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This meeting took place in 2020



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Islet Biology: From Gene to Cell to Micro-Organ (J6)


Organizer(s) Patrick MacDonald, Wen-hong Li, Anna Gloyn and Anette-Gabriele Ziegler
January 27—31, 2020
Santa Fe Community Convention Center • Santa Fe, NM USA
Discounted Abstract Deadline: Oct 2, 2019
Abstract Deadline: Oct 30, 2019
Scholarship Deadline: Oct 2, 2019
Discounted Registration Deadline: Dec 3, 2019

Sponsored by Novo Nordisk A/S


Summary of Meeting:
Recent years have seen great strides in understanding pancreatic endocrine islet cells. Spurred by new and emerging technologies, we are making discoveries about the impact of genetic variation on islet cells; how islet cell subpopulations differ; communication between islet cells and with the local environment, including components of the immune system; and how these interact to effect islet loss and dysfunction. A more integrated understanding of these processes will lead to important insights into diabetes and its treatment. Connecting researchers in the complimentary fields of genomics, immunology, islet cell function, and single-cell biology will be crucial to realizing this. One of the goals of this Keystone conference is to promote greater integration in our approaches to studying islet biology - spanning from genes, to single cells, to islets as micro-organs, and to the interaction of these with their local environment. Conference participants will learn about new methods and technological approaches among islet-biology investigators. This conference will also help to facilitate the development of new collaborations among attendees. We anticipate that this conference will highlight the challenges and potential new solutions in bringing integrated approaches to islet biology for the advancement of diabetes-related knowledge.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Monday, January 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Friday, January 31 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Saturday, February 1 in order to fully experience the meeting.

MONDAY, JANUARY 27

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Sweeney F

TUESDAY, JANUARY 28

07:00—08:00
Breakfast

Sweeney F
07:30—08:00
Poster Setup

Sweeney F
08:00—19:00
Poster Viewing

Sweeney F
08:00—09:00
Welcome and Keynote Address (Joint)

Sweeney Ballroom A-E
* Patrick MacDonald, University of Alberta, Canada

* Alan D. Attie, University of Wisconsin-Madison, USA

Morris J. Birnbaum, Pfizer Inc., USA
The Development of Therapeutics for T2DM and Related Diseases

09:00—11:30
All About Insulin: Signaling, Secretion, and Action (Joint)

Sweeney Ballroom A-E
* Patrick MacDonald, University of Alberta, Canada

* Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

Coffee Break

Michael P. Czech, University of Massachusetts Medical School, USA
Molecular Mechanisms of Insulin Resistance

Maureen Anne Gannon, Vanderbilt University Medical Center, USA
Promoting β-cell Survival and Preserving Functional β-cell Mass by Targeting PGE2 Receptors

Morris F. White, Boston Children's Hospital, Harvard Medical School, USA
The Systemic Integration of Hepatic Insulin Resistance

Arya Mani, Yale University, USA
Short Talk: Mutations in the Cela2a Gene Unravel the Function of the Encoded Protein as a Novel Incretin

Amelia K. Linnemann, Indiana University School of Medicine, USA
Short Talk: IFN-alpha Mediates Heterogenous ROS Accumulation in Human Islet Beta-Cells

11:30—12:15
Lunch

Sweeney F
12:00—14:30
Poster Session 1

Sweeney F
14:30—16:30
Workshop 1: What Do GWAS Genes Do in Islets?

Sweeney Ballroom A-B
* Karen L. Mohlke, University of North Carolina at Chapel Hill, USA

* James D. Johnson, University of British Columbia, Canada

Joseph Angleson, University of Denver, USA
Melanocortin Receptor-4 Regulates α-Cell Function and the Counter-Regulatory Response to Insulin-Induced Hypoglycemia in Mice

Malin Fex, Lund University, Sweden
Loss of Melatonin Type 1A Receptor Results in Dysregulated Whole-Body Metabolism Characterised by Hyperglucagonemia, Glucose Intolerance and Enhanced Insulin Secretion

YongKyung Kim, University of Colorado Anschutz Medical Campus, USA
PTPN2 Plays a Novel Role in the Beta Cells to Regulate Mitochondrial Function in Type 1 Diabetes Progression

Taiyi Kuo, Columbia University, USA
Identification of C2CD4A as a Human Diabetes Susceptibility Gene with a Role in β-Cell Insulin Secretion

Haopeng Lin, Alberta Diabetes Institute, Canada
SENP1 in Compensation and Failure of Insulin Secretion with High-Fat Diet

Dapeng Yang, Memorial Sloan Kettering Cancer Center, USA
Sequential CRISPR Screening Uncovers a Novel Role of HHEX in Specifying Human Pancreatic Differentiation

Taylor S. Morriseau, University of Manitoba, Canada
New Insights into the HNF-1αG319S Variant in Early-Onset T2D Among Manitoba Indigenous Youth

14:30—15:30
Workshop: Therapeutic Strategies for Targeting Insulin Action

Sweeney Ballroom C-E
* Silvia Corvera, University of Massachusetts Medical School, USA

Thiago M. Batista, Joslin Diabetes Center, USA
Dissection of Protein Phosphorylation Networks Underlying Muscle Insulin Resistance in Type 2 Diabetes

Jaroslawna Meister, NIDDK, National Institutes of Health, USA
Role of β2-adrenergic Receptor Signaling in Skeletal Muscle Glucose Metabolism

Paul M. Titchenell, University of Pennsylvania, USA
Regulation of Skeletal Muscle Metabolism by Insulin Signaling

Jacqueline Stoeckli, University of Sydney, Australia
ABHD15: A Novel Player in Insulin Regulation of Lipolysis in Adipocytes

15:30—16:30
Panel Discussion

Sweeney Ballroom C-E
* David E. James, University of Sydney, Australia

* Deborah M. Muoio, Duke University Medical Center, USA

Morris J. Birnbaum, Pfizer Inc., USA

Michael P. Czech, University of Massachusetts Medical School, USA

Peter A. Crawford, University of Minnesota, USA

Daniel P. Kelly, University of Pennsylvania, USA

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Islet Plasticity

Sweeney Ballroom A-B
* Jean Buteau, University of Alberta, Canada

* Bridget Wagner, Broad Institute, USA

George K. Gittes, Children's Hospital of Pittsburgh of UPMC, USA
Beta Cell Neogenesis and Protection

Julie B. Sneddon, University California, San Francisco, USA
Elucidating Human Endocrine Cell Fate Selection

Seung K. Kim, Stanford University, USA
Alternative Systems to Study Pancreatic Islet Development and Function

Christine A. Beamish, Houston Methodist Research Institute, USA
Short Talk: Loss of Endocrine Cell Identity Correlates with Pre-Surgical HOMA-β in Patients with Chronic Pancreatitis Undergoing Islet Auto-Transplantation

Mathieu Latreille, Imperial College London, UK
Short Talk: Beta-Cell Dedifferentiation Is Associated with Epithelial-Mesenchymal Transition In Diabetes

17:00—19:00
Novel Approaches for Monitoring Carbon Traffic Control

Sweeney Ballroom C-E
* Peter A. Crawford, University of Minnesota, USA

Joshua D. Rabinowitz, Princeton University, USA
Isotope Tracing for Deciphering Metabolic Network Usage

David H. Wasserman, Vanderbilt University School of Medicine, USA
Extramyocellular Barriers to Insulin-Stimulated Muscle Glucose Uptake

Barbara M. Bakker, University Medical Center Groningen, Netherlands
Modeling for Young and Old: Tackling the Complexity of Fatty Acid Oxidation in Metabolic Disease

Maciek R. Antoniewicz, University of Delaware, USA
Short Talk: Metabolite Cross-Feeding Interactions in Adipocyte-Hepatocyte Co-Cultures Elucidated with a Novel 13C-Metabolic Flux Analysis Technique

Jose M. Orozco, Massachusetts Institute of Technology, USA
Short Talk: Dihydroxyacetone Phosphate Signals Glucose Availability to mTORC1

19:00
On Own for Dinner


WEDNESDAY, JANUARY 29

07:00—08:00
Breakfast

Sweeney F
08:00—11:15
Visualizing Islet Function in vitro, in situ, and in vivo

Sweeney Ballroom A-B
* Amelia K. Linnemann, Indiana University School of Medicine, USA

* Wen-hong Li, UTSW Medical Ctr, USA

Sebastian Barg, Uppsala University, Sweden
Exocytosis of Insulin and Glucagon Granules in Type-2 Diabetes

Joana Almaca, University of Miami, USA
Control of Islet Hormone Secretion by Vascular Pericytes

Coffee Break

Robin A. Kimmel, University Innsbruck, Austria
In Vivo Imaging of Pancreatic Islet Morphogenesis in Zebrafish

Stephan Speier, Helmholtz Zentrum München, Germany
Imaging Islet Physiology in situ and in vivo

Yu Hsuan Carol Yang, Max Planck Institute for Heart and Lung Research, Germany
Short Talk: Innervation Modulates the Functional Connectivity between Pancreatic Endocrine Cells

Nicole Hallahan, University of Sydney, Australia
Short Talk: Reconstruction of the Polar Domains of Pancreatic Beta-Cells Affects Synaptic Protein Localisation and GSIS

Barak Blum, University of Wisconsin, USA
Short Talk: Roundabout Receptors Regulate Three-Dimensional Architecture and Facilitate Synchronized Ca2+ Oscillations In Vivo in the Islet of Langerhans

08:00—11:00
Ketones and Ketogenesis; Super-Fuel or Nuclear Signal?

Sweeney Ballroom C-E
* Judith A. Simcox, University of Wisconsin - Madison, USA

Richard Veech, NIAAA, National Institutes of Health, USA
The Effects of Ketone Body Metabolism on the Great Controlling Nucleotide Couples and their Application to Common Diseases

Peter A. Crawford, University of Minnesota, USA
Tracing the Role of Intrahepatic Ketone Turnover in Fatty Liver Disease

Coffee Break

Daniel P. Kelly, University of Pennsylvania, USA
Ketones and Heart Failure

Justin Lengfeld, University of Minnesota, USA
Short Talk: Chronic Low-Dose Ethanol Intake Exacerbates High-Fat Diet Induced Hepatic Fibrosis

Meilian Liu, University of New Mexico Health Sciences Center, USA
Short Talk: Adipocyte COX-2/PGE2 Pathway is Required for Intermittent Fasting-Induced Treg Development and Improvement of Insulin Sensitivity

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Sweeney F
13:00—22:00
Poster Viewing

Sweeney F
16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Molecular and Functional Analysis of Islet Cell Heterogeneity

Sweeney Ballroom A-B
* Claes B. Wollheim, University of Geneva Medical Centre, Switzerland

* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

Wen-hong Li, UTSW Medical Ctr, USA
Functional Heterogeneity of Islet beta Cells

Richard KP Benninger, University of Colorado, USA
Imaging Islet Heterogeneity and Connectivity

Anna Martinez Casals, Science for Life Laboratories, Sweden
Single Cell Protein Variability in Pancreas by CODEX Highly-Multiplexed Imaging

James C. Lo, Weill Cornell Medicine, USA
Short Talk: Adipsin Blocks Beta Cell Failure in Diabetic Mice and Associates with Protection from Diabetes in Humans

Lydia Amanda Farack, Weizmann Institute of Science, Israel
Short Talk: Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas Reveals Division of Labor between ‘Basal Secretor’ Extreme Beta Cells and ‘Glucose Responder’ Non-Extreme Beta Cells

17:00—19:00
Supercomplexities of Mitochondrial Dynamics and Bioenergetics

Sweeney Ballroom C-E
* Dave Pagliarini, Washington University in St. Louis, USA

Jared Rutter, University of Utah, USA
Metabolism and Cellular Decisions

Orian S. Shirihai, University of California, Los Angeles, USA
Mitochondrial Heterogeneity in the Adipocyte

Deborah M. Muoio, Duke University Medical Center, USA
Understanding and Preventing Lipid-Induced Mitochondrial Stress

Ayon Ibrahim, University of Pennsylvania, USA
Short Talk: Mitochondrial ATP Production Drives Endothelial Fatty Acid Uptake and Transport

Heather A. Lawson, Washington University in St. Louis, USA
Short Talk: Natural Brown Adipose Expansion and Remission of Hyperglycemia in Obese SM/J Mice

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F
19:30—22:00
Poster Session 2

Sweeney F

THURSDAY, JANUARY 30

07:00—08:00
Breakfast

Sweeney F
08:00—11:15
Stem Cells and Micro-Organs

Sweeney Ballroom A-B
* Malin Fex, Lund University, Sweden

* Jochen Lang, Université de Bordeaux, France

Jennifer E. Bruin, Carleton University, Canada
Environmental Toxins and Embryonic Pancreas Development

Burcak Yesildag, InSphero AG, Switzerland
Biomimetic Microtissues: Novel Methods for Studying Islet Biology in Health and Disease

Coffee Break

Anne Grapin-Botton, University of Copenhagen, Denmark
Three Dimensional Models of Human Pancreas Organogenesis to Understand Diabetes

Mark D. Ungrin, University of Calgary, Canada
Generation and Characterization of Human Pseudoislets

Phillip L. Lewis, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Development of a Fluidic Platform to Study Insulin Secretion from Pluripotent Stem Cell-Derived Human Insulin-Secreting Cells

Ali Hasan Shilleh, University of Colorado, Anschutz Medical Campus, Barbara Davis Center, USA
Short Talk: Determining the Fate of Stem Cell Derived Pancreatic β-like Cells (sBCs) Upon Transplantation Using Genetic Lineage Tracing

Katharina Scheibner, Helmholtz Zentrum Munich, Germany
Short Talk: New Approaches to Produce Beta Cells from Human Stem Cells

08:00—11:00
Molecules Mediating Tissue Crosstalk

Sweeney Ballroom C-E
* Mark A. Herman, Duke University Medical Center, USA

Joseph A. Baur, University of Pennsylvania, USA
Mitochondrial NAD Transport

Mark A. Febbraio, Monash Institute of Pharmaceutical Sciences, Australia
Extracellular Vesicles Mediating Cross-Talk during Exercise

Coffee Break

Judith A. Simcox, University of Wisconsin - Madison, USA
Role of Acylcarnitines as Peripheral Metabolic Signals

Barbara B. Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Lipokines as Nutrient Sensors and Signals

Silvia Corvera, University of Massachusetts Medical School, USA
Short Talk: A Placenta to Adipose Tissues Signaling Axis Controls IGF-1 Availability and Insulin Sensitivity in Pregnancy

Peter K. Jackson, Stanford University, USA
Short Talk: Omega-3 Fatty Acids Activate Ciliary FFAR4/GPR120 to Trigger cAMP-Dependent Differentiation of Preadipocytes

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Sweeney F
13:00—22:00
Poster Viewing

Sweeney F
16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—19:00
Inflammation, Killing, and Islet Dysfunction

Sweeney Ballroom A-B
* Bruce Verchere, University of British Columbia, Canada

* Rebecca Hull, University of Washington, USA

Anette-Gabriele Ziegler, Helmholtz Zentrum München, Germany
Islet Autoimmunity

Irina Maria Stefana, University of Oxford, UK
Hyperphosphorylated Tau is Expressed in Human Pancreatic Islets and Accumulates in the β-cell Cytoplasm during Ageing

Rebecca Hull, University of Washington, USA
Islet Inflammation in CFRD

Mollie Huber, University of Florida, USA
Short Talk: Investigating Type 1 Diabetes Pathogenesis Using Live Pancreas Tissue Slices

Diane C. Saunders, Vanderbilt University Medical Center, USA
Short Talk: Macrophages Are a Prominent Immune Cell Population in the Developing Human Pancreas

17:00—19:00
Gut Control of Metabolism

Sweeney Ballroom C-E
* Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland

Darleen A. Sandoval, University of Colorado, USA
Using Bariatric Surgery to Understand the Regulatory Role of the Gut in Metabolism

Mark A. Herman, Duke University Medical Center, USA
Molecular Aspects of Fructose-Induced Metabolic Dysregulation

Eric Yen, University of Wisconsin-Madison, USA
Intestinal Lipid Processing and Pancreatic Islet Function: A Gut Reaction?

Marc Liesa, University of California, Los Angeles, USA
Short Talk: Mitochondrial ABCB10 Increases Bilirubin Actions on the Redox State to Promote Insulin Resistance and Steatosis in Liver

Sophie L. Lewandowski, University of Wisconsin-Madison, USA
Short Talk: Additive Effects of β-Cell Pyruvate Kinase Activation and GLP-1 Receptor Signaling on Insulin Secretion

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F
19:30—22:00
Poster Session 3

Sweeney F

FRIDAY, JANUARY 31

07:00—08:00
Breakfast

Sweeney F
08:00—09:00
Keynote Address (Joint)

Sweeney Ballroom A-E
* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

* Anna L. Gloyn, Stanford University, USA

Maike Sander, University of California, San Diego, USA
Metabolic Influences on Pancreatic Beta Cells

09:00—11:30
Genetics/Genomics of T2D (Joint)

Sweeney Ballroom A-E
* Maureen Anne Gannon, Vanderbilt University Medical Center, USA

* Anna L. Gloyn, Stanford University, USA
Unravelling Mechanisms for Pancreatic Islet Dysfunction from GWAS

Coffee Break

Karen L. Mohlke, University of North Carolina at Chapel Hill, USA
Adipose Tissue Genomics and Type 2 Diabetes

Alan D. Attie, University of Wisconsin-Madison, USA
Genetics of Insulin Secretion

Marcus M. Seldin, University of California, Irvine, USA
Short Talk: Systems Genetics Approaches to Dissect Inter-tissue Communication

Christopher Emfinger, University of Wisconsin-Madison, USA
Short Talk: Zfp148 Regulates a Transcriptional Network Suppressing Insulin Secretion

11:30—17:00
On Own for Lunch

14:30—16:30
Workshop 2: The Human Islet Research Network - Human Pancreas Analysis Programs

Sweeney Ballroom A-B
* Marcela Brissova, Vanderbilt University, USA

* Nicolai M. Doliba, University of Pennsylvania, USA

Catherine Lee May, University of Pennsylvania, USA
The Human Pancreas Analysis Program – Type 1 Diabetes

Alvin C. Powers, Vanderbilt University School of Medicine, USA
The Human Pancreas Analysis Program - Type 2 Diabetes

Xiaoqing Dai, University of Alberta, Canada
Pancreatic α-cell Function and Identity in Type 1 Diabetes Mellitus

Matthew Haemmerle, University of Pennsylvania, USA
The PCBP RNA Binding Proteins as Post-Transcriptional Regulators of β Cell Identity

Tiffany Richardson, Vanderbilt University, USA
Pancreatic Islet and Exocrine Tissue Innervation is Not Altered in Type 1 Diabetes

Rafael Arrojo e Drigo, The Salk Institute Research Institute, USA
Aging of Human Endocrine Pancreatic Cell Types Is Heterogeneous and Sex-Specific

16:30—17:00
Coffee Available

Sweeney Ballroom Foyer
17:00—18:45
Novel Approaches to Single Cell Biology

Sweeney Ballroom A-B
* Mathieu Latreille, Imperial College London, UK

* Julie B. Sneddon, University California, San Francisco, USA

Heiko Lickert, Institute of Diabetes and Regeneration, Germany
Deciphering Mechanisms of β-Cell Failure and Regeneration by Single Cell RNA Sequencing

Diego Balboa, Centre for Genomic Regulation, Spain
Improving Diabetes Disease Modelling with Single Cell RNA Sequencing of Stem Cell Derived Pancreatic Cells

Patrick MacDonald, University of Alberta, Canada
Connecting Single-Cell Function and Transcriptomics

Rachel E. Jennings, University of Manchester, UK
Short Talk: A Single Cell Atlas of the Developing Human Pancreas

17:00—18:45
From Systems Biology to Metabolic Physiology

Sweeney Ballroom C-E
* Barbara M. Bakker, University Medical Center Groningen, Netherlands

Kristina Schoonjans, École Polytechnique Fédérale de Lausanne – EPFL, Switzerland
Emerging Roles of Bile Acid Signaling in Metabolism and Stemness

Dave Pagliarini, Washington University in St. Louis, USA
Regulation of Mitochondrial Metabolism by Reversible Phosphorylation

David E. James, University of Sydney, Australia
The Role of Reactive Oxygen Species in Insulin Resistance

Takumi Kitamoto, Columbia University, USA
Short Talk: The Genomic Architecture of the FoxO1 Response to Fasting and Refeeding in Liver

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sweeney Ballroom A-B
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Sweeney Ballroom C-E
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Sweeney F
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Sweeney F

SATURDAY, FEBRUARY 1

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

Novo Nordisk A/S

We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK122818-01

Funding for this conference was made possible (in part) by 1R13DK122818-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



InSphero Inc.


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: Sarah Lavicka, Director of Corporate Relations, Email: sarahl@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179