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This meeting took place in 2002
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Nuclear Receptor Superfamily (D4)
Organizer(s) Pierre H. Chambon, David J. Mangelsdorf and Benita S. Katzenellenbogen
April 13—19, 2002
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Dec 13, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 13, 2002
Sponsored by Bristol-Meyers Squibb Pharmaceutical Research Institute
Summary of Meeting:
Nuclear receptors are ligand-dependent transcriptional regulators that govern virtually every aspect of fetal and adult life in metazoans. In addition to the well-characterized receptors that respond to steroid and thyroid hormones, retinoids, and other lipophilic metabolites, this family includes a number of orphan receptors whose ligands and physiologic functions are under intense investigation. Nuclear receptors are also important therapeutic targets, because of their involvement in reproduction, metabolic and endocrine diseases, and cancer. Major questions in this field are focused on elucidating the molecular mechanisms underlying transcriptional activation and repression of target genes, and the translation of these processes into physiological responses at the organismal level. This meeting will bring together leading experts in structural and molecular biology, functional genomics and engineered mouse genetics, as well as younger investigators and trainees, from both academia and industry, to present their current research and discuss new approaches that can address these key issues.
View Scholarships/Awards
Nuclear receptors are ligand-dependent transcriptional regulators that govern virtually every aspect of fetal and adult life in metazoans. In addition to the well-characterized receptors that respond to steroid and thyroid hormones, retinoids, and other lipophilic metabolites, this family includes a number of orphan receptors whose ligands and physiologic functions are under intense investigation. Nuclear receptors are also important therapeutic targets, because of their involvement in reproduction, metabolic and endocrine diseases, and cancer. Major questions in this field are focused on elucidating the molecular mechanisms underlying transcriptional activation and repression of target genes, and the translation of these processes into physiological responses at the organismal level. This meeting will bring together leading experts in structural and molecular biology, functional genomics and engineered mouse genetics, as well as younger investigators and trainees, from both academia and industry, to present their current research and discuss new approaches that can address these key issues.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, APRIL 13
SUNDAY, APRIL 14
MONDAY, APRIL 15
TUESDAY, APRIL 16
WEDNESDAY, APRIL 17
THURSDAY, APRIL 18
FRIDAY, APRIL 19
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, APRIL 13
19:30—20:30
Keynote Address
*
Pierre H. Chambon,
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
08:00—11:00
Structure/Function of NRs, NR Coregulators and Transcription Factors
*
Robert G. Roeder,
Rockefeller University, USA
Gary Felsenfeld,
NIDDK, National Institutes of Health, USA
Chromatin Boundaries and the Developmental Regulation of Gene Expression
Chromatin Boundaries and the Developmental Regulation of Gene Expression
Roderick E. Hubbard,
University of York, UK
What Can Structure Tell Us About Function in the Estrogen Receptors?
What Can Structure Tell Us About Function in the Estrogen Receptors?
Dino Moras,
Institute of Genetics, Molecular and Cellular Biology, France
Chasing Effective Ligands for Orphan Nuclear Receptors
Chasing Effective Ligands for Orphan Nuclear Receptors
Timothy M. Willson,
GlaxoSmithKline, USA
Structure and Function of Orphan Nuclear Receptors
Structure and Function of Orphan Nuclear Receptors
14:00—16:00
Workshop 1: Hot Topics and/or Presentations by Young Investigators
Matthew R. Redinbo†,
University of North Carolina at Chapel Hill, USA
Structural Insights into the Promiscuity and Function of the Human Xenobiotic Nuclear Receptor PXR
Structural Insights into the Promiscuity and Function of the Human Xenobiotic Nuclear Receptor PXR
Ashley C.W. Pike,
University of York, UK
Structural Snapshots of Agonist-Bound ERbeta-LBD
Structural Snapshots of Agonist-Bound ERbeta-LBD
Robert Gampe,
GlaxoSmithKline, USA
Molecular Specificity of New Rexinoids Bound to the PPARgamma/RXRalpha Ligand Binding Domain Heterodimer
Molecular Specificity of New Rexinoids Bound to the PPARgamma/RXRalpha Ligand Binding Domain Heterodimer
Matthias Becker,
National Cancer Institute, National Institutes of Health, USA
Dynamic Behavior of Transcription Factors on a Natural Promoter in Living Cells
Dynamic Behavior of Transcription Factors on a Natural Promoter in Living Cells
Anobel Tamrazi,
Johns Hopkins University, USA
Functional Fluorescent Estrogen Receptors (ER): Homo- and Heterodimerization, Coregulator Recruitment and Site-Specific Regional Dynamics of ER-Ligand Binding Domain (LBD) Subtypes
Functional Fluorescent Estrogen Receptors (ER): Homo- and Heterodimerization, Coregulator Recruitment and Site-Specific Regional Dynamics of ER-Ligand Binding Domain (LBD) Subtypes
Frederick J. Schaufele,
University of California, San Francisco, USA
Cellular Imaging of Nuclear Receptor Action
Cellular Imaging of Nuclear Receptor Action
*
Debu Chakravarti,
Northwestern University, Feinberg School of Medicine, USA
Hormones, HATs & INHAT: Regulation of Transcription and Circadian Timing
Hormones, HATs & INHAT: Regulation of Transcription and Circadian Timing
16:30—18:30
Coactivators, Corepressors and Transcription I
*
Gary Felsenfeld,
NIDDK, National Institutes of Health, USA
Leonard P. Freedman,
Global Biological Standards Institute, USA
Mediating Transcriptional Activation by Nuclear Receptors
Mediating Transcriptional Activation by Nuclear Receptors
Mitchell A. Lazar,
Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Hormone Receptor Corepressors
Nuclear Hormone Receptor Corepressors
19:30—21:30
Poster Session 1: Nuclear Receptor and Cofactors, Structure/Function and Transcription
08:00—11:00
Coactivators, Corepressors and Transcription II
*
Ronald M. Evans,
HHMI/The Salk Institute, USA
Robert G. Roeder,
Rockefeller University, USA
Role of the TRAP Complex in the Function of Diverse Nuclear Receptor Pathways
Role of the TRAP Complex in the Function of Diverse Nuclear Receptor Pathways
Bert W. O'Malley,
Baylor College of Medicine, USA
New Facets of Steroid Receptor Coactivator Action
New Facets of Steroid Receptor Coactivator Action
14:00—16:00
Workshop 2: Hot Topics and/or Presentations by Young Investigators
*
Bert W. O'Malley,
Baylor College of Medicine, USA
W. Lee Kraus,
University of Texas Southwestern Medical Center, USA
Chromatin Exposes Intrinsic Differences in the Transcriptional Activities of Estrogen Receptors Alpha and Beta
Chromatin Exposes Intrinsic Differences in the Transcriptional Activities of Estrogen Receptors Alpha and Beta
Dipali Sharma,
University of Maryland, USA
Temporal Assembly and Sequential Promoter Recruitment of Distinct Thyroid Hormone Receptor-Coactivator Complexes in Mammalian Cells
Temporal Assembly and Sequential Promoter Recruitment of Distinct Thyroid Hormone Receptor-Coactivator Complexes in Mammalian Cells
Catherine C. Thompson,
Pfizer, USA
Hairless is a Novel Nuclear Receptor Corepressor
Hairless is a Novel Nuclear Receptor Corepressor
Meei-Huey Jeng,
Indiana University School of Medicine, USA
Interaction of c-Src with Steroid Receptor Coactivators
Interaction of c-Src with Steroid Receptor Coactivators
Simak Ali,
Imperial College London, UK
Regulation of Estrogen Receptor Activity by Phosphorylation
Regulation of Estrogen Receptor Activity by Phosphorylation
Liang Wang,
University of Rochester, USA
Inhibition of the Human Androgen Receptor through a Glycogen Synthase Kinase 3 Beta Signaling Pathway
Inhibition of the Human Androgen Receptor through a Glycogen Synthase Kinase 3 Beta Signaling Pathway
E. Brad Thompson,
University of Texas Medical Branch, USA
Importance on Inter- and Intra-Molecular Signaling in the Structure and Function of the Glucocorticoid Receptor AF1 Domain
Importance on Inter- and Intra-Molecular Signaling in the Structure and Function of the Glucocorticoid Receptor AF1 Domain
Jae In Lee,
Amgen Inc., USA
16:30—18:30
Post-Translational Modification of NRs and Coregulators - Cross-Talk. Session Sponsored in part by Affinity BioReagents, Inc.
*
Walter Wahli,
Nanyang Technological University, Singapore
Michael G. Rosenfeld,
University of California, San Diego, USA
Nuclear Receptor Coregulators in Control of Growth and Development
Nuclear Receptor Coregulators in Control of Growth and Development
Michael R. Stallcup,
University of Southern California, USA
Synergy Between p160 Coactivators, HATs, and Methyltransferases; and Hormone-Regulated, CARM1-Directed Methylation of Histone H3
Synergy Between p160 Coactivators, HATs, and Methyltransferases; and Hormone-Regulated, CARM1-Directed Methylation of Histone H3
Keith R. Yamamoto,
University of California, San Francisco, USA
Selective Function and Continuous Recycling of Receptor-Containing Regulatory Complexes
Selective Function and Continuous Recycling of Receptor-Containing Regulatory Complexes
08:00—11:00
Intermediary Metabolism
*
Günther Schütz,
German Cancer Research Center, Germany
Ronald M. Evans,
HHMI/The Salk Institute, USA
Orphan Receptors in Lipid Metabolism
Orphan Receptors in Lipid Metabolism
David J. Mangelsdorf,
University of Texas Southwestern Medical Center, USA
Nuclear Receptors as The Body’s Lipid Sensors
Nuclear Receptors as The Body’s Lipid Sensors
Walter Wahli,
Nanyang Technological University, Singapore
Regulation of the Adaptive Response to Fasting by PPAR alpha
Regulation of the Adaptive Response to Fasting by PPAR alpha
Johan Auwerx,
École Polytechnique Fédérale de Lausanne, Switzerland
Control of Metabolism by PPARgamma and its Cofactors
Control of Metabolism by PPARgamma and its Cofactors
14:00—16:00
Workshop 3: Hot Topics and/or Presentations by Young Investigators
*
Frank J. Gonzalez,
National Institutes of Health, USA
Role of Hepatic PPARgamma in Lipid Homeostasis
Role of Hepatic PPARgamma in Lipid Homeostasis
Bryan A. Laffitte,
Genomics Institute of the Novartis Research Foundation, USA
LXR-Dependent Effects of Oxidized Lipids on Macrophage Gene Expression
LXR-Dependent Effects of Oxidized Lipids on Macrophage Gene Expression
Joyce J. Repa,
University of Texas Southwestern Medical Center, USA
Regulation of ATP-Binding Cassette Sterol Transporters, ABCG5 and ABCG8, by the Oxysterol Receptors, LXRalpha and LXRbeta
Regulation of ATP-Binding Cassette Sterol Transporters, ABCG5 and ABCG8, by the Oxysterol Receptors, LXRalpha and LXRbeta
Mercedes Ricote,
Centro Nacional de Investigaciones Cardiovasculares, Spain
Regulation of Machrophage Gene Expression by RXR Heterodimers
Regulation of Machrophage Gene Expression by RXR Heterodimers
Wen Xie,
University of Pittsburgh, USA
Activation of Phase II Detoxicificating UDP-Glucuronosyltransferase (UGTs) by Nuclear Receptors SXR/PXR and its Implication in Hormonal Homeostasis
Activation of Phase II Detoxicificating UDP-Glucuronosyltransferase (UGTs) by Nuclear Receptors SXR/PXR and its Implication in Hormonal Homeostasis
Henry M. Sucov,
University of Southern California, USA
Developmental Roles of Retinoid Receptors
Developmental Roles of Retinoid Receptors
Anton M. Jetten,
NIEHS, National Institutes of Health, USA
Absence of Lymph Nodes and High Incidence of T-Cell Lymphomas in Mice Deficient in the Retinoid-Related Orphan Receptor RORgamma
Absence of Lymph Nodes and High Incidence of T-Cell Lymphomas in Mice Deficient in the Retinoid-Related Orphan Receptor RORgamma
16:30—18:30
Orphan Receptors
*
David J. Mangelsdorf,
University of Texas Southwestern Medical Center, USA
Thomas Perlmann,
Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Role of Nuclear Receptors in Neuron Development and Survival
Role of Nuclear Receptors in Neuron Development and Survival
Carl S. Thummel,
University of Utah School of Medicine, USA
Molecular Mechanisms of Hormone Action in Drosophila
Molecular Mechanisms of Hormone Action in Drosophila
Steven A. Kliewer,
University of Texas Southwestern Medical Center, USA
Regulation of Xenobiotic and Lipid Metabolism by Nuclear Receptors
Regulation of Xenobiotic and Lipid Metabolism by Nuclear Receptors
19:30—21:30
Poster Session 3: Nuclear Receptor Orphan Potpourri
08:00—11:00
Development and Integrated Functions I
*
Michael G. Rosenfeld,
University of California, San Diego, USA
Pierre H. Chambon,
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Genetic Dissection of the Retinoid Signaling Pathway in the Mouse
Genetic Dissection of the Retinoid Signaling Pathway in the Mouse
Orla M. Conneely,
Baylor College of Medicine, USA
Reproductive Functions of Progesterone Receptor Isoforms
Reproductive Functions of Progesterone Receptor Isoforms
Günther Schütz,
German Cancer Research Center, Germany
Molecular Genetic Analysis of Glucocorticoid Receptor Function in Mice
Molecular Genetic Analysis of Glucocorticoid Receptor Function in Mice
14:00—16:00
Workshop 4: Hot Topics and/or Presentations by Young Investigators
*
Michael B. Sporn,
Dartmouth Medical School, USA
Cancer Prevention: Rexinoids, Deltanoids, SERMs and SPARMs
Cancer Prevention: Rexinoids, Deltanoids, SERMs and SPARMs
Adriana Maggi,
University of Milan, Italy
In vivo Imaging of Estrogen Receptor Activity in Transgenic Mice
In vivo Imaging of Estrogen Receptor Activity in Transgenic Mice
Jean-Francois Arnal,
INSERM, France
Estrogen Receptors and Vascular Physiology and Pathophysiology
Estrogen Receptors and Vascular Physiology and Pathophysiology
Barry Marc Forman,
City of Hope, USA
Orphan Nuclear Receptors and Lipid Homeostasis
Orphan Nuclear Receptors and Lipid Homeostasis
Daniel Metzger,
Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Impaired Adipogenesis, Lipolysis and Glucose Homeostasis in the Mouse Upon Selective Ablation of RXRalpha in Adipocytes
Impaired Adipogenesis, Lipolysis and Glucose Homeostasis in the Mouse Upon Selective Ablation of RXRalpha in Adipocytes
Martin Petkovich,
Queen's University, Canada
The Murine RARgamma-Null Mutation is a Suppressor of the CYP26A1-Null Embryonic- Lethal Phenotype
The Murine RARgamma-Null Mutation is a Suppressor of the CYP26A1-Null Embryonic- Lethal Phenotype
Carole R. Mendelson,
University of Texas Southwestern Medical Center, USA
Coactivators in Lung Development and Surfactant Protein Gene Expression
Coactivators in Lung Development and Surfactant Protein Gene Expression
16:30—18:30
NRs and Cancer
*
Kenneth S. Korach,
NIEHS, National Institutes of Health, USA
Shigeaki Kato,
University of Tokyo, Japan
Function of Androgen Receptor
Function of Androgen Receptor
Kathryn B. Horwitz,
University of Colorado Health Sciences Center, USA
N-Terminal Structure and Function in Breast Cancers of the Progesterone Receptor (PR)-A and PR-B Isoforms
N-Terminal Structure and Function in Breast Cancers of the Progesterone Receptor (PR)-A and PR-B Isoforms
19:30—21:30
Poster Session 4: Nuclear Receptor in Development and Physiology
08:00—11:00
Development and Integrated Functions II
Kenneth S. Korach,
NIEHS, National Institutes of Health, USA
Analyzing Differential Receptor Function Using Gene Targeting
Analyzing Differential Receptor Function Using Gene Targeting
David D. Moore,
Baylor College of Medicine, USA
CAR Integrates Responses to Exogenous and Endogenous Toxic Compounds
CAR Integrates Responses to Exogenous and Endogenous Toxic Compounds
Jacques Samarut,
Centre National de la Recherche Scientifique, France
Genetic Dissection of the Function of Thyroid Hormone Receptor Isoforms in the Development of the Mouse
Genetic Dissection of the Function of Thyroid Hormone Receptor Isoforms in the Development of the Mouse
16:30—18:30
Impact of Functional Genomics and Novel Technologies on Drug Discovery
Richard A. Heyman,
ORIC Pharmaceuticals, USA
Vertical Integration of Orphan Nuclear Receptors as Drug Discovery Targets
Vertical Integration of Orphan Nuclear Receptors as Drug Discovery Targets
Donald P. McDonnell,
Duke University School of Medicine, USA
The Molecular Determinants of Estrogen Receptor Pharmacology
The Molecular Determinants of Estrogen Receptor Pharmacology
Hinrich Gronemeyer,
Institut de Génétique et de Biologie Molécullaire et Cellulaire, Strasbourg, France
Regulation of Life and Death by Retinoid Receptors
Regulation of Life and Death by Retinoid Receptors
19:30—21:30
Poster Session 5: Late Breaking Topics in Nuclear Receptor Action
*Session Chair †Invited, not yet responded.
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