Snowbird Resort Floorplan
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NOTES:
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
This meeting will be conducted in English.
All programs are subject to change. Check this site for updates.
Download Flyer
No registration fees are used to fund entertainment or alcohol at this conference
The meeting will begin on Sunday, April 16 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 19 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, April 20 in order to fully experience the meeting.
SUNDAY, APRIL 16
MONDAY, APRIL 17
TUESDAY, APRIL 18
WEDNESDAY, APRIL 19
THURSDAY, APRIL 20
Conference Program Print | View meeting in 12 hr (am/pm) time
The meeting will begin on Sunday, April 16 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 19 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, April 20 in order to fully experience the meeting.
SUNDAY, APRIL 16
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.
08:00—09:00
Welcome and Keynote Address (Joint)
Vishva M. Dixit,
Genentech, Inc., USA
Why So Many Ways to Die?
Why So Many Ways to Die?
Coffee Break
09:30—11:15
Evolutionary Origin of Innate Immunity
Rotem Sorek,
Weizmann Institute of Science, Israel
Innate Immunity in Bacteria
Innate Immunity in Bacteria
Emily Troemel,
University of California, San Diego, USA
Innate Immunity in C. Elegans
Innate Immunity in C. Elegans
Sara R. Cherry,
University of Pennsylvania, USA
Innate Immunity in Drosophila
Innate Immunity in Drosophila
Tianmin Fu,
Ohio State University, USA
Short Talk: Structures and Functions of a Bacterial Inflammasome-like System
Short Talk: Structures and Functions of a Bacterial Inflammasome-like System
09:30—11:15
Profiling Human Myeloid Cells and Targeting them in Disease
Muzlifah A. Haniffa,
Wellcome Sanger Institute, UK
Decoding Human Prenatal Myeloid Cell Development and Function
Decoding Human Prenatal Myeloid Cell Development and Function
Gwendalyn J. Randolph,
Washington University, USA
Human Peritoneal Macrophages in Health and Disease
Human Peritoneal Macrophages in Health and Disease
Boris Reizis,
New York University Langone Medical Center, USA
Human Dendritic Cell Development During Adult Hematopoiesis
Human Dendritic Cell Development During Adult Hematopoiesis
Kevin Barry,
Fred Hutchinson Cancer Center, USA
Short Talk: Innate Immune Regulation of Protective Immunity and Immunotherapy Responses in Melanoma
Short Talk: Innate Immune Regulation of Protective Immunity and Immunotherapy Responses in Melanoma
14:30—16:30
Workshop 1: Late-Breaking Research
Pascal Devant,
Harvard Medical School/Boston Children's Hospital, USA
Structural Insights into Cytokine Cleavage by an Inflammatory Caspase
Structural Insights into Cytokine Cleavage by an Inflammatory Caspase
Adam Lacy-Hulbert,
Benaroya Research Institute, USA
LITAF Promotes Resistance to Cell Death Induced by Bacterial Pore-forming Toxins and Endogenous Membrane Pores
LITAF Promotes Resistance to Cell Death Induced by Bacterial Pore-forming Toxins and Endogenous Membrane Pores
Natalia G. Sampaio,
Hudson Institute of Medical Research, Australia
MDA5 Guards against Infection by Surveying Cellular RNA Homeostasis
MDA5 Guards against Infection by Surveying Cellular RNA Homeostasis
Tian Tian,
UCONN Health, USA
Structural Basis for a Unique Regulation of GSDMB Pore Formation and the Recognition of GSDMB by Shigella Effector IpaH7.8
Structural Basis for a Unique Regulation of GSDMB Pore Formation and the Recognition of GSDMB by Shigella Effector IpaH7.8
Jakub Began,
University of Lausanne, Switzerland
Molecular Characterization of GBP1-driven Non-canonical Inflammasome Assembly
Molecular Characterization of GBP1-driven Non-canonical Inflammasome Assembly
Jazlyn P. Borges,
Hospital for Sick Children, Canada
NINJ1 Forms Large Pore-Like Structures within the Plasma Membrane During Pyroptosis
NINJ1 Forms Large Pore-Like Structures within the Plasma Membrane During Pyroptosis
Danyel Lee,
Rockefeller University, USA
Inborn Errors of OAS–RNase L in SARS-CoV-2–related Multisystem Inflammatory Syndrome in Children
Inborn Errors of OAS–RNase L in SARS-CoV-2–related Multisystem Inflammatory Syndrome in Children
Alex G. Johnson,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Structure of a Bacterial Gasdermin Pore
Structure of a Bacterial Gasdermin Pore
14:30—16:30
Workshop 1: Single Cell Multiomics Analysis of Myeloid Cells
Amélie Collins,
Columbia University Irving Medical Center, USA
Fetal Emergency Myelopoiesis is Restricted by Maternal Inflammation
Fetal Emergency Myelopoiesis is Restricted by Maternal Inflammation
Anthony Wong,
University of Toronto, Canada
Epigenetic and Transcriptional Mechanisms Regulating Cardiac Macrophage Heterogeneity
Epigenetic and Transcriptional Mechanisms Regulating Cardiac Macrophage Heterogeneity
Cathy Yea Won Sung,
NIH, USA
Single Nucleus RNA Sequencing Identifies Two Unique Macrophage Subsets in Control and Cisplatin-treated Mouse Cochleae
Single Nucleus RNA Sequencing Identifies Two Unique Macrophage Subsets in Control and Cisplatin-treated Mouse Cochleae
Mia J. Phillipson,
Uppsala University, Sweden
Macrophages Support Healing of Ischemic Injury by Transdifferentiating Towards Mural Cells and Adopting Functions Important for Vascular Support
Macrophages Support Healing of Ischemic Injury by Transdifferentiating Towards Mural Cells and Adopting Functions Important for Vascular Support
Manuela Pereira Abrantes,
Cancer Research Center of Lyon, France
The Multifaceted Neutrophils and their Partners on the Human Colorectal Cancer Road
The Multifaceted Neutrophils and their Partners on the Human Colorectal Cancer Road
Anne B. Krug,
Ludwig Maximilians University Munich, Germany
Yellow Fever Vaccination Induces Coordinated Activation of Human Blood Dendritic Cell and Monocyte Subpopulations Correlating with Plasma Cytokine Levels and Antibody Titers
Yellow Fever Vaccination Induces Coordinated Activation of Human Blood Dendritic Cell and Monocyte Subpopulations Correlating with Plasma Cytokine Levels and Antibody Titers
Maximilian Nitschké,
Genentech, Inc., USA
Notch2 Blockade Expands a Population of Recruited Macrophages in the Lung that Regulate Responses to Tissue Injury
Notch2 Blockade Expands a Population of Recruited Macrophages in the Lung that Regulate Responses to Tissue Injury
Kalyn R. Thayer,
Feinberg School of Medicine, Northwestern University, USA
Lineage-tracing and Single-cell Transcriptomics Identifies Marginal Zone, Metallophilic, and Tingible Body Macrophages in Mouse Spleen and their Human Homologs
Lineage-tracing and Single-cell Transcriptomics Identifies Marginal Zone, Metallophilic, and Tingible Body Macrophages in Mouse Spleen and their Human Homologs
17:00—19:00
Innate Sensing I
Hao Wu,
Harvard Medical School, Boston Children's Hospital, USA
Inflammasomes
Inflammasomes
Veit Hornung,
Ludwig-Maximilians-University Munich, Germany
Inflammasomes
Inflammasomes
Liman Zhang,
Oregon Health & Science University, USA
Inflammasomes
Inflammasomes
Cornelius Y. Taabazuing,
University of Pennsylvania Perelman School of Medicine, USA
Inflammatory Caspases and Inflammasomes
Inflammatory Caspases and Inflammasomes
17:00—19:00
Lineage Tracing and Lineage Reprogramming
Rosandra Natasha Kaplan,
NCI, National Institutes of Health, USA
Reprogramming Myeloid Cells in Tumors
Reprogramming Myeloid Cells in Tumors
Shalin H. Naik,
Walter & Eliza Hall Institute, Australia
DC Lineage Mapping
DC Lineage Mapping
Juliana Idoyaga,
Stanford University, USA
Talk Title to be Announced
Talk Title to be Announced
Alissa J. Trzeciak,
Sloan Kettering Institute, USA
Short Talk: WNK1 Enforces Macrophage Lineage Fidelity
Short Talk: WNK1 Enforces Macrophage Lineage Fidelity
Mark B. Headley,
Fred Hutch Cancer Center, USA
Short Talk: A Division of Labor in Dendritic Cell-mediated Immunosurveillance of Lung Airway vs Vasculature
Short Talk: A Division of Labor in Dendritic Cell-mediated Immunosurveillance of Lung Airway vs Vasculature
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Innate Immunity and Disease
Katrin D. Mayer-Barber,
NIAID, National Institutes of Health, USA
The Role of Eosinophils in Tuberculosis
The Role of Eosinophils in Tuberculosis
Michael Crackower,
Ventus Therapeutics, USA
Structure and Computation-Based Drug Discovery in Innate Immunity
Structure and Computation-Based Drug Discovery in Innate Immunity
Coffee Break
Edward A. Miao,
Duke University, USA
Caspase-7 Activates ASM to Repair Gasdermin and Perforin Pores
Caspase-7 Activates ASM to Repair Gasdermin and Perforin Pores
Sylvia Torres Odio,
Texas A&M Health Science Center, USA
Short Talk: CMPK2 Governs Pro-inflammatory Responses in Myeloid Innate Immune Cells
Short Talk: CMPK2 Governs Pro-inflammatory Responses in Myeloid Innate Immune Cells
Vivian Chih-Wei Chen,
Duke-NUS Medical School, Singapore
Short Talk: Bat ASC2 Suppresses Inflammasomes and Ameliorates Inflammatory Diseases
Short Talk: Bat ASC2 Suppresses Inflammasomes and Ameliorates Inflammatory Diseases
Kevin MingJie Gao,
UMass Chan Medical School, USA
Short Talk: STING Gain-of-function in Endothelial Cells Initiates Interstitial Lung Disease
Short Talk: STING Gain-of-function in Endothelial Cells Initiates Interstitial Lung Disease
Marcia Goldberg,
Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages
Short Talk: Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages
08:00—11:00
Lineage Commitment, Identity, and Maintenance
Roxane Tussiwand,
NIDCR, National Institutes of Health, USA
Redefining the Myeloid-Lymphoid Split
Redefining the Myeloid-Lymphoid Split
Kenneth M. Murphy,
Washington University School of Medicine, USA
Transcriptional Regulation of Dendritic Cell Development
Transcriptional Regulation of Dendritic Cell Development
Coffee Break
Charlotte L. Scott,
University of Ghent & VIB, Belgium
Functional Heterogeneity of Hepatic Macrophages
Functional Heterogeneity of Hepatic Macrophages
Christopher K. Glass,
University of California, San Diego, USA
Epigenetic Regulation of Macrophage Identity
Epigenetic Regulation of Macrophage Identity
Ty D. Troutman,
Cincinnati Children's Hospital Medical Center, USA
Short Talk: Systematic Analysis of Transcriptional and Epigenetic Effects of Genetic Variation in Kupffer Cells Enables Discrimination of Cell Intrinsic and Environment-Dependent Mechanisms
Short Talk: Systematic Analysis of Transcriptional and Epigenetic Effects of Genetic Variation in Kupffer Cells Enables Discrimination of Cell Intrinsic and Environment-Dependent Mechanisms
Fabiola Osorio,
University of Chile, Chile
Short Talk: Control of Intestinal Th17 Cell Homeostasis by the Unfolded Protein Response Sensor IRE1 in Dendritic Cells
Short Talk: Control of Intestinal Th17 Cell Homeostasis by the Unfolded Protein Response Sensor IRE1 in Dendritic Cells
17:00—19:00
Innate Immunity and Infection
Russell E. Vance,
University of California, Berkeley, USA
Innate Immunity and the Pathogenesis of Tuberculosis
Innate Immunity and the Pathogenesis of Tuberculosis
Megan H. Orzalli,
University of Massachusetts Medical School, USA
Innate Immunity in Viral Infections
Innate Immunity in Viral Infections
Feng Shao,
National Institute of Biological Sciences, China
Pyroptosis and Infection
Pyroptosis and Infection
Qiankun Wang,
Washington University in St. Louis, USA
Short Talk: CARD8 Inflammasome Drives CD4+ T Cell Depletion in HIV-1 Infection
Short Talk: CARD8 Inflammasome Drives CD4+ T Cell Depletion in HIV-1 Infection
Harshad Ingle,
Washington University in St. Louis, USA
Short Talk: IFN-L Derived from Non-permissive Enterocytes Acts on Tuft Cells to Limit Norovirus Persistence
Short Talk: IFN-L Derived from Non-permissive Enterocytes Acts on Tuft Cells to Limit Norovirus Persistence
17:00—19:00
Myeloid Cells in Integrated Tissue Immunity
Slava Epelman,
University of Toronto, Canada
A Common Starting Point to Understand Resident Macrophage Heterogeneity
A Common Starting Point to Understand Resident Macrophage Heterogeneity
Yasmine Belkaid,
NIAID, National Institutes of Health, USA
Microbiome / Myeloid Cell Interactions in Shaping Immunity
Microbiome / Myeloid Cell Interactions in Shaping Immunity
Jesse Warren Williams,
University of Minnesota, USA
Foamy Macrophages Rely on Trem2 for Survival during Atherosclerosis
Foamy Macrophages Rely on Trem2 for Survival during Atherosclerosis
Andreas Schlitzer,
University of Bonn, Germany
Short Talk: GPR183 Targets Lung-resident CD301b+ Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor-mediated Survival Niche within the Adventitial Cuff
Short Talk: GPR183 Targets Lung-resident CD301b+ Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor-mediated Survival Niche within the Adventitial Cuff
Tim Willinger,
Karolinska Institutet, Sweden
Short Talk: Tracking Macrophage Origin in Human Airway Disease Reveals Continuous Macrophage Differentiation and Expansion of GPR183+ Monocytes
Short Talk: Tracking Macrophage Origin in Human Airway Disease Reveals Continuous Macrophage Differentiation and Expansion of GPR183+ Monocytes
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
08:00—11:00
Innate Leukocytes
Eric Vivier,
Aix Marseille University and Innate Pharma, France
Leveraging Innate Lymphocytes for Anti-Tumor Therapy
Leveraging Innate Lymphocytes for Anti-Tumor Therapy
Lydia Lynch,
Harvard Medical School, USA
Obesity and Diet on iNKT Cells, NK Cells and T Cells
Obesity and Diet on iNKT Cells, NK Cells and T Cells
Coffee Break
Marco Colonna,
Washington University School of Medicine, USA
Innate Lymphoid Cells (ILCs) in Mucosal Immunity
Innate Lymphoid Cells (ILCs) in Mucosal Immunity
Ankit Malik,
University of Chicago, USA
Short Talk: Compartmentalized Antigen Presentation between Epithelial Cells and Macrophages Orchestrates Gut Immunity
Short Talk: Compartmentalized Antigen Presentation between Epithelial Cells and Macrophages Orchestrates Gut Immunity
Andrew Oberst,
University of Washington, USA
Short Talk: "Necroptosis" as an Innate Immune Signaling Pathway
Short Talk: "Necroptosis" as an Innate Immune Signaling Pathway
Hannah E. Meibers,
University of Cincinnati and Cincinnati Children's Hospital Medical Center, USA
Short Talk: Effector Memory T Cells Induce Innate Inflammation by Triggering a DC-intrinsic DNA Damage Response and Subsequent Non-canonical STING Pathway
Short Talk: Effector Memory T Cells Induce Innate Inflammation by Triggering a DC-intrinsic DNA Damage Response and Subsequent Non-canonical STING Pathway
Isabella Rauch,
OHSU, USA
Short Talk: Activation of the NAIP–NLRC4 Inflammasome in Tuft Cells Leads to a Prostaglandin D2 Mediated Antibacterial Response in the Small Intestine
Short Talk: Activation of the NAIP–NLRC4 Inflammasome in Tuft Cells Leads to a Prostaglandin D2 Mediated Antibacterial Response in the Small Intestine
08:00—11:00
Myeloid Cell Dynamics in Health and Disease
Milka Sarris,
University of Cambridge, UK
Myeloid Cell Dynamics in Zebrafish Wounds
Myeloid Cell Dynamics in Zebrafish Wounds
Carole A. Parent,
University of Michigan, USA
Cell Migration in Inflammation and Metastasis
Cell Migration in Inflammation and Metastasis
Coffee Break
Minsoo Kim,
University of Rochester, USA
Dynamic Interaction of Myeloid Cells during the Initiation and Resolution of Infection
Dynamic Interaction of Myeloid Cells during the Initiation and Resolution of Infection
De' Broski R. Herbert,
University of Pennsylvania, USA
Myeloid Cell-Derived IL-33
Myeloid Cell-Derived IL-33
Kavita Rawat,
Dartmouth College, USA
Short Talk: CCL5-producing Migratory Dendritic Cells Guide CCR5+ Monocytes into the Draining Lymph Nodes
Short Talk: CCL5-producing Migratory Dendritic Cells Guide CCR5+ Monocytes into the Draining Lymph Nodes
Roarke A. Kamber,
University of California, San Francisco, USA
Short Talk: CRISPR Screens Identify Regulators of Live and Dead Cell Phagocytosis by Macrophages
Short Talk: CRISPR Screens Identify Regulators of Live and Dead Cell Phagocytosis by Macrophages
14:30—16:30
Workshop 2
Ranit Kedmi,
Weizmann Institute of Science, Israel
Dendritic Cell Heterogeneity: A Story of Redundancy or Overlooked Specificity?
Dendritic Cell Heterogeneity: A Story of Redundancy or Overlooked Specificity?
Kennady Abbott,
University of Texas Southwestern Medical Center, USA
Dynamic Regulation of STING Expression and Signaling in T cells from Development to Maturity
Dynamic Regulation of STING Expression and Signaling in T cells from Development to Maturity
Carlos Donado,
Harvard Medical School, USA
Granzyme K Activates a New Complement Pathway
Granzyme K Activates a New Complement Pathway
Devon Jeltema,
University of Texas Southwestern Medical Center, USA
Role of PARP7 in Negative Feedback Regulation of Type I Interferon Signaling
Role of PARP7 in Negative Feedback Regulation of Type I Interferon Signaling
Yupeng Wang,
Pyrotech Beijing Biotechnology Co., Ltd, China
Development of Selective and Potent ALPK1 Inhibitors for Treating Inflammatory Diseases
Development of Selective and Potent ALPK1 Inhibitors for Treating Inflammatory Diseases
Shan Li,
Huazhong Agricultural University, China
Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-deacylization of Caspases
Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-deacylization of Caspases
Adriana M. Mujal,
Memorial Sloan Kettering, USA
Tissue-specific Determinants of NK Cell Responses
Tissue-specific Determinants of NK Cell Responses
14:30—16:30
Workshop 2
Jing Chen,
Washington University in St. Louis, USA
The Role of EMT Transcription Factor ZEB2 in Fetal Hematopoiesis
The Role of EMT Transcription Factor ZEB2 in Fetal Hematopoiesis
Ryan Marshall Devlin,
Cancer Research UK Beatson Institute, UK
Altering Future Immune Challenges, Priming and Metastasis Through Long-Term Changes to Acute IAV Infection
Altering Future Immune Challenges, Priming and Metastasis Through Long-Term Changes to Acute IAV Infection
Matthew D. Park,
Icahn School of Medicine at Mount Sinai, USA
Cholesterol Mobilization Governs Dendritic Cell Maturation and the Immunogenic Response to Lung Cancer
Cholesterol Mobilization Governs Dendritic Cell Maturation and the Immunogenic Response to Lung Cancer
Hannah Theobald,
Life and Medical Sciences Institute, University of Bonn, Germany, Germany
Environmentally Induced Lung-specific Innate Immune Training is Controlled by Apolipoprotein E and Dectin-1
Environmentally Induced Lung-specific Innate Immune Training is Controlled by Apolipoprotein E and Dectin-1
Gavyn Chern Wei Bee,
New York University School of Medicine, USA
Age-dependent Differences in Efferocytosis Determine the Outcome of CD11b-mediated Protection from Invasive Pathogens
Age-dependent Differences in Efferocytosis Determine the Outcome of CD11b-mediated Protection from Invasive Pathogens
Matous Voboril,
University of Minnesota, USA
Type III Interferons Drive Thymic DC1 Activation to Promote Central Tolerance
Type III Interferons Drive Thymic DC1 Activation to Promote Central Tolerance
Julia Gschwend,
University of Zurich, Switzerland
Diverse Sources of GM-CSF Control Tissue Myeloid Cell Homeostasis
Diverse Sources of GM-CSF Control Tissue Myeloid Cell Homeostasis
Katrina Lichauco,
University of Washington, USA
Itaconate Mediated Control of Inflammatory Hemophagocyte Differentiation
Itaconate Mediated Control of Inflammatory Hemophagocyte Differentiation
17:00—18:45
Innate Sensing II
Andrea Ablasser,
Ecole Polytechnique Fédérale de Lausanne, Switzerland
cGAS-STING Pathway
cGAS-STING Pathway
Gregory M. Barton,
University of California, Berkeley, USA
Toll-Like Receptors
Toll-Like Receptors
Judy Lieberman,
Harvard University, USA
Pyroptosis in Infection and Cancer
Pyroptosis in Infection and Cancer
Zhijian James Chen,
University of Texas Southwestern Medical Center, USA
cGAS-STING in Biology
cGAS-STING in Biology
17:00—18:45
Myeloid Cells in Cancer and Metastasis
Matthew F. Krummel,
University of California, San Francisco, USA
Immune Archetypes for Targeting Myeloid Cells in Cancer
Immune Archetypes for Targeting Myeloid Cells in Cancer
Natalia Gomez-Ospina,
Stanford University, USA
Targeting Tissue Myeloid Niches with Engineered Stem Cells to Treat Disease
Targeting Tissue Myeloid Niches with Engineered Stem Cells to Treat Disease
Zemin Zhang,
Peking University, China
The Power of Single Cell Genomics in Tumor Biology
The Power of Single Cell Genomics in Tumor Biology
Randolph K. Larsen,
St. Jude Graduate School of Biomedical Sciences, USA
NETosis Promotes DICER1 Syndrome-associated Rhabdomyosarcoma
NETosis Promotes DICER1 Syndrome-associated Rhabdomyosarcoma
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.
*Session Chair †Invited, not yet responded.
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