Keystone Symposia

Fairmont Hotel Vancouver Floorplan

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This meeting took place in 2020


Here are the related meetings in 2021:
MEETING CANCELLED: Organoids as Tools for Fundamental Discovery and Translation (Q4)
MEETING CANCELLED: Engineering Multi-Cellular Living Systems (Q3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Tissue Organoids as Models of Host Physiology and Pathophysiology of Disease (J1)


Organizer(s) Thaddeus S. Stappenbeck and Linda G. Griffith
January 19—23, 2020
Fairmont Hotel Vancouver • Vancouver, BC Canada
Discounted Abstract Deadline: Sep 25, 2019
Abstract Deadline: Oct 17, 2019
Scholarship Deadline: Sep 25, 2019
Discounted Registration Deadline: Nov 20, 2019

Sponsored by Merck & Co., Inc., Roche and Thermo Fisher Scientific Inc.

Summary of Meeting:
Tissue organoids are becoming an increasingly sophisticated experimental system that is of importance in investigative work on nearly every organ system. There has been a recent explosion of techniques and platforms that enable dissection of fundamental questions, modeling cellular alterations in disease states and screening of compounds and molecules to discover new pathways. Fundamental work into organoid properties has developed the potential of organoids to become new methods for diagnosis, therapeutic selection and even to serve as regenerative medicine therapeutics themselves. This conference will bring together experts in organoids from various tissues and will create valuable cross-fertilization of ideas and approaches that will benefit many fields. A major gap is that this technology is being siloed in areas of specific tissues and molecular pathways. A general conference that cuts across all organs and major utilities will be of high value and will encourage groups to share ideas across organ systems. The conference program will also include engineering approaches that will highlight novel developments in organoid technology. As a result of this conference, it is anticipated that participants will have a much better understanding of the capabilities of organoid systems and see new avenues for exploration. This conference is designed to emphasize synthesis over reductionism. An additional aim of this conference is to help investigators make the connection to develop new diagnostic and therapeutic tools using organoids.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, January 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, January 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour and entertainment. We recommend return travel on Friday, January 24 in order to fully experience the meeting.

SUNDAY, JANUARY 19

16:00—20:00
Arrival and Registration

British/Columbia Foyer
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

British/Columbia Foyer

MONDAY, JANUARY 20

07:30—08:30
Breakfast

Pacific Ballroom
08:00—08:30
Poster Setup

Pacific Ballroom
08:30—19:00
Poster Viewing

Pacific Ballroom
08:30—09:30
Welcome and Keynote Address

British Ballroom
* Thaddeus S. Stappenbeck, Cleveland Clinic, USA

* Linda G. Griffith, Massachusetts Institute of Technology, USA

Rudolf Jaenisch, Whitehead Institute for Biomedical Research, USA
Modeling of Human Diseases in Mouse - Human Chimeras

09:30—12:00
Modeling Pathogen Interactions with Organoids

British Ballroom
* Thaddeus S. Stappenbeck, Cleveland Clinic, USA

* Linda G. Griffith, Massachusetts Institute of Technology, USA

Mary K. Estes, Baylor College of Medicine, USA
Human Intestinal Organoids: Transformative Tools to Study Gastrointestinal Infections

Coffee Break

L. David Sibley, Washington University School of Medicine, USA
New Models of Cryptosporidium Culture in Primary Intestinal Epithelial Cells

Melanie M. Ott, Gladstone Institutes, USA
Hepatitis C Virus (HCV) Infects and Perturbs Liver Stem Cells

Seongmi Kim, Washington University in St. Louis, USA
Short Talk: Primary Cells Isolated from Mice with Prior UTI History Revealed that Bladder Epithelial Stem Cells Undergo Epigenetic Changes Upon Chronic Infection

Mouhita Humayun, University of Wisconsin-Madison, USA
Short Talk: Immune Cell Response to Toxoplasma gondii Infection in a 3D Organotypic Intestinal Model

12:00—12:45
Lunch

Pacific Ballroom
12:00—14:30
Poster Session 1

Pacific Ballroom
14:30—16:30
Workshop 1

British Ballroom
* Mary K. Estes, Baylor College of Medicine, USA

Joannie Allaire, University of British Columbia, Canada
Defining the Roles of IL37/SIGIRR in Regulating Innate Signaling by Intestinal Epithelial Cells using Enteroids

Carolina Arias, University of California, Santa Barbara, USA
Retinal Organoids as Physiological Proxies for the Study of Ocular Viral Infections

Ka-Yee Grace Choi, University of British Columbia, Canada
Effects of Host Defence Peptides on Pseudomonas aeruginosa Lung Infections using Organoids and Mice

Alyssa Fasciano, Tufts University School of Medicine, USA
Breaching the Barrier: Investigating Selective Yersinia Entry into M Cells using Human Ileal Enteroid Monolayers

Grace Hudson, University of Calgary, Canada
Understanding the Infection Dynamics of Mycobacterium Paratuberculosis (MAP)

Dasja Pajkrt, Amsterdam University Medical Center, Netherlands
Studies on Picornavirus Infection using Human Organoids

Annika Niehrs, Heinrich-Pette Institut, Germany
Hepatocyte Organoids as a Model System to Study Immune Cell Recognition of HBV-Infected Hepatocytes

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Modeling Immunity into Organoid Systems

British Ballroom
* Charles E. Whitehurst, Boehringer Ingelheim Pharmaceuticals, Inc., USA

Senthil K. Muthuswamy, Harvard Medical School, USA
Stem Cell and Tumor Derived Organoids for Cancer Biology and Personalized Therapeutics

Fred H. Gage, The Salk Institute for Biological Studies, USA
Enhanced Glial Corporation and Vascularization of Brain Organoids

Sebastian M. Löbl, Heinrich Pette Institute Leibniz Institute for Experimental Virology, Germany
Short Talk: Lymphocytes and Angiocrine Signaling in Liver Regeneration

19:00
On Own for Dinner


TUESDAY, JANUARY 21

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:30
Developmental Programs of Organoid Stem Cells for Therapy

British Ballroom
* Randolph Scott Ashton, University of Wisconsin, USA

Takanori Takebe, Cincinnati Children's Hospital Medical Center, Japan
Modeling Hepato-Biliary-Pancreatic Organogenesis towards Therapy

Todd C. McDevitt, Gladstone Institutes, USA
Axial Elongation of Caudalized Human PSC Organoids Mimics Neural Tube Development

Coffee Break

Mitsuru Morimoto, RIKEN, Center for Developmental Biology, Japan
Canonical and Non-Canonical Wnt Signaling Coordinate Trachea Development in vivo and in vitro

Andres J. Garcia, Georgia Institute of Technology, USA
Synthetic Hydrogels as Engineered Niches for Organoids

Sarah Saxton, University of Washington, USA
Short Talk: Hepatoblast Organoids have Bipotential Fate in Engineered Liver Tissue

Catarina Brito, Instituto de Biologia Experimental e Tecnológica, Portugal
Short Talk: Modelling Neuronal Microenvironment Dynamics in Disease

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Metabolic Crosstalk with Organoids and the Environment

British Ballroom
* Nastaran Zahir, NCI, National Institutes of Health, USA

Ömer Hidir Yilmaz, Massachusetts Institute of Technology, USA
Dietary Control of Intestinal Stem Cells in Physiology and Disease

Boudewijn MT Burgering, Utrecht University, Netherlands
Interplay between Metabolic Identities in the Intestinal Crypt

William D. Rees, University of British Columbia, Canada
Short Talk: Colon-Derived Enteroids from Inflammatory Bowel Disease Patients have Dysregulated Endoplasmic Reticulum Stress Pathways that Drive Dendritic Cell Maturation

Elisabeth Gleisinger, Technical University of Munich, Germany
Short Talk: Mitochondrial Impairment Drives Intestinal Stem Cell Transition into Dysfunctional Paneth Cells Predicting Crohn’s Disease Recurrence

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 2

Pacific Ballroom

WEDNESDAY, JANUARY 22

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:30
Cancer Cell Organoids

British Ballroom
* Simon Andrew Hirota, University of Calgary, Canada

Herve Tiriac, University of California, San Diego, USA
Pancreatic Cancer Patient-Derived Organoids as a Tool for Personalized Medicine

Nicola Valeri, Institute of Cancer Research, UK
Patient-Derived Organoids: Promises, Hurdles and Potential Clinical Applications

Coffee Break

Claus Jorgensen, Cancer Research UK, UK
A Microenvironment Inspired Synthetic 3D Model for Pancreatic Ductal Adenocarcinoma

Shuibing Chen, Weill Cornell Medical College, USA
Human Pluripotent Stem Cells, Colonic Organoids and Colorectal Cancer

Karuna Ganesh, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Regenerative Origin of Metastasis Initiating Cells

Germain C. Ho, BC Cancer Research Centre, Canada
Short Talk: Single-Cell Sequencing of Normal Endometrial Organoids to Investigate Contribution of Secretory and Ciliated Cells to Endometrial Carcinomas

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Pacific Ballroom
13:00—22:00
Poster Viewing

Pacific Ballroom
16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—19:00
Modeling Tissue Repair with Organoids

British Ballroom
* Andres J. Garcia, Georgia Institute of Technology, USA

Konstantina Nikolakopoulou, University of Cambridge, UK
Organoids for the Study of Endometrial Physiology and Disease

Thaddeus S. Stappenbeck, Cleveland Clinic, USA
Modeling the Mechanisms That Control Injury Cycles of Intestinal Epithelial Stem Cells

Randolph Scott Ashton, University of Wisconsin, USA
Bioengineering Early CNS Morphogenesis for Scalable Assessment of Neural Tube Defect Risk

Elisa M. Murray, Washington University in St. Louis, USA
Short Talk: Deciphering the Role of Her2 and Apc Mutations on the Intestinal Epithelium using Gastrointestinal Organoids

Sakurako Kobayashi, Tokyo Medical and Dental University, Japan
Short Talk: Conceptual Basis of Lineage Shift between Intestinal Epithelium and Hepatocytes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
19:30—22:00
Poster Session 3

Pacific Ballroom

THURSDAY, JANUARY 23

07:30—08:30
Breakfast

Pacific Ballroom
08:30—11:30
Engineering Solutions to Improve Organoid Growth

British Ballroom
* Todd C. McDevitt, Gladstone Institutes, USA

Linda G. Griffith, Massachusetts Institute of Technology, USA
Integrating Synthetic Biomaterials and Perfusion to Enhance Organoid Function

Sarah Heilshorn, Stanford University, USA
Protein-Engineered Materials as Synthetic Niches for Organoids

Coffee Break

Zev Gartner, University of California, San Francisco, USA
The Role of Self-Organization in the Maintenance and Breakdown of Tissue Structure during Breast Cancer Progression

Jennifer A. Lewis, Harvard University, SEAS, USA
Ex Vivo Vascularization of Organoid-on-Chip Models and 3D Tissues

Kevin Achberger, University of Tuebingen, Germany
Short Talk: Retina-on-a-Chip- An in vitro Tool to Study the Complexity of the Human Retina

Katarina Klett, Stanford University, USA
Short Talk: Tunable Engineered Matrix for the Culture of Human Intestinal Organoids

11:30—17:00
On Own for Lunch

15:00—16:30
Workshop II

British Ballroom
* Mark Kennedy, Thermo Fisher Scientific, USA

Bo Yu, University of Washington, USA
Establishing Acute Infection in a Fallopian Tube Organoid Model

Claudia Beaurivage, University of Sheffield, Netherlands
Establishment of a High Throughput Microfluidic Gut-on-a-Chip Model using Human Intestinal Organoids to Assess Compound Efficacy and Perform Target Validation in Inflammatory Bowel Disease

Yoonseok Choi, University of Ulsan, South Korea
Development of an ex vivo Microfluidic Platform that Enabled the Preclinical Immune Response Interaction Monitoring followed by the Immune Checkpoint Blockade

Jose Fabian Oceguera-Yanez, Kyoto University, Japan
Applications of Genetically Engineered Human iPSCs to Understand Skin Cancer Development and Pathology

H.-H. Greco Song, Massachusetts Institute of Technology, USA
Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues

16:30—17:00
Coffee Available

British/Columbia Foyer
17:00—18:45
Integrating Vasculature, Nerve Networks, and Dynamic Behaviors into Organoids

British Ballroom
* Thomas Åskov Pedersen, Novo Nordisk, Denmark

Michael A. Helmrath, Cincinnati Children's Hospital, USA
Integrating Models of Human Intestinal Development

Roger D. Kamm, Massachusetts Institute of Technology, USA
Microphysiological Models of Neurological Disease

Peter W. Zandstra, University of British Columbia, Canada
Engineering Stem Cell Fate and Function

Adrianna K. San Roman, Whitehead Institute, USA
Short Talk: Cell-Autonomous Effects of Sex Chromosome Dosage on Global Gene Expression

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

British Ballroom
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Pacific Ballroom
20:00—23:00
Entertainment
Entertainment is not subsidized by conference registration fees nor any U.S. federal government grants. Funding for this expense is provided by other revenue sources.

Pacific Ballroom

FRIDAY, JANUARY 24

 
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

Merck & Co., Inc. Roche
Thermo Fisher Scientific Inc.
 

We gratefully acknowledge additional support from these exhibitors at this conference:

10x Genomics PeproTech, Inc.
STEMCELL Technologies, Inc.
 
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13EB029303-01

Funding for this conference was made possible (in part) by 1R13EB029303-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government. This award is co-funded by the National Institute of Biomedical Imaging and Bioengineering and from the National Cancer Institute.


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