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This meeting took place in 2019

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Positive-Strand RNA Viruses (E2)

Organizer(s) Frank van Kuppeveld and Andrea Gamarnik
June 9—13, 2019
INEC Killarney Convention Centre • Killarney, Co. Kerry Ireland
Discounted Abstract Deadline: Feb 7, 2019
Abstract Deadline: Mar 6, 2019
Scholarship Deadline: Feb 7, 2019
Discounted Registration Deadline: Apr 9, 2019

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
The Keystone Symposia conference on positive-strand RNA viruses provides an international forum for research on human, animal, insect, plant and bacterial viruses with positive-strand RNA genomes. This group of viruses contains many clinically relevant and well-known pathogens (e.g., poliovirus, hepatitis C virus, Dengue and West Nile virus). Furthermore, the enormous diversity of positive-strand RNA viruses in animals and insects, combined with their evolutionary and adaptive potential following a species-jump, poses a threat to the human population as demonstrated by the growing list of emerging viruses, including zoonotic as well as arbovirus-transmitted pathogens such as MERS-CoV, Chikungunya and Zika virus. Detailed insight into the “virosphere”, the “virome”, viral evolution, as well as in the molecular details of viral replication and spreading, tissue tropism, and viral recognition by the host immune system is critical to understand virus transmission, viral pathogenesis as well as to develop novel therapeutic and preventive measures. This conference brings together experienced and junior experts to discuss the latest developments in molecular biology, cell biology, vector biology, immunology, vaccinology, and antiviral drug development applied to the field of positive-strand RNA viruses.

View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Sunday, June 9 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, June 13 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, June 14 in order to fully experience the meeting.


Arrival and Registration

INEC Foyer
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

INEC Foyer


Welcome and Keynote Address

INEC Main Auditorium
* Frank van Kuppeveld, Utrecht University, Netherlands

* Andrea Gamarnik, Fundación Instituto Leloir, Argentina

Michael S. Diamond, Washington University School of Medicine, USA
Receptor Hunting for Alphaviruses: A Travel Through Time

The Virosphere and the Virome

INEC Main Auditorium
* Alexander E. Gorbalenya, Leiden University Medical Center, Netherlands

* Andrew E. Firth, University of Cambridge, UK

Eugene V. Koonin, National Institutes of Health, USA
Origins and Evolution of the Global RNA Virome

Coffee Break

Julie K. Pfeiffer, University of Texas Southwestern Medical Center, USA
Origins of Animal Innate Immunity

Marilyn J. Roossinck, Pennsylvania State University, USA
Viruses as Symbionts

Vyacheslav Yurchenko, University of Ostrava, Czech Republic
Short Talk: Positive-Strand RNA Viruses in Trypanosomatid Parasites

On Own for Lunch

Poster Setup

1st Floor INEC
Poster Viewing

1st Floor INEC
Workshop 1: Burning Questions, Opportunities and Challenges in RNA Virology

INEC Main Auditorium
* Eric J. Snijder, Leiden University Medical Center, Netherlands

Ralf Bartenschlager, Heidelberg University, Germany
Resolved and Future Research Challenges of Plus-Strand RNA Virus Replication Strategies

Peter Sarnow, Stanford University School of Medicine, USA
Changing the Shape of Viral RNA to Subvert Host Pathways

Drew Weissman, University of Pennsylvania, USA
mRNA-Based Vaccines and Therapeutics – Advances and Challenges

Ann Palmenberg, University of Wisconsin-Madison, USA
Women: Plurality or Equality?

Coffee Available

INEC Foyer
Virus Structure and Entry

INEC Main Auditorium
* Toby Tuthill, Pirbright Institute, UK

* Berend Jan Bosch, Utrecht University, Netherlands

David Veesler, University of Washington, USA
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

Shee Mei Lok, , Singapore
Capsid Protein Structure in Zika Virus Reveals the Flavivirus Assembly Process

Richard J. Kuhn, Purdue University, USA
Short Talk: Budding Induces Symmetry Defects in Flavivirus Virions

Yifei Lang, Utrecht University, Netherlands
Short Talk: Betacoronavirus S and HE Proteins are in Functional Balance: Evidence for Convergent Evolution of Betacorona and Influenza Viruses

Kelly Watters, University of Wisconsin, USA
Short Talk: CDHR3 Extracellular Domain EC1 Mediates Rhinovirus C Attachment to Cells and its Recombinant Derivatives Inhibit Virus Infection

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
Poster Session 1

1st Floor INEC


RNA Structure and Function

INEC Main Auditorium
* Diego Alvarez, Universidad Nacional de San Martín, Argentina

* Ian Goodfellow, University of Cambridge, UK

Andrea Gamarnik, Fundación Instituto Leloir, Argentina
Function and Evolution of RNA Structures in the Flavivirus Genome

Jeffrey S. Kieft, University of Colorado School of Medicine, USA
Understanding Viral RNA Function by Linking Structural Biology to Virology

Coffee Break

Stacy M. Horner, Duke University Medical Center, USA
RNA Modifications Go Viral

Anna Marie Pyle, Yale University, USA
Regulatory Structures in Viral RNA Genomes

Omer Ziv, University of Cambridge, UK
Short Talk: RNA Communication between Viruses and their Hosts

Rebecca S. Brown, Albert Einstein College of Medicine, USA
Short Talk: PAR-CLIP Analysis of the Alphavirus Capsid Protein Demonstrates Unique Recognition of the Genomic RNA

European Virus Archive

INEC Main Auditorium
Christine MA Prat, European Virus Archive, France

On Own for Lunch

Poster Setup

1st Floor INEC
Poster Viewing

1st Floor INEC
Workshop 2

INEC Main Auditorium
* Anna K. Overby, Umeå University, Sweden

* Eric Jan, University of British Columbia, Canada

Alexander E. Gorbalenya, Leiden University Medical Center, Netherlands
Domain Linkage in the Largest Expansion of RNA Virus Genomes

Benjamin Götte, Karolinska Institutet, Sweden
Separate Domains of G3BP Promote Efficient Clustering of Alphavirus Replication Complexes and Recruitment of the Translation Initiation Machinery

Jelke J. Fros, Wageningen University, Netherlands
Newly Discovered Antiviral Pathways Control RNA Virus Replication and Drive Virus Evolution

Holly Ramage, University of Pennsylvania, USA
Using Proteomics Tools to Discover New Mechanisms in Flaviviral Infection

Montserrat Barcena, Leiden University Medical Center, Netherlands
The Origin of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy

Thomas Morrison, University of Colorado School of Medicine, USA
Scavenger Receptors on Liver Phagocytes Mediate Clearance of Blood-Borne Alphaviruses through Recognition of Modified Lysine Residues in Viral Glycoproteins

Colin Xinru Cheng, Duke-NUS Medical School, Singapore
Impact of Nuclear vs Cytoplasmic Localisation of Dengue Virus NS5

Jing Jin, Vitalant Research Institute, USA
Antigen-Crosslinking Dependent Antiviral Mechanisms

Lisa Chon Lindesmith, University of North Carolina at Chapel Hill, USA
Molecular Delineation of the Serum Antibody Repertoire Reveals Structural Mechanisms for Broad Antibody Responses following Human Norovirus Vaccination

Alexander A. Khromykh, University of Queensland, Australia
Determinants of Zika Virus Host Tropism Uncovered by Deep Mutational Scanning

Coffee Available

INEC Foyer
Virus Replication, Evolution and Virus-Cell Interactions

INEC Main Auditorium
* Jason Mackenzie, University of Melbourne, Australia

* Volker Lohmann, Heidelberg University, Germany

Frank van Kuppeveld, Utrecht University, Netherlands
A Novel Viral Mechanism to Prevent Translation Inhibition and Activation of the Integrated Stress Response

Peter D. Nagy, University of Kentucky, USA
Viral and Host Players in Tombusvirus Replication

Raul Andino, University of California, San Francisco, USA
Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication

Karim Majzoub, Stanford University, USA
Short Talk: An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection

Robert N. Kirchdoerfer, The Scripps Research Institute, USA
Short Talk: Structure of the SARS-CoV NSP12 Polymerase Bound to NSP7 and NSP8 Co-Factors

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
Poster Session 2

1st Floor INEC


Immunology of Infection and Viral Evasion Mechanisms

INEC Main Auditorium
* Susan C. Baker, Loyola University Chicago, USA

Michaela U. Gack, University of Chicago, USA
Intracellular Virus Sensing Pathways and Viral Evasion Strategies

Marlene Dreux, INSERM U1111 International Center for Research in Infectionology (CIRI) Lyon, France
Plasmacytoid Dendritic Cells and Infected Cells form an Interferogenic Synapse Required for Antiviral Responses

Coffee Break

Sujan Shresta, La Jolla Institute for Immunology, USA
Antigenic Cross-Reactivity between Dengue and Zika Viruses: Time for a Pan-Flavivirus Vaccine?

Stephanie Karst, University of Florida, USA
The Influence of the Intestinal Microbiota on Norovirus Pathogenesis

Jason Mackenzie, University of Melbourne, Australia
Short Talk: Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis

* Ana Fernandez-Sesma, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Inhibition of Human Innate Immune Responses by Chikungunya Virus (CHIKV)

The Virus Pathogen Resource (ViPR)
ViPR is a freely-available NIH/NIAID-funded online Bioinformatics Resource Center supporting viral pathogen research. ViPR provides access to sequence records, immune epitopes and 3D protein structures, and unique annotations generated from ViPR bioinformatics pipelines including genotype/subtype assignments, mature peptide predications and sequence feature variant types. ViPR also provides analysis tools and supports many analysis workflows, including metadata/subtype-based genome and mature peptide sequence search, phylogenetic analysis with metadata/subtype visualization, sequence variation analysis using various approaches, and more. This workshop will provide a live demonstration of ViPR's major search and analysis capabilities through a Zika virus use case.

INEC Main Auditorium
Yun Zhang, J. Craig Venter Institute, USA

On Own for Lunch

Poster Setup

1st Floor INEC
Poster Viewing

1st Floor INEC
Workshop 3

INEC Main Auditorium
* Vineet D. Menachery, University of Texas Medical Branch, USA

* Gregory D. Ebel, Colorado State University, USA

Mayra Alejandra Diosa-Toro, Duke-NUS Medical School, Singapore
Identification and Characterization of Mosquito RNA-Binding Proteins that Regulate Dengue Virus Infection

Christopher J. Neufeldt, University of Heidelberg, Germany
ER-Shaping Atlastin Proteins Differentially Contribute to Flavivirus Replication and Assembly

Rushika Perera, Colorado State University, USA
Host Metabolism: Friend or Foe in Flavivirus Biogenesis and Disease

Jana Van Dycke, KU Leuven – Rega Institute, Belgium
Zebrafish Larvae as an in vivo Replication Model of Human Norovirus

Marjolein Kikkert, Leiden University Medical Center, Netherlands
The Deubiquitinating Activity of Middle East Respiratory Syndrome Coronavirus Papain-Like Protease Contributes to Innate Immune Evasion and Enhances Viral Virulence

Kizzmekia S. Corbett, NIAID, National Institutes of Health, USA
Prefusion MERS Coronavirus Spike Trimer Vaccination Elicits Protective Antibodies Targeting Epitopes Outside of Receptor Binding Domain

Lara J. Herrero, Griffith University, Australia
Alphaviruses and Chondrocytes: New Insights into the Mechanisms of Viral Arthritic Disease

Maria Isabel Giraldo, University of Texas Medical Branch, USA
Flavivirus Envelope Protein Ubiquitination Drives Virus Entry and Pathogenesis

Gorben Pijlman, Wageningen University, Netherlands
Subgenomic Flavivirus RNA Binds the Antiviral Mosquito DEAD/H-Box Helicase ME31B and Determines Zika Virus Transmission by Aedes Aegypti

Coffee Available

INEC Foyer
Vaccines, Therapeutic Antibodies and Antiviral Drugs

INEC Main Auditorium
* Stanley Perlman, University of Iowa, USA

Davide Corti, Humabs BioMed SA, Switzerland
Passive Antibody Therapies Against Endemic, Emerging and Re-Emerging Infectious Diseases

Alexander Ploss, Princeton University, USA
Model Systems to Assess Vaccine-Induced Immune Responses in vivo

Bali Pulendran, Stanford University School of Medicine, USA
Probing the Immune Response to Vaccination with Systems Based Approaches

* Priscilla L. Yang, Harvard Medical School, USA
Short Talk: Targeted Protein Degradation as an Antiviral Strategy

Lucia Carrau, Institut Pasteur, France
Short Talk: Chikungunya Virus Vaccine Candidates with Decreased Mutational Robustness are Attenuated in vivo and have Compromised Transmissibility

Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
Poster Session 3

1st Floor INEC


Poster Setup

1st Floor INEC
Poster Viewing

1st Floor INEC
Virus Transmission, Tropism and Pathogenesis

INEC Main Auditorium
* Ricardo Rajsbaum, University of Texas Medical Branch, USA

Carolyn B. Coyne, University of Pittsburgh, USA
The Role of the Neonatal Fc Receptor in Echovirus Entry and Pathogenesis.

Christian Drosten, Charité - Universitätsmedizin Berlin, Germany
Ecology, Inter-species Transmission, and Pathogenic Potential of Emerging Coronaviruses

Coffee Break

Diane E. Griffin, Johns Hopkins Bloomberg School of Public Health, USA
Role of Alphavirus nsP3 in Replication and Neurovirulence

Xiang-Jin Meng, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, USA
Hepatitis E Virus: The Ever-Expanding Host Range and Cross-Species Infection

* Eva Harris, Division of Infectious Diseases and Vaccinology, School of Public Health, USA
Short Talk: Molecular Mechanisms and Determinants of Flavivirus NS1-Induced Endothelial Permeability, Vascular Leak, and Virus Dissemination

Stacey Lynne Schultz-Cherry, St. Jude Children's Research Hospital, USA
Short Talk: Astrovirus Capsid is a Novel Viral Enterotoxin


INEC Foyer
Poster Session 4

1st Floor INEC
Coffee Available

INEC Foyer
Invertebrate Viruses and their Vectors

INEC Main Auditorium
* Gorben Pijlman, Wageningen University, Netherlands

* Laura D. Kramer, Wadsworth Center, New York State Department of Health; SUNY Albany, USA

Erol Fikrig, Yale University School of Medicine, USA
Aedes aegypti AgBR1 Influences Early Zika Virus Infection

Maria-Carla Saleh, Institut Pasteur, France
Principal Components of Innate Immunity Pathways Constrain Viral Evolution

Ronald P. van Rij, Radboud University Medical Center, Netherlands
Biogenesis and Functions of Virus and Host-Derived piRNAs in Vector Mosquitoes

Diego Alvarez, Universidad Nacional de San Martín, Argentina
Short Talk: RNA Recombination Allows Chikungunya Virus to Overcome Barriers Imposed during Mosquito Transmission

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

INEC Main Auditorium
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

INEC Foyer
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

INEC Foyer



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge additional support from these exhibitors at this conference:

European Virus Archive
Please stop by to meet these exhibitors during the conference.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13AI145246-01

Funding for this conference was made possible (in part) by 1R13AI145246-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

We gratefully acknowledge additional support for this conference from:

American Society of Gene & Cell Therapy (ASGCT) GeneTex, Inc.

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:

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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:

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Phone:+1 970-262-2690

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