Keystone Symposia

Fairmont Chateau Whistler Floorplan

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This meeting took place in 2020



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Noncoding RNAs: Mechanism, Function and Therapies (A1)


Organizer(s) Howard Y. Chang, Frank W. Rigo and Lynne E. Maquat
January 12—16, 2020
Fairmont Chateau Whistler • Whistler, BC Canada
Discounted Abstract Deadline: Sep 24, 2019
Abstract Deadline: Oct 10, 2019
Scholarship Deadline: Sep 24, 2019
Discounted Registration Deadline: Nov 12, 2019

Sponsored by Ionis Pharmaceuticals, Inc. and Moderna

Summary of Meeting:
A revolution is sweeping the RNA world. The human genome contains over 60,000 long noncoding RNA genes, three times the number of protein coding genes. Many important questions are outstanding, including physiologic functions of regulatory RNAs, their molecular mechanisms, and therapeutic potential. This conference will bring together leaders in RNA biology, technology, and medicine to present the latest findings in these respective areas. We anticipate that this conference will provide an integrated view of the cutting edge of this rapidly advancing scientific area and create many opportunities for synergy and cross fertilization.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 12 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 16 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 17 in order to fully experience the meeting.

SUNDAY, JANUARY 12

16:00—20:00
Arrival and Registration

MacDonald Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

MacDonald Foyer

MONDAY, JANUARY 13

07:00—08:00
Breakfast

MacDonald DEF
08:00—09:00
Welcome and Keynote Address

MacDonald ABC
* Howard Y. Chang, Stanford University, USA

* Lynne E. Maquat, University of Rochester Medical Center, USA

Joan A. Steitz, Yale University, USA
Viral Noncoding RNAs: Approaching Answers

09:00—11:30
LncRNA Mechanisms

MacDonald ABC
* Joshua T. Mendell, University of Texas Southwestern Medical Center, USA

Lynne E. Maquat, University of Rochester Medical Center, USA
3’UTR-Mediated Post-transcriptional Effects on Human Gene Expression via Staufen and SINEs

Coffee Break

Montserrat Anguera, University of Pennsylvania, USA
X-Chromosome Inactivation Maintenance in Immune Cells

Elsa R. Flores, Moffitt Cancer Center, USA
Pan-Cancer Analysis Reveals Alternate Mechanisms for AKT Activation through TAp63 Regulated Oncogenic lncRNAs (TROLLs)

Nicolas Jaé, Goethe-University Frankfurt, Germany
Short Talk: Control of Vessel Permeability by the Splicing-Regulatory lncRNA NTRAS

Amanda J. Whipple, Harvard University, USA
Short Talk: Imprinted Maternally-Expressed MicroRNAs Antagonize Paternally-Driven Gene Programs in Neurons

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

MacDonald DEF
13:00—22:00
Poster Viewing

MacDonald DEF
16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
Regulatory RNA Physiologic Functions

MacDonald ABC
* Lynne E. Maquat, University of Rochester Medical Center, USA

Alena Shkumatava, Institut Curie-Centre de Recherche, France
LncRNA in Vertebrate Development

Upasna Sharma, University of California, Santa Cruz, USA
Intergenerational Epigenetic Inheritance by Sperm Small RNAs

Tamer Sallam, University of California, Los Angeles, USA
LncRNA in Cardiometabolic Disease

Sathya Puthanveettil, The Scripps Research Institute, USA
Short Talk: Activity Dependent Synaptic Targeting of Intronic lncRNA for Long-Term Memory Storage

Daniel Kim, University of California, Santa Cruz, USA
Short Talk: Noncoding RNA Landscape of Mutant KRAS-Driven Cellular Transformation

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacDonald DEF
19:30—22:00
Poster Session 1

MacDonald DEF

TUESDAY, JANUARY 14

07:00—08:00
Breakfast

MacDonald DEF
08:00—11:15
LncRNA Mechanisms

MacDonald ABC
* Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA

Howard Y. Chang, Stanford University, USA
Genome Regulation by Long Noncoding RNAs

Susan B. Carpenter, University of California, Santa Cruz, USA
Characterization of the Conserved lncRNA, GAPLINC, and Its Role in Endotoxic Shock

Coffee Break

Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
Regulation and Function of Mammalian Noncoding RNAs

John L. Rinn, University of Colorado Boulder, USA
Differential Contribution of Steady-State RNA and Active Transcription in Chromatin Organization

Nadya Dimitrova, Yale University, USA
Short Talk: Investigation of the Mechanisms of lncRNAs in Tumorigenesis

Adam Schmitt, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Cancers Escape Tumor Suppression through Loss of the Long Noncoding RNA Dino

Prasanth V. Kannanganattu, University of Illinois, USA
Short Talk: A Family of Nucleolus-Enriched ncRNAs Regulate rDNA Expression by Coating the NOR-Containing Autosomes in a Monoallelic Fashion

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

MacDonald DEF
13:00—22:00
Poster Viewing

MacDonald DEF
15:00—16:30
Workshop

MacDonald ABC
* Robert Spitale, University of California, Irvine, USA

Chen Davidovich, Monash University, Australia
RNA Mediates Context-Specific Regulation of Gene Repression through Interactions with the Regulatory Centre of the Histone Methyltransferase PRC2

Simon A. Hardwick, Weill Cornell Medicine, USA
High Resolution Analysis of Long Non-Coding RNA Isoforms in Mouse Cortex

Tim Vierbuchen, University of Massachusetts Medical School, USA
Regulation of Type I Interferon Responses in Human Phagocytes by the Long Non-Coding RNAs LUCAT1 and lncRNA-CMPK2

Ryan Alexander Flynn, Stanford University, USA
Mammalian Small RNAs Are Modified at Discrete Guanosine Residues with N-Glycans

Tasha Alease Morrison, National Institutes of Health, USA
Identification of a Long Noncoding RNA within an NK-Specific Super-Enhancer Uncovers Critical Role Ugcg Plays in NK Cells

Christiane Olivero, Yale University, USA
p53 Activates the lncRNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:15
RNA Structure and Function

MacDonald ABC
* Christine Mayr, Memorial Sloan Kettering Cancer Center, USA

Yue Wan, Genome Institute of Singapore, Singapore
Studying RNA Structures Using Direct RNA Sequencing on Nanopores

Karissa Y. Sanbonmatsu, Los Alamos National Laboratory, USA
Zinc-Finger Protein CNBP Alters the 3-D Structure of lncRNA Braveheart in Solution

Robert Spitale, University of California, Irvine, USA
Emergent Chemical Methods for Probing RNA Structure Inside Living Cells

Allison Marly Porman, University of Colorado Anschutz Medical Campus, USA
Short Talk: N6-Methyladenosine and YTHDC1 Regulate Long Noncoding RNA HOTAIR Function in Breast Cancer

Hala Abou Assi, Duke University, USA
Short Talk: Investigating the Impact of Epitranscriptomic Modifications on RNA Structural Dynamics

Chase Weidmann, University of North Carolina at Chapel Hill, USA
Short Talk: RNP-MaP: RNA-Protein Interaction Networks in Living Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacDonald DEF
19:30—22:00
Poster Session 2

MacDonald DEF

WEDNESDAY, JANUARY 15

07:00—08:00
Breakfast

MacDonald DEF
08:00—11:00
RNA Technologies

MacDonald ABC
* Sara R. Cherry, University of Pennsylvania, USA

Gene W. Yeo, University of California, San Diego, USA
RNP Discovery and Manipulation

J. Mauro Calabrese, University of North Carolina at Chapel Hill, USA
Studying lncRNAs through K-Mer Based Methods of Sequence Comparison

Coffee Break

Mitchell Guttman, California Institute of Technology, USA
A Widespread Role for RNA in Demarcating Distinct 3D Spatial Territories within the Nucleus

Mitchell R. O'Connell, University of Rochester Medical Center, USA
Programmable RNA-Targeting by CRISPR-Cas Enzymes

Hyaeyeong Kim, Weill Cornell Medicine, USA
Short Talk: Chemogenetic Control of Phase Separations in Live Cells Templated by Small Molecule-Regulated RNA Dimerization

Kengo Sato, Keio University, Japan
Short Talk: A Max-Margin Training of RNA Secondary Structure Prediction Integrated with the Thermodynamic Model

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
Circular RNAs and RNA Modification

MacDonald ABC
* Nadya Dimitrova, Yale University, USA

Chuan He, University of Chicago, USA
RNA Methylation in Gene Expression Regulation

Dimitrios Papaioannou, Ohio State University, USA
Short Talk: CircPCMTD1: A Protein-Coding Circular RNA That Regulates DNA Synthesis in Leukemia

Rui Zhou, Johns Hopkins University School of Medicine, USA
Short Talk: Function and Regulation of the Circular RNA Edis in Innate Immunity and Neurodevelopment

Christopher Lee Holley, Duke University, USA
Short Talk: Modification of Messenger RNA by 2′-O-Methylation Regulates Gene Expression

Tristan R. Grams, University of Florida, USA
Short Talk: Targeting the Viral lncRNA LAT of Herpes Simplex Virus 1 Reduces Reactivation in vivo

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacDonald DEF

THURSDAY, JANUARY 16

07:00—08:00
Breakfast

MacDonald DEF
08:00—11:00
RNA Therapeutics

MacDonald ABC
* Frank Rigo, Ionis Pharmaceuticals, USA

Sven Diederichs, University of Freiburg, Germany
RNA-Dependent Proteins and Non-Coding RNAs in Cancer

Sara R. Cherry, University of Pennsylvania, USA
Defining the Landscape of Antiviral Long Noncoding RNAs

Coffee Break

Scott A. Ribich, Accent Therapeutics, USA
The RNA Editor ADAR1 is a Therapeutic Target in Cancers with Intrinsic Elevated Type I Interferon Signaling

James Barsoum, Arrakis Therapeutics, USA
Targeting RNA Structures with Drug-Like Small Molecules

Timothy Bredy, University of Queensland, Australia
Short Talk: RNA Modifications and Experience-Dependent Plasticity

Chun-Kan Chen, Stanford University School of Medicine, USA
Short Talk: Structured Elements Drive Circular RNA Translation and Expand the Human Proteome

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—18:45
Regulatory RNA in Development

MacDonald ABC
* Alena Shkumatava, Institut Curie-Centre de Recherche, France

Christine Mayr, Memorial Sloan Kettering Cancer Center, USA
Enhancer-Mediated Control of 3′UTR Ratios Regulates PTEN Phosphatase Activity

Jason Shepherd, University of Utah, USA
Virus-Like Intercellular RNA Transfer in the Nervous System

Kevin G. Nyberg, Northwestern University, USA
Short Talk: Investigation of the Role of a Pair of Divergent lncRNAs in Drosophila Eggshell Development

Haruna Yamashiro, University of Tokyo, Japan
Short Talk: Molecular Mechanism underlying Inter-Organelle Translocation of piRNA Precursor

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions

MacDonald ABC
Frank Rigo, Ionis Pharmaceuticals, USA

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

MacDonald DEF
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

MacDonald DEF

FRIDAY, JANUARY 17

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Ionis Pharmaceuticals, Inc. Moderna

We gratefully acknowledge additional support from these exhibitors at this conference:

Eclipse Bioinnovations, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge additional support for this conference from:

Zymo Research Corporation Arraystar Inc.

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



Accent Therapeutics


Arrakis Therapeutics


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179