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This meeting took place in 2022



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Neuronal Control of Appetite (X5)


Organizer(s) Richard B. Simerly, J. Nicholas Betley and Stephanie E. Fulton
March 20—23, 2022
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Dec 7, 2021
Scholarship Deadline: Nov 30, 2021
Discounted Registration Deadline: Feb 3, 2022

Sponsored by BioLegend, Inc. and Novo Nordisk A/S

Joint Meeting: Gut-Brain Axis (X6)

Summary of Meeting:
How the brain coordinates multiple physiological and environmental signals to regulate body weight remains an important and actively investigated biological question. The answer to this question has direct clinical relevance to the management of obesity. The majority of research in this area has focused, appropriately, on neuroendocrine regulation of food intake and energy expenditure. Here we focus on recent work that builds on this progress to further expand our understanding of energy balance regulation within the context of motivated behavior. In a dynamic world, the decision to consume food is made after weighing competing needs that also must be addressed to ensure survival as individuals seek, consume and store energy. Additionally, neural systems also reward inappropriate food intake. This symposium focuses on work being done at both the circuit and systems level, in humans and animal models, to understand how and when food intake is prioritized, how the brain integrates relevant sensory information, balances competing needs, and coordinates adaptive behavior and associated physiological responses to effectively manage energy balance. This symposium will also explore development of the neural systems that accomplish these integrative processes. Additionally, we will examine how environmental and interoceptive signals, as well as neuroinflammation, can change the organization and function of these neural systems. A diverse array of experimental approaches will be on display that both support and challenge current concepts of energy balance regulation and promise to provide a rich framework for discussion and collaboration.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, March 20 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, March 23 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, March 24 in order to fully experience the meeting.

SUNDAY, MARCH 20

16:00—20:00
Arrival and Registration (4pm Start)

Shaughnessy
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Beatty/Coleman

MONDAY, MARCH 21

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—09:30
Welcome and Keynote Session (Joint) (8am Start)

Van Horne A/B
* Richard B. Simerly, Vanderbilt University, USA
Session Chair

* Ann Weber, Kallyope, USA
Session Chair

David J. Anderson, California Institute of Technology, USA
Neural Mechanisms of Aggression and Defense and of Their Associated Internal States

Charles S. Zuker, HHMI, Columbia University, USA
The Neural Basis of Sugar and Fat Preference

Coffee Break

09:50—11:30
Vagal Circuits (Joint) (9:50am Start)

Van Horne A/B
* Richard B. Simerly, Vanderbilt University, USA
Session Chair

* Amber L. Alhadeff, Monell Chemical Senses Center, USA
Session Chair

Misha Ahrens, Janelia Research Campus, USA
Imaging of Gut-Brain Circuits in Zebrafish

Jeffrey M. Friedman, Rockefeller University, USA
Molecular Mechanisms Regulating Feeding and Body Weight

Laura Rupprecht, Duke University, USA
Short Talk: A Gut Cell for Food Reward

Chen Ran, Harvard Medical School, USA
Short Talk: The Coding of Visceral Senses in the Brainstem

11:30—17:00
On Own for Lunch

11:30—13:00
Poster Setup

Van Horne C/President's Hall
13:00—22:00
Poster Viewing

Van Horne C/President's Hall

Following Session is for Gut-Brain Axis (X6)

14:30—16:30
Workshop (2:30pm Start)

Van Horne B
* Sarkis K. Mazmanian, California Institute of Technology, USA
Session Chair

Alan de Araujo, University of Florida, USA
Asymmetric Vagal Control of Food Intake

Shannon Marie Landon, University of Texas at San Antonio, USA
GRASP in the Gustatory System: Observing Synaptic Connectivity and Dynamics in Peripheral Taste Circuits

Kyle H. Flippo, University of Iowa Carver College of Medicine, USA
Suppression of Sucrose and Alcohol Consumption by FGF21 are Mediated by Distinct Central Circuits

Winston W. Liu, Duke University, USA
Neural Recognition of Bacterial Patterns in the Gut

Hallie R. Wachsmuth, University of Arizona, USA
Colonic Butyrate Lowers Hepatic Glucose Production via FFAR2-dependant Vagal Afferent Neuronal Signaling

Tyler M. Cook, Loyola University Chicago, USA
Vagal Free Fatty Acid Receptor 3 (FFAR3) Regulates Feeding Behavior

Joep Beumer, Hubrecht Institute, Netherlands
Human Intestinal Organoids Model Function and Development of Enteroendocrine Cells

Phyllis Phuah, Imperial College London, UK
The Microbial Tryptophan Metabolite Indole Modulates the GLP-1 System to Improve Glucose Homeostasis

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Food Appeal: Neural Circuits Encoding Perception and Value (5pm Start)

Van Horne A
* Martin G. Myers, Jr., University of Michigan, USA
Session Chair

Mark L. Andermann, Beth Israel Deaconess Medical Center, USA
The Interplay of Anxiety and Hunger in Anorexia Nervosa

Dana M. Small, Yale University School of Medicine, USA
Images of Desire

J. Nicholas Betley, University of Pennsylvania, USA
A Cerebellar Satiation Center

Lauren Seabrook, University of Calgary, Canada
Short Talk: Obesity Induced Disinhibition of the Orbitofrontal Cortex Leads to Impairment in Goal Directed Behaviour

Jemma Rezitis, Garvan Institute of Medical Research, Australia
Short Talk: Chronic Stress Inhibition of Y1 Neurons in the LHb Overrides Homeostatic Control on Feeding Behavior


Following Session is for Gut-Brain Axis (X6)

17:00—19:00
Enteroendocrine Cells and Gut Hormone Signaling (5pm Start)

Van Horne B
Holly A. Ingraham, University of California, San Francisco, USA
Remote Presentation: Enterochromaffin Cells: Detection and Transduction of Environmental, Metabolic and Homeostatic Information from the Gut Directly to the Nervous System

* Matheus de Castro Fonseca, Brazilian Biosciences National Laboratory, Brazil
Good Bug or Bad Bug: Calcium Overload and α-Synuclein Aggregation Induced by the Gut Bacterium Akkermansia Muciniphila in EECs

Diego V. Bohórquez, Duke University, USA
Transduction of a Sense from Gut to Brain

Lihua Ye, Ohio State University, USA
Short Talk: An Enteroendocrine-vagal Sensory Pathway that Transmits Gut Bacterial Signal to the Brain

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall
19:30—22:00
Poster Session 1 (7:30pm Start)

Van Horne C/President's Hall

TUESDAY, MARCH 22

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—11:00
Food Intake and Decision-Making: Networks Promoting Food Intake in the Face of Competing Needs (8am Start)

Van Horne A
* Stephanie E. Fulton, University of Montreal, Canada
Session Chair

Hilke Plassmann, INSEAD, France
Is the Gut-Microbiome-Brain Axis Involved in How Impatient We Are for Food and Other Rewards?

Giovanni Marsicano, INSERM U1215, France
CB1 Cannabinoid Receptors and Food Intake: A Tale of Space and Time

Coffee Break

Sarah N. Garfinkel, University College London, UK
How Interoception Influences Affective State

Yuki Oka, California Institute of Technology, USA
Regulation of Thirst and Sodium Appetite

Laura L. Kaiser, Pennington Biomedical Research Center, USA
Short Talk: Preoptic Area Leptin Receptor (POALepr) Neurons Mediate Temperature-dependent Food Intake Adaptations via Pro-opiomelanocortin (POMC) Neurons


Following Session is for Gut-Brain Axis (X6)

08:00—11:00
Mucosal Immune System (8am Start)

Van Horne B
* Daniel Mucida, Rockefeller University, USA
Neuro-Immune Communication in the Control of Inflammation in the Gut

Jennifer L. Gommerman, University of Toronto, Canada
Under the Influence: B Cells, the Microbiome and CNS Inflammation in an Animal Model of Multiple Sclerosis

Coffee Break

Matthias H. Tschöp, Helmholtz Munich, Germany
Harnessing Gut-Brain Signals for Metabolic Health: Discovery and Clinical Validation of Incretin Polyagonists

Sabrina Huwart, UCLouvain, MNut, Belgium
Short Talk: Behavioral and Neuronal Alterations of the Food Reward System are Associated with Neuroinflammation: Roles of Gut Microbes?

David Tyus, University of Virginia, USA
Short Talk: Adrenergic Signaling Drives C. Difficile Infection Disease Severity

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Van Horne C/President's Hall
13:00—22:00
Poster Viewing

Van Horne C/President's Hall
14:30—16:30
Career Roundtable (Joint) (2:30pm Start)

Alhambra (main hotel)
Christopher Reyes, Bloom Science, Inc., USA

Rachel N. Lippert, Neurocircuit Development and Function German Institute of Human Nutrition, Germany

Dana M. Small, Yale University School of Medicine, USA

Rachel A. Ross, Albert Einstein College of Medicine, USA

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—19:00
Diet-Induced Neuroinflammation and Metabolic Circuitry (5pm Start)

Van Horne A
* Thierry Alquier, CRCHUM-University of Montreal, Canada
Session Chair

Stephanie E. Fulton, University of Montreal, Canada
Neuroimmune Correlates of Diet-Induced Mood Deficits

Cristina García Cáceres, LMU & Helmholtz Zentrum München GmbH, Germany
Disruption of Astrocyte-Neuron Crosstalk in Obesity

Ashley E. Frakes, National Institutes of Health/ NIDDK, USA
Astrocytes: Cell Non-autonomous Regulators of Metabolic Homeostasis and Longevity

Anzela Niraula, University of Washington, USA
Short Talk: Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-induced Obesity


Following Session is for Gut-Brain Axis (X6)

17:00—19:00
Signaling and the Brain (5pm Start)

Van Horne B
* Scott M. Sternson, HHMI/University of California, San Diego, USA
Algorhythms for Appetite

Lotte Bjerre Knudsen, Novo Nordisk A/S, Denmark
Emerging Therapies for Obesity and Alzheimer's Disease – GLP-1 in the Brain

Amber L. Alhadeff, Monell Chemical Senses Center, USA
Gut-Brain Influence on Motivated Behavior

Molly J. McDougle, University of Florida, USA
Short Talk: Fats and Sugars Recruit Distinct Gut-Brain Circuits to Control Food Intake and Reward

Seongju Lee, Korea Advanced Institute of Science and Technology, South Korea
Short Talk: Gut-Brain Axis Mediating the Responses to Protein Deprivation in Flies and Mice

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall
19:30—22:00
Poster Session 2 (7:30pm Start)

Van Horne C/President's Hall

WEDNESDAY, MARCH 23

07:00—08:00
Breakfast

Van Horne C/President's Hall
08:00—11:00
Neurodevelopmental Programming of Feeding Behavior (8am Start)

Van Horne A
* J. Nicholas Betley, University of Pennsylvania, USA
Session Chair

Rachel N. Lippert, Neurocircuit Development and Function German Institute of Human Nutrition, Germany
Dopamine, Behavior and the Effects of Maternal Overnutrition

Marcelo O. Dietrich, Yale University, USA
Ontogeny of Feeding Behavior

Coffee Break

Linda Rinaman, Florida State University, USA
Postnatal Plasticity of Vagal Gut-Brain Circuits

Richard B. Simerly, Vanderbilt University, USA
Developmental Neurobiology of Hypothalamic Sensory-Motor Integration

Ayden C. Gouveia, Max Planck Institute for Metabolism Research, Germany
Short Talk: Sensory Cues in Early Life Program Long-Term Metabolism and Central Response to Food

Roberta Haddad-Tóvolli, IDIBAPS, Spain
Short Talk: Pregnancy Food Craving-like Episodes are Mediated by Accumbal D2R Neurons


Following Session is for Gut-Brain Axis (X6)

08:00—11:00
Microbiome (8am Start)

Van Horne B
Mauro Costa-Mattioli, Baylor College of Medicine, USA
Remote Presentation: Gut Microbe Control of CNS Driven-Behavior and Brain Function

* Elaine Y. Hsiao, University of California, Los Angeles, USA
Microbiome Influence on Brain and Behavior

Coffee Break

Maria Rodriguez Aburto, University College Cork, Ireland
Deciphering the Role of Early Life Microbiota in Neuro-glia-vascular Development

Adam Michael Hamilton, Emory University, USA
Short Talk: Dysbiosis Contributes to Impaired Gastrointestinal Physiology Following Spinal Cord Injury

11:00—17:00
On Own for Lunch

16:30—17:00
Coffee Available

Van Horne Foyer
17:00—18:45
Circadian and Environmental Impacts on Metabolism (5pm Start)

Van Horne A
* Giles S.H. Yeo, University of Cambridge, UK
Session Chair

Roger D. Cone, University of Michigan, USA
Talk Title to be Announced

John Stuart O'Neill, MRC Laboratory of Molecular Biology, UK
Insulin Signalling Stimulates PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
FGF21 and Alcohol: Eat and Drink, But Don't Get Too Merry

Rachel Van Drunen, UTHealth, USA
Short Talk: The Rhythmic Role of the Paraventricular Hypothalamus in Diurnal Energy Balance


Following Session is for Gut-Brain Axis (X6)

17:00—18:45
Therapeutic Approaches (5pm Start)

Van Horne B
* Ann Weber, Kallyope, USA
Session Chair

Alison Nicole McRae, Mayo Clinic, USA
Regulator of G-Protein Signaling 9 in Enteroendocrine Cells Dysfunction, Weight Loss and Obesity

Sarkis K. Mazmanian, California Institute of Technology, USA
Microbiome-Based Therapeutics for Autism

Shirly Pinto, Kallyope, USA
Harnessing Innovation for the Discovery of New Therapeutics for the Treatment of Metabolic Disorders

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Van Horne A

Following Session is for Gut-Brain Axis (X6)

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (6:45pm Start)

Van Horne B
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Van Horne C/President's Hall

THURSDAY, MARCH 24

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

BioLegend, Inc. Novo Nordisk A/S

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1R13DK132923-01

Funding for this conference was made possible (in part) by 1R13DK132923-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


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