Keystone Symposia

Snowbird Resort Floorplan

NOTES:
This meeting will be conducted in English.

All programs are subject to change. Check this site for updates.


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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


The meeting will begin on Sunday, April 16 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Wednesday, April 19 with a closing plenary session from 17:00 to 19:00, followed by a social hour. We recommend return travel on Thursday, April 20 in order to fully experience the meeting.

SUNDAY, APRIL 16

16:00—20:00
Arrival and Registration

Ballroom Lobby
18:00—20:00
Welcome Mixer
No registration fees are used to fund alcohol served at this function.

Ballroom Lobby

MONDAY, APRIL 17

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address (Joint)

Ballroom 1-3
Vishva M. Dixit, Genentech, Inc., USA
Why So Many Ways to Die?

Coffee Break

09:30—11:15
Evolutionary Origin of Innate Immunity

Ballroom 2-3
Rotem Sorek, Weizmann Institute of Science, Israel
Innate Immunity in Bacteria

Emily Troemel, University of California, San Diego, USA
Innate Immunity in C. Elegans

Sara R. Cherry, University of Pennsylvania, USA
Innate Immunity in Drosophila

Tianmin Fu, Ohio State University, USA
Short Talk: Structures and Functions of a Bacterial Inflammasome-like System

09:30—11:15
Profiling Human Myeloid Cells and Targeting them in Disease

Ballroom 1
Muzlifah A. Haniffa, Wellcome Sanger Institute, UK
Decoding Human Prenatal Myeloid Cell Development and Function

Gwendalyn J. Randolph, Washington University, USA
Human Peritoneal Macrophages in Health and Disease

Boris Reizis, New York University Langone Medical Center, USA
Human Dendritic Cell Development During Adult Hematopoiesis

Kevin Barry, Fred Hutchinson Cancer Center, USA
Short Talk: Innate Immune Regulation of Protective Immunity and Immunotherapy Responses in Melanoma

11:15—17:00
On Own for Lunch

11:15—13:00
Poster Setup

Superior/Wasatch
13:00—22:00
Poster Viewing

Superior/Wasatch
14:30—16:30
Workshop 1: Late-Breaking Research

Ballroom 2-3
Pascal Devant, Harvard Medical School/Boston Children's Hospital, USA
Structural Insights into Cytokine Cleavage by an Inflammatory Caspase

Adam Lacy-Hulbert, Benaroya Research Institute, USA
LITAF Promotes Resistance to Cell Death Induced by Bacterial Pore-forming Toxins and Endogenous Membrane Pores

Natalia G. Sampaio, Hudson Institute of Medical Research, Australia
MDA5 Guards against Infection by Surveying Cellular RNA Homeostasis

Tian Tian, UCONN Health, USA
Structural Basis for a Unique Regulation of GSDMB Pore Formation and the Recognition of GSDMB by Shigella Effector IpaH7.8

Jakub Began, University of Lausanne, Switzerland
Molecular Characterization of GBP1-driven Non-canonical Inflammasome Assembly

Jazlyn P. Borges, Hospital for Sick Children, Canada
NINJ1 Forms Large Pore-Like Structures within the Plasma Membrane During Pyroptosis

Danyel Lee, Rockefeller University, USA
Inborn Errors of OAS–RNase L in SARS-CoV-2–related Multisystem Inflammatory Syndrome in Children

Alex G. Johnson, Dana-Farber Cancer Institute, Harvard Medical School, USA
Structure of a Bacterial Gasdermin Pore

14:30—16:30
Workshop 1: Single Cell Multiomics Analysis of Myeloid Cells

Ballroom 1
Amélie Collins, Columbia University Irving Medical Center, USA
Fetal Emergency Myelopoiesis is Restricted by Maternal Inflammation

Anthony Wong, University of Toronto, Canada
Epigenetic and Transcriptional Mechanisms Regulating Cardiac Macrophage Heterogeneity

Cathy Yea Won Sung, NIH, USA
Single Nucleus RNA Sequencing Identifies Two Unique Macrophage Subsets in Control and Cisplatin-treated Mouse Cochleae

Mia J. Phillipson, Uppsala University, Sweden
Macrophages Support Healing of Ischemic Injury by Transdifferentiating Towards Mural Cells and Adopting Functions Important for Vascular Support

Manuela Pereira Abrantes, Cancer Research Center of Lyon, France
The Multifaceted Neutrophils and their Partners on the Human Colorectal Cancer Road

Anne B. Krug, Ludwig Maximilians University Munich, Germany
Yellow Fever Vaccination Induces Coordinated Activation of Human Blood Dendritic Cell and Monocyte Subpopulations Correlating with Plasma Cytokine Levels and Antibody Titers

Maximilian Nitschké, Genentech, Inc., USA
Notch2 Blockade Expands a Population of Recruited Macrophages in the Lung that Regulate Responses to Tissue Injury

Kalyn R. Thayer, Feinberg School of Medicine, Northwestern University, USA
Lineage-tracing and Single-cell Transcriptomics Identifies Marginal Zone, Metallophilic, and Tingible Body Macrophages in Mouse Spleen and their Human Homologs

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Innate Sensing I

Ballroom 2-3
Hao Wu, Harvard Medical School, Boston Children's Hospital, USA
Inflammasomes

Veit Hornung, Ludwig-Maximilians-University Munich, Germany
Inflammasomes

Liman Zhang, Oregon Health & Science University, USA
Inflammasomes

Cornelius Y. Taabazuing, University of Pennsylvania Perelman School of Medicine, USA
Inflammatory Caspases and Inflammasomes

17:00—19:00
Lineage Tracing and Lineage Reprogramming

Ballroom 1
Rosandra Natasha Kaplan, NCI, National Institutes of Health, USA
Reprogramming Myeloid Cells in Tumors

Shalin H. Naik, Walter & Eliza Hall Institute, Australia
DC Lineage Mapping

Juliana Idoyaga, Stanford University, USA
Talk Title to be Announced

Alissa J. Trzeciak, Sloan Kettering Institute, USA
Short Talk: WNK1 Enforces Macrophage Lineage Fidelity

Mark B. Headley, Fred Hutch Cancer Center, USA
Short Talk: A Division of Labor in Dendritic Cell-mediated Immunosurveillance of Lung Airway vs Vasculature

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Wasatch
19:30—22:00
Poster Session 1

Superior/Wasatch

TUESDAY, APRIL 18

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Innate Immunity and Disease

Ballroom 2-3
Katrin D. Mayer-Barber, NIAID, National Institutes of Health, USA
The Role of Eosinophils in Tuberculosis

Michael Crackower, Ventus Therapeutics, USA
Structure and Computation-Based Drug Discovery in Innate Immunity

Coffee Break

Edward A. Miao, Duke University, USA
Caspase-7 Activates ASM to Repair Gasdermin and Perforin Pores

Sylvia Torres Odio, Texas A&M Health Science Center, USA
Short Talk: CMPK2 Governs Pro-inflammatory Responses in Myeloid Innate Immune Cells

Vivian Chih-Wei Chen, Duke-NUS Medical School, Singapore
Short Talk: Bat ASC2 Suppresses Inflammasomes and Ameliorates Inflammatory Diseases

Kevin MingJie Gao, UMass Chan Medical School, USA
Short Talk: STING Gain-of-function in Endothelial Cells Initiates Interstitial Lung Disease

Marcia Goldberg, Massachusetts General Hospital and Harvard Medical School, USA
Short Talk: Pattern Recognition Receptor for Bacterial Lipopolysaccharide in the Cytosol of Human Macrophages

08:00—11:00
Lineage Commitment, Identity, and Maintenance

Ballroom 1
Roxane Tussiwand, NIDCR, National Institutes of Health, USA
Redefining the Myeloid-Lymphoid Split

Kenneth M. Murphy, Washington University School of Medicine, USA
Transcriptional Regulation of Dendritic Cell Development

Coffee Break

Charlotte L. Scott, University of Ghent & VIB, Belgium
Functional Heterogeneity of Hepatic Macrophages

Christopher K. Glass, University of California, San Diego, USA
Epigenetic Regulation of Macrophage Identity

Ty D. Troutman, Cincinnati Children's Hospital Medical Center, USA
Short Talk: Systematic Analysis of Transcriptional and Epigenetic Effects of Genetic Variation in Kupffer Cells Enables Discrimination of Cell Intrinsic and Environment-Dependent Mechanisms

Fabiola Osorio, University of Chile, Chile
Short Talk: Control of Intestinal Th17 Cell Homeostasis by the Unfolded Protein Response Sensor IRE1 in Dendritic Cells

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Superior/Wasatch
13:00—22:00
Poster Viewing

Superior/Wasatch
14:30—16:30
Career Roundtable (Joint)

Ballroom 2-3
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Innate Immunity and Infection

Ballroom 2-3
Russell E. Vance, University of California, Berkeley, USA
Innate Immunity and the Pathogenesis of Tuberculosis

Megan H. Orzalli, University of Massachusetts Medical School, USA
Innate Immunity in Viral Infections

Feng Shao, National Institute of Biological Sciences, China
Pyroptosis and Infection

Qiankun Wang, Washington University in St. Louis, USA
Short Talk: CARD8 Inflammasome Drives CD4+ T Cell Depletion in HIV-1 Infection

Harshad Ingle, Washington University in St. Louis, USA
Short Talk: IFN-L Derived from Non-permissive Enterocytes Acts on Tuft Cells to Limit Norovirus Persistence

17:00—19:00
Myeloid Cells in Integrated Tissue Immunity

Ballroom 1
Slava Epelman, University of Toronto, Canada
A Common Starting Point to Understand Resident Macrophage Heterogeneity

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Microbiome / Myeloid Cell Interactions in Shaping Immunity

Jesse Warren Williams, University of Minnesota, USA
Foamy Macrophages Rely on Trem2 for Survival during Atherosclerosis

Andreas Schlitzer, University of Bonn, Germany
Short Talk: GPR183 Targets Lung-resident CD301b+ Conventional Dendritic Cells Type 2 to a Subtissular TSLP – TSLP Receptor-mediated Survival Niche within the Adventitial Cuff

Tim Willinger, Karolinska Institutet, Sweden
Short Talk: Tracking Macrophage Origin in Human Airway Disease Reveals Continuous Macrophage Differentiation and Expansion of GPR183+ Monocytes

19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Wasatch
19:30—22:00
Poster Session 2

Superior/Wasatch

WEDNESDAY, APRIL 19

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Innate Leukocytes

Ballroom 2-3
Eric Vivier, Aix Marseille University and Innate Pharma, France
Leveraging Innate Lymphocytes for Anti-Tumor Therapy

Lydia Lynch, Harvard Medical School, USA
Obesity and Diet on iNKT Cells, NK Cells and T Cells

Coffee Break

Marco Colonna, Washington University School of Medicine, USA
Innate Lymphoid Cells (ILCs) in Mucosal Immunity

Ankit Malik, University of Chicago, USA
Short Talk: Compartmentalized Antigen Presentation between Epithelial Cells and Macrophages Orchestrates Gut Immunity

Andrew Oberst, University of Washington, USA
Short Talk: "Necroptosis" as an Innate Immune Signaling Pathway

Hannah E. Meibers, University of Cincinnati and Cincinnati Children's Hospital Medical Center, USA
Short Talk: Effector Memory T Cells Induce Innate Inflammation by Triggering a DC-intrinsic DNA Damage Response and Subsequent Non-canonical STING Pathway

Isabella Rauch, OHSU, USA
Short Talk: Activation of the NAIP–NLRC4 Inflammasome in Tuft Cells Leads to a Prostaglandin D2 Mediated Antibacterial Response in the Small Intestine

08:00—11:00
Myeloid Cell Dynamics in Health and Disease

Ballroom 1
Milka Sarris, University of Cambridge, UK
Myeloid Cell Dynamics in Zebrafish Wounds

Carole A. Parent, University of Michigan, USA
Cell Migration in Inflammation and Metastasis

Coffee Break

Minsoo Kim, University of Rochester, USA
Dynamic Interaction of Myeloid Cells during the Initiation and Resolution of Infection

De' Broski R. Herbert, University of Pennsylvania, USA
Myeloid Cell-Derived IL-33

Kavita Rawat, Dartmouth College, USA
Short Talk: CCL5-producing Migratory Dendritic Cells Guide CCR5+ Monocytes into the Draining Lymph Nodes

Roarke A. Kamber, University of California, San Francisco, USA
Short Talk: CRISPR Screens Identify Regulators of Live and Dead Cell Phagocytosis by Macrophages

11:00—17:00
On Own for Lunch

11:00—13:00
Poster Setup

Superior/Wasatch
13:00—22:00
Poster Viewing

Superior/Wasatch
14:30—16:30
Workshop 2

Ballroom 2-3
Ranit Kedmi, Weizmann Institute of Science, Israel
Dendritic Cell Heterogeneity: A Story of Redundancy or Overlooked Specificity?

Kennady Abbott, University of Texas Southwestern Medical Center, USA
Dynamic Regulation of STING Expression and Signaling in T cells from Development to Maturity

Carlos Donado, Harvard Medical School, USA
Granzyme K Activates a New Complement Pathway

Devon Jeltema, University of Texas Southwestern Medical Center, USA
Role of PARP7 in Negative Feedback Regulation of Type I Interferon Signaling

Yupeng Wang, Pyrotech Beijing Biotechnology Co., Ltd, China
Development of Selective and Potent ALPK1 Inhibitors for Treating Inflammatory Diseases

Shan Li, Huazhong Agricultural University, China
Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-deacylization of Caspases

Adriana M. Mujal, Memorial Sloan Kettering, USA
Tissue-specific Determinants of NK Cell Responses

14:30—16:30
Workshop 2

Ballroom 1
Jing Chen, Washington University in St. Louis, USA
The Role of EMT Transcription Factor ZEB2 in Fetal Hematopoiesis

Ryan Marshall Devlin, Cancer Research UK Beatson Institute, UK
Altering Future Immune Challenges, Priming and Metastasis Through Long-Term Changes to Acute IAV Infection

Matthew D. Park, Icahn School of Medicine at Mount Sinai, USA
Cholesterol Mobilization Governs Dendritic Cell Maturation and the Immunogenic Response to Lung Cancer

Hannah Theobald, Life and Medical Sciences Institute, University of Bonn, Germany, Germany
Environmentally Induced Lung-specific Innate Immune Training is Controlled by Apolipoprotein E and Dectin-1

Gavyn Chern Wei Bee, New York University School of Medicine, USA
Age-dependent Differences in Efferocytosis Determine the Outcome of CD11b-mediated Protection from Invasive Pathogens

Matous Voboril, University of Minnesota, USA
Type III Interferons Drive Thymic DC1 Activation to Promote Central Tolerance

Julia Gschwend, University of Zurich, Switzerland
Diverse Sources of GM-CSF Control Tissue Myeloid Cell Homeostasis

Katrina Lichauco, University of Washington, USA
Itaconate Mediated Control of Inflammatory Hemophagocyte Differentiation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—18:45
Innate Sensing II

Ballroom 2-3
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne, Switzerland
cGAS-STING Pathway

Gregory M. Barton, University of California, Berkeley, USA
Toll-Like Receptors

Judy Lieberman, Harvard University, USA
Pyroptosis in Infection and Cancer

Zhijian James Chen, University of Texas Southwestern Medical Center, USA
cGAS-STING in Biology

17:00—18:45
Myeloid Cells in Cancer and Metastasis

Ballroom 1
Matthew F. Krummel, University of California, San Francisco, USA
Immune Archetypes for Targeting Myeloid Cells in Cancer

Natalia Gomez-Ospina, Stanford University, USA
Targeting Tissue Myeloid Niches with Engineered Stem Cells to Treat Disease

Zemin Zhang, Peking University, China
The Power of Single Cell Genomics in Tumor Biology

Randolph K. Larsen, St. Jude Graduate School of Biomedical Sciences, USA
NETosis Promotes DICER1 Syndrome-associated Rhabdomyosarcoma

18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 2-3
18:45—19:00
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)

Ballroom 1
19:00—20:00
Social Hour with Lite Bites
No registration fees are used to fund alcohol served at this function.

Superior/Wasatch
19:30—22:00
Poster Session 3

Superior/Wasatch

THURSDAY, APRIL 20

08:00—08:00
Departure


*Session Chair †Invited, not yet responded.



Keystone Symposia thanks our Sponsors(s) for generously supporting this meeting:

AbbVie Inc. Amgen Inc.
Chinese Society for Cell Biology, (Cell Research) Genentech, Inc.
GlaxoSmithKline Biologicals Merck & Co., Inc.

We gratefully acknowledge additional support from these exhibitors at this conference:

BioLegend, Inc.
Please stop by to meet these exhibitors during the conference.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AI174639-01

Funding for this conference was made possible (in part) by 1 R13 AI174639-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.


We gratefully acknowledge additional support for this conference from:

AdipoGen Life Sciences Science Immunology / AAAS
Science Signaling / AAAS
 

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:



GlaxoSmithKline / DDDW


We appreciate the organizations that provide Keystone Symposia with additional support, such as marketing and advertising:


Click here to view more of these organizations


Special thanks to the following for their support of Keystone Symposia initiatives to increase participation at this meeting by scientists from underrepresented backgrounds:


Click here to view more of these organizations


If your organization is interested in joining these entities in support of Keystone Symposia, please contact: John Monson, Director of Corporate Relations, Email: johnm@keystonesymposia.org,
Phone:+1 970-262-2690

Click here for more information on Industry Support and Recognition Opportunities.

If you are interested in becoming an advertising/marketing in-kind partner, please contact:
Nick Dua, Senior Director, Communications, Email: nickd@keystonesymposia.org,
Phone:+1 970-262-1179