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This meeting took place in 2005

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Dendritic Cells at the Center of Innate and Adaptive Immunity: Eradication of Pathogens and Cancer and Control of Immunopathology (B2)

Organizer(s) Anne O'Garra, Jacques Banchereau and Alan Sher
February 1—7, 2005
Fairmont Hotel Vancouver • Vancouver, BC Canada
Abstract Deadline: Sep 30, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Dec 1, 2004

Supported by The Director's Fund

Summary of Meeting:
The decision to activate an immune response is made by unique antigen presenting cells, called dendritic cells that are resting until they encounter foreign microorganisms or inflammatory stimuli. Early activated dendritic cells trigger innate immune responses that represent the first line of defense against invading pathogens to limit the infections. At later times activated they prime antigen-specific immune responses to clear infectious pathogens and give rise to immunological memory. Dendritic cells control the responses of several types of lymphocytes, and are key in the transition between innate and adaptive immunity. They determine the class of the T cell response, including the development of Th1 cells to eradicate pathogens, or conversely unresponsiveness or tolerance, and thus are critical for the development of an effective immune response with minimum immunopathology. This multifaceted role of the dendritic cell will be covered in this meeting in the following areas: (1) Activation and maturation of dendritic cells for the design of successful adjuvants: (2) Molecular signaling pathways in dendritic cells in response to pathogen-derived products and inflammatory mediators: (3) Cell biology of dendritic cells in antigen handling, processing and presentation: (4) Innate functions of dendritic cells in dictating adaptive immune responses: (5) Dendritic cells in allergy and autoimmunity: (6) Dendritic cells in infectious diseases: (7) Dendritic cells and cancer immunotherapy.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time



BC Foyer

BC Foyer
Keynote Address

British/Columbia Ballrooms
* Anne O'Garra, Francis Crick Institute, UK

Ralph M. Steinman, Rockefeller University, USA
Harnessing Dendritic Cells for Immunity and Tolerance



Pacific Ballroom
Activation and Maturation of Dendritic Cells: Adjuvant Properties of Dendritic Cells

British/Columbia Ballrooms
* Jacques F. Banchereau, The Jackson Laboratory for Genomic Medicine, USA
Human Plasmacytoid and Myeloid Dendritic Cells Encompass Dinstint Subsets

* Yong-Jun Liu, Sanofi, USA
Plasmacytoid Dendritic Cells as Frontline Antiviral Agents

Carl G. Figdor, Radboud University Medical Center, Netherlands
C-Type Lectins as Antigen Uptake Receptors on Dendritic Cells

Siamon Gordon, Chang Gung University / University of Oxford, UK
Immune Recognition and Regulation by Macrophages

Frederic Geissmann, Memorial Sloan Kettering Cancer Center, USA
Short Talk: Isolation, Clonogenic Potential and in vivo Differentiation of a Common M-CSF-Dependant Bone Marrow Progenitor Specific for Dendritic Cells and Macrophages

SangKon Oh, Baylor Research Institute, USA
Short Talk: Role of IL-15/IL-15Ralpha in Dendritic Cell Activation of T Cells

Coffee Break

BC Foyer
Poster Setup

Pacific Ballroom
Poster Viewing

Pacific Ballroom
Workshop 1: DC Activation and Maturation

British/Columbia Ballrooms
* Marika Sarfati, Centre de Recherche du CHUM, Canada
CD47 is a Negative Regulator of Dendritic Cells in vivo

Jonathan D. Silk, University of Oxford, UK
Integration of Signals Induced with TLR Ligands with Activation of iNKT Cells Leads to DC Maturation and Enhanced T Cell Expansion in vivo

Dmitry I. Gabrilovich, AstraZeneca, USA
Bone Marrow Stroma Mediated Regulation of Dendritic Cell differentiation Depends on the Nature of Notch Ligands

Adam M. Boruchov, Memorial Sloan-Kettering Cancer Center, USA
Co-expressed Activating and Inhibitory Fc gamma Rs Have Opposing Functions on Human DCs

Jinhua Lu, National University of Singapore, Singapore
CD83 is Preformed Inside Monocytes, Macrophages and Dendritic Cells but it is Only Stably Expressed on Activated Dendritic Cells

Diana Dudziak, Rockefeller University, USA
33D1 Defines a Novel population of CD11Chigh Splenic Dendritic Cells

Aurélie Groseil, Genethon, France
The Notch Ligand delta-like-1 Induces Hematopoietic Differentiation into the Plasmacytoid Dendritic Cell Lineage

Aimin Jiang, Yale University, USA
Regulation of Dendritic Cell Maturation by E-cadherin/beta-catenin Signaling

Kenji Kabashima, Kyoto University, Japan
Lymphotoxin-beta Receptor Signaling Promotes Dendritic Cell Proliferation in Lymphoid Tissues

Yumiko Kamogawa-Schifter, Ginkgobiomedical Institute, Japan
Ly49Q Defines Two Subsets of pDCs in Mice

Coffee & Snacks Available

BC Foyer
Signaling in Dendritic Cells I

British/Columbia Ballrooms
* Ruslan Medzhitov, HHMI/Yale University School of Medicine, USA
TLR-Mediated Control of Dendritic Cell Functions

* Richard A. Flavell, HHMI/Yale University School of Medicine, USA
Positive And Negative Signaling in Innate and Adaptive Immunity and It’s Role in the Development of Anti Infectious and Autoimmune Responses

Alan Aderem, Center for Infectious Disease Research, USA
Systems Biology and Immunity: “A systems approach to dissecting immunity”

Hiroshi Watarai, Riken Research Center for Allergy and Immunology, Japan
Short Talk: Molecular Characterization of Three Novel Triggering Receptors on Mouse Splenic DCs

Social Hour

Pacific Ballroom
Poster Session 1

Pacific Ballroom



Pacific Ballroom
Dendritic Cells in the Adaptive Immune Response

British/Columbia Ballrooms
* Anne O'Garra, Francis Crick Institute, UK
Pro-Inflammatory and Anti-Inflammatory Signals from Dendritic Cells Direct the Adaptive Immune Response

* Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Human Dendritic Cells and their Role in Triggering T Cell Responses

Ronald N. Germain, NIAID, National Institutes of Health, USA
Visualizing Dendritic Cell - Lymphocyte Interactions in vivo

Muriel Moser, Université Libre de Bruxelles, Belgium
Dendritic Cells as Inducers and Controllers of Immunity

Hans-Christian Reinecker, Massachusetts General Hospital, USA
Short Talk: Control of Dendritic Cell Access to the Intestinal Lumen and of Bacterial Clearance

Bali Pulendran, Stanford University School of Medicine, USA
Short Talk: Dendritic Cell Signaling Networks and Innate Immune Receptors that Induce Th1, Th2 and Tolerogenic Responses

Coffee Break

BC Foyer
Poster Setup

Pacific Ballroom
Poster Viewing

Pacific Ballroom
Workshop 2: Dendritic Cells in the Adaptive Immune Response

British/Columbia Ballrooms
* Martien L. Kapsenberg, University of Amsterdam, Netherlands

* Tsuneyasu Kaisho, RIKEN Research Center for Allergy and Immunology, Japan
How Dendritic Cells Process Nucleic Acid Signal?

Alice V. Banz, DNAX, USA
TSLP Induces Maturation of CD11c+ DC to Support Th2 Polarization

Lentiviral Vectors Encoding Antigens Transduce Dendritic Cells in Vivo and Initiate CD4 and CD8 Immune Responses

Gilles Dadaglio, Institut Pasteur, France
Murine Plasmacytoid Dendritic Cells Induce Effector/Memory CD8+ T-cell Responses in Vivo After Viral Stimulation

Alexander Faith, King's College London, UK
Human Respiratory Tract Dendritic Cells are Susceptible to Modulation: Exposure to GM-CSF Promotes a Th2 Response

Dragana Jankovic, NIAID, National Institutes of Health, USA
Distinct DC Activation States Associated with Parasite-Induced Th1/Th2 Effector Choice

Eynav Klechevsky, Washington University School of Medicine, USA
Langerhans Cells within CD34-DC Efficiently Prime Melanoma Specific CD8+ T Cells

John W. Upham, Princess Alexandra Hospital, Australia
The Expression of Allergen Specific T-cell Memory is Critically Dependent on DC Activation/Maturation

Coffee & Snacks Available

BC Foyer
Signaling in Dendritic Cells II

British/Columbia Ballrooms
* Ralph M. Steinman, Rockefeller University, USA

Kasper Hoebe, The Scripps Research Institute, USA
TIR-Dependent and -Independent Immunoadjuvant Pathways

* Brian L. Kelsall, NIAID, National Institutes of Health, USA
Regulation of Dendritic Cell Function by G-Protein Coupled Receptors

Cynthia A. Leifer, Cornell University, USA
Short Talk: TLR9 ER Localization and Early Endosome Targeting are Controlled by Discrete Cytoplasmic Motifs

Atsushi Kumanogoh, Osaka University, Japan
Short Talk: A Class IV Semaphorin Sema4A Plays Non-Redundant Roles in T-Cell Priming and Th1/Th2 Regulation

Russell D. Salter, University of Pittsburgh, USA
Short Talk: Title to be Determined

Social Hour

Pacific Ballroom
Poster Session 2

Pacific Ballroom



Pacific Ballroom
Cell Biology of Dendritic Cells

British/Columbia Ballrooms
* Ira Mellman, Genentech, Inc., USA
Inside Dendritic Cells, Brightly

* Sebastian Amigorena, Institut Curie, France
Dendritic Cell-T Cell Interactions for the Induction of Priming and Tolerance

Jatin M. Vyas, Massachusetts General Hospital, USA
Short Talk: CD63 and Class II MHC Colocalization within the DC Endocytic Pathway

Michel C. Nussenzweig, HHMI/Rockefeller University, USA
Dendritic Cell Networks in Intact Lymph Nodes

Barbara Fazekas de St. Groth, Centenary Institute, Australia
Short Talk: Transfer of Intact Peptide-MHC II Complexes between Dendritic Cells in vivo

Amy K. Bergtold, Columbia University, USA
Short Talk: Antigens Acquired Through FcRII on Dendritic Cells Are Retained and Recycled to the Cell Surface for B Cell Priming

Coffee Break

BC Foyer
Poster Setup

Pacific Ballroom

Pacific Ballroom
Poster Session 3

Pacific Ballroom
Workshop 3: Antigen Processing By Dendritic Cells

British Ballroom
* Philippe D. Pierre, Centre d'Immunologie Marseille-Luminy, CIML, France

Arne Bakker, Netherlands Cancer Institute, Netherlands
The Efficiency Of Cross-Presentation By Dendritic Cells

Laura A. Johnson, Abramson Family Cancer Research Institute, University of Pennsylvania, USA
ABCB9 is an ABC-transporter Gene that Plays a Crucial Role in Cross-Priming by Dendritic Cells

Liying Chen, Karolinska Institute, Sweden
Alternative Processing for MHC Class I Presentation by Immature and CpG-activated Dendritic Cells.

Vivien Watson, University of Southampton, UK
Calreticulin Does Not Enhance Presentation of A Model Antigen by Dendritic Cells

Andrew W. Lee, Cardiology Associates Medical Group, USA
Human Cytomegalovirus Causes Redistribution of MHC Class II Away from the Cell Surface in Mature Langerhans Cells.

Randy S. Longman, Weill Cornell Medical College, USA
Yellow Fever 17D Infects Human Dendritic Cells Allowing for Processing/Presentation of Endogenous and Model T cell Epitopes

Workshop 4: Dendritic Cells in Tolerance

Columbia Ballroom
* Ranjeny Thomas, University of Queensland, Australia
Antigen Specific Effector Cells Inhibit Tolerance Induction in Autoimmune-Prone NOD Mice

Anuradha Ray, University of Pittsburgh School of Medicine, USA
Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation Versus Tolerance

Hozefa S. Bandukwala, Rheos Medicines, USA
Signaling via Fc gamma Receptors on Dendritic Cells Modulates Their Cytokine Production and Ability to Direct T cell Differentiation in Vitro and in Vivo.

Franck J. Barrat, Hospital for Special Surgery, USA
Oligonucleotide-based Inhibitors of TLR -7, -8 and -9 and Their Potential for the Treatment of Lupus

Lorenza Frisoni, University of Pennsylvania, USA
Autoantigen-dependent Phagocytosis by Dendritic Cells: A Pathogenic Role for Opsonized Apoptotic Blebs in Systemic Lupus Erythematosus

Stéphanie Hugues, Université de Genève, Switzerland
Distinct T Cell Dynamics In Lymph Nodes During the Induction of Tolerance and Immunity

Grant C. Hughes, University of Washington, USA
Estrogen Regulates Plasmacytoid Dendritic Cell Functions

Cherry I. Kingsley, Brigham and Women's Hospital, USA
Mucosal Tolerance Induction: The Role of the ICOS-ICOSL Pathway

Kristin V. Tarbell, Amgen, USA
Islet-specific CD4+CD25+ Regulatory T Cells Can be Expanded From a Polyclonal Repertoire by Using Dendritic Cells

Coffee & Snacks Available

BC Foyer
Dendritic Cells In Autoimmunity and Allergy

British/Columbia Ballrooms
Virginia Pascual, Cornell University, USA
Dendritic Cell Guilt in Systemic Lupus and Systemic Arthritis

* Robert L. Coffman, Dynavax Technologies, USA
Regulation of Dendritic Cells by Stimulatory and Inhibitory Oligonucleotides

* Fiona M. Powrie, University of Oxford, UK
Role of Dendritic Cells in the Regulation of Intestinal Inflammation

Bart N. Lambrecht, VIB, Ghent University, Belgium
Short Talk: Dendritic Cell Subsets and Control of Allergic Airway Inflammation

Michel Gilliet, University Hospital of Lausanne, Switzerland
Short Talk: Plasmacytoid Dendritic Cells in Psoriasis



Pacific Ballroom
Dendritic Cells in Infectious Diseases I

British/Columbia Ballrooms
Marc K. Jenkins, University of Minnesota Medical School, USA
In situ Analysis of Antigen Presentation to CD4 T Cells

* Caetano Reis e Sousa, Francis Crick Institute, UK
Innate Pathways for Activation of Dendritic Cells

* Paola Ricciardi-Castagnoli, Toscana Life Science Foundation, Italy
Dendritic Cells in the Innate Response to Bacteria

Christine A. Biron, Brown University, USA
Dendritic Cells in the Innate Response to Viral Infections

Akiko Iwasaki, HHMI/Yale University School of Medicine, USA
Short Talk: Role of Tlrs in the Response of Dendritic Cells to Viruses

Robert A. Seder, NIAID, National Institutes of Health, USA
Short Talk: Comparative Analysis of TLR 7/8, TLR 8 Agonists and CpG ODN as Vaccine Adjuvants with HIV Gag Protein in Non-Human Primates

Sylvie Bertholet, GlaxoSmithKline Vaccines, USA
Short Talk: The Presentation of Antigens Released into the Leishmania Phagosome is TAP-independent and thus Avoid the Efficient Presentation Machinery Associated with ER-Mediated Phagocytosis by Dendritic Cells

Coffee Break

BC Foyer
Poster Setup

Pacific Ballroom

Pacific Ballroom
Poster Session 4

Pacific Ballroom
Workshop 5: Dendritic Cells In Infectious Diseases

British Ballroom
* Kingston H.G. Mills, Trinity College Dublin, Ireland
Pathogen-Derived Molecules Direct Regulatory T Cell Induction by Modulating Dendritic Cell Activation

Winfried Barchet, University Hospital of Bonn, Germany
Dendritic Cells Respond to Influenza Virus through TLR7- and PKR-Independent Pathways

Silvia B. Boscardin, University of São Paulo, Brazil
Vaccination Using A Plasmodium Protein Delivered Directly to Dendritic Cells

Sandra S. Diebold, , UK
Toll-Like Receptor 3 Mediates Dendritic Cell Activation by Virus-Infected Cells and Promotes Cross-Priming in vivo

Malin Sundquist, Gothenburg university, Sweden
Mechanism of in vivo Dendritic Cell Maturation in Response to Oral Salmonella Infection

Jean Langhorne, Francis Crick Institute, UK
The Role of Subsets of Dendritic Cells in Malaria Infection

Kazuhiko Takahara, Kyoto University, Japan
Microbe Recognition and Involvement in TLR4-Mediated Response of SIGNR1, a Mouse DC-SIGN Homologue

Jianfang Zhou, University of Hong Kong, China
Upregulation of Death Receptor Ligands in Human Antigen Presenting Cells by Avian Flu Viruses: a Mechanism for the Unusual Severity of Human Diseases?

Workshop 6: Dendritic Cells and Cancer Immunotherapy

Columbia Ballroom
* Laurence Zitvogel, Institut Gustave Roussy, France

Caroline Aspord, EFS / Inserm 823, France
Human Breast Cancer and Melanoma Differentially Modulate Dendritic Cells in OncoHumouse

Dirk G. Brockstedt, FLX Bio, Inc., USA
Killed but Metabolically Active Recombinant Listeria monocytogenes as an Antigen Delivery and Activation Platform for Human Dendritic Cell-Based Cancer Immunotherapy

Kevin C. Evel-Kabler, University of California, San Francisco, USA
Critical Regulation of Antigen Presentation by SOCS1 in Dendritic Cells and Enhancement of Antitumor Immunity by SOCS1 Silencing

Yutaro Nakamura, University of Pittsburgh, Hillman Cancer Center, USA
Heterologous "CD8 Help" Promotes the Induction of Therapeutic Tumor Immunity

Kang Liu, Columbia University Medical Center, USA
Tumor Cell Uptake by Dendritic Cells Maturing to Innate NKT Lymphocytes Confers Superior Adaptive Immunity

Weiping Zou, University of Michigan, USA
Tumor Environmental Regulatory T Cells Disable Dendritic Cell Immunogenecity by Triggering B7-H4

Nizar J. Bahlis, University of Calgary, Canada
Dendritic Cells Support the Survival of Malignant Plasma Cells in Multiple Myeloma

Coffee & Snacks Available

BC Foyer
Dendritic Cells in Infectious Diseases II

British/Columbia Ballrooms
* Alan Sher, NIAID, National Institutes of Health, USA
Initiating and Th1 Polarizing Functions of Dendritic Cells in the Immune Response to Toxoplasma gondii

Nicolas Glaichenhaus, Centre National de la Recherche Scientifique, France
NK cells are slow motile cells localized in the lymph node outerparacortex where they make contacts with dendritic cells

* Edward J. Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Short Talk: Dendritic Cell Regulation of Helminth Induced Th2 Responses

Elina I. Zuniga, University of California, San Diego, USA
Influence of Virus Infection on Dendritic Cell Generation

John E. Connolly, Tessa Therapeutics Ltd., Singapore
Short Talk: Respiratory Syncytial Virus Blocks Antigen Presentation by Dendritic Cells



Pacific Ballroom
Dendritic Cells and Cancer Immunotherapy

British/Columbia Ballrooms
Gerold Schuler, University Hospital of Erlangen, Germany
Vaccination with Mature Monocyte-Derived Dendritic Cells against Metastatic Melanoma

Hideki Ueno, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Immunomonitoring in Therapeutic Intervention in Clinical Disease

* Olivera J. Finn, University of Pittsburgh School of Medicine, USA
Interaction of Tumor Antigens and Dendritic Cells, a Trap and a Way Out

Cornelis J. M. Melief, Leiden University Medical Center & ISA Pharmaceuticals BV, Netherlands
Activation of Dendritic Cells that Cross-Present Tumor Derived Antigen Licences CD8+ Cytotoxic T-Lymphocytes to Cause Tumor Eradication1

Arthur M. Krieg, Checkmate Pharmaceuticals, USA
Short Talk: Improved Chemotherapy Response Rate In Metastatic Non-Small Cell Lung Cancer By In Vivo Plasmacytoid Dendritic Cell Activation With CPG 7909, A TLR9 Agonist

W. Martin Kast†, University of Southern California, USA
Short Talk: HPV can Escape Immune Recognition through Langerhans Cell PI3-Kinase Activation

Coffee Break

BC Foyer
Workshop 7: Dendritic Cells In Infectious Diseases

British/Columbia Ballrooms
* Julio Aliberti, NIAID, National Institutes of Health, USA
SOCS-2 is Essential for Lipoxin-Mediated Inhibition of Dendritic Cell IL-12 Production

* Anne Hosmalin, Institut Cochin, Inserm U1016, Université Paris Descartes, France
HIV Antigen Presentation by Dendritic Cells

Erica Andersen-Nissen, Hutchinson Centre Research Institute of South Africa, South Africa
Toll-Like Receptor 5 Evasion by Flagellated Bacteria

Bumsuk Hahm, University of Missouri-Columbia, USA
Virus-Induced Suppression of Dendritic Cell Development through Type I Interferon-Mediated STAT2-Dependent but STAT1-Independent Signaling

Hiroki Kato, Institute for Virus Research, Japan
Cell Type Specific Involvement of RIG-I in Antiviral Response

Anna Smed Sörensen, Karolinska Institutet, Sweden
Differential Susceptibility to HIV-1 Infection of Myeloid and Plasmacytoid Dendritic Cells

Sachiko Akashi-Takamura, Aichi Medical University, Japan
Anti-Toll Like Receptor 4 Antibody Protects Mice from Acute Lethal Hepatitis Induced by Tumor Necrosis Factor-alpha

Santhi Gorantla, University of Nebraska Medical Center, USA
Short Talk: Human Dendritic Cells Transduced with Herpes Simplex Virus (HSV) Amplicons Encoding HIV-1gp120 Elicit Adaptive Immune Responses from Human Cells Engrafted into NOD/SCID Mice and Confer Partial Protection against HIV-1 Challenge

Coffee & Snacks Available

BC Foyer
Dendritic Cells in the Innate Immune Response

British/Columbia Ballrooms
Tadatsugu Taniguchi, University of Tokyo, Japan
Interferons and IRFs in TLR Activation of Dendritic Cells

* Giorgio Trinchieri, NCI, National Institutes of Health, USA
Role of Plasmacytoid Dendritic Cells in vivo

Christopher W. Schmidt, Queensland Institute of Medical Research, Australia
Short Talk: Correlation of Clinical and Immunological Responses Following Dendritic Cell Immunotherapy

Social Hour

Pacific Ballroom

Pacific Ballroom



*Session Chair †Invited, not yet responded.

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Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13-AI063797-01

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Novartis Institutes for BioMedical Research

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