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This meeting took place in 2019



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Helminths: New Insights from Immunity to Global Health (T4)


Organizer(s) De' Broski Herbert, P'ng Loke, Nicola L. Harris and Frank Brombacher
December 8—12, 2019
Southern Sun Cape Sun • Cape Town, Western Cape South Africa
Discounted Abstract Deadline: Aug 8, 2019
Abstract Deadline: Sep 24, 2019
Scholarship Deadline: Aug 8, 2019
Discounted Registration Deadline: Oct 10, 2019

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Parasitic worms, or helminths, infect roughly one in five people on the planet and cause pathology in hundreds of millions. Given the global impact on human health and welfare, there is a great need to develop novel therapies and/or vaccines that target helminths. In addition, the unique nature of how these parasites interact with their hosts has brought tremendous insight into the mammalian immune system. Experimental studies of helminth infection have led to the identification of new cell types involved in type 2 immunity, including innate lymphoid cells, tuft cells, and new roles for neurons, in addition to revealing novel pathways of tissue repair and immune-modulation. The interactions of helminths with the microbiome has also come to light in recent years. This conference will highlight some of the most impactful advances in the fields of helminth genomics, helminth biology, vaccine design and host protective immunity, in addition to new discoveries highlighting the ability of these organisms to modulate the immune system, human disease and the microbiome.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, December 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 12 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 13 in order to fully experience the meeting.

SUNDAY, DECEMBER 8

16:00—20:00
Arrival and Registration

3rd Floor Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby

MONDAY, DECEMBER 9

08:30—09:30
Welcome and Keynote Address

VOC
* De' Broski R. Herbert, University of Pennsylvania, USA

David Artis, Cornell University, USA
Regulation of Type 2 Immunity at Barrier Surfaces

09:30—12:00
Epithelial Cells and ILC2s in Helminth Infection

VOC
* Nicola L. Harris, Monash University, Australia

* Wiliam Horsnell, University of Cape Town, South Africa

Amy H. Buck, University of Edinburgh, UK
RNA Communication in the Gut: New Mechanisms of Host Modulation by Helminths

Coffee Break

Menno J. Oudhoff, Norwegian University of Science and Technology, Norway
Short Talk: AI-Based Organoid Image Analysis Combined with Cell Compositional and Transcriptome Analysis to Define Type II Epithelial Responses

Jakob H. von Moltke, University of Washington, USA
Small Intestinal Tuft Cells: Sentinels and Effectors of Type 2 Immunity

David Voehringer, University Hospital of Erlangen, Germany
Short Talk: Control of Intestinal Helminth Infections by Epithelial Cells and Alternatively Activated Macrophages

De' Broski R. Herbert, University of Pennsylvania, USA
LINGO Proteins Control Helminth Immunity at the Mucosal Interface

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

VOC
13:00—22:00
Poster Viewing

VOC
14:30—16:30
Workshop 1

VOC
* Jakob H. von Moltke, University of Washington, USA

* Sara Lustigman, New York Blood Center, USA

Pedro Gazzinelli-Guimaraes, NIAID, National Institutes of Health, USA
IL-5 Producing CD4 Th2 Cells and IL-13/IL-13Ra1 Signaling Axis Driven by Pulmonary Allergic Inflammation Promote an Eosinophil-Dependent Arrest on Helminth Larval Development in the Lungs

Nada Abdel Aziz, Cairo University, Egypt
IL-4Rα Signaling on Foxp3+ Regulatory T Cells in Controlling Helminth-Induced Tissue Damage

Paballo Pertunia Mosala, University of Cape Town, South Africa
Cysteinyl Leukotriene Receptor-1 Mediates Worm Expulsion Following Nippostrongylus Brasiliensis Infection in Mice

Jacqueline Araujo Fiuza, René Rachou Institute, Brazil
The Role of Microbial Translocation in the Pathogenesis of S. Mansoni Associated Morbidity

Aldian Irma Amaruddin, Leiden University Medical Center, Netherlands
Helminth Infection and the Gut Microbiome in High and Low Socioeconomic School Children in Urban Area in Makassar, Indonesia

Thabo RV Mpotje, University of Cape Town, South Africa
Intestinal Microbiota Drives Host Susceptibility to Chronic Schistosoma Mansoni Infection in Murine Models

Murilo Sena Amaral, Instituto Butantan, Brazil
Integrative Phenotypic, Transcriptomic and Epigenetic Analysis of the Effects of a Selective Inhibitor of Histone Deacetylase 8 on the Parasite Schistosoma mansoni

16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Maternal and Microbial Regulation of Helminth Infection

VOC
* Richard M. Maizels, University of Glasgow, UK

* Elia Tait Wojno, University of Washington, USA

Richard K. Grencis, University of Manchester, UK
Microbiota, Whipworm Infection and Immune Regulation

Wiliam Horsnell, University of Cape Town, South Africa
Short Talk: Pre-Conception Maternal Helminth Infection Transfers via Nursing Long Lasting Cellular Immunity against Helminths to Offspring

Ken H. Cadwell, New York University School of Medicine, USA
Mechanisms of Helminth-Microbiota Interactions

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Helminth Infection Interactions with the Human Immune System Studied through Deworming or Controlled Human Infection

Hermelijn H. Smits, Leiden University Center, Netherlands
Short Talk: Alterations in Microbiome Composition and Intestinal Permeability during Chronic Murine Schistosomiasis: Consequences for Immune Polarisation?

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 1

VOC

TUESDAY, DECEMBER 10

08:30—11:30
Helminth Biology and Genetics

VOC
* Philip T. LoVerde, University of Texas Health Science Center, USA

* Coralie Martin, Natural History Museum, France

James Collins, University of Texas Southwestern Medical Center, USA
Sex, Drugs, and Snails: Molecular Studies of Schistosome Biology

Tim J.C. Anderson, Texas Biomedical Research Institute, USA
Genetic Analysis of Adaptive Traits in a Surprisingly Tractable Human Parasite

Coffee Break

Dror Avni, Sheba Medical Center, Israel
Short Talk: Schistosomes Extracellular Vesicles miRNAs: Modulators of Host T Helper (CD+) Cell Differentiation

Makedonka Mitreva, Washington University School of Medicine, USA
Applied Multi-Omics: Identifying Inhibitors that Target the Parasitic Nematodes Intestine

Bonnie Douglas, University of Pennsylvania, USA
Using a Transgenic 2W1S-Expressing Gastrointestinal (GI) Nematode to Evaluate Antigen-Specific CD4+ T Cell Function during Helminth Infection

11:30—17:00
On Own for Lunch

11:45—13:00
Poster Setup

VOC
13:00—22:00
Poster Viewing

VOC
16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Epidemiology and Ecology of Helminth Infections

VOC
* Jennifer Keiser, Swiss Tropical and Public Health Institute, Switzerland

* Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa

Andrea L. Graham, Princeton University, USA
Ecological Determinants of Helminth Susceptibility and the Duration of Infection

Philip J. Cooper, St George's, University of London, UK
Epidemiology of Soil Transmitted Helminth Infections

Taryn A. McLaughlin, Emory University, USA
Short Talk: Adults from Kisumu, Kenya Have Robust γδ T Cell Responses to Schistosoma Mansoni Adult Worms Which Are Modulated by Tuberculosis

Benjamin Dewals, University of Liege - FNRS, Belgium
Short Talk: Helminth Infection Is Associated with the Accumulation of Lung Interstitial Macrophages and Increased Susceptibility to Gammaherpesvirus Infection in C57BL/6 Mice

Pritesh Desai, Washington University St. Louis, USA
Short Talk: Coinfection with Enteric Helminths and Neurotropic Flaviviruses Alters Gastrointestinal Tract Functions, Impairs CD8 T Cell Responses, and Results in Lethal Disease

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 2

VOC

WEDNESDAY, DECEMBER 11

08:30—09:30
Keynote Address

VOC
* P'ng Loke, New York University School of Medicine, USA

Judith E. Allen, University of Manchester, UK
Tissue Repair and Macrophage Activation

09:30—12:00
Myeloid Cells in Helminth Infection

VOC
* David Voehringer, University Hospital of Erlangen, Germany

* Richard K. Grencis, University of Manchester, UK

William C. Gause, Rutgers New Jersey Medical School, USA
Myeloid Cell Polarization and Function in Helminth-Induced Type 2 Responses

Coffee Break

Elia Tait Wojno, University of Washington, USA
Notch Signaling Controls a Basophil-Th2 Cell Interplay during Helminth Infection

P'ng Loke, New York University School of Medicine, USA
Alternatively Activated Macrophages of Tissue or Monocyte Origin

Bart Everts, Leiden University Medical Center, Netherlands
Short Talk: Unique Metabolic Requirements for Dendritic Cell-Driven T Helper 2 Polarization

Mark C. Siracusa, Rutgers New Jersey Medical School, USA
Short Talk: Host-Protective Responses to Helminth Parasites Are Supported by Dual Mast Cell/Erythrocyte Progenitors

12:00—17:00
On Own for Lunch

12:00—13:00
Poster Setup

VOC
13:00—22:00
Poster Viewing

VOC
16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Helminth Control: Drug Development

VOC
* Makedonka Mitreva, Washington University School of Medicine, USA

* Peter Nejsum, Aarhus University, Denmark, Denmark

Philip T. LoVerde, University of Texas Health Science Center, USA
Novel Strategies for Drug Development

Justin Nono Komguep, Medical Research Centre, Institute of Medical Research and Medicinal Plant Studies, IMPM, Cameroon
Short Talk: Controlling Schistosomiasis: Appraisal of the Scope of Action of Praziquantel, the Only Available WHO-Approved Drug

Severin Donald Kamdem, University of Cape Town, South Africa
Short Talk: Host Genetics Primarily Regulates Liver Fibrosis in Children from Schistosomiasis Endemic Areas in Rural Cameroon

Jennifer Keiser, Swiss Tropical and Public Health Institute, Switzerland
Improved Treatments for Soil-Transmitted Helminthiases

Sabine Specht, Drugs for Neglected Diseases, DNDi, Switzerland
Short Talk: Development of Alternative Treatments against Filarial Diseases

Sitara Swarna Rao Ajjampur, Christian Medical College, India
Short Talk: DeWorm3: Results from the Baseline Survey for Soil-Transmitted Helminths

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
19:30—22:00
Poster Session 3

VOC

THURSDAY, DECEMBER 12

08:30—09:30
Keynote Address

VOC
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands

Richard M. Maizels, University of Glasgow, UK
Helminth Derived Modulators of Host Immunity

09:30—11:45
Helminth Control: Vaccine Development

VOC
* Alex Loukas, James Cook University, Australia

* Andrea L. Graham, Princeton University, USA

Thomas B. Nutman, NIAID, National Institutes of Health, USA
Resistance Against Human Helminth Infection

Coffee Break

Yoanne Darelle Mouwenda, Leiden University Medical Center, Netherlands
Short Talk: Identification of Immune Network Involved in Helminths Infection and Its Effects on Vaccine Development

Sara Lustigman, New York Blood Center, USA
Onchocerca Volvulus Products that Stimulate Immunity

Maria Elena Bottazzi, Baylor College of Medicine, USA
The Road from Basic Biology to Vaccines against Neglected Tropical Diseases: Development and Testing of Anthelminthic Vaccines

11:45—17:00
On Own for Lunch

14:30—16:30
Workshop 2

VOC
* Mark C. Siracusa, Rutgers New Jersey Medical School, USA

* Hermelijn H. Smits, Leiden University Center, Netherlands

Adefunke Esther Ogunkanbi, University of Manchester, UK
Immune-Modulatory Strategies by Mouse Whipworm, Trichuris muris

Norman Nausch, University Hospital Duesseldorf, Germany
The Effects of Mansonella Perstans Infection on Anti-Mycobacterial Immune Responses

Robert Blomgran, Linköping University, Sweden
Beneficial Effects of Helminth Antigen Exposure for the Control of Mycobacterium Tuberculosis Infection in Monocytes and Macrophages, Contrasting the Effect of Chronic Helminth Infection

Cecilia Casaravilla, Universidad de la República, Uruguay
Induction of Regulatory Markers in Macrophages during Chronic Infection by Larval Echinococcus Granulosus Can Be Mimicked by Injection of Particles from the Acellular Larval Coat

Tiffany Bouchery, Monash University AMREP Campus, Australia
The Lipoxygenase Alox 12/15 Regulates Macrophage Function after Type 2 Polarization in an Arginase-1 Independent Manner

Juan M. Inclan Rico, Rutgers New Jersey Medical School, USA
Basophils Regulate Innate Lymphoid Cell Responses by Modulating Neuropeptide Receptor Expression

Shuchi Smita, Institute of Life Sciences, India
Adoptive Transfer of ZEB1 Depleted cDC1 Dendritic Cells Clears Helminth Infection In Mice by Enhancing Th2 Responses

16:30—17:00
Coffee Available

3rd Floor Lobby
17:00—19:00
Helminth Modulation of Host Immunity

VOC
* William C. Gause, Rutgers New Jersey Medical School, USA

* Judith E. Allen, University of Manchester, UK

Alex Loukas, James Cook University, Australia
The Hookworm Pharmacopoeia for Inflammatory Diseases

Nicola L. Harris, Monash University, Australia
How Hookworm Escapes Innate Immunity

Richard Edwin Sanya, MRC/UVRI and LSHTM Uganda Research Unit, Uganda
Short Talk: Effect of Helminth Infection and Its Treatment on Metabolic Outcomes: Results of a Cluster-Randomised Trial

Frank Brombacher, International Center for Genetic Engineering and Biotechnology, South Africa
Cysteine Leukotrienes Drive Granulomatous Pathology around Trapped Parasite Eggs during Chronic Schistosomiasis

Katie Smith, Cardiff Institute of Infection and Immunity, UK
Short Talk: Helminth Modulation of Fatty Acid Metabolite Production Promotes Colitis-Associated Colorectal Cancer

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

VOC
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

3rd Floor Lobby
20:00—21:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

VOC South

FRIDAY, DECEMBER 13

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor for generously supporting this meeting:

Bill & Melinda Gates Foundation

We gratefully acknowledge additional support from these exhibitors at this conference:

CTL Europe GmbH inqaba biotec
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health
National Center for Advancing Translational Sciences (NCATS)

Grant No. 1R13AI147679-01

Funding for this conference was made possible (in part) by 1R13AI147679-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This award is co-funded by National Center for Advancing Translational Sciences (NCATS) and the National Institute of Allergy and Infectious Diseases.


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