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This meeting took place in 2018
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Leveraging Genomic Diversity to Promote Animal and Human Health (S5)
Organizer(s) Michèle Ramsay, Han Brunner and Appolinaire Djikeng
November 25—29, 2018
Speke Resort & Conference Centre • Kampala, Uganda
Discounted Abstract Deadline: Aug 8, 2018
Abstract Deadline: Aug 23, 2018
Scholarship Deadline: Aug 8, 2018
Discounted Registration Deadline: Oct 6, 2018
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Genomic variation is a driving force of animal and human health, and susceptibility to disease. Yet our knowledge rarely spans human ethnic genomic diversity and genomic variation between animal breeds, limiting their translational impact. This symposium aims to: 1) Highlight translational genomics in humans and animals (clinical medicine and animal breeding for health and productivity; 2) Explore synergies and cross-disciplinary learning; 3) Explore opportunities to leverage genomic diversity to push the current boundaries to translation; and 4) Address translation and affordability in low- and middle-income settings. Large-scale genomics initiatives like Genome England, the US Precision Medicine initiative, and the Human Heredity and Health in African Consortium are providing extraordinarily large data sets to explore useful genotype-phenotype connections. Equivalent initiatives for animal data are starting. This meeting will explore the translation of genomic research in animals and humans, high and low-resourced environments, ethnic diversity, and cultural context. Identifying common strands in animal and human health opens up opportunities for repurposing of ideas and applications, and for finding innovative solutions for translational genomics through cross-boundary communities of practice.
View Scholarships/Awards
Genomic variation is a driving force of animal and human health, and susceptibility to disease. Yet our knowledge rarely spans human ethnic genomic diversity and genomic variation between animal breeds, limiting their translational impact. This symposium aims to: 1) Highlight translational genomics in humans and animals (clinical medicine and animal breeding for health and productivity; 2) Explore synergies and cross-disciplinary learning; 3) Explore opportunities to leverage genomic diversity to push the current boundaries to translation; and 4) Address translation and affordability in low- and middle-income settings. Large-scale genomics initiatives like Genome England, the US Precision Medicine initiative, and the Human Heredity and Health in African Consortium are providing extraordinarily large data sets to explore useful genotype-phenotype connections. Equivalent initiatives for animal data are starting. This meeting will explore the translation of genomic research in animals and humans, high and low-resourced environments, ethnic diversity, and cultural context. Identifying common strands in animal and human health opens up opportunities for repurposing of ideas and applications, and for finding innovative solutions for translational genomics through cross-boundary communities of practice.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, November 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, November 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, November 30 in order to fully experience the meeting.
SUNDAY, NOVEMBER 25
MONDAY, NOVEMBER 26
TUESDAY, NOVEMBER 27
WEDNESDAY, NOVEMBER 28
THURSDAY, NOVEMBER 29
FRIDAY, NOVEMBER 30
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, November 25 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, November 29 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, November 30 in order to fully experience the meeting.
SUNDAY, NOVEMBER 25
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
09:00—10:30
Welcome and Keynote Address
*
Michèle Ramsay,
University of Witwatersrand, South Africa
Evan E. Eichler,
HHMI/University of Washington, USA
Relevance of Primate Evolution to Human and Animal Diversity
Relevance of Primate Evolution to Human and Animal Diversity
Coffee Break
11:00—12:00
Genomic Diversity in Health
*
Han G. Brunner,
Radboud Maastricht University Medical Center, Netherlands
Charles N. Rotimi,
NHGRI, National Institutes of Health, USA
Global Genomic Diversity: History, Adaptation and Health
Global Genomic Diversity: History, Adaptation and Health
15:00—16:30
Workshop: Impact of Animal Pathogens on Human Health
*
Evan E. Eichler,
HHMI/University of Washington, USA
Jeremiah Okoro Ijomanta,
National Veterinary Research Institute, Nigeria
Continuous Circulation of Human-Derived Pandemic H1N1pdm09 Influenza Virus in Nigerian Pigs: Implication for Public Health and Pandemic Preparedness
Continuous Circulation of Human-Derived Pandemic H1N1pdm09 Influenza Virus in Nigerian Pigs: Implication for Public Health and Pandemic Preparedness
Elijah Kolawole Oladipo,
Adeleke University, Nigeria
Genetic Characterization of H5N1 Influenza A Virus Isolated from Pigs in Ogbomoso, Nigeria
Genetic Characterization of H5N1 Influenza A Virus Isolated from Pigs in Ogbomoso, Nigeria
Patricia Ihuaku Otuh,
University of Ibadan, Nigeria
Molecular Analyses Unravel Mycobactrium ulcerans Transmission Pathway from Animal Host and Environment to Human in Ogun State, Nigeria
Molecular Analyses Unravel Mycobactrium ulcerans Transmission Pathway from Animal Host and Environment to Human in Ogun State, Nigeria
Abdul Walusansa,
Islamic University in Uganda, Uganda
Non-Typhoidal Salmonella and Zoonotic E. coli as Potential Drivers of Antimicrobial Resistance in Pastoralist Communities in Kasese District, Uganda
Non-Typhoidal Salmonella and Zoonotic E. coli as Potential Drivers of Antimicrobial Resistance in Pastoralist Communities in Kasese District, Uganda
Oluwatoyin Modupe Aladejana,
Kings University Odeomu, Nigeria
Occurrence and Multiple-Antibiotics Resistance Profile of Enterobacteriaceae Isolated from Bats Faecal Samples in Osun State, Nigeria
Occurrence and Multiple-Antibiotics Resistance Profile of Enterobacteriaceae Isolated from Bats Faecal Samples in Osun State, Nigeria
17:00—19:00
Human Translational Genomics
*
Christian T. Happi,
Redeemer's University, Nigeria
Han G. Brunner,
Radboud Maastricht University Medical Center, Netherlands
Genetic Diagnosis of Intellectual Disability
Genetic Diagnosis of Intellectual Disability
Brunhilde Wirth,
University Hospital Cologne, Germany
Therapeutic Approaches to SMA: In the Challenges is a Solution
Therapeutic Approaches to SMA: In the Challenges is a Solution
Lea M. Starita,
University of Washington, USA
Using Multiplexed Functional Assays to Understand the Effects of Genetic Variation
Using Multiplexed Functional Assays to Understand the Effects of Genetic Variation
Mohamed Z. Alimohamed,
University Medical Center Groningen, Netherlands
Short Talk: Routine Use of Targeted NGS Panel in a Dutch Cardiomyopathy Cohort
Short Talk: Routine Use of Targeted NGS Panel in a Dutch Cardiomyopathy Cohort
Jorge Da Rocha,
University of the Witwatersrand, South Africa
Short Talk: Addressing Cancer Treatment in an African Setting: A Bioinformatics Analysis of Pharmacogenomically Relevant Variants
Short Talk: Addressing Cancer Treatment in an African Setting: A Bioinformatics Analysis of Pharmacogenomically Relevant Variants
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
09:00—12:00
Livestock Translational Genomics
*
Farai C. Muchadeyi,
Agricultural Research Council, South Africa
Michel A.J. Georges,
University of Leige GIGA Institute B34, Belgium
Translation of Animal Genomics to Health: European Perspective
Translation of Animal Genomics to Health: European Perspective
Coffee Break
Appolinaire Djikeng,
Centre for Tropical Livestock Genetics and Health, University of Edinburgh, UK
Development of Genomic-Based Tools and Resources for Tropical Animal Productivity and Resilience-Talk to be Delivered by John Hickey
Development of Genomic-Based Tools and Resources for Tropical Animal Productivity and Resilience-Talk to be Delivered by John Hickey
Vivien Jepchirchir Chebii,
Nelson Mandela African Institution of Science and Technology, Tanzania
Short Talk: Exploring Association of Copy Number Variations in Wild African Goats (Capra nubiana) Adaptations
Short Talk: Exploring Association of Copy Number Variations in Wild African Goats (Capra nubiana) Adaptations
Edward J. Smith,
Virginia Polytechnic Institute and State University, USA
Genomic Characterization of Zambian Indigenous Cattle Breeds
Genomic Characterization of Zambian Indigenous Cattle Breeds
17:00—19:00
Technological Innovations for Tomorrow
*
Niklas Blomberg,
ELIXIR Europe, UK
Christian T. Happi,
Redeemer's University, Nigeria
Genomics in Stemming the Tide of Infectious Epidemics
Genomics in Stemming the Tide of Infectious Epidemics
Simon Lillico,
University of Edinburgh, UK
Editing Livestock Genomes: Harnessing and Expanding Genomic Diversity
Editing Livestock Genomes: Harnessing and Expanding Genomic Diversity
Luísa Pereira,
Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
The Power of Local Ancestry Inference Algorithms in Mapping Candidate Genes: The Case Study of African Ancestry Protection against Hemorrhagic Dengue Fever
The Power of Local Ancestry Inference Algorithms in Mapping Candidate Genes: The Case Study of African Ancestry Protection against Hemorrhagic Dengue Fever
Martha Kivecu,
KEMRI, Kenya
Short Talk: Evaluation of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Kenya
Short Talk: Evaluation of Plasmodium falciparum Histidine-Rich Protein 2 and 3 Gene Deletions in Kenya
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
09:00—12:00
Solutions for Implementation of Genomic Tests
*
Michèle Ramsay,
University of Witwatersrand, South Africa
Farai C. Muchadeyi,
Agricultural Research Council, South Africa
Landscape Genomics as a Tool to Understand Genetic Adaptation to Local Conditions
Landscape Genomics as a Tool to Understand Genetic Adaptation to Local Conditions
John M. Hickey,
University of Edinburgh, UK
Modern Breeding Programs for Local and Global Economies
Modern Breeding Programs for Local and Global Economies
Coffee Break
David Evans,
University of Queensland, Australia
Using Genetics to Investigate the Developmental Origins of Health and Disease
Using Genetics to Investigate the Developmental Origins of Health and Disease
Elizabeth Sibongile Tshabalala,
Council of Scientific and Industrial Research, South Africa
Short Talk: Genetic Diversity of Pharmacogenes in a Bantu-Speaking Cohort and Evaluation of Variants Associated with Tenofovir-Induced Nephrotoxicity
Short Talk: Genetic Diversity of Pharmacogenes in a Bantu-Speaking Cohort and Evaluation of Variants Associated with Tenofovir-Induced Nephrotoxicity
Liberata Mwita,
Muhimbili University of Health and Allied Sciences, Tanzania
Short Talk: Genome-Wide Associations of Liver Function in Sickle Cell Patients in Tanzania
Short Talk: Genome-Wide Associations of Liver Function in Sickle Cell Patients in Tanzania
Chiaka I. Anumudu,
University of Ibadan, Nigeria
Short Talk: Improving Schistosomiasis Control Using Genomics and Proteomics Tools
Short Talk: Improving Schistosomiasis Control Using Genomics and Proteomics Tools
15:30—16:30
Virtual Lab Tour: Makerere University
Come view the labs virtually and meet local researchers, Professor Moses Joloba and Dr. David Kateete, representing the following:
Genomics and Molecular Biology facilities
Bioinformatics/Computational Infrastructure
H3Africa Biorepository
Mycobacteriology Laboratory
Immunology facilities
Bacteriology facilities
Genomics and Molecular Biology facilities
Bioinformatics/Computational Infrastructure
H3Africa Biorepository
Mycobacteriology Laboratory
Immunology facilities
Bacteriology facilities
17:00—19:00
Genomics in Animal and Human Health
*
Han G. Brunner,
Radboud Maastricht University Medical Center, Netherlands
Mark S. Fife,
Pirbright Institute, UK
Genetic Diversity of Immune Loci in Chickens across Africa and Europe
Genetic Diversity of Immune Loci in Chickens across Africa and Europe
Michèle Ramsay,
University of Witwatersrand, South Africa
Impact of Demographic History and Local Adaptation on Population Diversity and Health: Studies from Africa
Impact of Demographic History and Local Adaptation on Population Diversity and Health: Studies from Africa
Soanandrasana Rahelinirina,
Institut Pasteur de Madagascar, Madagascar
Short Talk: First Molecular Detection of Pathogenic Leptospira in Livestock from Slaughterhouses in Madagascar
Short Talk: First Molecular Detection of Pathogenic Leptospira in Livestock from Slaughterhouses in Madagascar
Isoken H. Igbinosa,
University of Benin, Nigeria
Short Talk: Characterization and Detection of Antibiotic Resistance, Virulence Gene Elements and Biofilm Formation in Aeromonas Species Isolated from Cattle
Short Talk: Characterization and Detection of Antibiotic Resistance, Virulence Gene Elements and Biofilm Formation in Aeromonas Species Isolated from Cattle
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
09:00—12:00
Enablers for Translational Genomics
Niklas Blomberg,
ELIXIR Europe, UK
Global Data Infrastructure for the Scientific Enterprise
Global Data Infrastructure for the Scientific Enterprise
Bassirou Bonfoh,
CSRS/Afrique One-African Science Partnership for Intervention Research Excellence, Côte D'Ivoire
Genomics: A Half-Full Glass in One Health
Genomics: A Half-Full Glass in One Health
Coffee Break
Nicholas Katsanis,
Northwestern University Feinberg School of Medicine, USA
Zebrafish Models for Diseases
Zebrafish Models for Diseases
Jim Kaufman,
University of Cambridge, UK
Short Talk: Typing MHC Haplotypes of African Village Chickens for Structure-Function Studies
Short Talk: Typing MHC Haplotypes of African Village Chickens for Structure-Function Studies
Acho Fon Abongwa,
Elizabeth Glaser Pediatric AIDS Foundation, Cameroon
Short Talk: Evolution of Plasmodium Falciparum Strains and Resistance Markers in Pregnant Women in Cameroon: 2008-2018
Short Talk: Evolution of Plasmodium Falciparum Strains and Resistance Markers in Pregnant Women in Cameroon: 2008-2018
14:30—15:30
Panel Discussion: How Do We Build the Ideal Cattle Breeds for Different Ecological Niches?
*
John M. Hickey,
University of Edinburgh, UK
Sumaya Y. Kambal,
Sudan University of Science and Technology, Sudan
Mitogenomic Analysis of Western Baggara Cattle Breed-Nyalawi Population
Mitogenomic Analysis of Western Baggara Cattle Breed-Nyalawi Population
Owen Powell,
Roslin Institute, University of Edinburgh, Scotland
Can Genomics Enable Genetic Evaluations with Phenotypes Recorded on Smallholder Dairy Farms?
Can Genomics Enable Genetic Evaluations with Phenotypes Recorded on Smallholder Dairy Farms?
15:30—16:30
Panel Discussion: What Do We Need to Know About Our Ancestry?
*
Han G. Brunner,
Radboud Maastricht University Medical Center, Netherlands
17:00—18:45
Toward a Perfect World – Emerging Themes
*
Charles N. Rotimi,
NHGRI, National Institutes of Health, USA
Elizabeth Marincola,
African Academy of Sciences, Kenya
How African Researchers Can Lead the Way in Global Science Communication
How African Researchers Can Lead the Way in Global Science Communication
Alison L. Van Eenennaam,
University of California, Davis, USA
Public Perception of Animal Biotechnology
Public Perception of Animal Biotechnology
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
*Session Chair †Invited, not yet responded.
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