Organized in Collaboration with Science Foundation Ireland

Sponsored by Astellas Pharma Inc.

Summary of Meeting:
The multi-disciplinary theme of crossing of biological barriers encompasses biology, chemistry, pharmaceutical formulation, polymeric and materials science, advanced cell biology, imaging, microfluidics, and drug-device combination research. This conference occurs at the interface between cell biology and the use of technologies to exploit such understanding in order to translate therapies to patients. The program comprises leading researchers from academia, institutes, as well as from the pharmaceutical and medical device industry. The goal of the conference is to profile cutting edge research in specific areas of achieving drug delivery across biological barriers where a large translational impact would result for both industry and patients. By inviting cell biologists, technology developers, and formulators to the same conference, this will provide in depth discussions and offer a thorough perspective on the tissue and cell barriers that must be crossed in order to help guide technology approaches to achieve these breakthrough treatments.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Monday, May 6 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, May 9 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, May 10 in order to fully experience the meeting.


Arrival and Registration

Concert Hall Foyer
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Hall 6


Poster Setup

Hall 6
Poster Viewing

Hall 6
Welcoming Remarks (Organizers)

Delivery Across Mucosal Sites: Oral and Pulmonary

Concert Hall
* Claus-Michael Lehr, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany

David Brayden, University College Dublin, Ireland
Oral Peptide Delivery Using Intestinal Permeation Enhancers and Nanoparticle Technology

Stephen Timothy Buckley, Novo Nordisk A/S, Denmark
Short Talk: Gastric Absorption of a Fatty Acid-Acylated Analog of Glucagon-Like Peptide-1 (GLP-1)

Anja Boisen, Technical University of Denmark, Denmark
Oral Drug Delivery Using Micro Devices

Coffee Break

Chris Porter, Monash University, Australia
Lipidated Drugs and Lipid-Based Formulations to Improve Solubility and Oral Bioavailability of BCS Class II Molecules

Anthony J. Hickey, University of North Carolina at Chapel Hill, USA
Biopharmaceutical Considerations in Pulmonary Drug Delivery

Daria Anna Korejwo, University of Fribourg, Switzerland
Short Talk: Interaction of Graphene-Related Materials with Cells of the Human Alveolar Tissue Barrier


Hall 6
Poster Session 1

Hall 6
Workshop 1: Nanoparticles in Discovery: Characterization and Mode of Action

Concert Hall
* Caitriona O'Driscoll, University College Cork, Ireland

Kenneth A. Dawson, University College Dublin, Ireland
Characterization Techniques for Nanoparticles

Orlagh Feeney, Monash University, Australia
Breaking Down Barriers: The Impact of Stromal Remodification on Nanoparticle Distribution in vivo

Morag Rose Hunter, AstraZeneca, UK
Investigating the Role of the Phosphatidylinositol Pathway in Lipid Nanoparticle Delivery

Shrey Sindhwani, University of Toronto, Canada
How Do Nanoparticles Enter Solid Tumours?

Muthiah Manoharan, Alnylam Pharmaceuticals, Inc., USA
Translation Aspects: The First Approved RNAi Therapeutic: Delivery of ONPATTRO (patisiran)

Coffee Available

Hall 6
Nanoparticles and Polymers for the Efficient Crossing of Biological Barriers

Concert Hall
Dan Peer, University of Tel Aviv, Israel
A Universal Platform for RNA Therapeutics

Giulia Brachi, Politecnico di Torino, Italy
Short Talk: Nanoparticles Transport in Glioblastoma from Intracranially-Administered Thermosensitive Hydrogels

Simple Kumar, Georgia Institute of Technology, USA
Short Talk: Serum Effects on Nanoparticle-Mediated Photoporation for Enhanced Macromolecular Delivery

Renata Pasqualini, Rutgers University, USA
Ligand-Directed Targeting and Molecular Imaging Based on Vascular Zip Codes Revealed by in vivo Phage Display

Maria J. Vicent, Centro de Investigación Príncipe Felipe, Spain
Polypeptide-Based Conjugates as Versatile Drug Delivery Carriers

On Own for Dinner


Materials and Devices for Diagnostics and Therapeutic Delivery

Concert Hall
* Clive Prestidge, University of South Australia, Australia

Tanja Weil, Max Planck Institute for Polymer Research, Germany
Quantum Materials, Customized and Adaptive Macromolecules for Precision Sensing and Therapy

Paula T. Hammond, Massachusetts Institute of Technology, USA
Electrostatic Assembly for Nanoparticle Targeting of Cells and Tissues

Crystal Shin, Baylor College of Medicine, USA
Short Talk: Cerium Oxide Nanowafer to Treat Corneal Neovascularization

Coffee Break

Joke A. Bouwstra, Leiden University, Netherlands
Drug Device Combinations for Vaccine Delivery

Vipul Yadav, Intract Pharma Limted, UK
Short Talk: Soteria®: Delivery of Antibodies in an Easy to Swallow Oral Pill

Julie A. Champion, Georgia Institute of Technology, USA
Developing Therapeutic Protein Materials: Controlling and Understanding Protein Particle Self-Assembly

Cathal J. Kearney, Royal College of Surgeons in Ireland, Ireland
Short Talk: On-Demand Delivery Scaffolds for Tissue Engineering

On Own for Lunch

Poster Setup

Hall 6
Poster Viewing

Hall 6
Coffee Available

Hall 6
Overcoming the Blood-Brain Barrier to Treat CNS Disease

Concert Hall
* Kinam Park, Purdue University, USA

Carl I. Webster, MedImmune, UK
Brain Delivery and Intracellular Sorting of Affinity Variants of the Anti-TfR Antibody OX26

Marco Campisi, Politecnico di Torino, Italy
Short Talk: Model of Nanoparticles Transport Across the Human Blood-Brain Barrier Microvasculature

Danica Stanimirovic, National Research Council of Canada, Canada
Novel Targets and Antibodies for Delivery of Therapeutics across the Blood-Brain Barrier

Florencia Natalia Linero, VIB-University of Gent, Belgium
Short Talk: Breaking Down Barriers: Nanobodies to Deliver Therapeutics Across the Blood-Cerebrospinal Fluid Barrier

Matthew Campbell, Trinity College Dublin, Ireland
Dose-Dependent Expression of Claudin-5 at the BBB

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 6
Poster Session 2

Hall 6


Delivery Solutions for Gene Medicines

Concert Hall
* Sally-Ann Cryan, Royal College of Surgeons in Ireland, Ireland

David V. Schaffer, University of California, Berkeley, USA
Directed Evolution of New Viruses for Therapeutic Gene Delivery

Ross Wilson, University of California, Berkeley, USA
Short Talk: Delivery of an Endosomolytic CRISPR-Cas9 RNP via Receptor-Mediated Endocytosis for Cell-Targeted Genome Editing

Khalid A. Hajj, Carnegie Mellon University, USA
Enabling the Medicines of Tomorrow: Lipid Nanoparticles for Enhanced Co-Delivery of RNAs

Coffee Break

Elias Fattal, Université Paris-Sud, France
CD44-Targeted Delivery of siRNA

Anna K. Blakney, Imperial College London, UK
Short Talk: The Skin You’re In: Design of Experiments Optimization of LNP saRNA Formulations in Human Skin Explants

Caitriona O'Driscoll, University College Cork, Ireland
Short Talk: Formulation and Characterisation of Nanoparticles Prepared by Co-Formulation of Cationic and Anionic Amphiphilic Cyclodextrins as Promising siRNA Delivery Systems

On Own for Lunch

NIH Grant Process: From Submission to Review: A Roundtable for Trainees and Young Faculty

Concert Hall
* Bita Nakhai, NIA, National Institutes of Health, USA

Workshop 2: Academic Drug Delivery Writing and Publishing in Top Journals

Concert Hall
* Alison L. Reynolds, University College Dublin, Ireland

Stephen Timothy Buckley, Novo Nordisk A/S, Denmark
Academic Writing on Drug Delivery for Top Journals: A Case Study

Gonzalo Cordova, Springer Nature B.V., Netherlands
What Editors Are Looking for in Delivery Papers

Coffee Available

Hall 6
Human Cell and Tissue Models of Biological Barriers to Assist Translation

Concert Hall
* David Brayden, University College Dublin, Ireland

Claus-Michael Lehr, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany
Modeling Biological Barriers to Drug Delivery in Infection Research

Ludivine Claude Delon, University of South Australia, Australia
Short Talk: Systematic Investigation of the Effect of Shear Stress in a Microfluidic Intestine-on-a-Chip Model to Study Oral Particle Delivery

Helena Kandarova, Slovak Toxicology Society SETOX, Slovakia
Reconstructed Human Skin Equivalents to Model the Transport and Toxicology of the Skin Barrier

Josué Sznitman, Technion - Israel Institute of Technology, Israel
Advanced in vitro Lung-on-Chip Platforms for Inhalation Screening Assays

Summary and Analysis

Concert Hall
* David Brayden, University College Dublin, Ireland

* Claus-Michael Lehr, Helmholtz-Institute for Pharmaceutical Research Saarland, Germany

Kinam Park, Purdue University, USA
An Assessment of the Current and Likely Impact of the Science of Crossing Biological Barriers on Medicine

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Hall 6
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Hall 6



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Astellas Pharma Inc. Organized in Collaboration with Science Foundation Ireland

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13EB028133-01

Funding for this conference was made possible (in part) by 1R13EB028133-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

ACS Chemical Biology Arcturus Therapeutics, Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:


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