Keystone Symposia

Snowbird Resort Floorplan

This meeting took place in 2022


Here are the related meetings in 2024:
Immunity and Aging (F3)

For a complete list of the meetings for the upcoming/current season, see our meeting list, or search for a meeting.

Cancer: Aging in the Driver's Seat (C4)


Organizer(s) Sheila A. Stewart, Judith Campisi, Manuel Serrano and Eiji Hara
March 27—30, 2022
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Dec 10, 2021
Scholarship Deadline: Dec 6, 2021
Discounted Registration Deadline: Feb 10, 2022

Sponsored by BioLegend, Inc.

Summary of Meeting:
Aging is the largest risk factor for the development of cancer, yet the classic aging research community and cancer researchers seldom interact. The goal of this meeting will be to bring together individuals who study the systemic and local impact of aging, including accelerated aging brought on by chemotherapy with cancer researchers to share their insight and develop a better understanding of how aging impacts tumor initiation, progression, recurrence and response to therapy. By bringing these experts together, the intent of this meeting will be to create a more complete picture of the potential therapeutic landscape. The unique feature of this meeting is its breadth of experts focused on both the systemic and local aging environment and cancer, who also recognize varied paracrine interactions with heterogeneous neoplastic cells. Presentations will focus on emerging studies to enable attendees’ access to senior investigators, as well as new investigators spanning the diversity of disciplines called ‘cancer biology’ and “aging.” In addition to invited speakers, time will be allotted for short oral presentations proffered form submitted abstracts and two integrated poster sessions.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 27 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 30 with a closing plenary session from 17:00 to 19:15, followed by a social hour. We recommend return travel on Thursday, March 31 in order to fully experience the meeting.

SUNDAY, MARCH 27

16:00—20:00
Arrival and Registration (4pm Start)

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, MARCH 28

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Keynote Address (8am Start)

Ballroom 2
* Eiji Hara, Osaka University, Japan
Session Chair

Judith Campisi, Buck Institute for Research on Aging, USA
Cellular Senescence: How a “Culture Artifact” Gained Respectability as a Driver of Cancer and Aging

09:00—11:30
Aging in the Tumor Microenvironment (9am Start)

Ballroom 2
* Damien Maggiorani, CR CHU-Sainte Justine, Canada
Session Chair

Sheila A. Stewart, Washington University School of Medicine, USA
Age-Related Stromal Changes Drive Metastatic Breast Cancer Progression

Coffee Break

Marco Demaria, European Research Institute for the Biology of Aging, Netherlands
Remote Presentation: Role of Cellular Senescence in Tumor Progression and Therapy-Induced Side Effects

Ashani T. Weeraratna, Johns Hopkins University, USA
Age and Tumor Initiation, Understanding the Drivers

* Derek A. Wainwright, Northwestern University Feinberg School of Medicine, USA
Aging-Dependent Changes in the Brain Stroma Drive Incurable Glioblastoma

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Superior/Wasatch
13:00—22:00
Poster Viewing

Superior/Wasatch
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
The Aging Immune Response, Cancer Sneaks In (5pm Start)

Ballroom 2
* Manuel Collado, Health Research Institute of Santiago de Compostela Foundation - FIDIS, Spain
Session Chair

Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
Remote Presentation: The Role of cGAS/STING and the Immune Response in Senescence

Arne N. Akbar, University College London, UK
Senescent Non Lymphoid Cells Inhibit Immunity in the Skin

Arya Biragyn, NIA, National Institutes of Health, USA
Short Talk: Cancer Outcome in Aging is Controlled by B Cells

Damien Maggiorani, CR CHU-Sainte Justine, Canada
Short Talk: Targeting Senescent Cells to Improve Tumor Immunotherapies

Anastasia Shindyapina, Harvard Medical School, USA
Short Talk: Integrative Analysis Reveals Aged Clonal B Cells, Microenvironment and c-Myc Activation in the Origin of Age-related Lymphoma

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Wasatch
19:30—22:00
Poster Session 1 (7:30pm Start)

Superior/Wasatch

TUESDAY, MARCH 29

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Stem Cells, Reprogramming and Cancer, How Is It All Related (8am Start)

Ballroom 2
Manuel Serrano, Institute for Research in Biomedicine, Spain
Remote Presentation: Cell States that Drive Reprogramming

* Amy J. Wagers, Harvard University, USA
Programming and Reprogramming Stem Cells for Regenerative Medicine

Coffee Break

Anne Brunet, Stanford University, USA
Remote Presentation: Epigenetic and Metabolism Crosstalk, Implications in Aging and Cancer

Stanislav Drapela, Moffitt Cancer Center, USA
Short Talk: HIRA is a Master Regulator of the Proliferation-to-Dormancy Switch in Breast Cancer

Brittany L. Angarola, The Jackson Laboratory, USA
Short Talk: Age-related Epigenomic and Transcriptomic Changes in Mammary Gland Tissue Predispose Cells to Cancer

Hari Easwaran, Johns Hopkins University, USA
Short Talk: Clonal Evolution of Epigenetic States during Ageing and Oncogene-driven Tumor Initiation

Manuel Collado, Health Research Institute of Santiago de Compostela Foundation - FIDIS, Spain
Short Talk: Reprogramming the Cancer Genome

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Superior/Wasatch
13:00—22:00
Poster Viewing

Superior/Wasatch
15:00—16:30
Career Roundtable (3pm Start)

Ballroom 2
David J. Glass, Regeneron Pharmaceuticals, Inc., USA

Curtis J. Henry, University of Colorado Cancer Center, USA

Ana O'Loghlen, Queen Mary University of London, UK

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:15
Inflammaging, What Does it Mean? (5pm Start)

Ballroom 2
* Brittany L. Angarola, The Jackson Laboratory, USA
Session Chair

Jennifer Elisseeff, Johns Hopkins University, USA
Impact of Senescence on the Immune System in Wound Healing, Cancer and Immunotherapy

Ana O'Loghlen, Queen Mary University of London, UK
Exosomes and Cytokines in Senescent Cells, How Do They Communicate?

Eiji Hara, Osaka University, Japan
Roles and Mechanisms of Cellular Senescence in Inflammation and Cancer

* Peter D. Adams, Sanford Burnham Prebys Medical Discovery Institute, USA
Investigating Aging as a Risk Factor and Target for Prevention of Liver Cancer – From Inside to Outside

Arrianna M. Zirbes, City of Hope, USA
Short Talk: Age-related Immune Suppressive Microenvironments in Breast Tissue Enhance Proliferation of Epithelial Cells Harboring Mutant PIK3CA Relative to Normal Cells

19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Wasatch
19:30—22:00
Poster Session 2 (7:30pm Start)

Superior/Wasatch

WEDNESDAY, MARCH 30

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Paracrine Signaling: What Drives Tumor Progression (8am Start)

Ballroom 2
* Arya Biragyn, NIA, National Institutes of Health, USA
Session Chair

Naoko Ohtani, Osaka City University Graduate School of Medicine, Japan
Gut-liver Axis-mediated Mechanism of SASP in Tumor Microenvironment of Obesity-associated Liver Cancer

* Curtis J. Henry, University of Colorado Cancer Center, USA
Delineating the Impact of Inflamm-aging on Leukemia Development and the Efficacy of Chimeric Antigen Receptor T-cell Therapy

Coffee Break

David J. Glass, Regeneron Pharmaceuticals, Inc., USA
Age-Related Gene and Signaling Perturbations that Increase the Probability of Oncogenesis

Ana Gomes, Moffitt Cancer Center, USA
Short Talk: Age-induced Chronic Accumulation of Cortisol Drives Chemotherapy Resistance in Lung Cancer

Jinyoung Lee, University of California, San Francisco, USA
Short Talk: p16INK4A+ Cancer-associated Fibroblast Reprograms Tumor Plasticity to Drive Progression of Lung Adenocarcinoma

Patrick R. Ryan, University of Massachusetts Amherst, USA
Short Talk: Bioengineered 3D Bone Models to Study Chemotherapy-induced Aging and Metastasis

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Targeting the Systemic Environment (5pm Start)

Ballroom 2
* Patrick R. Ryan, University of Massachusetts Amherst, USA
Session Chair

* Sandra S. McAllister, Brigham & Women's Hospital/Harvard Medical School, USA
Impact of Immunological Age on Breast Cancer Progression and Response to Therapy

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Remote Presentation: Selective Autophagy, Eating your Way to Cancer

Pura Muñoz Cánoves, Altos Lab, USA
Remote Presentation: Muscle Wasting in Aging

Scott W. Lowe, Memorial Sloan Kettering Cancer Center, USA
Immune Surveillance of Senescent Cells

19:00—19:15
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (7pm Start)

Ballroom 2
19:15—20:15
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Ballroom 1

THURSDAY, MARCH 31

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsor(s) for generously supporting this meeting:

BioLegend, Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 CA257240-01

Funding for this conference was made possible (in part) by 1 R13 CA257240-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

American Association for Cancer Research (AACR) Cancer Discovery

We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


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Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


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If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Josh May, Director, Technology and Digital Media, Email: joshuam@keystonesymposia.org,
Phone:+1 970-262-1179