Firenze Fiera - Nazioni Floorplan
This meeting took place in 2022
Here are the related meetings in 2024:
Single-Cell Biology: Tissue Genomics, Technologies and Disease (A2)
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Single Cell Biology: Pushing New Frontiers in the Life Sciences (T9)
Organizer(s) Nikolaus Rajewsky and Massimiliano Pagani
April 5—9, 2022
Firenze Fiera - Nazioni • Florence, Italy
Abstract Deadline: Jan 6, 2022
Scholarship Deadline: Jan 6, 2022
Discounted Registration Deadline: Feb 7, 2022
Sponsored by BioLegend, Inc., Fondazione Internazionale Menarini, Novo Nordisk A/S, Surface Oncology, Surface Oncology, Takeda Pharmaceutical Company Limited, and Thermo Fisher Scientific Inc.
Summary of Meeting:
Life has evolved profound heterogeneity of cells within a tissue, and the function of a tissue or organ can only be understood by understanding how these cells interact. Diseases often arise within a subset of cells within a tissue, or have different consequences in different cells. Thus, it is key to capture and interpret cellular heterogeneity. Recent technology advances are beginning to make multiplexed molecular analysis of millions of individual cells a reality. An emerging challenge is to connect these very rapidly evolving technical advances and “Big Data” to molecular mechanisms so that an understanding of cellular heterogeneity in health and disease (beyond description) emerges. The overall goal of the conference is to connect and synergize the “technical advance” community and the broader biology/medical community. Specifically, (i) to expose participants to cutting-edge techniques in single cell analysis and (ii) to provide a forum for researchers to share their work with colleagues and facilitate development of mutually beneficial collaborations. Several aspects of our proposed conference make it unique and of significant interest. One such aspect is our broader focus beyond the transcriptome of dissociated single cells as is common. Our proposal encompasses analysis of the epigenome, proteome, lipidome and metabolome of single cells in a dissociated state and, more importantly, in situ, preserving crucial spatial information. Additionally, our proposed conference uniquely has a focus on application of single cell analysis directly to diseases to understand mechanisms and discover potential therapeutic treatments.
View Scholarships/Awards
Life has evolved profound heterogeneity of cells within a tissue, and the function of a tissue or organ can only be understood by understanding how these cells interact. Diseases often arise within a subset of cells within a tissue, or have different consequences in different cells. Thus, it is key to capture and interpret cellular heterogeneity. Recent technology advances are beginning to make multiplexed molecular analysis of millions of individual cells a reality. An emerging challenge is to connect these very rapidly evolving technical advances and “Big Data” to molecular mechanisms so that an understanding of cellular heterogeneity in health and disease (beyond description) emerges. The overall goal of the conference is to connect and synergize the “technical advance” community and the broader biology/medical community. Specifically, (i) to expose participants to cutting-edge techniques in single cell analysis and (ii) to provide a forum for researchers to share their work with colleagues and facilitate development of mutually beneficial collaborations. Several aspects of our proposed conference make it unique and of significant interest. One such aspect is our broader focus beyond the transcriptome of dissociated single cells as is common. Our proposal encompasses analysis of the epigenome, proteome, lipidome and metabolome of single cells in a dissociated state and, more importantly, in situ, preserving crucial spatial information. Additionally, our proposed conference uniquely has a focus on application of single cell analysis directly to diseases to understand mechanisms and discover potential therapeutic treatments.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Tuesday, April 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, April 10 in order to fully experience the meeting.
TUESDAY, APRIL 5
WEDNESDAY, APRIL 6
THURSDAY, APRIL 7
FRIDAY, APRIL 8
SATURDAY, APRIL 9
SUNDAY, APRIL 10
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Tuesday, April 5 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Saturday, April 9 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Sunday, April 10 in order to fully experience the meeting.
TUESDAY, APRIL 5
16:00—20:00
Arrival and Registration (4pm Start)
Firenze Fiera - Nazioni Padiglione
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
Firenze Fiera - Nazioni Padiglione
08:00—09:00
Breakfast
Individual Hotel
08:30—09:00
Poster Setup
Nazioni B
09:00—17:00
Poster Viewing
Nazioni B
09:00—10:00
Welcome and Keynote Address (9am Start)
Nazioni A
*
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
Session Chair
Session Chair
*
Massimiliano Pagani,
IFOM ETS - The AIRC Institute of Molecular Oncology, Italy
Session Chair
Session Chair
Eileen E.M. Furlong,
European Molecular Biology Laboratory, Germany
Dissecting Regulatory Principles of Embryonic Development One Cell at a Time
Dissecting Regulatory Principles of Embryonic Development One Cell at a Time
10:00—12:00
Interrogating Disease Models at Single Cell (10am Start)
Nazioni A
*
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
Session Chair
Session Chair
*
Massimiliano Pagani,
IFOM ETS - The AIRC Institute of Molecular Oncology, Italy
Session Chair
Session Chair
Barbara Treutlein,
ETH Zürich, Switzerland
Remote Presentation: Understanding Organoids by Disassembling and Analysing Component Lineages Using Single-Cell RNA Sequencing
Remote Presentation: Understanding Organoids by Disassembling and Analysing Component Lineages Using Single-Cell RNA Sequencing
Coffee Break
Maike Sander,
University of California, San Diego, USA
Insights into Pancreatic Islet Cell Gene Regulation and Disease Mechanisms of Diabetes from Single-Cell Analyses
Insights into Pancreatic Islet Cell Gene Regulation and Disease Mechanisms of Diabetes from Single-Cell Analyses
Roshan Sharma,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Characterization of Tumor Progression and Metastasis of Pancreatic Ductal Adenocarcinoma
Short Talk: Characterization of Tumor Progression and Metastasis of Pancreatic Ductal Adenocarcinoma
12:00—13:00
Lunch
Nazioni B
12:30—14:30
Poster Session 1 (12:30pm Start)
Nazioni B
14:30—16:30
Workshop 1: Emerging Technologies for Unbiased Single Cell Analysis (2:30pm Start)
Nazioni A
Benjamin Babcock,
Emory University, USA
Systemic Perturbations to scRNA-seq Reveal Dropout-susceptible Transcripts as the Primary Driver of Batch Effects that can be Mitigated by Normalization Strategies
Systemic Perturbations to scRNA-seq Reveal Dropout-susceptible Transcripts as the Primary Driver of Batch Effects that can be Mitigated by Normalization Strategies
*
Christophe Toussaint,
Helmholtz Centre for Infection Research, Germany
scSLAM-seq Records Macrophage Polarization Reprogramming after Bacterial Invasion
scSLAM-seq Records Macrophage Polarization Reprogramming after Bacterial Invasion
Amy F. Chen,
Stanford University, USA
NEAT-seq: Simultaneous Profiling of Intra-nuclear Proteins, Chromatin Accessibility, and Gene Expression in Single Cells
NEAT-seq: Simultaneous Profiling of Intra-nuclear Proteins, Chromatin Accessibility, and Gene Expression in Single Cells
Florian Andreas Schober,
Max Planck Institute of Biochemistry, Germany
Spatial Resolution in Single-cell Type Proteomics - a Liver Roadmap
Spatial Resolution in Single-cell Type Proteomics - a Liver Roadmap
*
Raffaele A. Calogero,
University of Torino, Italy
Sparsely Connected Autoencoders: A multi-purpose Tool for Single Cell OMICs Analysis
Sparsely Connected Autoencoders: A multi-purpose Tool for Single Cell OMICs Analysis
16:30—17:00
Coffee Available
Nazioni B
17:00—19:00
Single Cell Computational Biology to Molecular Mechanisms (5pm Start)
Nazioni A
*
Sarah Teichmann,
Wellcome Sanger Institute, UK
Cell States and Transcriptional Programmes in the Adult Human Heart
Cell States and Transcriptional Programmes in the Adult Human Heart
*
Fabian Theis,
Helmholtz Zentrum München, Germany
Computational Approaches in Single Cell Trajectory Analysis and Modeling
Computational Approaches in Single Cell Trajectory Analysis and Modeling
Matthias Mann,
Max Planck Institute of Biochemistry, Germany
Proteomics and Systems Biology in the Age of Single Cell Analysis
Proteomics and Systems Biology in the Age of Single Cell Analysis
Mark Keller,
Harvard Medical School, USA
Short Talk: Framework for Integrative Visualization of Multi-modal Single-cell Data
Short Talk: Framework for Integrative Visualization of Multi-modal Single-cell Data
Robin Browaeys,
VIB-UGent Center for Inflammation Research, Belgium
Short Talk: MultiNicheNet: Studying Cell-cell Communication from Multi-sample Multi-Condition Single-cell Transcriptomics Data
Short Talk: MultiNicheNet: Studying Cell-cell Communication from Multi-sample Multi-Condition Single-cell Transcriptomics Data
19:00
On Own for Dinner
08:00—09:00
Breakfast
Individual Hotel
08:30—09:00
Poster Setup
Nazioni B
09:00—17:00
Poster Viewing
Nazioni B
09:00—12:00
Development and Cell Fate at Single Cell Resolution I (9am Start)
Nazioni A
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
Design Principles of Gene Expression by Single Cell-Sequencing
Design Principles of Gene Expression by Single Cell-Sequencing
*
Alexander F. Schier,
University of Basel, Switzerland
Cellular Biographies: Reconstructing Zebrafish Development
Cellular Biographies: Reconstructing Zebrafish Development
Coffee Break
*
Stefano Piccolo,
University of Padua, Italy
Combined Single-Cell and Histopathology Datasets Reveal Spalial Location of Glioblastoma Stem Cells and New Plasticity Determinants
Combined Single-Cell and Histopathology Datasets Reveal Spalial Location of Glioblastoma Stem Cells and New Plasticity Determinants
Lara Michele Feulner,
University of Montreal, Canada
Short Talk: Single Cell Characterization of Valve Development
Short Talk: Single Cell Characterization of Valve Development
Yaara Oren,
Tel Aviv University, USA
Short Talk: Cycling Cancer Persister Cells arise from Lineages with Distinct Transcriptional and Metabolic Programs
Short Talk: Cycling Cancer Persister Cells arise from Lineages with Distinct Transcriptional and Metabolic Programs
12:00—13:00
Lunch
Nazioni B
12:30—14:30
Poster Session 2 (12:30pm Start)
Nazioni B
15:00—16:30
Workshop 2: Exploring the Complexity of the Immune System (3pm Start)
Nazioni A
Massimo Andreatta,
University of Lausanne, Switzerland
Reference-based Analysis of Single T Cells in Acute and Chronic Infection
Reference-based Analysis of Single T Cells in Acute and Chronic Infection
Julia Frede,
Dana-Farber Cancer Institute, USA
Defining the Differentiation States of Multiple Myeloma at Single Cell Resolution Reveals Opportunities for Immunotherapy
Defining the Differentiation States of Multiple Myeloma at Single Cell Resolution Reveals Opportunities for Immunotherapy
Giorgia Alvisi,
Humanitas Research Hospital, Italy
Multimodal Single-cell Profiling of Intrahepatic Cholangiocarcinoma Defines Hyperactivated Tregs as a Potential Therapeutic Target
Multimodal Single-cell Profiling of Intrahepatic Cholangiocarcinoma Defines Hyperactivated Tregs as a Potential Therapeutic Target
*
Maria Xydia,
RCI Regensburg Center for Interventional Immunology, Germany
Conversion of Conventional T Cells into Suppressive Regulatory T Cells in Breast Cancer Patients
Conversion of Conventional T Cells into Suppressive Regulatory T Cells in Breast Cancer Patients
Blagoje Soskic,
Human Technopole, Italy
Immune Disease Risk Variants Regulate Gene Expression Dynamics during CD4+ T Cell Activation
Immune Disease Risk Variants Regulate Gene Expression Dynamics during CD4+ T Cell Activation
Leo Kunz,
Roche Glycart AG, Switzerland
Imaging-based Single Cell Analysis of Inflamed and Excluded Tumor Microenvironments Shows Similar Response to Cancer Immunotherapy
Imaging-based Single Cell Analysis of Inflamed and Excluded Tumor Microenvironments Shows Similar Response to Cancer Immunotherapy
16:30—17:00
Coffee Available
Nazioni B
17:00—19:00
Spatially-Resolved Omics at Single Cell Resolution (5pm Start)
Nazioni A
*
Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine, Germany
Session Chair
Session Chair
Ivano Legnini,
Berlin Institute for Medical Systems Biology, Germany
Optogenetic Perturbations of RNA Expression in Tissue Space
Optogenetic Perturbations of RNA Expression in Tissue Space
Panagiotis Karras,
VIB Center for Cancer Biology, Belgium
Short Talk: Spatially Distinct Cellular Niches Unravel a Developmental Hierarchy During Melanoma Growth
Short Talk: Spatially Distinct Cellular Niches Unravel a Developmental Hierarchy During Melanoma Growth
Edward Schrom,
National Institutes of Health, USA
Short Talk: Spatial Analysis of Cell Ensembles (SPACE): A General Framework for Characterizing Spatial Relationships among Cell Types in Tissues
Short Talk: Spatial Analysis of Cell Ensembles (SPACE): A General Framework for Characterizing Spatial Relationships among Cell Types in Tissues
Kyoung Won,
Cedars-Sinai Medical Center, USA
Short Talk: Cellular Resolution Tissue Territory Detection from Spatial Transcriptomics Data
Short Talk: Cellular Resolution Tissue Territory Detection from Spatial Transcriptomics Data
Chananchida Sang-aram,
Ghent University, Belgium
Short Talk: Benchmarking Deconvolution Methods for Spatial Transcriptomics Data
Short Talk: Benchmarking Deconvolution Methods for Spatial Transcriptomics Data
19:00
On Own for Dinner
08:00—09:00
Breakfast
Individual Hotel
09:00—12:00
Single Cell Analysis in Tumor Microenvironment (9am Start)
Nazioni A
Massimiliano Pagani,
IFOM ETS - The AIRC Institute of Molecular Oncology, Italy
Deciphering the Tumor Microenvironment by Multiomics Analyses
Deciphering the Tumor Microenvironment by Multiomics Analyses
*
Evan W. Newell,
Fred Hutchinson Cancer Research Center, USA
Using Antigen Specificity to Parse the High Dimensional Profiles of Tumor Infiltrating T Cells
Using Antigen Specificity to Parse the High Dimensional Profiles of Tumor Infiltrating T Cells
Coffee Break
*
Peter Lichter,
Deutsches Krebsforschungszentrum, Germany
Experiences in Assessing Intra-Tumor Heterogeneity by Single Cell Sequencing
Experiences in Assessing Intra-Tumor Heterogeneity by Single Cell Sequencing
Kara L. Davis,
Stanford University, USA
Unraveling Treatment Resistance in Acute Leukemia: Single-Cell Approaches for Clinical Translation
Unraveling Treatment Resistance in Acute Leukemia: Single-Cell Approaches for Clinical Translation
Samuel Rose,
Memorial Sloan Kettering Cancer Center, USA
Short Talk: Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment Informs Novel Combination Cancer Therapy Strategies
Short Talk: Transcriptional Connectivity of Regulatory T Cells in the Tumor Microenvironment Informs Novel Combination Cancer Therapy Strategies
Renato Ostuni,
Ospedale San Raffaele S.r.l., Italy
Short Talk: A Subset of Tumor-associated Macrophages Shapes Pathogenic Inflammation in Pancreatic Cancer
Short Talk: A Subset of Tumor-associated Macrophages Shapes Pathogenic Inflammation in Pancreatic Cancer
12:00—16:30
On Own for Lunch
12:00—12:30
Poster Setup
Nazioni B
12:00—20:00
Poster Viewing
Nazioni B
16:30—17:00
Coffee Available
Nazioni B
17:00—19:00
Development and Cell Fate at Single Cell Resolution II (5pm Start)
Nazioni A
*
Massimiliano Pagani,
IFOM ETS - The AIRC Institute of Molecular Oncology, Italy
Session Chair
Session Chair
Ido Amit,
Weizmann Institute, Israel
The Power of ONE: Immunology in the Age of Single Cell Genomics
The Power of ONE: Immunology in the Age of Single Cell Genomics
YeEun Kim,
Stanford University, USA
Short Talk: A Highly Multiplexed Single Cell Proteomic Screen Reveals Novel Human Lymphoid Progenitors
Short Talk: A Highly Multiplexed Single Cell Proteomic Screen Reveals Novel Human Lymphoid Progenitors
Qiong Wang,
City of Hope/BRI, USA
Short Talk: A Unique Adipocyte Progenitor Population Promotes Age-related Adiposity
Short Talk: A Unique Adipocyte Progenitor Population Promotes Age-related Adiposity
Sruthi Sivakumar,
University of Pittsburgh, USA
Short Talk: Is Aging Accompanied by ‘Biological Wisdom' at the Single-cell Level?
Short Talk: Is Aging Accompanied by ‘Biological Wisdom' at the Single-cell Level?
Yonatan Stelzer,
Weizmann Institute of Science, Israel
Short Talk: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell Commitment
Short Talk: Rethinking Mammalian Embryonic Development: An Integrated View of Epigenetics and Cell Commitment
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
Nazioni B
19:30—21:30
Poster Session 3 (7:30pm Start)
Nazioni B
08:00—09:00
Breakfast
Individual Hotel
09:00—12:00
Single Cell Analysis in Neuroscience (9am Start)
Nazioni A
*
Ana Pombo,
Max Delbrück Centre for Molecular Medicine, Germany
Specialization of 3D Genome Topologies in Specific Cell Types and States
Specialization of 3D Genome Topologies in Specific Cell Types and States
*
Florent Ginhoux,
Singapore Immunology Network, Singapore
Talk Title to be Announced
Talk Title to be Announced
Coffee Break
Fabian Müller,
Saarland University, Germany
Short Talk: Chromatin and Gene-regulatory Dynamics of the Developing Human Cerebral Cortex at Single-cell Resolution
Short Talk: Chromatin and Gene-regulatory Dynamics of the Developing Human Cerebral Cortex at Single-cell Resolution
Luna Zea Redondo,
MDC-BIMSB, Germany
Short Talk: Role of Chromatin Remodeling in Regulating Activity-dependent Gene Expression in Dopaminergic Neurons and its Potential Implication on Drug Addiction
Short Talk: Role of Chromatin Remodeling in Regulating Activity-dependent Gene Expression in Dopaminergic Neurons and its Potential Implication on Drug Addiction
Ana Gabriela Cristancho,
Children's Hospital of Philadelphia, USA
Short Talk: Cell Type Specific Epigenetic Trajectories are Globally Disrupted by Prenatal Hypoxia in the Developing Brain
Short Talk: Cell Type Specific Epigenetic Trajectories are Globally Disrupted by Prenatal Hypoxia in the Developing Brain
Rahul Dhodapkar,
Yale University, USA
Short Talk: Cross-species Single-cell Transcriptomic Analysis Reveals Factors Limiting Müller Glia-mediated Regeneration in Humans
Short Talk: Cross-species Single-cell Transcriptomic Analysis Reveals Factors Limiting Müller Glia-mediated Regeneration in Humans
Piyush Joshi,
DKFZ, Germany
Short Talk: Single-nucleus Developmental Human Hindbrain atlas and Pediatric Brainstem Tumor Lineage of Origins
Short Talk: Single-nucleus Developmental Human Hindbrain atlas and Pediatric Brainstem Tumor Lineage of Origins
Nina Urban,
Valted Seq, USA
Short Talk: A Novel Approach for Leveraging Transcriptomic Analysis from Post-mortem Tissue: High-Efficiency Single-nucleus RNA Sequencing (HiF-snRNAseq) in Neurodegenerative Disorders
Short Talk: A Novel Approach for Leveraging Transcriptomic Analysis from Post-mortem Tissue: High-Efficiency Single-nucleus RNA Sequencing (HiF-snRNAseq) in Neurodegenerative Disorders
12:00—14:30
On Own for Lunch
14:30—16:30
Workshop 3: Single Cell Technologies Toward Precision Medicine (2:30pm Start)
Nazioni A
Emily Speranza,
National Institutes of Health, USA
Determining the Spatial and Transcriptomic Response to RNA Virus Infection at Single Cell Resolution
Determining the Spatial and Transcriptomic Response to RNA Virus Infection at Single Cell Resolution
Jennifer Wiederspahn,
Charité Universitätsmedizin, Germany
Modeling the Tumor Microenvironment in Patient-derived Organoid Culture
Modeling the Tumor Microenvironment in Patient-derived Organoid Culture
Anna Doffini,
Menarini Biomarkers Singapore, Singapore
Single Cell Analysis in Prenatal Diagnosis
Single Cell Analysis in Prenatal Diagnosis
Sevahn Vorperian,
Stanford University, USA
Applying Single Cell Transcriptomic Atlases to Resolve Cell Types of Origin in Cell Free RNA Liquid Biopsy
Applying Single Cell Transcriptomic Atlases to Resolve Cell Types of Origin in Cell Free RNA Liquid Biopsy
Manu Singh,
Garvan Institute of Medical Research, Australia
Multi-omic Profiling of Rogue Lymphocytes in Celiac Disease
Multi-omic Profiling of Rogue Lymphocytes in Celiac Disease
*
Benjamin J. Ober-Reynolds,
Stanford University, USA
Integrated Single-cell Transcriptomic and Epigenetic Analyses Identify Candidate Causal Variants in Alopecia Areata
Integrated Single-cell Transcriptomic and Epigenetic Analyses Identify Candidate Causal Variants in Alopecia Areata
Yumie Tokunaga,
GIGA, University of Liege, Belgium
Single Cell RNA Sequencing to Uncover Intestinal Cell-type Specific cis-eQTL Driving Inherited Predisposition to IBD
Single Cell RNA Sequencing to Uncover Intestinal Cell-type Specific cis-eQTL Driving Inherited Predisposition to IBD
Xiang Zheng,
Novo Nordisk Foundation Center for Protein Research, Denmark
Leveraging Artificial Intelligence-driven Single-cell Deep Visual Proteomics to Uncover Reliable Mycosis Fungoides-specific Diagnostic and Prognostic Classifiers
Leveraging Artificial Intelligence-driven Single-cell Deep Visual Proteomics to Uncover Reliable Mycosis Fungoides-specific Diagnostic and Prognostic Classifiers
16:30—17:00
Coffee Available
Nazioni B
17:00—18:45
Single Cell Analysis in Infection Biology (5pm Start)
Nazioni A
*
Muzlifah A. Haniffa,
Wellcome Sanger Institute, UK
Decoding the Developing Human Immune System
Decoding the Developing Human Immune System
*
Emmanuel Saliba,
Helmholtz Institute for RNA based infection research, Germany
Regulatory and Virulence Mechanisms in Host-Pathogen Interactions
Regulatory and Virulence Mechanisms in Host-Pathogen Interactions
Angela Ciuffi,
Institute of Microbiology - CHUV/UNIL, Switzerland
Single Cell Analysis of Viral Pathogenesis
Single Cell Analysis of Viral Pathogenesis
Nadia R. Roan,
University of California, San Francisco, USA
Short Talk: T-TRACE: A scRNAseq Approach for Deep Multimodal Characterization of Blood and Nasal SARS-CoV-2-specific T Cells
Short Talk: T-TRACE: A scRNAseq Approach for Deep Multimodal Characterization of Blood and Nasal SARS-CoV-2-specific T Cells
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)
Nazioni A
19:00—20:30
Social Hour with Lite Bites
Nazioni B
08:00—08:00
Departure
*Session Chair †Invited, not yet responded.
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