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This meeting took place in 2004
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Golgi Apparatus and Secretory Pathway of Eukaryotic Cells (J4)
Organizer(s) L. Andrew Staehelin, Benjamin Glick and Kathryn E. Howell
January 20—25, 2004
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Sep 22, 2003
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Nov 20, 2003
Supported by Keystone Symposia
Joint Meeting:
Traffic Control: Rab GTPases in Vesicular Transport (J3)
Summary of Meeting:
The Golgi apparatus plays a central role in the biosynthesis, post-translational modification, and sorting and packaging of secretory molecules. The principal biosynthetic functions of this organelle include the assembly of proteoglycans and polysaccharides for the extracellular matrix or cell wall, the processing of the oligosaccharide side chains of soluble and membrane-associated glycoproteins, and the synthesis and processing of membrane lipids. The trafficking functions of the Golgi include the transport of cargo molecules from their sites of synthesis to their final destinations. Finally, the sorting and packaging functions involve the incorporation of various cargo molecules into different types of transport carriers for delivery to other organelles, as well as the internal recycling of resident Golgi molecules. In contrast to these well-defined functions, the structural and dynamic properties of the Golgi apparatus have remained controversial. At the center of this controversy is the fact that the Golgi apparatus continually exchanges components with other organelles, including the ER, endosomes, lysosomes/vacuoles, and the plasma membrane. A further complication is that Golgi architecture differs between organisms, can change during the cell cycle, and can vary in a tissue- and developmental stage-specific manner. The resulting diversity of experimental data has continued to fuel debate about how cargo molecules move through the Golgi, how the different cisternal elements maintain their identities despite the constant flux of components, and how and where cargo molecules are sorted and packaged into transport carriers. The central goal of this symposium is to bring together a broad group of researchers interested in the secretory pathway, with an emphasis on events that occur during transport to, through, and from the Golgi apparatus. Speakers include not only researchers studying yeast and mammalian cells but also a representative group of plant researchers. This meeting addresses biosynthetic functions of the Golgi in addition to the more frequently addressed cell biological functions. In retrospect, it is now obvious that the 1998 Golgi Centennial Meeting in Pavia, Italy was instrumental in promoting the paradigm shift from the vesicular transport model to the cisternal progression/maturation model of Golgi trafficking. The central challenge for this meeting will be to identify the current frontiers in secretory pathway research, and to stimulate new avenues of investigation by integrating insights from a wide range of experimental systems.
View Scholarships/Awards
The Golgi apparatus plays a central role in the biosynthesis, post-translational modification, and sorting and packaging of secretory molecules. The principal biosynthetic functions of this organelle include the assembly of proteoglycans and polysaccharides for the extracellular matrix or cell wall, the processing of the oligosaccharide side chains of soluble and membrane-associated glycoproteins, and the synthesis and processing of membrane lipids. The trafficking functions of the Golgi include the transport of cargo molecules from their sites of synthesis to their final destinations. Finally, the sorting and packaging functions involve the incorporation of various cargo molecules into different types of transport carriers for delivery to other organelles, as well as the internal recycling of resident Golgi molecules. In contrast to these well-defined functions, the structural and dynamic properties of the Golgi apparatus have remained controversial. At the center of this controversy is the fact that the Golgi apparatus continually exchanges components with other organelles, including the ER, endosomes, lysosomes/vacuoles, and the plasma membrane. A further complication is that Golgi architecture differs between organisms, can change during the cell cycle, and can vary in a tissue- and developmental stage-specific manner. The resulting diversity of experimental data has continued to fuel debate about how cargo molecules move through the Golgi, how the different cisternal elements maintain their identities despite the constant flux of components, and how and where cargo molecules are sorted and packaged into transport carriers. The central goal of this symposium is to bring together a broad group of researchers interested in the secretory pathway, with an emphasis on events that occur during transport to, through, and from the Golgi apparatus. Speakers include not only researchers studying yeast and mammalian cells but also a representative group of plant researchers. This meeting addresses biosynthetic functions of the Golgi in addition to the more frequently addressed cell biological functions. In retrospect, it is now obvious that the 1998 Golgi Centennial Meeting in Pavia, Italy was instrumental in promoting the paradigm shift from the vesicular transport model to the cisternal progression/maturation model of Golgi trafficking. The central challenge for this meeting will be to identify the current frontiers in secretory pathway research, and to stimulate new avenues of investigation by integrating insights from a wide range of experimental systems.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
TUESDAY, JANUARY 20
WEDNESDAY, JANUARY 21
THURSDAY, JANUARY 22
FRIDAY, JANUARY 23
SATURDAY, JANUARY 24
SUNDAY, JANUARY 25
Conference Program Print | View meeting in 12 hr (am/pm) time
TUESDAY, JANUARY 20
19:30—21:30
Keynote Session (Joint)
*
Benjamin Glick,
University of Chicago, USA
Randy W. Schekman,
University of California at Berkeley, USA
The Molecular Mechanism of Protein Sorting Early in the Secretory Pathway
The Molecular Mechanism of Protein Sorting Early in the Secretory Pathway
Marino Zerial,
Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Rab Domains in Endosome Organization and Signaling
Rab Domains in Endosome Organization and Signaling
08:00—11:00
Redefining Golgi Architecture and Composition
*
Alberto Luini,
Consozio Mario Negri Sud, Italy
L. Andrew Staehelin,
University of Colorado, USA
Testing of Structural Predictions of the Golgi Cisternal Progression Model by Electron Tomography
Testing of Structural Predictions of the Golgi Cisternal Progression Model by Electron Tomography
Kathryn E. Howell,
University of Colorado Health Sciences Center, USA
Part 1: 3D Structure Supports Multiple Transport Mechanisms To, Through and From the Golgi Complex Part 2: Characterization of a Novel Post Translational Modification of A Dimethyl-Argenine Protein
Part 1: 3D Structure Supports Multiple Transport Mechanisms To, Through and From the Golgi Complex Part 2: Characterization of a Novel Post Translational Modification of A Dimethyl-Argenine Protein
Todd R. Graham,
Vanderbilt University, USA
Drs2p: A Lipid-Flipping, Vesicle-Forming ATPase in the Yeast Golgi Complex
Drs2p: A Lipid-Flipping, Vesicle-Forming ATPase in the Yeast Golgi Complex
John R. Yates III,
The Scripps Research Institute, USA
Mass Spectrometry of Large Cellular Structures
Mass Spectrometry of Large Cellular Structures
08:00—11:00
Cargo Loading and Vesicle Budding
*
Charles K. Barlowe,
Dartmouth Medical School, USA
Suzanne R. Pfeffer,
Stanford University, USA
A GDI Displacement Factor to Localize Rab GTPases
A GDI Displacement Factor to Localize Rab GTPases
Stephen Ferguson,
Robarts Research Institute, UWO, Canada
Angiotensin II Type 1A Receptor Trafficking and Rab GTPases
Angiotensin II Type 1A Receptor Trafficking and Rab GTPases
Keith E. Mostov,
University of California, San Francisco, USA
Regulation of Membrane Traffic in Polarized Epithelial Cells
Regulation of Membrane Traffic in Polarized Epithelial Cells
17:00—19:00
Golgi-Cytoskeletal Interaction
*
Jennifer A. Lippincott-Schwartz,
Howard Hughes Medical Institute - Janelia Farm, USA
Mark A. McNiven,
Mayo Clinic, USA
A Dynamin and Cortactin Complex Mediates Membrane Traffic in the Endocytic and Secretory Pathways
A Dynamin and Cortactin Complex Mediates Membrane Traffic in the Endocytic and Secretory Pathways
Viki J. Allan,
University of Manchester, UK
Cytoplasmic Dynein in the Secretory Pathway during Apoptosis and during Mitosis
Cytoplasmic Dynein in the Secretory Pathway during Apoptosis and during Mitosis
Chris Hawes,
Oxford Brookes University, UK
ER Exit Sites and Golgi Dynamics in Plants
ER Exit Sites and Golgi Dynamics in Plants
17:00—19:00
Vesicle Tethering
*
Suzanne R. Pfeffer,
Stanford University, USA
William T. Wickner,
Dartmouth Medical School, USA
Yeast Vacuole Fusion
Yeast Vacuole Fusion
Francis Barr,
University of Oxford, UK
Grasp-Golgin Complexes: Rab Effectors Required for Normal Golgi Function
Grasp-Golgin Complexes: Rab Effectors Required for Normal Golgi Function
Rytis Prekeris,
University of Colorado Health Sciences Center, USA
Short Talk: FIP3 is a Rab11 and ARF6 Binding Protein Involved in Regulating of Cell Motility
Short Talk: FIP3 is a Rab11 and ARF6 Binding Protein Involved in Regulating of Cell Motility
Cecilia I. Alvarez,
Facultad de Ciencias Quimicas, Argentina
Short Talk: Rab1-Mediated COPI Recruitment
Short Talk: Rab1-Mediated COPI Recruitment
Ellen Tisdale,
Wayne State University, USA
Short Talk: Rab2 Interacts Directly with Atypical Protein Kinase C iota/lambda to Regulate Microtubule Dynamics at the VTC
Short Talk: Rab2 Interacts Directly with Atypical Protein Kinase C iota/lambda to Regulate Microtubule Dynamics at the VTC
08:00—11:00
Regulation of Vesicle Production and ER-to-Golgi Transport (Joint)
William E. Balch,
The Scripps Research Institute, USA
Rab Trafficking Networks
Rab Trafficking Networks
Charles K. Barlowe,
Dartmouth Medical School, USA
Mechanisms in Transport between the ER and Golgi without Ypt1p
Mechanisms in Transport between the ER and Golgi without Ypt1p
Susan Ferro-Novick,
University of California, San Diego, USA
Vesicle Traffic and Organelle Inheritance
Vesicle Traffic and Organelle Inheritance
Benjamin Glick,
University of Chicago, USA
Golgi Structure and Inheritance in Budding Yeasts
Golgi Structure and Inheritance in Budding Yeasts
17:00—19:00
Transport Through the Golgi Apparatus
*
Judith Klumperman,
University Medical Center Utrecht, Netherlands
Felix Wieland,
Universität Heidelberg, Germany
Biogenesis of a Transport Vesicle: Players and Rules
Biogenesis of a Transport Vesicle: Players and Rules
Alberto Luini,
Consozio Mario Negri Sud, Italy
Morpho-Functional Analysis of a Single Traffic Wave Passing through an Individual Stack: The Mode of Intra-Golgi Traffic
Morpho-Functional Analysis of a Single Traffic Wave Passing through an Individual Stack: The Mode of Intra-Golgi Traffic
Anne Spang,
Max-Planck-Gesellschaft, Germany
Short Talk: Why Don't Vesicles Fuse Back to the Donor Membrane
Short Talk: Why Don't Vesicles Fuse Back to the Donor Membrane
David K. Banfield,
Hong Kong University of Science and Technology, China
Short Talk: COPI-Coated Vesicle Formation and SNAREs
Short Talk: COPI-Coated Vesicle Formation and SNAREs
17:00—19:00
Exocytosis
*
Burton F. Dickey,
University of Texas MD Anderson Cancer Center, USA
Peter Novick,
University of California, San Diego, USA
Spatial Regulation of Exocytosis in Yeast
Spatial Regulation of Exocytosis in Yeast
Michael L. Nonet,
Washington University, USA
Regulation of Transmitter Release by Rab-3 and Associated Regulators
Regulation of Transmitter Release by Rab-3 and Associated Regulators
Thomas C. Südhof,
Stanford School of Medicine, USA
Rab Function in Synaptic Vesicle Exocytosis
Rab Function in Synaptic Vesicle Exocytosis
08:00—11:00
Biosynthesis and Bioengineering of Carbohydrates
*
L. Andrew Staehelin,
University of Colorado, USA
Kelley W. Moremen,
University of Georgia, USA
Class 1 alpha1,2-mannosidase Structure and Function in N-Glycan Biosynthesis and Quality Control
Class 1 alpha1,2-mannosidase Structure and Function in N-Glycan Biosynthesis and Quality Control
Gideon Davies,
University of York, UK
The Structural Enzymology of Glycosyl Transfer: Structures and Mechanisms
The Structural Enzymology of Glycosyl Transfer: Structures and Mechanisms
Loic Faye,
Université de Rouen, France
From Glycobiology to Glycoengineering in Plants
From Glycobiology to Glycoengineering in Plants
Tillman U. Gerngross,
Adimab, Inc., USA
Engineering the Secretory Pathway of the Yeast Pichia pastoris to Produce Mammalian-Type Glycoproteins
Engineering the Secretory Pathway of the Yeast Pichia pastoris to Produce Mammalian-Type Glycoproteins
08:00—11:00
Rab-Cytoskeletal Interactions
*
Peter Novick,
University of California, San Diego, USA
Stéphanie Miserey-Lenkei,
Institut Curie, France
Role of the Golgi-Associated Rab6 GTPase in Interphasic and Mitotic Cells
Role of the Golgi-Associated Rab6 GTPase in Interphasic and Mitotic Cells
John A. Hammer,
NHLBI, National Institutes of Health, USA
Roles of Rab GTPases in Motor:Organelle Interactions
Roles of Rab GTPases in Motor:Organelle Interactions
James R. Goldenring,
Vanderbilt University Medical Center, USA
Regulation of Plasma Membrane Recycling by Myosin Vb and Rab11-FIP2
Regulation of Plasma Membrane Recycling by Myosin Vb and Rab11-FIP2
Jacques Neefjes,
Netherlands Cancer Institute, Netherlands
Rab7 Controlling Transport of MHC Class II Molecules
Rab7 Controlling Transport of MHC Class II Molecules
17:00—19:00
Sorting of Cargo to Post Golgi Sites
*
Kathryn E. Howell,
University of Colorado Health Sciences Center, USA
Judith Klumperman,
University Medical Center Utrecht, Netherlands
Sorting Domains in the Secretory Pathway
Sorting Domains in the Secretory Pathway
Sean Munro,
Medical Research Council, UK
Arf-Like GTPases in Vesicular Transport
Arf-Like GTPases in Vesicular Transport
Willaim J. Brown†,
Cornell University, USA
Short Talk: The Surprising Properties of the Lysophospholipid Acyltransferase Inhibitor CI-976 on Membrane Tubule and Vesicle Formation
Short Talk: The Surprising Properties of the Lysophospholipid Acyltransferase Inhibitor CI-976 on Membrane Tubule and Vesicle Formation
Christopher Burd,
University of Pennsylvania School of Medicine, USA
Short Talk: ARF Like GTPases (ARL1p) is the Golgi Receptor for GRIP Domains
Short Talk: ARF Like GTPases (ARL1p) is the Golgi Receptor for GRIP Domains
17:00—19:00
Membrane Association and Structure
*
William E. Balch,
The Scripps Research Institute, USA
Miguel C. Seabra,
Imperial College London, UK
Membrane Targeting of Rab GTPases
Membrane Targeting of Rab GTPases
David G. Lambright,
University of Massachusetts Medical School, USA
Structural Insights into the Mechanism and Specificity of Rab Regulated Membrane Trafficking
Structural Insights into the Mechanism and Specificity of Rab Regulated Membrane Trafficking
Roger S. Goody,
Max Planck Institute for Molecular Physiology, Germany
Structural and Mechanistic Aspects of Rab GTPases in Intracellular Vesicular Transport
Structural and Mechanistic Aspects of Rab GTPases in Intracellular Vesicular Transport
08:00—11:00
Lipid Biosynthesis, Signaling and Sorting
*
Maria Antonella De Matteis,
Consorzio Mario Negri Sud, Italy
Vytas A. Bankaitis,
Texas A&M University, USA
Phosphatidylinositol Transfer Protein-Dependent Signaling and Yeast Golgi Function
Phosphatidylinositol Transfer Protein-Dependent Signaling and Yeast Golgi Function
Scott D. Emr,
Cornell University, USA
Lipid Signaling and Ubiquitin-Dependent Sorting at the Endosome in Yeast
Lipid Signaling and Ubiquitin-Dependent Sorting at the Endosome in Yeast
Vivek Malhotra,
ICREA, Spain
Regulating Vesicle Formation from Golgi Membranes and Using Golgi to Regulate Mitotic Progression
Regulating Vesicle Formation from Golgi Membranes and Using Golgi to Regulate Mitotic Progression
Marisa S. Otegui,
University of Wisconsin, USA
Short Talk: Analysis of Golgi and Multivesicular Body Functions during Protein Storage Vacuole Formation in Arabidopsis thaliana
Short Talk: Analysis of Golgi and Multivesicular Body Functions during Protein Storage Vacuole Formation in Arabidopsis thaliana
Vangelis Kondylis,
University Medical Center, Utrecht, Netherlands
Short Talk: Do Golgi Matrix Proteins also Play a Role in tER Organization?
Short Talk: Do Golgi Matrix Proteins also Play a Role in tER Organization?
08:00—11:00
Regulation of the Rab GTPase Cycle
*
William T. Wickner,
Dartmouth Medical School, USA
Nava Segev,
University of Illinois at Chicago, USA
Exocytic Ypt/Rab GTPases: Novel Mechanisms and Coordination
Exocytic Ypt/Rab GTPases: Novel Mechanisms and Coordination
Yoshimi Takai,
Osaka University Graduate School of Medicine, Japan
Rab3 Regulators
Rab3 Regulators
Ruth N. Collins,
Cornell University, USA
Molecular Genetic Studies of Rab GTPase Activation
Molecular Genetic Studies of Rab GTPase Activation
Jean M. Wilson,
University of Arizona, USA
Short Talk: The Small GTPase Rab14 Regulates Apical Trafficking
Short Talk: The Small GTPase Rab14 Regulates Apical Trafficking
Ryota Kunita,
Institute of Medical Sciences, Tokai University, Japan
Short Talk: ALS2 is a Novel Guanine Nucleotide Exchange Factor for Rab5 and in Implicated in Endosomal Dynamics
Short Talk: ALS2 is a Novel Guanine Nucleotide Exchange Factor for Rab5 and in Implicated in Endosomal Dynamics
Angela Wandinger-Ness,
University of New Mexico, USA
Short Talk: Regulation of Late Endosomal Phosphatidylinositol Lipid Dynamics by Rab7
Short Talk: Regulation of Late Endosomal Phosphatidylinositol Lipid Dynamics by Rab7
17:00—19:00
Golgi Maintenance and Inheritance
*
Benjamin Glick,
University of Chicago, USA
Maria Antonella De Matteis,
Consorzio Mario Negri Sud, Italy
The Role of the Cycling of the Matrix Protein GM130 in the Biogenesis of the Golgi Complex
The Role of the Cycling of the Matrix Protein GM130 in the Biogenesis of the Golgi Complex
Graham B. Warren,
Medical University of Vienna, USA
Tethers of the Golgi Apparatus
Tethers of the Golgi Apparatus
Jennifer A. Lippincott-Schwartz,
Howard Hughes Medical Institute - Janelia Farm, USA
A Role For Arf1 In Mitotic Golgi Disassembly, Chromosome Segregation and Cytokinesis
A Role For Arf1 In Mitotic Golgi Disassembly, Chromosome Segregation and Cytokinesis
17:00—19:00
Intersection with Signaling
Philip D. Stahl,
Washington University in St. Louis, School of Medicine, USA
Rab5 and Rin1 - Regulation of Receptor Mediated Endocytosis
Rab5 and Rin1 - Regulation of Receptor Mediated Endocytosis
Giorgio Scita,
IFOM Foundation at Campus IFOM-IEO, Italy
Up and Down Small GTPases: Signaling Mechanisms Regulating Actin Based Endocytosis
Up and Down Small GTPases: Signaling Mechanisms Regulating Actin Based Endocytosis
Peter van der Sluijs,
University Medical Center Utrecht, Netherlands
Rab4 Function in Recycling from Endosomes
Rab4 Function in Recycling from Endosomes
*Session Chair †Invited, not yet responded.
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