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This meeting took place in 2005

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Molecular Helminthology: An Integrated Approach (X5)

Organizer(s) Philip T. LoVerde
April 9—13, 2005
Copper Mountain Resort • Copper Mountain, Colorado USA
Abstract Deadline: Dec 8, 2004
Late Abstract Deadline:
Scholarship Deadline:
Early Registration Deadline: Feb 9, 2005

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation and Sponsored by the International Center for Tropical Disease Research

Summary of Meeting:
This is an exciting time for the field of helminth host-parasite co-evolution. Advances in molecular and cellular biology of helminth parasite interactions with their hosts are being and are expected to accelerate as the genomic sequence of Schistosoma mansoni and Brugia malayi will each be at 3X coverage and more than 200,000 ESTs for Schistosoma and over 100,000 ESTs for nematode species will be available by the end of 2003. A renaissance of approach with studies on the transcriptome and proteome and of technology and tools, such as gene transfers, gene knockouts and RNA interference is underway. These tools, the manipulations and hypotheses they will allow, will be the topics for this unique conference. By the year 2005 the fruits of the new information and technological advances will be available. The Conference which combines broad areas of helminth research ranging from basic science such as developmental biology, signal transduction, neurobiology and functional genomics translated to the applied aspects such as targets for vaccine and drug design and drug resistance has as its theme how host and parasite molecules each contribute to host-parasite co-evolution. It is expected that the conference will promote collaboration among researchers with the goal of identifying new targets for the development of drugs, vaccines, and diagnostic tests, by providing the biological and informatic resources and tools for their rapid characterization and analysis, by analyzing the biological basis of host-parasite interactions and by attracting new young talent to the field. Certainly there are fascinating scientific questions waiting to be answered about helminths. Some of those questions have as their central theme the very nature of parasitism.

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No registration fees are used to fund entertainment or alcohol at this conference

Conference Program    Print  |   View meeting in 12 hr (am/pm) time




Keynote Address

Bighorn B
Vincent P. Laudet, Ecole Normale Superieure, France
Evolution of Nuclear Receptors

Keynote Address

Bighorn C
Michael H. Gelb, University of Washington, USA
Protein Farnesyltransferase Inhibitors as Agents Against Malaria: Drug Development at Universities with Help from Industry



Status of Helminth Genome Projects

Bighorn B
* Najib M. El-Sayed, University of Maryland, USA
The Schistosoma mansoni Genome Project

Matthew Berriman, Wellcome Sanger Institute, UK
Short Talk: The Schistosoma mansoni Genome Project at the Sanger Institute and access via SchistoDB

Elodie Ghedin, New York University, USA
Whole-Genome Analysis of the Parasitic Nematode Brugia malayi

Barton E. Slatko, New England Biolabs, USA
The Genome of Wolbachia: A Parasite within the Human Filarial Parasite, Brugia malayi

Makedonka Mitreva, Washington University School of Medicine, USA
Investigating Hookworm Genomes by Comparative Analysis of Two Ancylostoma Species

Fiona J. Thompson, University of Oxford, UK
Short Talk: An EST Analysis of the Life-Cycle of the Parasitic Nematode Strongyloides ratti

Comparative Biology. Session Sponsored by The Ellison Medical Foundation

Bighorn C
* Dyann F. Wirth, Harvard School of Public Health, USA

Alan H. Fairlamb, University of Dundee, UK
Enzymes of Trypanothione Metabolism

Daniel E. Goldberg, Washington University, USA
Plasmepsins as Antimalarial Targets

Kasturi Haldar, University of Notre Dame, USA
Host-Pathogen Interactions as Targets in Malarial Infection

William N. Hunter, University of Dundee, UK
Isoprenoid Biosynthetic Enzymes

Tomoyoshi Nozaki, Gunma University Graduate School of Medicine, Japan
Short Talk: Sulfur-Containing Amino Acid Degradation as a Drug Target for Amebiasis: Biochemical and Structural analyses of Methionine gamma-Lyase from Entamoeba histolytica

Achim Schnaufer, University of Edinburgh, UK
Short Talk: RNA Editing as a Drug Target in Trypanosomatids

Coffee Break

Poster Setup

Poster Viewing

Workshop: Funding Opportunities

Bighorn C
* Akhil B. Vaidya, Drexel University College of Medicine, USA

Robert Ridley, World Health Organization, Switzerland

Solomon O. Nwaka, World Health Organization, Switzerland
Virtual Drug Discovery: lessons learned from public-private partnerships

Martin John Rogers, NIAID, National Institutes of Health, USA

Philip E. Coyne, Uniformed Services University of the Health Sciences, USA

Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

Coffee & Snacks Available

Transcriptome and Proteome of Helminths

Bighorn B
* Karl F. Hoffmann, University of Cambridge, UK
Identifying Drug Targets From Transcriptome Analysis Of Schistosome Conjugal Biology

Peter Ashton, University of York, UK
Studies on the Schistosome Proteome

Cornelis H. Hokke, Leiden University Medical Center, Netherlands
Schistosome Glycoproteomics: Global Approaches - Detailed Findings

Ben-Wen Li, Washington University School of Medicine, USA
Short Talk: Profiling of Gender-Regulated Gene Transcripts in the Filarial Nematode Brugia malayi by cDNA Oligonucleotide Array Analysis

Steven A. Williams, Smith College, USA
Short Talk: An Update on the New Bruzui Malayi Microarray and other Resources Available through FR3

Functional Genomics

Bighorn C
* Stephen M. Beverley, Washington University School of Medicine, USA

Brendan S. Crabb, Burnet Institute, Australia
The Plasmodium falciparum SERA Proteases are Novel Drug Targets

Gary E. Ward, University of Vermont, USA
Using Small Molecules to Study Host Cell Invasion by T. gondii

Elizabeth A. Winzeler, University of California, San Diego, USA
Short Talk: Systematic Determination of the Targets of Drug Resistance and Immunity

Bo Wu, University of Pennsylvania, USA
Short Talk: Heme Metabolism in Apicomplexan Parasites

Paul Hunt, University of Edinburgh, UK
Short Talk: Linkage Group Selection – A Rapid Molecular Genetics Strategy for Identifying loci Underlying Drug Resistance

Social Hour

Poster Session 1

Bighorn B



Tools to Manipulate Helminth Gene Expression

Bighorn B
* Richard E. Davis, University of Colorado School of Medicine, USA
In vivo and in vitro Analysis of Gene Expression in Helminths

Timothy P. Yoshino, University of Wisconsin-Madison, USA
Gene “muffling” by RNAi in larval schistosomes: an effective functional genomics tool?

Christoph G. Grevelding, Institute for Parasitology, Germany
Short Talk: Transgenic Schistosomes: Progress and Challenges

Mark L. Blaxter, University of Edinburgh, UK
Comparative Nematode Genomics: Exploiting Expressed Sequence Tag and Genome Surveys of Nuclear and Symbiont Genomes

James B. Lok, University of Pennsylvania, USA
Transfection in Strongyloides

Sara Lustigman, New York Blood Center, USA
Short Talk: Cysteine Proteases of Filarial Nematodes: From Genome to Biology

Established Drugs and Targets

Bighorn C
* James H. McKerrow, University of California, San Diego, USA

Sanjeev Krishna, St. George's Hospital Medical School, UK
Artemisinin Targets

Francisco Gamarro, Consejo Superior de Investigaciones Científicas, Spain
Mechanism of Miltefosine Resistance in Leishmania

Stephen A. Ward, Liverpool School of Tropical Medicine, UK
Quinoline QSAR and Heme Access

Paul D. Roepe, Georgetown University, USA
Analysis of Pfcrt Function: Toward a Molecular Understanding of Chloroquine Resistance

Barry P. Rosen, Florida International University, USA
Short Talk: Pentostam Activation and Uptake in Leishmania major: Role of the Sb(V) Reductase LmAcr2 and the Aquaglyceroporin LmAqp1

Maria Paola Costi, University of Modena and Reggio Emilia, Italy
Short Talk: Inhibition of the Folate Pathway in Parasites: Do Antifolates Still Work?

Coffee Break

Poster Setup

Poster Viewing

Workshop: RNAi/Transfections in Helminths

* Christoph G. Grevelding, Institute for Parasitology, Germany

* Sara Lustigman, New York Blood Center, USA

Karen L. Bennett, University of Missouri, USA
Cross-Species RNAi: Ascaris Genes Sterilize C. elegans

Jason M. Correnti, Thomas Jefferson University, USA
Longterm Suppression of Cathepsin B Levels by RNAi Retards Schistosome Growth

Julie-Anne Fritz, Australian National University, Australia
Functional Analysis of Nematode-Specific Genes using the Free-Living Nematode, Caenorhabditis elegans

Nicholas Patocka, McGill University, Canada
Cloning and Gene Silencing of a SERT – like Serotonin Transporter of Schistosoma Mansoni

Ahmed Abd El-Aziz Sayed, Illinois State University, USA
Validation by RNAi of Schistosoma mansoni Peroxiredoxins as Essential Parasite Proteins

Warwick N. Grant, , New Zealand
Efficient RNA Inhibition in Trichostrongylus colubriformis

Bernd H. Kalinna, , Germany
Structural Analysis of the Transcribed Sequence of Boudicca, a Schistosoma mansoni Retrotransposon

Coffee & Snacks Available

Signaling Pathways in Helminths

Bighorn B
* Philip T. LoVerde, University of Texas Health Science Center, USA
Nuclear Receptors in Schistosomes

Ahmed Osman Egiza, University at Buffalo, State University of New York, USA
Transforming Growth Factor-beta (TGF-beta) Signaling in Schistosoma mansoni

Colette Dissous, INSERM, Institut Pasteur, France
Short Talk: Conservation and Divergence of Receptor Tyrosine Kinase Signaling in the Platyhelminth Schistosoma mansoni

Klaus Ruediger Brehm, Universität Würzburg, Germany
Signaling in Tapeworms

Libraries and Screens

Bighorn C
* Simon L. Croft, London School of Hygiene & Tropical Medicine, UK

Meg Phillips, University of Texas Southwestern Medical Center, USA
Targeting Plasmodium Dihydroorotate Dehydrogenase

Mary Ann Powles, Merck Research Laboratories, USA
Discovery of Anti-Infective Agents

Sean T. Prigge, Johns Hopkins Bloomberg School of Public Health, USA
Short Talk: Inhibition of Malaria Fatty Acid Biosynthesis: Targeting the beta-ketoacyl-ACP Synthase Enzymes

David A. Fidock, Columbia University Medical Center, USA
Short Talk: Inhibition of Plasmodium falciparum Enoyl ACP Reductase as a Target for Antimalarial Drug Development

Karl A. Werbovetz, Ohio State University, USA
Short Talk: Activity, Metabolism, and Pharmacokinetics of Antikinetoplastid Antimitotic N1,N4-substituted 3,5-Dinitro Sulfanilamides

Social Hour

Poster Session 2

Bighorn B



Parasite Molecules that Modulate Host Immune Response

Bighorn B
* Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
The Immunoregulatory Network in Helminth Infections and the Lipid/Immune System Cross Talk

Kalyanasundaram Ramaswamy, University of Illinois, USA
Schistosome-derived molecule in Host Immunoregulation

William Harnett, Strathclyde Institute for Pharmacy and Biomedical Sciences, UK
Immunomodulatory Properties of the Filarial Nematode Secreted Product, ES-62

Susanne Hartmann, Humboldt University at Berlin, Germany
Short Talk: Filarial tropomyosin: A Potential Allergen and Inducer of IL-10 via TLR-2 Signalling

Malcolm W. Kennedy, University of Glasgow, UK
Short Talk: Atomic Structure and Function of the Polyprotein Allergens of Nematodes

Alison M. Elliott, MRC/UVRI & LSHTM Uganda Research Unit, Uganda
Short Talk

Inhibitor Design

Bighorn C
* Wim G.J. Hol, University of Washington, USA

Ian H. Gilbert, University of Dundee, UK
Steroid Biosynthesis as a Drug Target in Parasitic Protozoa

Vern L. Schramm, Albert Einstein College of Medicine, USA
Exploiting the Unique Pathways for Purine and Polyamine Metabolism in Malaria

Lizbeth Hedstrom, Brandeis University, USA
IMP Dehydrogenase and the Dynamics of Drug Selectivity

Pradipsinh K. Rathod, University of Washington, USA
Drug-Induced Mutagenesis in Malaria

Amy C. Anderson, University of Connecticut, USA
Short Talk: A New Architecture for Bifunctional Dihydrofolate Reductase-Thymidylate Synthase: The Structure of the Enzyme from Cryptosporidium hominis

R. Kip Guy, St. Jude Children's Research Hospital, USA
Privileged Scaffold Discovery Libraries for Anti-Protozoan Drug Discovery

Frederick S. Buckner, University of Washington, USA
Short Talk: Protein Farnesyltransferase as a Target for Trypanosoma brucei Drug Development

Coffee Break

Coffee & Snacks Available

Contributions of Immune System to Helminth Development

Bighorn B
* James H. McKerrow, University of California, San Diego, USA
Factors Determining Schistosome Development in the Host Vasculature

Isabelle Christiane Wolowczuk, Institut Pasteur / Institut de Biologie, France
Role of Interleukin-7 in Schistosome development

Sheila M. Donnelly, University of Technology, Sydney, Australia
Short Talk: The Effect of Cathepsin L and Thioredoxin Peroxidase on Macrophages Promotes the Development of Th2 Responses during Infection with Fasciola hepatica

Linda S. Mansfield, Michigan State University, USA
Short Talk

Clinical Advances

Bighorn C
* Terry Shapiro, Johns Hopkins University, USA

Federico Gómez de las Heras, GlaxoSmithKline, Spain
Discovery of New Antimalarial Drugs

Jonathan L. Vennerstrom, University of Nebraska Medical Center, USA
Synthetic Peroxides as Antimalarials

Christian Burri, Swiss Tropical Institute, Switzerland
Difficulties in the Conduct of Clinical Trials for Registration of New Drugs against Neglected Diseases in Africa

Social Hour

Ptarmigan Foyer




*Session Chair †Invited, not yet responded.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1R13-AI063801-01

We gratefully acknowledge additional support for this conference from:

Bill & Melinda Gates Foundation Burroughs Wellcome Fund

International Center for Tropical Disease Research

New England Biolabs, Inc.

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