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This meeting took place in 2019
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Helminths: New Insights from Immunity to Global Health (T4)
Organizer(s) De' Broski Herbert, P'ng Loke, Nicola L. Harris and Frank Brombacher
December 8—12, 2019
Southern Sun Cape Sun • Cape Town, Western Cape South Africa
Discounted Abstract Deadline: Aug 8, 2019
Abstract Deadline: Sep 24, 2019
Scholarship Deadline: Aug 8, 2019
Discounted Registration Deadline: Oct 10, 2019
Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation
Summary of Meeting:
Parasitic worms, or helminths, infect roughly one in five people on the planet and cause pathology in hundreds of millions. Given the global impact on human health and welfare, there is a great need to develop novel therapies and/or vaccines that target helminths. In addition, the unique nature of how these parasites interact with their hosts has brought tremendous insight into the mammalian immune system. Experimental studies of helminth infection have led to the identification of new cell types involved in type 2 immunity, including innate lymphoid cells, tuft cells, and new roles for neurons, in addition to revealing novel pathways of tissue repair and immune-modulation. The interactions of helminths with the microbiome has also come to light in recent years. This conference will highlight some of the most impactful advances in the fields of helminth genomics, helminth biology, vaccine design and host protective immunity, in addition to new discoveries highlighting the ability of these organisms to modulate the immune system, human disease and the microbiome.
View Scholarships/Awards
Parasitic worms, or helminths, infect roughly one in five people on the planet and cause pathology in hundreds of millions. Given the global impact on human health and welfare, there is a great need to develop novel therapies and/or vaccines that target helminths. In addition, the unique nature of how these parasites interact with their hosts has brought tremendous insight into the mammalian immune system. Experimental studies of helminth infection have led to the identification of new cell types involved in type 2 immunity, including innate lymphoid cells, tuft cells, and new roles for neurons, in addition to revealing novel pathways of tissue repair and immune-modulation. The interactions of helminths with the microbiome has also come to light in recent years. This conference will highlight some of the most impactful advances in the fields of helminth genomics, helminth biology, vaccine design and host protective immunity, in addition to new discoveries highlighting the ability of these organisms to modulate the immune system, human disease and the microbiome.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, December 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 12 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 13 in order to fully experience the meeting.
SUNDAY, DECEMBER 8
MONDAY, DECEMBER 9
TUESDAY, DECEMBER 10
WEDNESDAY, DECEMBER 11
THURSDAY, DECEMBER 12
FRIDAY, DECEMBER 13
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, December 8 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, December 12 with a closing plenary session from 17:00 to 19:15, followed by a social hour and entertainment. We recommend return travel on Friday, December 13 in order to fully experience the meeting.
SUNDAY, DECEMBER 8
16:00—20:00
Arrival and Registration
3rd Floor Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
3rd Floor Lobby
08:30—09:30
Welcome and Keynote Address
VOC
*
De' Broski R. Herbert,
University of Pennsylvania, USA
Session Chair
Session Chair
09:30—12:00
Epithelial Cells and ILC2s in Helminth Infection
VOC
*
Nicola L. Harris,
Monash University, Australia
Session Chair
Session Chair
*
Wiliam Horsnell,
University of Cape Town, South Africa
Session Chair
Session Chair
Amy H. Buck,
University of Edinburgh, UK
RNA Communication in the Gut: New Mechanisms of Host Modulation by Helminths
RNA Communication in the Gut: New Mechanisms of Host Modulation by Helminths
Coffee Break
Menno J. Oudhoff,
Norwegian University of Science and Technology, Norway
Short Talk: AI-Based Organoid Image Analysis Combined with Cell Compositional and Transcriptome Analysis to Define Type II Epithelial Responses
Short Talk: AI-Based Organoid Image Analysis Combined with Cell Compositional and Transcriptome Analysis to Define Type II Epithelial Responses
Jakob H. von Moltke,
University of Washington, USA
Small Intestinal Tuft Cells: Sentinels and Effectors of Type 2 Immunity
Small Intestinal Tuft Cells: Sentinels and Effectors of Type 2 Immunity
David Voehringer,
University Hospital of Erlangen, Germany
Short Talk: Control of Intestinal Helminth Infections by Epithelial Cells and Alternatively Activated Macrophages
Short Talk: Control of Intestinal Helminth Infections by Epithelial Cells and Alternatively Activated Macrophages
De' Broski R. Herbert,
University of Pennsylvania, USA
LINGO Proteins Control Helminth Immunity at the Mucosal Interface
LINGO Proteins Control Helminth Immunity at the Mucosal Interface
12:00—17:00
On Own for Lunch
12:00—13:00
Poster Setup
VOC
13:00—22:00
Poster Viewing
VOC
14:30—16:30
Workshop 1
VOC
*
Jakob H. von Moltke,
University of Washington, USA
Session Chair
Session Chair
*
Sara Lustigman,
New York Blood Center, USA
Session Chair
Session Chair
Pedro Gazzinelli-Guimaraes,
NIAID, National Institutes of Health, USA
IL-5 Producing CD4 Th2 Cells and IL-13/IL-13Ra1 Signaling Axis Driven by Pulmonary Allergic Inflammation Promote an Eosinophil-Dependent Arrest on Helminth Larval Development in the Lungs
IL-5 Producing CD4 Th2 Cells and IL-13/IL-13Ra1 Signaling Axis Driven by Pulmonary Allergic Inflammation Promote an Eosinophil-Dependent Arrest on Helminth Larval Development in the Lungs
Nada Abdel Aziz,
Cairo University, Egypt
IL-4Rα Signaling on Foxp3+ Regulatory T Cells in Controlling Helminth-Induced Tissue Damage
IL-4Rα Signaling on Foxp3+ Regulatory T Cells in Controlling Helminth-Induced Tissue Damage
Paballo Pertunia Mosala,
University of Cape Town, South Africa
Cysteinyl Leukotriene Receptor-1 Mediates Worm Expulsion Following Nippostrongylus Brasiliensis Infection in Mice
Cysteinyl Leukotriene Receptor-1 Mediates Worm Expulsion Following Nippostrongylus Brasiliensis Infection in Mice
Jacqueline Araujo Fiuza,
René Rachou Institute, Brazil
The Role of Microbial Translocation in the Pathogenesis of S. Mansoni Associated Morbidity
The Role of Microbial Translocation in the Pathogenesis of S. Mansoni Associated Morbidity
Aldian Irma Amaruddin,
Leiden University Medical Center, Netherlands
Helminth Infection and the Gut Microbiome in High and Low Socioeconomic School Children in Urban Area in Makassar, Indonesia
Helminth Infection and the Gut Microbiome in High and Low Socioeconomic School Children in Urban Area in Makassar, Indonesia
Thabo RV Mpotje,
University of Cape Town, South Africa
Intestinal Microbiota Drives Host Susceptibility to Chronic Schistosoma Mansoni Infection in Murine Models
Intestinal Microbiota Drives Host Susceptibility to Chronic Schistosoma Mansoni Infection in Murine Models
Murilo Sena Amaral,
Instituto Butantan, Brazil
Integrative Phenotypic, Transcriptomic and Epigenetic Analysis of the Effects of a Selective Inhibitor of Histone Deacetylase 8 on the Parasite Schistosoma mansoni
Integrative Phenotypic, Transcriptomic and Epigenetic Analysis of the Effects of a Selective Inhibitor of Histone Deacetylase 8 on the Parasite Schistosoma mansoni
16:30—17:00
Coffee Available
3rd Floor Lobby
17:00—19:00
Maternal and Microbial Regulation of Helminth Infection
VOC
*
Richard M. Maizels,
University of Glasgow, UK
Session Chair
Session Chair
*
Elia Tait Wojno,
University of Washington, USA
Session Chair
Session Chair
Richard K. Grencis,
University of Manchester, UK
Microbiota, Whipworm Infection and Immune Regulation
Microbiota, Whipworm Infection and Immune Regulation
Wiliam Horsnell,
University of Cape Town, South Africa
Short Talk: Pre-Conception Maternal Helminth Infection Transfers via Nursing Long Lasting Cellular Immunity against Helminths to Offspring
Short Talk: Pre-Conception Maternal Helminth Infection Transfers via Nursing Long Lasting Cellular Immunity against Helminths to Offspring
Ken H. Cadwell,
New York University School of Medicine, USA
Mechanisms of Helminth-Microbiota Interactions
Mechanisms of Helminth-Microbiota Interactions
Maria Yazdanbakhsh,
Leiden University Medical Center, Netherlands
Helminth Infection Interactions with the Human Immune System Studied through Deworming or Controlled Human Infection
Helminth Infection Interactions with the Human Immune System Studied through Deworming or Controlled Human Infection
Hermelijn H. Smits,
Leiden University Center, Netherlands
Short Talk: Alterations in Microbiome Composition and Intestinal Permeability during Chronic Murine Schistosomiasis: Consequences for Immune Polarisation?
Short Talk: Alterations in Microbiome Composition and Intestinal Permeability during Chronic Murine Schistosomiasis: Consequences for Immune Polarisation?
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
3rd Floor Lobby
19:30—22:00
Poster Session 1
VOC
08:30—11:30
Helminth Biology and Genetics
VOC
*
Philip T. LoVerde,
University of Texas Health Science Center, USA
Session Chair
Session Chair
*
Coralie Martin,
Natural History Museum, France
Session Chair
Session Chair
James Collins,
University of Texas Southwestern Medical Center, USA
Sex, Drugs, and Snails: Molecular Studies of Schistosome Biology
Sex, Drugs, and Snails: Molecular Studies of Schistosome Biology
Tim J.C. Anderson,
Texas Biomedical Research Institute, USA
Genetic Analysis of Adaptive Traits in a Surprisingly Tractable Human Parasite
Genetic Analysis of Adaptive Traits in a Surprisingly Tractable Human Parasite
Coffee Break
Dror Avni,
Sheba Medical Center, Israel
Short Talk: Schistosomes Extracellular Vesicles miRNAs: Modulators of Host T Helper (CD+) Cell Differentiation
Short Talk: Schistosomes Extracellular Vesicles miRNAs: Modulators of Host T Helper (CD+) Cell Differentiation
Makedonka Mitreva,
Washington University School of Medicine, USA
Applied Multi-Omics: Identifying Inhibitors that Target the Parasitic Nematodes Intestine
Applied Multi-Omics: Identifying Inhibitors that Target the Parasitic Nematodes Intestine
Bonnie Douglas,
University of Pennsylvania, USA
Using a Transgenic 2W1S-Expressing Gastrointestinal (GI) Nematode to Evaluate Antigen-Specific CD4+ T Cell Function during Helminth Infection
Using a Transgenic 2W1S-Expressing Gastrointestinal (GI) Nematode to Evaluate Antigen-Specific CD4+ T Cell Function during Helminth Infection
11:30—17:00
On Own for Lunch
11:45—13:00
Poster Setup
VOC
13:00—22:00
Poster Viewing
VOC
16:30—17:00
Coffee Available
3rd Floor Lobby
17:00—19:00
Epidemiology and Ecology of Helminth Infections
VOC
*
Jennifer Keiser,
Swiss Tropical and Public Health Institute, Switzerland
Session Chair
Session Chair
*
Frank Brombacher,
International Center for Genetic Engineering and Biotechnology, South Africa
Session Chair
Session Chair
Andrea L. Graham,
Princeton University, USA
Ecological Determinants of Helminth Susceptibility and the Duration of Infection
Ecological Determinants of Helminth Susceptibility and the Duration of Infection
Philip J. Cooper,
St George's, University of London, UK
Epidemiology of Soil Transmitted Helminth Infections
Epidemiology of Soil Transmitted Helminth Infections
Taryn A. McLaughlin,
Emory University, USA
Short Talk: Adults from Kisumu, Kenya Have Robust γδ T Cell Responses to Schistosoma Mansoni Adult Worms Which Are Modulated by Tuberculosis
Short Talk: Adults from Kisumu, Kenya Have Robust γδ T Cell Responses to Schistosoma Mansoni Adult Worms Which Are Modulated by Tuberculosis
Benjamin Dewals,
University of Liege - FNRS, Belgium
Short Talk: Helminth Infection Is Associated with the Accumulation of Lung Interstitial Macrophages and Increased Susceptibility to Gammaherpesvirus Infection in C57BL/6 Mice
Short Talk: Helminth Infection Is Associated with the Accumulation of Lung Interstitial Macrophages and Increased Susceptibility to Gammaherpesvirus Infection in C57BL/6 Mice
Pritesh Desai,
Washington University, USA
Short Talk: Coinfection with Enteric Helminths and Neurotropic Flaviviruses Alters Gastrointestinal Tract Functions, Impairs CD8 T Cell Responses, and Results in Lethal Disease
Short Talk: Coinfection with Enteric Helminths and Neurotropic Flaviviruses Alters Gastrointestinal Tract Functions, Impairs CD8 T Cell Responses, and Results in Lethal Disease
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
3rd Floor Lobby
19:30—22:00
Poster Session 2
VOC
08:30—09:30
Keynote Address
VOC
*
P'ng Loke,
New York University School of Medicine, USA
Session Chair
Session Chair
Judith E. Allen,
University of Manchester, UK
Tissue Repair and Macrophage Activation
Tissue Repair and Macrophage Activation
09:30—12:00
Myeloid Cells in Helminth Infection
VOC
*
David Voehringer,
University Hospital of Erlangen, Germany
Session Chair
Session Chair
*
Richard K. Grencis,
University of Manchester, UK
Session Chair
Session Chair
William C. Gause,
Rutgers New Jersey Medical School, USA
Myeloid Cell Polarization and Function in Helminth-Induced Type 2 Responses
Myeloid Cell Polarization and Function in Helminth-Induced Type 2 Responses
Coffee Break
Elia Tait Wojno,
University of Washington, USA
Notch Signaling Controls a Basophil-Th2 Cell Interplay during Helminth Infection
Notch Signaling Controls a Basophil-Th2 Cell Interplay during Helminth Infection
P'ng Loke,
New York University School of Medicine, USA
Alternatively Activated Macrophages of Tissue or Monocyte Origin
Alternatively Activated Macrophages of Tissue or Monocyte Origin
Bart Everts,
Leiden University Medical Center, Netherlands
Short Talk: Unique Metabolic Requirements for Dendritic Cell-Driven T Helper 2 Polarization
Short Talk: Unique Metabolic Requirements for Dendritic Cell-Driven T Helper 2 Polarization
Mark C. Siracusa,
Rutgers New Jersey Medical School, USA
Short Talk: Host-Protective Responses to Helminth Parasites Are Supported by Dual Mast Cell/Erythrocyte Progenitors
Short Talk: Host-Protective Responses to Helminth Parasites Are Supported by Dual Mast Cell/Erythrocyte Progenitors
12:00—17:00
On Own for Lunch
12:00—13:00
Poster Setup
VOC
13:00—22:00
Poster Viewing
VOC
16:30—17:00
Coffee Available
3rd Floor Lobby
17:00—19:00
Helminth Control: Drug Development
VOC
*
Makedonka Mitreva,
Washington University School of Medicine, USA
Session Chair
Session Chair
*
Peter Nejsum,
Aarhus University, Denmark
Session Chair
Session Chair
Philip T. LoVerde,
University of Texas Health Science Center, USA
Novel Strategies for Drug Development
Novel Strategies for Drug Development
Justin Nono Komguep,
Institute of Medical Research and Medicinal Plant Studies, IMPM, Cameroon
Short Talk: Controlling Schistosomiasis: Appraisal of the Scope of Action of Praziquantel, the Only Available WHO-Approved Drug
Short Talk: Controlling Schistosomiasis: Appraisal of the Scope of Action of Praziquantel, the Only Available WHO-Approved Drug
Severin Donald Kamdem,
University of Utah, USA
Short Talk: Host Genetics Primarily Regulates Liver Fibrosis in Children from Schistosomiasis Endemic Areas in Rural Cameroon
Short Talk: Host Genetics Primarily Regulates Liver Fibrosis in Children from Schistosomiasis Endemic Areas in Rural Cameroon
Jennifer Keiser,
Swiss Tropical and Public Health Institute, Switzerland
Improved Treatments for Soil-Transmitted Helminthiases
Improved Treatments for Soil-Transmitted Helminthiases
Sabine Specht,
Drugs for Neglected Diseases, DNDi, Switzerland
Short Talk: Development of Alternative Treatments against Filarial Diseases
Short Talk: Development of Alternative Treatments against Filarial Diseases
Sitara Swarna Rao Ajjampur,
Christian Medical College, India
Short Talk: DeWorm3: Results from the Baseline Survey for Soil-Transmitted Helminths
Short Talk: DeWorm3: Results from the Baseline Survey for Soil-Transmitted Helminths
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
3rd Floor Lobby
19:30—22:00
Poster Session 3
VOC
08:30—09:30
Keynote Address
VOC
*
Maria Yazdanbakhsh,
Leiden University Medical Center, Netherlands
Session Chair
Session Chair
Richard M. Maizels,
University of Glasgow, UK
Helminth Derived Modulators of Host Immunity
Helminth Derived Modulators of Host Immunity
09:30—11:45
Helminth Control: Vaccine Development
VOC
*
Alex Loukas,
James Cook University, Australia
Session Chair
Session Chair
*
Andrea L. Graham,
Princeton University, USA
Session Chair
Session Chair
Thomas B. Nutman,
NIAID, National Institutes of Health, USA
Resistance Against Human Helminth Infection
Resistance Against Human Helminth Infection
Coffee Break
Yoanne Darelle Mouwenda,
Leiden University Medical Center, Netherlands
Short Talk: Identification of Immune Network Involved in Helminths Infection and Its Effects on Vaccine Development
Short Talk: Identification of Immune Network Involved in Helminths Infection and Its Effects on Vaccine Development
Sara Lustigman,
New York Blood Center, USA
Onchocerca Volvulus Products that Stimulate Immunity
Onchocerca Volvulus Products that Stimulate Immunity
Maria Elena Bottazzi,
Baylor College of Medicine, USA
The Road from Basic Biology to Vaccines against Neglected Tropical Diseases: Development and Testing of Anthelminthic Vaccines
The Road from Basic Biology to Vaccines against Neglected Tropical Diseases: Development and Testing of Anthelminthic Vaccines
11:45—17:00
On Own for Lunch
14:30—16:30
Workshop 2
VOC
*
Mark C. Siracusa,
Rutgers New Jersey Medical School, USA
Session Chair
Session Chair
*
Hermelijn H. Smits,
Leiden University Center, Netherlands
Session Chair
Session Chair
Adefunke Esther Ogunkanbi,
University of Manchester, UK
Immune-Modulatory Strategies by Mouse Whipworm, Trichuris muris
Immune-Modulatory Strategies by Mouse Whipworm, Trichuris muris
Norman Nausch,
University Hospital Duesseldorf, Germany
The Effects of Mansonella Perstans Infection on Anti-Mycobacterial Immune Responses
The Effects of Mansonella Perstans Infection on Anti-Mycobacterial Immune Responses
Robert Blomgran,
Linköping University, Sweden
Beneficial Effects of Helminth Antigen Exposure for the Control of Mycobacterium Tuberculosis Infection in Monocytes and Macrophages, Contrasting the Effect of Chronic Helminth Infection
Beneficial Effects of Helminth Antigen Exposure for the Control of Mycobacterium Tuberculosis Infection in Monocytes and Macrophages, Contrasting the Effect of Chronic Helminth Infection
Cecilia Casaravilla,
Universidad de la República, Uruguay
Induction of Regulatory Markers in Macrophages during Chronic Infection by Larval Echinococcus Granulosus Can Be Mimicked by Injection of Particles from the Acellular Larval Coat
Induction of Regulatory Markers in Macrophages during Chronic Infection by Larval Echinococcus Granulosus Can Be Mimicked by Injection of Particles from the Acellular Larval Coat
Tiffany Bouchery,
Monash University AMREP Campus, Australia
The Lipoxygenase Alox 12/15 Regulates Macrophage Function after Type 2 Polarization in an Arginase-1 Independent Manner
The Lipoxygenase Alox 12/15 Regulates Macrophage Function after Type 2 Polarization in an Arginase-1 Independent Manner
Juan M. Inclan Rico,
Rutgers New Jersey Medical School, USA
Basophils Regulate Innate Lymphoid Cell Responses by Modulating Neuropeptide Receptor Expression
Basophils Regulate Innate Lymphoid Cell Responses by Modulating Neuropeptide Receptor Expression
Shuchi Smita,
Institute of Life Sciences, India
Adoptive Transfer of ZEB1 Depleted cDC1 Dendritic Cells Clears Helminth Infection In Mice by Enhancing Th2 Responses
Adoptive Transfer of ZEB1 Depleted cDC1 Dendritic Cells Clears Helminth Infection In Mice by Enhancing Th2 Responses
16:30—17:00
Coffee Available
3rd Floor Lobby
17:00—19:00
Helminth Modulation of Host Immunity
VOC
*
William C. Gause,
Rutgers New Jersey Medical School, USA
Session Chair
Session Chair
*
Judith E. Allen,
University of Manchester, UK
Session Chair
Session Chair
Alex Loukas,
James Cook University, Australia
The Hookworm Pharmacopoeia for Inflammatory Diseases
The Hookworm Pharmacopoeia for Inflammatory Diseases
Richard Edwin Sanya,
MRC/UVRI and LSHTM Uganda Research Unit, Uganda
Short Talk: Effect of Helminth Infection and Its Treatment on Metabolic Outcomes: Results of a Cluster-Randomised Trial
Short Talk: Effect of Helminth Infection and Its Treatment on Metabolic Outcomes: Results of a Cluster-Randomised Trial
Frank Brombacher,
International Center for Genetic Engineering and Biotechnology, South Africa
Cysteine Leukotrienes Drive Granulomatous Pathology around Trapped Parasite Eggs during Chronic Schistosomiasis
Cysteine Leukotrienes Drive Granulomatous Pathology around Trapped Parasite Eggs during Chronic Schistosomiasis
Katie Smith,
Cardiff Institute of Infection and Immunity, UK
Short Talk: Helminth Modulation of Fatty Acid Metabolite Production Promotes Colitis-Associated Colorectal Cancer
Short Talk: Helminth Modulation of Fatty Acid Metabolite Production Promotes Colitis-Associated Colorectal Cancer
19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
VOC
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
3rd Floor Lobby
20:00—21:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.
VOC South
11:00—11:00
Departure
*Session Chair †Invited, not yet responded.
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