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This meeting took place in 2002
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Epigenetics in Development and Disease (J5)
Organizer(s) Alan P. Wolffe, Stephen B. Baylin and Trevor K. Archer
February 21—26, 2002
Taos Convention Center (meeting only) • Taos, NM USA
Abstract Deadline: Oct 22, 2001
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 20, 2001
Joint Meeting:
RNA Interference, Cosuppression and Related Phenomena (J6)
Summary of Meeting:
Remarkable progress is being made in appreciation and the role of epigenetics in topics as diverse as somatic gene therapy, cloning and transgenic strategies in plants and animals, aspects of cancer biology, the study of viral latency, the activity of mobile elements, genomic imprinting, and developmental abnormalities in animals and plants. Epigenetics presents a wonderful fusion of sciences relevant to human medicine, animal and plant biotech, and basic science. The excitement in this research area comes from the realization that diverse organisms have common molecular mechanisms that contribute to epigenetic control. This Keystone Symposium on 'Epigenetics in Development and Disease' will review the enormous progress and opportunities in this fast moving field. The meeting will have substantial representation from academic, medical and biotechnology perspectives. Therapeutic and commercial applications of epigenetics will be considered in depth.
View Scholarships/Awards
Remarkable progress is being made in appreciation and the role of epigenetics in topics as diverse as somatic gene therapy, cloning and transgenic strategies in plants and animals, aspects of cancer biology, the study of viral latency, the activity of mobile elements, genomic imprinting, and developmental abnormalities in animals and plants. Epigenetics presents a wonderful fusion of sciences relevant to human medicine, animal and plant biotech, and basic science. The excitement in this research area comes from the realization that diverse organisms have common molecular mechanisms that contribute to epigenetic control. This Keystone Symposium on 'Epigenetics in Development and Disease' will review the enormous progress and opportunities in this fast moving field. The meeting will have substantial representation from academic, medical and biotechnology perspectives. Therapeutic and commercial applications of epigenetics will be considered in depth.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
THURSDAY, FEBRUARY 21
FRIDAY, FEBRUARY 22
SATURDAY, FEBRUARY 23
SUNDAY, FEBRUARY 24
MONDAY, FEBRUARY 25
TUESDAY, FEBRUARY 26
Conference Program Print | View meeting in 12 hr (am/pm) time
THURSDAY, FEBRUARY 21
19:30—21:30
Keynote Address (Joint)
Peter A. Jones,
Van Andel Research Institute, USA
Epigenetics of Cancer
Epigenetics of Cancer
08:00—11:15
DNA Methylation and Human Disease
Brian D. Hendrich,
University of Edinburgh, UK
Methyl-CpG Binding Proteins in Development and Disease
Methyl-CpG Binding Proteins in Development and Disease
*
Stephen B. Baylin,
Johns Hopkins University School of Medicine, USA
Promoter Hypermethylation and Silencing of Genes in Cancer
Promoter Hypermethylation and Silencing of Genes in Cancer
En Li,
China Novartis Institutes for BioMedical Research, China
Functions of Dnmt3a, Dnmt3b, and Dnmt3L in Mammalian Development
Functions of Dnmt3a, Dnmt3b, and Dnmt3L in Mammalian Development
Kirk B. Jensen,
Rockefeller University, USA
The Consequences of Loss of Function of the FMRP and Nova RNA Binding Proteins in Neurons and in Neurologic Disease
The Consequences of Loss of Function of the FMRP and Nova RNA Binding Proteins in Neurons and in Neurologic Disease
Gerd P. Pfeifer,
Beckman Research Institute, USA
Short Talk: MBD3L, a Gene Homologous to the Methyl-CpG-Binding Domain Protein Genes MBD3 and MBD2, is Expressed Specifically in Postmeiotic Cells of the Testis
Short Talk: MBD3L, a Gene Homologous to the Methyl-CpG-Binding Domain Protein Genes MBD3 and MBD2, is Expressed Specifically in Postmeiotic Cells of the Testis
David C. Schultz,
Case Western Reserve University, USA
Short Talk: SETDB1: A Novel SET Domain Protein that Contains Histone H3-Lysine 9 Specific Methylase Activity, and Recruits HP1 to Endogenous, Euchromatic Targets
Short Talk: SETDB1: A Novel SET Domain Protein that Contains Histone H3-Lysine 9 Specific Methylase Activity, and Recruits HP1 to Endogenous, Euchromatic Targets
08:00—11:00
RNAi and Cosuppression in Different Organisms I
*
Richard W. Carthew,
Northwestern University, USA
RNAi in Drosophila
RNAi in Drosophila
Jan M. Kooter,
Free University, Netherlands
RNA Interference and DNA Methylation in Plants
RNA Interference and DNA Methylation in Plants
Lisa Timmons,
University of Kansas, USA
RNAi in Caenorhabditis elegans: The Spreading Effect
RNAi in Caenorhabditis elegans: The Spreading Effect
Elisabetta Ullu,
Yale University, USA
In vivo Analysis of RNA Interference in Trypanosoma brucei
In vivo Analysis of RNA Interference in Trypanosoma brucei
14:30—16:30
Workshop Sponsored by Rett Syndrome Research Foundation. This Workshop will include a dedication to Dr. Alan Wolff.
Jeffrey J. Hayes,
University of Rochester, USA
Nucleosomes are Substrates for hFEN1 Endonuclease and hDNA Ligase I
Nucleosomes are Substrates for hFEN1 Endonuclease and hDNA Ligase I
Mona D. Shahbazian,
Baylor College of Medicine, USA
Short Talk: Characterization of a Mouse Model for Rett Syndrome
Short Talk: Characterization of a Mouse Model for Rett Syndrome
Paul A. Wade,
NIEHS, National Institutes of Health, USA
Mutational Analysis of MBD Proteins: Insights into Structure and Function
Mutational Analysis of MBD Proteins: Insights into Structure and Function
Karine Monier,
Ecole Normale Superieure de Lyon, France
Short Talk: Nuclear Architecture Remodeling during in vitro Neuronal Differntiation
Short Talk: Nuclear Architecture Remodeling during in vitro Neuronal Differntiation
Fyodor D. Urnov,
University of California, Berkeley, USA
Chromatin and the Epigenome
Chromatin and the Epigenome
17:00—19:00
DNA Methylation and Development
David J. Katz,
Princeton University, USA
Epigenetic Regulation of Mammalian Growth
Epigenetic Regulation of Mammalian Growth
*
Wolf Reik,
Babraham Institute, UK
Function and Mechanisms of Imprinting and Epigenetic Reprogramming
Function and Mechanisms of Imprinting and Epigenetic Reprogramming
F. Alex Feltus,
Emory University School of Medicine, USA
Short Talk: Large Scale Mapping of DNMT1-Induced Hypermethylated CpG Island Loci
Short Talk: Large Scale Mapping of DNMT1-Induced Hypermethylated CpG Island Loci
Fumitoshi Ishino,
Medical Research Institute, Tokyo Medical and Dental University, Japan
Short Talk: Epigenetic Regulation of Cloned Mice Produced from Somatic Cells and Primordial Germ Cells
Short Talk: Epigenetic Regulation of Cloned Mice Produced from Somatic Cells and Primordial Germ Cells
17:00—19:00
RNAi and Cosuppression in Different Organisms II
*
Giuseppe Macino,
Universita' la Sapienza, Italy
Quelling and Questing in Neurospora crassa
Quelling and Questing in Neurospora crassa
James A. Birchler,
University of Missouri, USA
Transcriptional and Post-Transcriptional Transgene Silencing in Drosophila
Transcriptional and Post-Transcriptional Transgene Silencing in Drosophila
David C. Baulcombe,
University of Cambridge, UK
RNA Polymerase and Other Factors Involved in Maintenance of Cosuppression in Arabidopsis
RNA Polymerase and Other Factors Involved in Maintenance of Cosuppression in Arabidopsis
20:00—22:00
Poster Session 1: DNA Methylation and Human Disease/DNA Methylation and Development
08:00—11:00
DNA Methylation/Epigenetics (Joint)
Herve Vaucheret,
Institut National de la Recherche Agronomique, France
DNA Methylation and Gene Silencing in Plants
DNA Methylation and Gene Silencing in Plants
*
Timothy H. Bestor,
Columbia University College of Physicians and Surgeons, USA
Disruption of Dnmt3L Prevents Establishment of Maternal Genomic Imprints
Disruption of Dnmt3L Prevents Establishment of Maternal Genomic Imprints
Marjori Ann Matzke,
Institute of Plant and Microbial Biology, Academy Sinica, Taiwan
RNA-Directed Methylation of Promoter Sequences
RNA-Directed Methylation of Promoter Sequences
Rudolf Jaenisch,
Whitehead Institute for Biomedical Research, USA
Mammalian Cloning and Epigenetic Reprogramming
Mammalian Cloning and Epigenetic Reprogramming
14:30—16:30
Oral Abstract Presentations
György Hutvágner,
, USA
How Distinct are RNAi and stRNA Pathways?
How Distinct are RNAi and stRNA Pathways?
Eugene Aleksandrovich Glazov,
FMI for Biomedical Research, Switzerland
A Gene Encoding an Exonuclease-Like Protein is Required for Postranscriptional Silencing in Arabidopsis.
A Gene Encoding an Exonuclease-Like Protein is Required for Postranscriptional Silencing in Arabidopsis.
Nelson C. Lau,
Boston University School of Medicine, USA
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Alexei A. Aravin,
California Institute of Technology, USA
Double Stranded RNA-Mediated Silencing of Genomic Tandem Repeats and Transposable Elements in Drosophila melanogaster Germline
Double Stranded RNA-Mediated Silencing of Genomic Tandem Repeats and Transposable Elements in Drosophila melanogaster Germline
Petr Svoboda,
, Switzerland
RNAi in Preimplantation Embryos: dsRNA Processing and Suppression of Transposable Elements.
RNAi in Preimplantation Embryos: dsRNA Processing and Suppression of Transposable Elements.
17:00—19:00
Epigenetic Mechanisms in Tumorigenesis 1
Ina Rhee,
Genentech, Inc., USA
DNMT1 and DNMT3B Cooperate to Silence Genes in Human Cancer Cells
DNMT1 and DNMT3B Cooperate to Silence Genes in Human Cancer Cells
Ulrike Hardeland,
Institute of Medical Radiobiology, Switzerland
Mechanisms Coordinating the Repair of G•T Mispairs Arising through 5-Methylcytosine Deamination
Mechanisms Coordinating the Repair of G•T Mispairs Arising through 5-Methylcytosine Deamination
*
Trevor K. Archer,
NIEHS, National Institutes of Health, USA
Chromatin Structure Regulates Promoter Function
Chromatin Structure Regulates Promoter Function
Christian Seiser,
University of Vienna, Austria
Short Talk: Essential Function of Histone Deacetylase 1in Proliferation Control and CDK Inhibitor Repression
Short Talk: Essential Function of Histone Deacetylase 1in Proliferation Control and CDK Inhibitor Repression
17:00—19:00
Regulatory RNA
*
Craig C. Mello,
University of Massachusetts Medical School, USA
Target-Dependent Accumulations of RNA Species Define Genetically Distinct Events During RNAi in C. elegans
Target-Dependent Accumulations of RNA Species Define Genetically Distinct Events During RNAi in C. elegans
Bruce M. Paterson,
National Cancer Institute, National Institutes of Health, USA
RNAi as Random Degradative PCR
RNAi as Random Degradative PCR
Victor R. Ambros,
University of Massachusetts, USA
Eukaryotic Genes Encoding Small Regulatory RNAs
Eukaryotic Genes Encoding Small Regulatory RNAs
20:00—22:00
Poster Session 2: DNA Methylation/Epigenetics/Epigenetic Mechanisms in Tumorigenesis
08:00—11:00
Epigenetic Mechanisms in Tumorigenesis 2
*
Pier Paolo Pandolfi,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Oncogenesis and Developmental Control
Oncogenesis and Developmental Control
Pier Giuseppe Pelicci,
European Institute of Oncology, Italy
Histone Deacetylases: a Common Molecular Target for Differentiation Treatment of Acute Myeloid Leukemias
Histone Deacetylases: a Common Molecular Target for Differentiation Treatment of Acute Myeloid Leukemias
Henk G. Stunnenberg,
Radboud University, Netherlands
HDAC and Leukemia
HDAC and Leukemia
Maarten Van Lohuizen,
Netherlands Cancer Institute, Netherlands
Functional Analysis of Mouse Polycomb-Repression: Implications for Development and Cancer
Functional Analysis of Mouse Polycomb-Repression: Implications for Development and Cancer
Yi-Ching Wang,
National Taiwan Normal University, Taiwan
Short Talk: Inactivation of hMLH1 by Genetic and Epigenetic Alterations, A Novel Mechanism Causing Non-Small Cell Lung Cancer
Short Talk: Inactivation of hMLH1 by Genetic and Epigenetic Alterations, A Novel Mechanism Causing Non-Small Cell Lung Cancer
08:00—11:00
Genome Defense
Thierry Heidmann,
Institut Gustave Roussy, France
Taming of Transposable Elements in Drosophila by Homology-Dependent Gene Silencing/Cosuppression
Taming of Transposable Elements in Drosophila by Homology-Dependent Gene Silencing/Cosuppression
*
Ronald H. Plasterk,
Ministry of Education, Culture and Science, Netherlands
Transposon Silencing and RNAi in C. elegans
Transposon Silencing and RNAi in C. elegans
Virginia Walbot,
Stanford University, USA
Control of Mutator Activity and Mu Transposons in Maize
Control of Mutator Activity and Mu Transposons in Maize
Heriberto D. Cerutti,
University of Nebraska, USA
Epigenetic Control of Transposon Mobility in Chlamydomonas
Epigenetic Control of Transposon Mobility in Chlamydomonas
14:30—16:30
Workshop on Chromosomal Domains
Dirk Schübeler,
Friedrich Miescher Institute for Biomedical Research, Switzerland
Gene Activation and Repression in Red Cells
Gene Activation and Repression in Red Cells
Adam G. West,
National Institutes of Health, USA
Organisation of Gene Expression by Chromatin Insulators
Organisation of Gene Expression by Chromatin Insulators
*
Wendy A. Bickmore,
University of Edinburgh, UK
Chromosomal Domains and Nuclear Compartments in the Human Genome
Chromosomal Domains and Nuclear Compartments in the Human Genome
Frank Weissmann,
German Cancer Research Center (DKFZ), Germany
Short Talk: Hypermethylation of the Drosophila Genome Results in Chromosome Condensation Defects and Aberrant Histone Modification
Short Talk: Hypermethylation of the Drosophila Genome Results in Chromosome Condensation Defects and Aberrant Histone Modification
14:30—16:30
Oral Abstract Presentations
Shou-Wei Ding,
University of California, Riverside, USA
An Animal RNA Virus Encodes a Potent Suppressor of Post-Transcriptional Gene Silencing
An Animal RNA Virus Encodes a Potent Suppressor of Post-Transcriptional Gene Silencing
Jozsef Burgyán,
Plant Virology Institute-CNR, Italy
P19 Protein of Tombusviruses Can Specifically Bind 21-25 nt Double-Stranded RNAs Generated by Posttranscriptional Gene Silencing and Prevent the Development of Local and Systemic Silencing
P19 Protein of Tombusviruses Can Specifically Bind 21-25 nt Double-Stranded RNAs Generated by Posttranscriptional Gene Silencing and Prevent the Development of Local and Systemic Silencing
Alla Grishok,
Columbia University Medical Center, USA
Target Dependent Accumulation of siRNAs During RNAi in C. elegans
Target Dependent Accumulation of siRNAs During RNAi in C. elegans
Anke Geick,
Alnylam Europe AG, Germany
Specific Inhibition of Cancer-Related Target Gene Expression by Short Double-Stranded RNA
Specific Inhibition of Cancer-Related Target Gene Expression by Short Double-Stranded RNA
David L. Lewis,
Arrowhead Research Corporation, USA
Specific Inhibition of Gene Expression in Post-Natal Mammals Using Small Interfering RNAs
Specific Inhibition of Gene Expression in Post-Natal Mammals Using Small Interfering RNAs
Alexandra Boutla,
European Molecular Biology Laboratory, Germany
Induction of Silencing in Invertebrates by Synthetic and Natural RNAs
Induction of Silencing in Invertebrates by Synthetic and Natural RNAs
17:00—19:15
Functional Specialization of Chromatin
*
Steven Henikoff,
Fred Hutchinson Cancer Research Center, USA
Adaptive Evolution of Centromeric Histone H3-Like Proteins
Adaptive Evolution of Centromeric Histone H3-Like Proteins
Robert E. Kingston,
Massachusetts General Hospital, USA
Biochemical Analysis of Polycomb - Group Repression
Biochemical Analysis of Polycomb - Group Repression
Laura Carrel,
Case Western Reserve University, USA
Chromosomal Control of Gene Expression on the Human Inactive X Chromosome
Chromosomal Control of Gene Expression on the Human Inactive X Chromosome
Fang-Lin Sun,
Tongji University, China
Short Talk: Chromatin Organization of the Drosophila melanogaster Fourth Chromosome: Interspersed Functional Domains and Inferred Boundaries
Short Talk: Chromatin Organization of the Drosophila melanogaster Fourth Chromosome: Interspersed Functional Domains and Inferred Boundaries
17:00—19:00
In Vitro Systems
*
Gregory J. Hannon,
University of Cambridge, UK
Mechanism of RNA Interference
Mechanism of RNA Interference
Phillip D. Zamore,
University of Massachusetts Medical School, USA
RNA Interference: An in vitro Approach to Understanding Mechanism
RNA Interference: An in vitro Approach to Understanding Mechanism
Thomas Tuschl,
HHMI/Rockefeller University, USA
Posttranscriptional Gene Regulation by 21-Nucleotide RNAs
Posttranscriptional Gene Regulation by 21-Nucleotide RNAs
20:00—22:00
Poster Session 3: Epigenetic Mechanisms in Tumorigenesis/Functional Specialization of Chromatin/Gene Silencing and Development/Overcoming Silencing for Somatic Gene Therapy
08:00—11:00
Gene Silencing and Development (Joint). Session Sponsored in part by Torrey Mesa Research Institute.
*
Robert A. Martienssen,
Cold Spring Harbor Laboratory, USA
Argonauts in Arabidopsis and Yeast
Argonauts in Arabidopsis and Yeast
Steven E. Jacobsen,
University of California, Los Angeles, USA
Genetics of DNA Methylation in Arabidopsis
Genetics of DNA Methylation in Arabidopsis
E. Jean Finnegan,
CSIRO Plant Industry, Australia
Epigenetic Regulation of Plant Development
Epigenetic Regulation of Plant Development
Ian Wilmut,
University of Edinburgh, UK
Cloning: Overcoming Silencing through Nuclear Transplantation
Cloning: Overcoming Silencing through Nuclear Transplantation
17:00—19:00
Overcoming Silencing for Somatic Gene Therapy
*
Donald B. Kohn,
University of California, Los Angeles, USA
Overcoming Gene Silencing in Somatic Gene Therapy
Overcoming Gene Silencing in Somatic Gene Therapy
James R. Ellis,
Hospital for Sick Children, Canada
Short Talk: Chromatin Marks, Silencer-Blocking Insulators, and Stem Cell Gene Therapy Vectors
Short Talk: Chromatin Marks, Silencer-Blocking Insulators, and Stem Cell Gene Therapy Vectors
17:00—19:15
Applications of RNAi and Cosuppression in Genomics
Peter Waterhouse,
Commonwealth Scientific & Industrial Research Organization, Australia
Construct Design for Efficient, Effective and High Throughput Gene Silencing in Plants
Construct Design for Efficient, Effective and High Throughput Gene Silencing in Plants
Guy della-Cioppa,
Large Scale Biology Corporation, USA
Virus Induced Gene Silencing for Functional Genomics in Plants
Virus Induced Gene Silencing for Functional Genomics in Plants
Christophe J. Echeverri,
Cenix BioScience GmbH, Germany
RNAi for Functional Genomics: From Worms to Humans
RNAi for Functional Genomics: From Worms to Humans
*Session Chair †Invited, not yet responded.
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