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This meeting took place in 2001

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Interfaces between Innate and Adaptive Immunity (J3)

Organizer(s) Albert S. Bendelac, Stefanie N. Vogel and Wayne M. Yokoyama
January 22—27, 2001
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 22, 2000
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 22, 2000

Summary of Meeting:
Recent advances indicate that, in addition to providing a first line of defense against pathogens, Innate Immunity plays a critical role in controlling and instructing adaptive responses in vertebrates. The principles and mechanisms of this regulation of adaptive immune responses by Innate Immunity are the focus of this symposium. The meeting will highlight the new frontiers of research on the cells, the receptors, and the signal transduction pathways that mediate innate immunity and control adaptive immunity.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time



Longs Foyer

Quandry Foyer

Keynote Address (Joint)

Douglas T. Fearon, Cold Spring Harbor Laboratory, USA
Interfaces Between Innate and Acquired Immunity

Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
Toll Receptor Family and Control of Immune Responses



Receptors of Innate Immunity I/Regulation of Macrophage Activation (Joint)

* Stefanie N. Vogel, University of Maryland, USA
Signal Integration in LPS-Stimulated Macrophages

Douglas Golenbock, University of Massachusetts Medical School, USA
The LPS Receptor

Akira Shizuo, Osaka University, Japan
Genetic Approaches to Signaling in Innate Immunity

Jonathon D. Sedgwick, Eli Lilly and Company, USA
Regulating Myeloid-Lineage Cells Through OX2 (CO200) Interactions

Coffee Break

Quandry Foyer
Poster Setup

WORKSHOP 1: Receptors of Innate Immunity

Quandry I-II
* Moshe Arditi, Cedars-Sinai Medical Center, USA
Functional Cooperation of Toll-Like Receptor 2 (TLR2) and TLR6 in Human Dermal Endothelial Cell (HMEC) Activation by Phenol Soluble Modulin (PSM). Role of Tollip in TLR2 and TLR4 Signaling

Eicke Latz, University of Bonn, Germany
Mutations of Toll-Like Receptor (TLR) 4 are Associated with Incidence and Severity of Spsis in Critically Ill Patients

Grayson B. Lipford, Janus Biotherapeutics, Inc., USA
Human TLR9 Expression Correlates with Responsiveness to Bacterial DNA

Jerome Pugin, University Hospital of Geneva, Switzerland
CD14, Toll-like Receptor (TLRs) and LPS Responses During Human Myeloid and Dendritic Cell (DC) Differentiation and Maturation

Maria T. Abreu, University of Miami, Miller School of Medicine, USA
Decreased Expression of TLR4 and MD2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Signaling and Activation by Bacterail Lipopolysccharide

Peter Hoffmann, National Jewish Medical and Research Center40155, USA
Essentail Role of a Phosphtidylserine Receptor in Uptake and Removal of Apoptotic Cells Independent of Inital Adhesive Ligand

Yann Leverrier, Ludwig Institute for Cancer Research, UK
Phagocytosis of Apoptotic Cells by macrophages

WORKSHOP 1: Signaling/Regulatory Mechanisms

Quandry III
* David C. Morrison, Grant Writers' Seminars & Workshops LLC, USA
Cellular Regulation of Macrophage Activation by Lypopolysaccharide

POSTER SESSION 1: Receptors of Innate Immunity

Social Hour with Lite Bites

Coffee Available

Quandry Foyer
Receptors of Innate Immunity II

Quandry I-II
Samuel D. Wright, CSL Behring, USA
Innate Recognition of Bacterial Lipids

* Siamon Gordon, Chang Gung University / University of Oxford, UK
Macrophage Receptors and Their Ligands

Alan Aderem, Center for Infectious Disease Research, USA
Macrophage Phagocytosis: From Genes to Function

Macrophage Effector Mechanisms

Quandry III
Charles A. Dinarello, University of Colorado Health Sciences Center, USA

Larry M. Wahl, National Institutes of Health, USA
Regulation of Monocyte Matrix Metalloproteinases

Matthew J. Fenton, NIAID, National Institutes of Health, USA
Roles of Toll-Like Receptor Agonists in Macrophage Responses to M. tuberculosis



Receptors of Innate Immunity III

Quandry I-II
* Alan Ezekowitz, Abide Therapeutics, USA
Pattern Recognition Molecules on Front Line Host Defense

Michael C. Carroll, Boston Children's Hospital, Harvard Medical School, USA
The Role of Complement in Regulation of B Lymphocyte Response to Self and Non-Self

John F. Kearney, University of Alabama, Birmingham, USA
Natural Antibodies and B Cell Subsets

Jean-Claude Weill, INSERM U1151 Institut Necker-Enfants Malades, France
Short Talk: CD40-CD40L Independent Immunoglobulin Gene Hypermutation

Martin F. Flajnik, University of Maryland, USA
Innate and Adaptive Antigen Receptors in Cartilaginous Fish

Regulation of Macrophage Activation II

Quandry III
David M. Mosser, University of Maryland, USA
Striking a Balance Between the Production of Pro- and Anti-Inflammatory Cytokines by Macrophages

Christopher L. Karp, Bill & Melinda Gates Foundation, USA
Complement and IL-12: Yin and Yang

Brian L. Kelsall, NIAID, National Institutes of Health, USA
Regulation of IL-12 Production: Redundant Pathways of Receptor-Mediated Inhibition

Rene de Waal Malefyt, Merck Research Labs, USA
Regulation of Macrophage Activation and Differentiation by T Cell Derived Cytokines

Coffee Break

Quandry Foyer
Poster Setup

WORKSHOP 2: Natural Adjuvants

Quandry I-II
* Arthur M. Krieg, Checkmate Pharmaceuticals, USA
CpG Motifs in Bacterial DNA as Triggers of Innate Immunity'

Ken J. Ishii, National Institute of Biomedical Innovation, Health and Nutrition, Japan
Double Stranded DNA Triggers the Maturation of Antigen Presenting Celss

Brent Berwin, Dartmouth, USA
Necrotic Cell Death, but no Apoptosis, Elicits the Release of Structurally Intact, Immunogenic GRP94(gp 96)

Mary Lee MacKichan, Chiron Corporation, USA
A Subset of Experimental Adjuvants Directly Activates Antigen Presenting Cells via an MYD88-Dependent Pathway

Nelson Randall Chu, , USA
Innate Immune Recgnition of the Immunotherapeutic Fusion Protein HspE7

James A. Lederer, Brigham and Women's Hospital, Harvard Medical School, USA
Injury Alters the Interaction Between the Innate and Adaptive Immune System

WORKSHOP 2: Effector Mechanisms and Immunoregulation

Quandry III
Jie Zhang-Hoover, Schepens Eye Research Institute, USA
Alveolar Marchophages from Inflamed Lujings Dowregulated Effector Phase of an Immune Resposne

Matthias Hesse, Cornell University College of Veterinary Medicine, USA
Alternative Activation of Arginase-1 or NOS-2 in Machrophages Controls Tissue Fibrosis and Granuloma Formation in a Murine Model of Schistosomiasis

* Donata Vercelli, University of Arizona, USA
CD14: A Bridge Between Innate Immunity and IgE Regulation

Edith Margarethe Janssen, La Jolla Institute for Allergy and Immunology, USA
Cross-Talk Between M0 and T Cell: Immunotheraeutic Effects of Allergen presentation by M0 in a Murine Model of Allergic Asthama

Nick Platt, University of Oxford, UK
Recognition and Phagocytosis of Apoptiotic Neurtophils by the Class A Macrophage Scavenger Receptor (SR-A)

Lynda M. Stuart, Bill & Melinda Gates Foundation, USA
Dendritic Cells Ingesting Apoptotic Neutrophils Fail to Mature in Response to LPS Stimulation

POSTER SESSION 2: Natural Adjuvants

Social Hour with Lite Bites

Coffee Available

Quandry Foyer
Macrophage/Pathogen Interactions (Joint)

* Emil R. Unanue, Washington University School of Medicine, USA
Symbiosis Between Phagocytes and Lymphocytes in Resistance to Listeria

Christian M. Bogdan, FAU Erlangen-Nürnberg, University Hospital Erlangen, Germany
Macrophages, Interferons and NO in Innate and Adaptive Immunity

Jean-Laurent Casanova, Rockefeller University, USA
Inherited Disorders of Human IL-12-Dependent IFNgamma-Mediated Immunity: Immunological Implications of Genotype-Phenotype Relationships



Natural Adjuvants

Quandry I-II
* Jonathan Sprent, Garvan Institute, Australia
T Cell Turnover and the Role of Interferons

Pramod K. Srivastava, University of Connecticut School of Medicine, USA
Heat Shock Proteins and Agents of Maturation of Dendritic Cells

Arthur M. Krieg, Checkmate Pharmaceuticals, USA

Polly Matzinger, NIAID, National Institutes of Health, USA
Dendritic Cell Responses to Necrotic and Apoptotic Cell Death

Macrophage/T-Cell Interactions

Quandry III
Kenneth M. Murphy, HHMI/Washington University School of Medicine, USA
Macrophage, T Cell Interactions/Innate IFNgamma

Craig B. Thompson, Memorial Sloan Kettering Cancer Center, USA
CD28 and ICOS Deliver Distinct Co-Stimulatory Signals: Implications for Functional Interaction Between the Innate and Acquired Immune Systems

David H. Munn, Georgia Regents University, USA
Macrophage Tryptophan Metabolism and T Cell Activation

Benjamin Segal, Ohio State University, USA
T Helper Cell/Antigen Presenting Cell Interactions in Autoimmunity

Coffee Break

Quandry Foyer
Poster Setup

WORKSHOP 3: Innate Lymphocytes (NK Cells, NKT Cells, gamma delta T Cells)

Quandry I-II
* Wendy L. Havran, The Scripps Research Institute, USA
A Role for epithelial gammadelta T Cells in Tissue Repair

Craig T. Morita, University of Iowa College of Medicine, USA
gamma delta T Cells Recognize a Putative Intermediate in the bacterial Deoxyxylulose Synthetic Pathway for Isopentenyl Pyrophosphate: Pattern Recognition by the Adaptive Immune System

Carla J. Miller, Guys Hospital, UK
Biochemical Responses of gamma delate T cells to Chemical Antigens

Bana Jabri, University of Chicago, USA
Isotypes of the NKG2 Family on NK Receptors Tightly Regulate the Function of Intestinal Alpha Beta T Lymphocytes

David J. Cosman, Aequus BioPharma, Inc., USA
The ULBPs, Novel MHC Class I-Related Moleculaes, Bind to Human Cytomegalovirus Glycoprotein, UL16, and to the NKG2D/DAp10 Receptor, to Stimulate NK Cytotoxicity and Cytokine Production

Peter D. Sun, NIAID, National Institutes of Health, USA
Molecular Recognition Bewteen NK Receptors and Their Ligands

Jayanthi Wolf, Merck & Co., Inc., USA
CD1: Novel Pathways for Antigen Presentatin

Abdijapar T. Shamshiev, University Hospital, Switzerland
The Alpha Beta T Cell Response to Self-Glyoclipids Show a Requirement for Complex Oligosaccharides and a Novel Mechamism of CD1b loading

WORKSHOP 3: Macrophages and Disease Pathogenesis

Quandry III
* Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Complement Factor 5 as a Susceptibility Gene in Asthma

Carrie M. Rosenberger, Genentech, Inc., USA
Expression Profiling of macrophage Responses to Salmonella Typhimurium, Lipopolsacchrides, and Interferon gamma Using Gene Arrays

Leanne Peiser, Gilead Sciences, USA
The Class A Macrophage Scavenger Receptor is a Major Receptor for Neisseria Menigitidis

Robert Marc Hoek, Amsterdam Medical Centre, Netherlands
OX@(CD200) Provides an Essential Down-Regulatory Checkpoint for the Macrophage Lineage

Jonathan D. Edgeworth, St. Georges Hospital Medical School, UK
Shigella Flexneri Killing of Macrophages and Dendritic Cells: Implications for Regulation of the Innate and Adaptive Immune Response

Hubert Ming Tse, Colorado State University, USA
Inhibition of the Mitogen Activated Protein Kinases Signaling Pathway Affects the Growth of Mycobacterium avium within Murine Macrophages

Gerard J. Nau, Brown University/Rhode Island Hospital, USA
Macrophage Gene Expression Profiles, Infections and Tuberculosis Pathogenesis

Barbara A. Butcher, Cornell University, USA
Toxoplasma Gondii Inhibits I kappa Beta Degradation and Blocks LPS-Induced Cytokine Production by Macrophages

POSTER SESSION 3: Innate Lymphocytes

Social Hour with Lite Bites

Coffee Available

Quandry Foyer
Th1/Th2 Regulation by Dendritic Cells and Macrophages

Quandry I-II
Bali Pulendran, Stanford University School of Medicine, USA
DC Subsets and Immunoregulation

Yong-Jun Liu, Sanofi, USA
Natural Interferon-alpha/beta-Producing Cells Link Innate and Adaptive Immunity

* Christine A. Biron, Brown University, USA
Innate Cytokines and NK Cells in Immunoregulation During Viral Infections

Regulation of Macrophage Activation III

Quandry III
Donna M. Paulnock, University of Wisconsin-Madison, USA
Analysis of Interferon-Gamma-Dependent and -Independent Pathways of Macrophage Activation

Brian M. J. Foxwell, Imperial College, UK
Adenoviruses as a Useful Probe for Macrophage and Dendritic Cell Function

Thomas A. Hamilton, Cleveland Clinic Foundation, USA
Regulation of Macrophage Gene Expression by Anti-Inflammatory Cytokines



NK Cells and Receptors

Quandry I-II
* Wayne M. Yokoyama, Washington University School of Medicine, USA
In vivo Responses of NK Cells

David H. Raulet, University of California, Berkeley, USA
Murine NKG2D and its Ligands, a New Component of the Innate Immune System

Marco Colonna, Washington University School of Medicine, USA
Blood 'Plasmacytoid Dendritic Cells' (P-DCs) Mature with Influenza Virus and CD40L and Drive a Potent Th1 Polarization

Thomas Spies, Fred Hutchinson Cancer Research Center, USA
Activation of T-Cells and NK Cells by NKG2D

Macrophage/Pathogen Interactions II

Quandry III
Alan Sher, NIAID, National Institutes of Health, USA
A Chemokine-Dependent Pathway for the Microbial Induction of Dendritic Cell Function

Joel D. Ernst, University of California, San Francisco, USA
Inhibition of Macrophage Responses to Interferon Gamma by Mycobacterium tuberculosis

Andrea Cooper, Colorado State University, USA
Mycobacteria and Macrophages: A Dynamic Interaction

David L. Sacks, NIAID, National Institutes of Health, USA
A Natural Model of Leishmania Major Infection for Analysis of Macrophages and Dendritic Cell Function in vivo

Coffee Break

Quandry Foyer
Coffee Available

Quandry Foyer
CD1 and Carbohydrate Recognition by T Cells

Quandry I-II
Adrian C. Hayday, King's College London School of Medicine, UK
Defining TCR gammadelta(+) and TCR alphabeta(+) Intraepithelial T Cells by the Genes they Express

D. Branch Moody, Brigham and Women's Hospital, USA
Presentation of Microbial Glycolipids by Group 1 CD1 Proteins

* Albert S. Bendelac, University of Chicago, USA
Innate Rather Than Adaptive Characteristics of the CD1d-restricted T Cell Population

Jay A. Berzofsky, NCI, National Institutes of Health, USA
Short Talk: The Role of CD1-Restricted NKT Cells and IL-13 in Regulating Tumor Immunosurveillance

Macrophage/Pathogen Interactions III

Quandry III
Sharon M. Wahl, NIDR, National Institutes of Health, USA
Macrophage Contribution to HIV-1 Pathogenesis

Ricardo T. Gazzinelli, Fundação Oswaldo Cruz-CPqRR, Brazil
Activation of TLR-2 by Glycosylphosphatidylinositol Anchors Derived from Trypanosoma cruzi Parasites

Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Role of Collectins SP-A and SP-D in Host Defense of the Lung

Social Hour with Lite Bites

Quandry Foyer



*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 AI48529-01

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