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This meeting took place in 2001
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Obesity and the Regulation of Energy Homeostasis (C4)
Organizer(s) Jeffrey S. Flier and Barbara B. Kahn
February 24—March 1, 2001
Taos Convention Center (meeting only) • Taos, NM USA
Abstract Deadline: Oct 24, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 21, 2000
Sponsored by Hoffmann-La Roche, Inc.
Summary of Meeting:
Our understanding of the regulation of energy balance, and defects in this system that result in obesity, has undergone dramatic progress in recent years. Insights gained from identifying the genetic basis of several monogenic obesities in rodents and humans have allowed us to define the existence of a novel regulated physiologic system by which the status of energy balance and energy stores in peripheral tissues is communicated to central nervous system circuits that regulate hunger, energy expenditure and neuroendocrine function. Critical areas of recent discovery involve the adipocyte hormone leptin, the mechanism for leptin signaling and action both within and outside the CNS, identification of a coordinated group of leptin target neurons in the hypothalamus, including the melanocortin pathway that involves antagonistic ligands and several receptors, mapping of downstream targets in the CNS, and elucidation of effector pathways, including those that influence energy expenditure by regulating mitochondrial coupling. The goal of this Keystone Symposium is to bring together investigators from diverse aspects of this field, including neurobiologists, geneticists, physiologists and pharmacologists, to integrate and provide new directions for this rapidly moving field.
View Scholarships/Awards
Our understanding of the regulation of energy balance, and defects in this system that result in obesity, has undergone dramatic progress in recent years. Insights gained from identifying the genetic basis of several monogenic obesities in rodents and humans have allowed us to define the existence of a novel regulated physiologic system by which the status of energy balance and energy stores in peripheral tissues is communicated to central nervous system circuits that regulate hunger, energy expenditure and neuroendocrine function. Critical areas of recent discovery involve the adipocyte hormone leptin, the mechanism for leptin signaling and action both within and outside the CNS, identification of a coordinated group of leptin target neurons in the hypothalamus, including the melanocortin pathway that involves antagonistic ligands and several receptors, mapping of downstream targets in the CNS, and elucidation of effector pathways, including those that influence energy expenditure by regulating mitochondrial coupling. The goal of this Keystone Symposium is to bring together investigators from diverse aspects of this field, including neurobiologists, geneticists, physiologists and pharmacologists, to integrate and provide new directions for this rapidly moving field.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, FEBRUARY 24
SUNDAY, FEBRUARY 25
MONDAY, FEBRUARY 26
TUESDAY, FEBRUARY 27
WEDNESDAY, FEBRUARY 28
THURSDAY, MARCH 1
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, FEBRUARY 24
19:30—20:30
Keynote Address
Jeffrey M. Friedman,
Rockefeller University, USA
Leptin and the Regulation of Body Weight
Leptin and the Regulation of Body Weight
08:00—11:00
Neural Integration of Energy Balance I
Paul E. Sawchenko,
The Salk Institute, USA
The Organization of Neural Systems Underlying Energy Balance
The Organization of Neural Systems Underlying Energy Balance
*
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
Central Pathways Underlying the Endocrine, Behavioral, and Autonomic Effects of Leptin
Central Pathways Underlying the Endocrine, Behavioral, and Autonomic Effects of Leptin
Michael W. Schwartz,
University of Washington, USA
Anabolic and Catabolic Pathways Underlying Energy Homeostasis
Anabolic and Catabolic Pathways Underlying Energy Homeostasis
Richard D. Palmiter,
HHMI/University of Washington, USA
Gene Knockouts and Energy Balance
Gene Knockouts and Energy Balance
William F. Colmers,
University of Alberta, Canada
Short Talk: A Neural Substrate of the Adipostat
Short Talk: A Neural Substrate of the Adipostat
Michael A. Cowley,
Monash University, Australia
Short Talk: Leptin Increases the Activity of Accurate POMC Neurons by Two Mechanisms
Short Talk: Leptin Increases the Activity of Accurate POMC Neurons by Two Mechanisms
18:30—20:30
Neural Integration of Energy Balance II
*
Suzanne Lee Dickson,
Sahlgrenska Academy, Gothenburg University, Sweden
Roger D. Cone,
University of Michigan, USA
Mechanisms of Melanocortin Action in the CNS
Mechanisms of Melanocortin Action in the CNS
Gregory S. Barsh,
Stanford University Medical Center, USA
Genetic and Genomic Approaches to Hypothalmic Regulation of Energy Homeostasis
Genetic and Genomic Approaches to Hypothalmic Regulation of Energy Homeostasis
Laurence H. Tecott,
University of California, San Francisco, USA
Late Onset Obesity and Abnormal Feeding Behavior in 5HT2C Receptor Mutant Mice
Late Onset Obesity and Abnormal Feeding Behavior in 5HT2C Receptor Mutant Mice
08:00—11:00
Neural Integration of Energy Balance III
*
Robert Steiner,
University of Washington, USA
Chien Li,
The Salk Institute, USA
Corticotropin-releasing Factor Family Peptides and Their Receptors
Corticotropin-releasing Factor Family Peptides and Their Receptors
Eleftheria Maratos-Flier,
Beth Israel Deaconess Medical Center, USA
Update on the MCH System and Energy Homeostasis
Update on the MCH System and Energy Homeostasis
Masashi Yanagisawa,
University of Tsukuba, Japan
To Eat or Sleep? Roles of the Orexin Pathway in Coordination of Feeding and Vigilance
To Eat or Sleep? Roles of the Orexin Pathway in Coordination of Feeding and Vigilance
Matthias H. Tschöp,
Helmholtz Zentrum München and Technische Universität München, Germany
A Role for Ghrelin in the Control of Energy Homeostasis
A Role for Ghrelin in the Control of Energy Homeostasis
Eduardo A. Nillni,
Brown University, Rhode Island Hospital, USA
Short Talk: Leptin Stimulates the Expression and Biosynthesis of prohormone Convertases 1 and 2 (PC1 and PC2) in Hypothalamic Neurons
Short Talk: Leptin Stimulates the Expression and Biosynthesis of prohormone Convertases 1 and 2 (PC1 and PC2) in Hypothalamic Neurons
Hubert C. Chen,
Pfenex Inc., USA
Short Talk: Increased Leptin Sensitivity in DGAT-Deficient Mice
Short Talk: Increased Leptin Sensitivity in DGAT-Deficient Mice
16:30—18:30
POSTER SESSION 2: The Adipocyte and Energy Balance/Molecular Basis for Energy Expenditure
18:30—20:30
The Adipocyte and Energy Balance
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
The Influence of Adipocytes on Energy Balance: Insights from Tissue Specific Knockout of Glucose Transporters
The Influence of Adipocytes on Energy Balance: Insights from Tissue Specific Knockout of Glucose Transporters
Marc L. Reitman,
NIDDK, National Institutes of Health, USA
Physiology of Fatless Mice
Physiology of Fatless Mice
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
New Insights into the Regulation of Obesity and Energy Homeostasis from Tissue Specific Knockout Mice
New Insights into the Regulation of Obesity and Energy Homeostasis from Tissue Specific Knockout Mice
08:00—11:00
Molecular Basis for Energy Expenditure
*
Eric Ravussin,
Louisiana State University, Pennington Biomedical Research Center, USA
Martin D. Brand,
Medical Research Council, UK
Mitochondrial Uncoupling and Energy Expenditure
Mitochondrial Uncoupling and Energy Expenditure
Bruce M. Spiegelman,
Harvard Medical School, USA
Regulation of Adipogenesis and Energy Expenditure Through PPARgamma and PGC-1
Regulation of Adipogenesis and Energy Expenditure Through PPARgamma and PGC-1
Bradford B. Lowell,
Beth Israel Deaconess Medical Center, USA
Uncoupling Proteins 2 and 3: Regulators of Intracellular Energy Metabolism in Health and Disease
Uncoupling Proteins 2 and 3: Regulators of Intracellular Energy Metabolism in Health and Disease
Daniel Ricquier,
Centre National de la Recherche Scientifique, France
Uncoupling Proteins: Biochemical and Physiological Studies
Uncoupling Proteins: Biochemical and Physiological Studies
Ville Wallenius,
Sahlgrenska University Hospital, Sweden
Short Talk: Interleukin-6 Knockout Causes Obesity in Mice
Short Talk: Interleukin-6 Knockout Causes Obesity in Mice
Bruce A. Witthuhn,
University of Minnesota, USA
Short Talk: Upregulation of Bone Morphogenetic Protein GDF-3/Vgr-2 Expression in Adipose Tissue of FABP4 Null Mice
Short Talk: Upregulation of Bone Morphogenetic Protein GDF-3/Vgr-2 Expression in Adipose Tissue of FABP4 Null Mice
18:30—20:30
Leptin and Novel Adipocyte Secreted Proteins
Luciano Rossetti,
Merck Research Laboratories, USA
Hypothalamic Regulation of Insulin Action
Hypothalamic Regulation of Insulin Action
*
Jeffrey Flier,
Harvard University, USA
Leptin Signaling and Leptin Resistance
Leptin Signaling and Leptin Resistance
Philipp E. Scherer,
University of Texas Southwestern Medical Center, USA
Short Talk: The Adipocyte-Specific Protein Acrp30 Acts as a Hepatic Insulin Sensitizer
Short Talk: The Adipocyte-Specific Protein Acrp30 Acts as a Hepatic Insulin Sensitizer
Takashi Kadowaki,
University of Tokyo, Japan
Short Talk: Adiponectin and Diabetes
Short Talk: Adiponectin and Diabetes
08:00—11:00
Genetics of Obesity
*
Harriet Wallberg-Henriksson,
Karolinska Institutet, Sweden
Philippe Froguel,
Imperial College of London, UK
Genes Involved in the Regulation of Energy Homeostasis
Genes Involved in the Regulation of Energy Homeostasis
Anthony Comuzzie,
Southwest Foundation for Biomedical Research, USA
The Emerging Pattern of the Genetic Contribution to Human Obesity: Evidence from Genome Scans
The Emerging Pattern of the Genetic Contribution to Human Obesity: Evidence from Genome Scans
Martin G. Myers, Jr.,
University of Michigan, USA
Short Talk: Leptin Receptor-STAT3 Signaling Integrates Energy Balance and Metabolic Homeostasis
Short Talk: Leptin Receptor-STAT3 Signaling Integrates Energy Balance and Metabolic Homeostasis
Kevin D. Niswender,
University of Washington, USA
Short Talk: Hypothalamic Phosphoinositide 3-Kinase Activity is Required for Leptin-Induced Anorexia
Short Talk: Hypothalamic Phosphoinositide 3-Kinase Activity is Required for Leptin-Induced Anorexia
Peter R. Shepherd,
University of Auckland, New Zealand
Short Talk: Macrophages as a Novel Target for Leptin Ation
Short Talk: Macrophages as a Novel Target for Leptin Ation
15:00—17:00
New Targets for Obesity Treatment
*
Timothy A. Stewart,
Genentech, USA
George D. Yancopoulos,
Regeneron Pharmaceuticals, Inc., USA
CNTF Acts Via a Leptin-like Pathway to Suppress Hunger Signals and Cause Weight Loss
CNTF Acts Via a Leptin-like Pathway to Suppress Hunger Signals and Cause Weight Loss
Constantine Londos,
National Institutes of Health, USA
The Perilipin Knock-Out Mouse Confirms a Central Role for Perilipin in the Management of Adipocyte Lipid Stores
The Perilipin Knock-Out Mouse Confirms a Central Role for Perilipin in the Management of Adipocyte Lipid Stores
Salih J. Wakil,
Baylor College of Medicine, USA
The Role of Acetyl-CoA Carboxylase 2 in Energy Balance
The Role of Acetyl-CoA Carboxylase 2 in Energy Balance
Effie Tozzo,
Millennium Pharmaceuticals, USA
Short Talk: Melanocortin Receptor Agonists for the Treatment of Syndrome X
Short Talk: Melanocortin Receptor Agonists for the Treatment of Syndrome X
*Session Chair †Invited, not yet responded.
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