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This meeting took place in 2005
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Molecular Biology of Cardiac Diseases and Regeneration (D2)
Organizer(s) Elizabeth McNally and Jonathan A. Epstein
April 3—8, 2005
Sheraton Steamboat Resort • Steamboat Springs, Colorado USA
Abstract Deadline: Dec 2, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 3, 2005
Supported by The Director's Fund
Summary of Meeting:
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Myocardial infarction and congestive heart failure, together, account for the majority of cardiovascular disease. An underlying theme in both myocardial infarction and congestive heart failure is an insufficient number of properly functioning cardiomyocytes. Repairing defective cardiomyocytes and/or regenerating cardiomyocytes are important experimental means to improve heart function. To this end, stem cells from embryonic and adult sources have been increasingly explored as a means of restoring cardiac function. Vascular growth remains a significant concern since vascular supply is essential to the survival of regenerated cardiomyocytes. To establish a fully functioning cardiomyocyte requires a detailed understanding of cardiomyocyte differentiation as well as a pluripotent stem cell capable of achieving the cardiomyocyte developmental pathway. At the cellular level, cardiomyocyte dysfunction arises from ischemic insult, genetic or toxic metabolic defects. The broad etiology responsible for the dysfunctioning cardiomyocyte has not limited the identification of molecular pathways in common to these many different forms of heart failure. Defects of intracellular calcium homeostasis are a frequent issue in failing cardiomyocytes. Perturbations of calcium homeostasis directly affect sarcomere function and simultaneously render an altered signaling cascade. The goal of this meeting is twofold. We will discuss cellular and molecular pathways necessary for cardiac regeneration. This will include a discussion of stem cell choice as well as a full evaluation of current stem cell transplant programs with an emphasis on full integration and differentiation of the transplanted stem cell. The second major emphasis of the meeting will be to discuss the failing cardiomyocyte focused on the common and critical molecular pathways found in the diseased cardiomyocyte. These two broad areas overlap considerably since both approaches will be required to successfully repair a failed cardiomyocyte.
View Scholarships/Awards
Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Myocardial infarction and congestive heart failure, together, account for the majority of cardiovascular disease. An underlying theme in both myocardial infarction and congestive heart failure is an insufficient number of properly functioning cardiomyocytes. Repairing defective cardiomyocytes and/or regenerating cardiomyocytes are important experimental means to improve heart function. To this end, stem cells from embryonic and adult sources have been increasingly explored as a means of restoring cardiac function. Vascular growth remains a significant concern since vascular supply is essential to the survival of regenerated cardiomyocytes. To establish a fully functioning cardiomyocyte requires a detailed understanding of cardiomyocyte differentiation as well as a pluripotent stem cell capable of achieving the cardiomyocyte developmental pathway. At the cellular level, cardiomyocyte dysfunction arises from ischemic insult, genetic or toxic metabolic defects. The broad etiology responsible for the dysfunctioning cardiomyocyte has not limited the identification of molecular pathways in common to these many different forms of heart failure. Defects of intracellular calcium homeostasis are a frequent issue in failing cardiomyocytes. Perturbations of calcium homeostasis directly affect sarcomere function and simultaneously render an altered signaling cascade. The goal of this meeting is twofold. We will discuss cellular and molecular pathways necessary for cardiac regeneration. This will include a discussion of stem cell choice as well as a full evaluation of current stem cell transplant programs with an emphasis on full integration and differentiation of the transplanted stem cell. The second major emphasis of the meeting will be to discuss the failing cardiomyocyte focused on the common and critical molecular pathways found in the diseased cardiomyocyte. These two broad areas overlap considerably since both approaches will be required to successfully repair a failed cardiomyocyte.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 3
MONDAY, APRIL 4
TUESDAY, APRIL 5
WEDNESDAY, APRIL 6
THURSDAY, APRIL 7
FRIDAY, APRIL 8
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 3
19:30—20:30
Keynote Address
Mark T. Keating,
Novartis Institutes for BioMedical Research, USA
Cardiac Regeneration
Cardiac Regeneration
08:00—11:15
Cardiovascular Development I
Didier Stainier,
Max Planck Institute for Heart and Lung Research, Germany
Zebrafish Models of Heart Development
Zebrafish Models of Heart Development
Deepak Srivastava,
Gladstone Institutes, USA
Cardiac Developmental Genes: Implications for Childhood and Adult Disease
Cardiac Developmental Genes: Implications for Childhood and Adult Disease
Eric N. Olson,
University of Texas Southwestern Medical Center, USA
Control of Heart Development by Transcriptional Coactivators and Corepressors
Control of Heart Development by Transcriptional Coactivators and Corepressors
Edward E. Morrisey,
University of Pennsylvania, USA
Short Talk: A Unique Role for Foxp4 in Late Cardiac Development
Short Talk: A Unique Role for Foxp4 in Late Cardiac Development
Kory J. Lavine,
Washington University School of Medicine, USA
Short Talk: Fibroblast Growth Factor Signals Regulate Myocardial Proliferation and Coronary Vasculogenesis in vivo
Short Talk: Fibroblast Growth Factor Signals Regulate Myocardial Proliferation and Coronary Vasculogenesis in vivo
17:00—19:00
Cardiovascular Development II
Kenneth R. Chien,
Karolinska Institutet, Sweden
The Islet-1+ Progenitor Story: Heart Cell Lineage Diversification in Develpment and Disease
The Islet-1+ Progenitor Story: Heart Cell Lineage Diversification in Develpment and Disease
*
Peter F. Carmeliet,
University of Leuven, VIB, Belgium
Mechanisms of Angiogenesis
Mechanisms of Angiogenesis
David A. Cheresh,
University of California, San Diego, USA
Growth Factor Signaling in the Tumor Endothelium, Limiting Ischemic Injury Following Myocardial Infarction
Growth Factor Signaling in the Tumor Endothelium, Limiting Ischemic Injury Following Myocardial Infarction
Eric C. Svensson,
University of Chicago, USA
Short Talk: Fog Genes are Required for Cardiac Looping in Zebrafish
Short Talk: Fog Genes are Required for Cardiac Looping in Zebrafish
08:00—11:00
Mechanisms of Cardiomyocyte Failure
Jonathan G. Seidman,
Harvard Medical School, USA
Cardac Morhology, Fibrosis, and Arrhythmia in Hypertrophic and PRKAG2 Cardiomyopathy
Cardac Morhology, Fibrosis, and Arrhythmia in Hypertrophic and PRKAG2 Cardiomyopathy
*
Elizabeth M. McNally,
Northwestern University, USA
Cytoskeletal Defects in Cardiomyopathy
Cytoskeletal Defects in Cardiomyopathy
Guido E. Tarone,
Universita di Torino, Italy
Short Talk: Melusin, a Muscle Specific Integrin Binding Protein, Protects from Cardiac Dilation in Response to Pressure Overload
Short Talk: Melusin, a Muscle Specific Integrin Binding Protein, Protects from Cardiac Dilation in Response to Pressure Overload
Joseph M. Metzger,
University of Minnesota Medical School, USA
Short Talk: Rescue of Dystrophic Cardiomyopathy Following Acute Administration of Polaxomer 188 in the mdx Mouse
Short Talk: Rescue of Dystrophic Cardiomyopathy Following Acute Administration of Polaxomer 188 in the mdx Mouse
Jennifer L. Hall,
University of Minnesota, USA
Short Talk: Identification and Regulation of Sprouty1, an Intrinsic Negative Inhibitor of the ERK Cascade, in the Human Heart
Short Talk: Identification and Regulation of Sprouty1, an Intrinsic Negative Inhibitor of the ERK Cascade, in the Human Heart
Rolf Bodmer,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Cardiac Development and Aging in Drosophila
Short Talk: Cardiac Development and Aging in Drosophila
17:00—19:15
Stem Cells in Cardiac Regeneration
*
Charles E. Murry,
University of Washington, USA
Stem Cell Transplantation for Cardiac Repair
Stem Cell Transplantation for Cardiac Repair
Michael D. Schneider,
Imperial College London, UK
Stem Cells in Cardiomyocyte Regeneration
Stem Cells in Cardiomyocyte Regeneration
Benoit G. Bruneau,
Gladstone Institutes, USA
The Homeodomain Transcription Factor Irx5 Establishes the Mouse Cardiac Ventricular Repolarization Gradient
The Homeodomain Transcription Factor Irx5 Establishes the Mouse Cardiac Ventricular Repolarization Gradient
Nadia A. Rosenthal,
The Jackson Laboratory, USA
Enhancing Cardiac Regeneration with Growth Factors
Enhancing Cardiac Regeneration with Growth Factors
08:00—11:15
Molecular Pathogenesis of Heart Failure
Andre Terzic,
Mayo Clinic College of Medicine, USA
KATP Channels in Stress Response
KATP Channels in Stress Response
Andrew R. Marks,
Columbia University College of Physicians and Surgeons, USA
Molecular Basis of Heart Failure and Cardiac Arrhythmias and Novel Therapy
Molecular Basis of Heart Failure and Cardiac Arrhythmias and Novel Therapy
*
R. John Solaro,
University of Illinois at Chicago, USA
Thin Filament Defects in the Failing Heart.
Thin Filament Defects in the Failing Heart.
Anthony J. Muslin,
Sanofi Global Research & Development, USA
Short Talk: Akt1 Promotes Physiologic, but Antagonizes Pathologic, Cardiac Growth
Short Talk: Akt1 Promotes Physiologic, but Antagonizes Pathologic, Cardiac Growth
Kenneth Walsh,
University of Virginia School of Medicine, USA
Short Talk: Disruption of Coordinated Tissue Growth and Angiogenesis in the Heart Mediates Progression from Adaptive Cardiac Hypertrophy to Heart Failure
Short Talk: Disruption of Coordinated Tissue Growth and Angiogenesis in the Heart Mediates Progression from Adaptive Cardiac Hypertrophy to Heart Failure
Pilar Ruiz-Lozano,
Stanford University, USA
Short Talk: Migratory Precursors and Myocyte Function
Short Talk: Migratory Precursors and Myocyte Function
17:00—19:00
Signaling Defects in Cardiomyocyte Failure
*
Jean E. Schaffer,
Harvard University, USA
Lipid Metabolic Defects as a Cause of Cardiomyopathy
Lipid Metabolic Defects as a Cause of Cardiomyopathy
Jeffery D. Molkentin,
Cincinnati Children's Hospital Medical Center, USA
Analysis of Cyclophilin D Function Reveals a Necessary Role for Mitochondrial Pore Permeability
Analysis of Cyclophilin D Function Reveals a Necessary Role for Mitochondrial Pore Permeability
Howard A. Rockman,
Duke University Medical Center, USA
New Concepts in Heptahelical Receptor Signaling in Heart Failure
New Concepts in Heptahelical Receptor Signaling in Heart Failure
Richard T. Lee,
Harvard University, USA
Short Talk: Injectable Self-Assembling Nanofibers for Targeted Myocardial Delivery
Short Talk: Injectable Self-Assembling Nanofibers for Targeted Myocardial Delivery
08:00—11:15
Cell Death and Mitochondrial Function
*
Michael T. Crow,
Johns Hopkins School of Medicine, USA
Control of Mitochaondrial Death Signaling in the Heart by ARC
Control of Mitochaondrial Death Signaling in the Heart by ARC
Peter J. Gruber,
University of Iowa, USA
Short Talk: Epigenetic Modifications Reduce the Severity of Ischemia-Reperfusion Injury in the Murine Heart
Short Talk: Epigenetic Modifications Reduce the Severity of Ischemia-Reperfusion Injury in the Murine Heart
Michael Seth Kapiloff,
Oregon Health & Science University, USA
Short Talk: The mAKAP Signaling Complex and the Induction of Cardiac Myocyte Hypertrophy
Short Talk: The mAKAP Signaling Complex and the Induction of Cardiac Myocyte Hypertrophy
April Stempien-Otero,
University of Washington, USA
Short Talk: Plasminogen Dependent Cardiac Fibrosis
Short Talk: Plasminogen Dependent Cardiac Fibrosis
Sameer S. Chopra,
Vanderbilt University School of Medicine, USA
Short Talk: The Voltage-Gated Sodium Channel SCN5A is Required for Embryonic Heart Development and Function in Zebrafish
Short Talk: The Voltage-Gated Sodium Channel SCN5A is Required for Embryonic Heart Development and Function in Zebrafish
17:00—19:00
Stem Cell Diversity
Mark F. Pittenger,
University of Maryland Medical Center, USA
Allogenetic Mesemchymal Stem Cells in Cardiac Therapeutics
Allogenetic Mesemchymal Stem Cells in Cardiac Therapeutics
*
Doris A. Taylor,
Texas Heart Institute, USA
Short Talk: Putting Vascular Back into Stem Cell based Cardiovascular Repair
Short Talk: Putting Vascular Back into Stem Cell based Cardiovascular Repair
Cindy M. Martin,
University of Minnesota, USA
Short Talk: Progenitor Cell Populations and their Participation in Myocardial Regeneration
Short Talk: Progenitor Cell Populations and their Participation in Myocardial Regeneration
Michel Pucéat,
INSERM, France
Short Talk: Stem Cells Improves Left Ventricular Function in Infarcted Sheep Myocardium
Short Talk: Stem Cells Improves Left Ventricular Function in Infarcted Sheep Myocardium
*Session Chair †Invited, not yet responded.
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