Keystone Symposia

Hilton Addis Ababa Floorplan

This meeting took place in 2019

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The Malaria Endgame: Innovation in Therapeutics, Vector Control and Public Health Tools (G1)

Organizer(s) Thierry Diagana, Philip Welkhoff and Flaminia Catteruccia
October 30—November 2, 2019
Hilton Addis Ababa • Addis Ababa, Ethiopia
Discounted Abstract Deadline: Jul 9, 2019
Abstract Deadline: Jul 30, 2019
Scholarship Deadline: Jul 9, 2019
Discounted Registration Deadline: Aug 29, 2019

Part of the Keystone Symposia Global Health Series, supported by the Bill & Melinda Gates Foundation

Summary of Meeting:
Malaria is most prevalent in the tropical belt and many malaria endemic countries have now engaged in elimination programs. However, we are facing a public health crisis because we have lost many of the public health tools that enabled the progress we have made to date. Many drugs are useless in most areas and resistance is threatening even artemisinin-based combination therapy (ACT). Diagnostics, bed-nets and insecticides are also losing their effectiveness and the Plasmodium vivax (P. vivax) parasite is finding new ways to transmit in Duffy negative patients. At the same time, there are multiple emerging threats such as artemisinin drug resistance, the rise of P. vivax malaria prevalence, and the discovery of the parasite Plasmodium knowlesi (P. knowlesi) in humans. However, there are some interesting developments such as deploying older suboptimal drugs in new, innovative and targeted control approaches like seasonal malaria chemoprevention (SMC) or intermittent preventive treatment of pregnant women/ infants (PTi/p). There are new drugs on the horizon that have pharmacological properties compatible with single dose cures and could prove to be powerful tools in the fight against malaria. For example, mass drug administration has demonstrated substantial impact as an intervention for Plasmodium elimination. By learning from recent successes in malaria elimination, epidemiological models of malaria transmission can be updated, and the impact of new interventions will critically inform the malaria endgame strategy. The conference is organized around three themes: defeating resistance (both to drugs and to insecticides), leveraging data science to better understand disease transmission and innovation in vector control strategies. This program will assess the current threats and gaps in our malaria armamentarium to enable malaria elimination and discuss the emerging innovative approaches for antimalarial drug discovery and development.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time

The meeting will begin on Wednesday, October 30 with registration from 10:00 to 20:00 and a welcome mixer from 18:00 to 19:45. Conference events conclude on Saturday, November 2 with a closing plenary session from 13:30 to 18:15, followed by a social hour. We recommend return travel on Sunday, November 3 in order to fully experience the meeting.


Arrival and Registration

Ballroom Foyer - Hilton Addis Ababa
Welcome Mixer

Ballroom Foyer - Hilton Addis Ababa
Joint Keynote Session with Grand Challenges
Where We Go Next: African Leadership for African Innovation

Welcome Remarks

Moussa Faki Mahamat, Chairperson, African Union Commission

Keynote Remarks
Tedros Adhanom Ghebreyesus, Director-General, World Health Organization
Keynote Remarks
Ethiopia Government Representative (TBC)
Keynote Remarks
Senegal Government Representative (TBC)
Keynote Remarks
Burkina Faso Government Representative (TBC)

Spotlight Talk
Segenet Kelemu, Director General & CEO, International Centre of Insect Physiology and Ecology

Conversation and Q&A: Gene Drive for Malaria Elimination
Moderator: Philip Welkhoff, Director, Malaria, Bill & Melinda Gates Foundation
Léonie Claudine Lougué, Minister of Health, Burkina Faso
Yaye Kène-Gassama Dia, Co-chair, African Union High Level Panel on Emerging Technologies
Jerome Singh, Head of Ethics and Law, CAPRISA, University of KwaZulu-Natal
Abdoulaye Diabaté, Research Lead, Target Malaria

Spotlight Talk
Faith Osier, Research Lead, KEMRI-Wellcome Trust Research Programme, Kenya

Closing Conversation
Moderator: Trevor Mundel, President, Global Health, Bill & Melinda Gates Foundation
Balram Bhargava, Director General, Indian Council of Medical Research (Invited)
Tedros Adhanom Ghebreyesus, Director-General, World Health Organization
Renu Swarup, Secretary, Department of Biotechnology Ministry of Science & Technology, India

Nelson Mandela Hall - African Union
Networking and Welcome Mixer with Grand Challenges

African Union


Poster Setup

Ballroom I&II
Poster Viewing

Ballroom I&II
Welcome and Keynote Address

Ballroom I&II
* Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA
Session Chair

* Philip Welkhoff, Bill & Melinda Gates Foundation, USA
Session Chair

* Flaminia Catteruccia, Harvard T.H. Chan School of Public Health, USA
Session Chair

Stephanie L. James, Foundation for the National Institutes of Health, USA
The Pathway for Development of a Genetic Biocontrol Tool to Prevent Malaria Transmission

Defeating Resistance I

Ballroom I&II
* Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA
Session Chair

Chanaki Amaratunga, Faculty of Tropical Medicine, Mahidol University, Thailand
Triple Artemisinin Combination Therapies: A New Paradigm for the Treatment of Malaria?

Coffee Break

Wiweka Kaszubska, Medicines for Malaria Venture, Switzerland
Building a Global Portfolio of Drugs to Anticipate Malaria Drug Resistance

Elizabeth A. Winzeler, University of California, San Diego, USA
The Malaria Drug Accelerator and the Search for Next-Generation Medicines for Malaria

Geoffrey Ian McFadden, University of Melbourne, Australia
Short Talk: Can We Build a Genetic Trap for Drug Resistant Malaria Parasites?


Rose Garden
Poster Session 1

Ballroom I&II
Coffee Available

Ballroom Foyer
Defeating Resistance II

Ballroom I&II
* Nancy O. Quashie, Noguchi Memorial Institute for Medical Research, Ghana
Session Chair

Manu Prakash, Stanford University, USA
Short Talk: Octopi: Open Configurable High-Throughput Imaging Platform for Malaria Diagnosis in the Field

Abdoulaye Djimde, University of Science, Techniques and Technologies, Mali
Is Artemisinin Resistance Coming to Sub-Saharan Africa?

Gordon A. Awandare, University of Ghana, Ghana
Keeping an Eye on the Non-Falciparum Plasmodium Species

Charles Wondji, Liverpool School of Tropical Medicine, UK
Molecular Genetics of Insecticide Resistance in Malaria Vectors

Lemu Golassa, Addis Ababa University, Ethiopia
Short Talk: Conventional Malaria Diagnostic Tools Neglect a Substantial Number of Low Density Asymptomatic Infections: Is Malaria Elimination Feasible in the Absence of New Tools?


Leveraging Data Science to Defeat Malaria I

Ballroom I&II
* Asnakew Yeshiwondim, PATH Malaria Control and Elimination Partnership in Africa, Ethiopia
Session Chair

Lucy C. Okell, Imperial College London, UK
Maximising the Impact of Antimalarial Treatment

Emilie Pothin, Swiss Tropical and Public Health Institute, Switzerland
Data-Driven Operational Stratification for National Malaria Control Programs

Coffee Break

Samson Kiware, Ifakara Health Institute, Tanzania
Mosquito Database Management System (MDbMS) Applicable to Diverse Entomological Studies

Hannah Slater, PATH MACEPA, USA
Short Talk: Modelling the Impact of Transmission-Intensity Targeted Intervention Packages for Different Levels of Malaria Transmission in Senegal

Duncan Kobia Athinya, Vestergaard Frandsen Limited, Kenya
Short Talk: Leveraging Available Data for Decision Making in Malaria Vector Control

Maria Tusell, Barcelona Institute for Global Health, Spain
Short Talk: MESA Track: Landscaping Research to Foreseen Emerging Evidence and Guide Decision-Making Processes

Michelle Hsiang, University of Texas Southwestern, USA
Short Talk: The Effectiveness of Malaria Reactive Focal Mass Drug Administration (rfMDA) and Reactive Vector Control (RAVC), a Cluster-Randomised Controlled Two-by-Two Factorial Design Trial from the Low-E

On Own for Lunch

Poster Setup

Ballroom I&II
Poster Viewing

Ballroom I&II

Ballroom I&II
* Maria M. Mota, Instituto de Medicina Molecular, Portugal
Session Chair

* Gordon A. Awandare, University of Ghana, Ghana
Session Chair

Maya Fraser, PATH, USA
Evaluating the Impact of Programmatic Mass Drug Administration in Zambia Using Routine Incidence Data

Laurent Dembele, Universite des Sciences Techniques et Technologiques de Bamako, Mali
Toward Novel Antimalarial Discovery against Plasmodium Relapsing Species P. Vivax and P. Ovale, Which Challenge Global Malaria Control and Elimination

Lauren Beth Arendse, University of Cape Town, South Africa
Establishing a Plasmodium Kinase Platform for Target-Based Malaria Drug Discovery

Monica Golumbeanu, Swiss Tropical and Public Health Institute, Switzerland
Quantifying the Effect of Vector Bionomics on the Impact of Vector Control Interventions against Malaria Transmitted by Anopheles Mosquitoes

Steven Gowelo, Wageningen University, Netherlands
Effect of Exposure to Sublethal Doses of Bacillus Thuringiensis Israelensis during Larval Development on Size, Oviposition and Survival of Anopheles coluzzii

Kitty F. Cardwell, Oklahoma State University, USA
Online Metagenome-Based Plasmodium Detection Tool - MiFi®

Coffee Available

Ballroom Foyer
Panel Discussion on Diversity & Inclusion

Leveraging Data Science to Defeat Malaria II

Ballroom I&II
* Philip Welkhoff, Bill & Melinda Gates Foundation, USA
Session Chair

Michael White, Institut Pasteur, France
Quantitative Approaches to Understanding P. vivax Epidemiology and Biology

Melissa Penny, Swiss Tropical and Public Health Institute, Switzerland
Models and Machine Learning to Inform Target Product Profiles of New Tools

Daniel Neafsey, Harvard T.H. Chan School of Public Health, USA
Using Parasite and Vector Genetic Relatedness to Inform Malaria Control and Elimination

Mphatso Phiri, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Malawi
Short Talk: The Duration of Protection from Azithromycin against Malaria When Given alongside Seasonal Malaria Chemoprevention: Secondary Analysis of Data from a Clinical Trial in Hounde, Burkina Faso and

Donnie Mategula, Malawi-Liverpool-Wellcome Trust, Malawi
Short Talk: Geostatistical Analysis of Malawi's Changing Malaria Transmission from 2010 to 2017

Social Hour with Lite Bites

Rose Garden
Poster Session 2

Ballroom I&II


Innovating to Enable Malaria Elimination I

Ballroom I&II
* Janice A. Culpepper, Bill & Melinda Gates Foundation, USA
Session Chair

Thierry T. Diagana, Novartis Institute for Tropical Diseases, USA
The Quest Towards Next Generation Antimalarials: Strengths, Weaknesses and Opportunities

Lluis Ballell, GlaxoSmithKline, Spain
Nurturing Novel Drug Discovery Technologies to Address the Malaria Endgame

Coffee Break

Maria M. Mota, Instituto de Medicina Molecular, Portugal
The Complexity and the Simplicity of Host-Plasmodium Interactions

Alejandro Llanos Cuentas, Universidad Peruana Cayetano Heredia, Peru
Clinical Development and Implementation of Tafenoquine for Vivax Malaria

Aissata Barry, Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso
Short Talk: Assessing Skin Sequestration in Gametocyte Donors in Balonghin; Burkina Faso

Ashenafi Assefa, Ethiopian Public Health Institute, Ethiopia
Short Talk: Short Course Primaquine for the Radical Cure of Plasmodium Vivax Malaria: A Randomized Placebo-Controlled Multicenter Trial

On Own for Lunch

Innovating to Enable Malaria Elimination II

Ballroom I&II
* Helen V. Jamet, Bill & Melinda Gates Foundation, USA
Session Chair

Flaminia Catteruccia, Harvard T.H. Chan School of Public Health, USA
Harnessing Mosquitoes to Kill Malaria Parasites

Nicholas M. Hamon, IVCC, UK
Innovation in Vector Control: Partnering for Impact and ‘ZERO by 40'

Austin Burt, Imperial College London, UK
Gene Drive: From the Bench to the Field

Lilian Mbaisi Ang'ang'o, International Centre of Insect Physiology and Ecology, Kenya
Short Talk: A Novel Microsporidian Blocks Plasmodium falciparum Transmission in Anopheles arabiensis Mosquitoes

Tibebu Habtewold, Imperial College London, UK
Short Talk: Biological and Methodological Considerations for an Accurate Evaluation of Genetically Engineered Mosquito Carrying Malaria Transmission Blocking Traits for Their Accelerated Rollout

Coffee Available

Ballroom Foyer
Innovating to Enable Malaria Elimination III

Ballroom I&II
* Flaminia Catteruccia, Harvard T.H. Chan School of Public Health, USA
Session Chair

Helen V. Jamet, Bill & Melinda Gates Foundation, USA
Innovative Vector Control Approaches

Fitsum G. Tadesse, AHRI, Ethiopia
The Contribution of Asymptomatic Infections to Transmission

Philip Welkhoff, Bill & Melinda Gates Foundation, USA
Innovation in Prevention of Transmission, Improved Case Management, and Enhanced Surveillance for Malaria Burden Reduction and Elimination

Kristine Werling, Harvard TH Chan School of Public Health, USA
Short Talk: Plasmodium Development in the Anopheles Mosquito: An Adaptable Relationship That Shapes Malaria Transmission and Control

Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom I&II
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Rose Garden



*Session Chair †Invited, not yet responded.

Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Bill & Melinda Gates Foundation

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inqaba biotec
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