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This meeting took place in 2006



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Alzheimer's Disease: Genes, Cellular Pathways and Therapies (J8)


Organizer(s) Rudolph E. Tanzi and Virginia M.-Y. Lee
February 21—26, 2006
Beaver Run Resort • Breckenridge, CO USA
Abstract Deadline: Oct 20, 2005
Late Abstract Deadline: Nov 14, 2005
Scholarship Deadline: Oct 20, 2005
Early Registration Deadline: Dec 21, 2005


Summary of Meeting:
Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common form of dementia in the elderly. Over the past two decades, studies of AD at the genetic, molecular, and cell biological level have revealed a host of genes, proteins, and biological pathways that impact on the pathogenesis of this disease. Characterization of these pathogenic pathways have suggested several promising therapeutic strategies for treating and preventing AD based on curbing the accumulation of the Abeta peptide in brain, regulating tau hyperphosphorylation, modulating inflammatory responses, and enhancing neurotransmitter function. This meeting will cover updates of the genetics of AD, Abeta generation and clearance pathways, regulation of tau, relevant animal models, novel therapeutic strategies, and advances in imaging and biomarkers for AD diagnosis.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time


TUESDAY, FEBRUARY 21

15:00—19:30
Registration

Foyer
18:30—19:30
Refreshments

Foyer
19:30—21:30
Keynote Session (Joint)

Peaks 1-5
* Rudolph E. Tanzi, Massachusetts General Hospital, USA

Sangram S. Sisodia, University of Chicago, USA
Molecular Neurobiology of Alzheimer's Disease

Cynthia Kenyon, Calico, USA
Insulin/IGF-1 Signaling, Polyglutamine Aggregation and Aging in C. elegans

* Jeffery W. Kelly, The Scripps Research Institute, USA


WEDNESDAY, FEBRUARY 22

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:00
Genetics and Epidemiology of AD

Peaks 1 - 4
* Rudolph E. Tanzi, Massachusetts General Hospital, USA

Steven G. Younkin, Mayo Clinic Jacksonville, USA
Novel Susceptibility Alleles and Biomarkers for Late Onset AD

Mario H. Bengtson, Genomics Institute of Novartis Foundation, USA
Short Talk: Tauopathy Caused by Mutation of a Novel E3 Ubiquitin Ligase

Lars Bertram, Massachusetts General Hospital, USA
The Current Status of Alzheimer's Genetics Research

Ellen M. Wijsman, University of Washington, USA
Complex Models in the Search for Late-onset AD Genes

Lisa A. Paige, Metabolon Inc., USA
Short Talk: Comparative Metabolomic Analysis of Plasma from Patients with Alzheimer’s Disease or Mild Cognitive Impairment

08:00—11:00
Functional Amyloidogenesis

Peak 5
Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
A Yeast Prion Provides a Mechanism for Phenotypic Plasticity

Martijn F.B.G. Gebbink, University Medical Center Utrecht, Netherlands
Activation of the Contact System and the Fibrinolytic System of Hemostasis by Amyloid Cross-beta Structure

Douglas M. Fowler, University of Washington, USA
The Role of Functional Amyloid Formation in Melanogenesis

* Matthew R. Chapman, University of Michigan, USA
Protein Misfolding Done Right: The Biogenesis of Bacterial Amyloid Fibers

Yakov A. Vitrenko, University of Illinois at Chicago, USA
Short Talk: Cross-Seeding between Yeast Sup35 and Rnq1 Prions Involves Formation of Aggregates Containing both Proteins

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Amyloid Precursor Protein Function

Peaks 1 - 4
* Christian Haass, Ludwig-Maximilians University Munich, Germany

Sam Gandy, Mount Sinai Medical Center, USA
Concentration of the Alzheimer Amyloid-beta Precursor Protein In the Neuronal trans-Golgi Network Elevates Abeta42, Mimicking the Effect of Mutant Presenilins

Roberto Malinow, University of California, San Diego, USA
AMPA-R: Role in AB induced Loss of Spines

Thomas C. Südhof, Stanford School of Medicine, USA
Alpha-Synuclein Cooperates with CSPalpha in Preventing Neurodegeneration

Constanze Reinhard, Center for Human Genetics, Belgium
Short Talk: Characterization of the sAPP Receptor(s)

17:00—19:00
Mechanisms of Amyloidogenesis

Peak 5
Christopher M. Dobson, University of Cambridge, UK
Protein Folding, Molecular Evolution and Human Disease

Roland Riek, The Salk Institute, USA
3D Structures of Amyloid Fibrils of HET-s Prion and Alzheimer Abeta(1-42) fibrils)

* David Eisenberg, University of California, Los Angeles, USA
Crystal Structure Analyses of Amyloid-like Fibrils

Michael Hecht, Princeton University, USA
Short Talk: Sequence Determinants of the Aggregation of Alzheimer’s Peptide, Abeta42

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 1

Peaks 14-17

THURSDAY, FEBRUARY 23

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Presenilin and Gamma Secretase

Peaks 1 - 4
* Karen Duff, Columbia University, USA

Dennis J. Selkoe, Harvard Medical School, USA
The Life Cycle of Amyloid ß-Protein: Mechanisms of Production Synaptotoxicity

Christian Haass, Ludwig-Maximilians University Munich, Germany
A Common Proteolytic Mechanism For Intramembrane Proteolysis By GxGD-Type Aspartyl Proteases

Bart De Strooper, University College London, UK
Genetic and Biochemical Analysis of the Gamma-Secretase Complexes in Mice

Jie Shen, Harvard Medical School, USA
Presenilins in Pre- and Post- Synaptic Plasticity and Neurodegeneration

Homira Behbahani, Karolinska Institutet, Sweden
Short Talk: Differential Role of Presenilin-1 and -2 on Mitochondrial Membrane Potential and Oxygen Consumption in Mouse Embryonic Fibroblasts

Taisuke Tomita, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
Short Talk: The Mechanism of gamma-Secretase-Mediated Cleavage Probed by Small Molecule Compounds

08:00—11:00
Protein Folding and Misfolding in Cells and Organisms

Peak 5
William E. Balch, The Scripps Research Institute, USA
Protein Misfolding and Folding in the Exocytic Pathway

Richard I. Morimoto, Northwestern University, USA
The Stress of isfolding Proteins: Aging and Neurodegenerative Disease

* Nancy M. Bonini, University of Pennsylvania, USA
Human Neurodegenerative Disease: Insights from Drosophila Genetics

Andrew G. Dillin, University of California, Berkeley, USA
The Genetics of Aging and Age Related Disease

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Beta-Secretase

Peaks 1 - 4
* Dennis J. Selkoe, Harvard Medical School, USA

Donald L. Price, Johns Hopkins University, USA
Neurodegenerative Diseases: Models, Mechanisms and Experimental Therapeutics

Jordan J. Tang, Oklahoma Medical Research Foundation, USA
Cellular Trafficking of Memapsin 2 and APP Mediated by Protein Factors

Edward B. Lee, Hospital of the University of Pennsylvania, USA
BACE Activity and the Subcellular Localization of APP Cleavage

Michael Willem, Adolf-Butenandt-Institute, Germany
Short Talk: Functional Analysis of BACE1

17:00—19:00
Therapeutic Strategies Towards Misfolding Diseases

Peak 5
Jeffery W. Kelly, The Scripps Research Institute, USA
Towards Understanding and Ameliorating Protein Misfolding Disease

Michel Bouvier, University of Montreal, Canada
Molecular Mechanisms of Action and Therapeutic Potential of Pharmacological Chaperones on Misfolded G Protein-Coupled Receptors

* Leslie M. Thompson, University of California, Irvine, USA
Therapeutic Strategies for Huntington’s Disease

Aaron D. Gitler, Stanford University School of Medicine, USA
Short Talk: Alpha-Synuclein Toxicity Involves Inhibition of Endoplasmic Reticulum (ER) to Golgi Trafficking

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 2

Peaks 14-17

FRIDAY, FEBRUARY 24

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Tau and FTD

Peaks 1 - 4
Lester I. Binder, Northwestern University, USA
Tau Alterations in Alzheimer's Disease

Karen Duff, Columbia University, USA
Phosphorylation as a Pathogenic Mechanism in AD

Eva-Maria Mandelkow, Max Planck Institut, Germany
The Modes and Pathways of Tau's Toxicity to Neurons in Neurodegeneration

Michael Hutton, Eli Lilly Research Center, UK
Genetics of the Tauopathies

Chad A. Dickey, University of South Florida, USA
Short Talk: Deletion of CHIP Leads to Caspase-3 Activation and Neuronal Apoptosis Associated with Increases in Non-Ubiquitinated, Soluble Phospho-Tau Species without Neurofibrillary Tangles

Kun Ping Lu, Beth Israel Deaconess Medical Center, USA
Short Talk: The Isomerase Pin1: a Potential New Link between Tangle and Plaque Pathologies of Alzheimer’s Disease

08:00—11:00
Cellular Mechanisms for Handling Misfolded Proteins

Peak 5
Eva-Maria Mandelkow, Max Planck Institut, Germany
Tau Protein Structure and Aggregation

* Randy Y. Hampton, University of California, San Diego, USA
ERAD as a Strategy of Protein Quantity Control

Jonathan S. Weissman, Whitehead Institute and MIT, USA
A Novel Branch of the Unfolded Protein Response

Randal J. Kaufman, Sanford-Burnham Medical Research Institute, USA
The Unfolded Protein Response: A Link between ER Stress and Inflammation

09:20—09:40
Coffee Break

Foyer
11:15—13:00
Poster Setup

Peaks 14-17
13:00—22:00
Poster Viewing

Peaks 14-17
16:30—17:00
Coffee Available

Foyer
17:00—19:00
Abeta Clearance

Peaks 1 - 4
* Cynthia A. Lemere, Brigham and Women's Hospital, Harvard Medical School, USA

David M. Holtzman, Washington University, USA
Effects of ApoE Levels, Isoform, and Lipidation on CNS Abeta Clearance and Fibrillogenesis

Berislav Zlokovic, University of Southern California, USA
Neurovascular Mechanisms and Targets in AD

Louis B. Hersh, University of Kentucky, USA
AB Degrading Peptidases

Matthew Townsend, Brigham and Women's Hospital, USA
Short Talk: The Cyclohexanehexol, AZD-103, Neutralizes Cell-derived ABeta Oligomers and Rescues Hippocampal Long-Term Potentiation

17:00—19:00
The Response to Damaged Proteins

Peak 5
* Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA

Paul Wentworth, Jr., The Scripps Research Institute, USA
Oxidative Metabolite Triggered Protein Misfolding

Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy in Aging: The Importance of Maintaining Cells Clean

Claudio A. Hetz, University of Chile, Chile
Short Talk: Proapoptotic BAX and BAK Modulate the Unfolded Protein Response through a Direct Interaction with Ire1alpha

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
19:30—22:00
Poster Session 3

Peaks 14-17

SATURDAY, FEBRUARY 25

07:00—08:00
Breakfast

Peaks 6-12
08:00—11:15
Animal Models and Therapeutics

Peaks 1 - 4
* Sam Gandy, Mount Sinai Medical Center, USA

Cynthia A. Lemere, Brigham and Women's Hospital, Harvard Medical School, USA
Modulating the Immune Response in Abeta Immunotherapy

Charles G. Glabe, University of California, Irvine, USA
Immunization of transgenic mouse models of degenerative disease against amyloid oligomers.

Dora M. Kovacs, Massachusetts General Hospital, USA
Cholesterol-Related AD Therapeutics

Abraham Fisher, Israel Institute for Biological Research, Israel
M1 Muscarinic Agonists - Promising Agents on Major Hallmarks of Alzheimer's Disease

Steven E. Jacobsen, University of California, Los Angeles, USA
Short Talk: Preclincal and Behavioral Models of Alzheimer’s Disease Passive Immunotherapy

Thomas A. Bayer, University of Saarland, Germany
Short Talk: Intraneuronal Aß, Neuron Loss and Axonopathy in Transgenic Mouse Models for Alzheimer's Disease

08:00—09:30
Emerging Misfolding Diseases

Peak 5
Gunilla T. Westermark, Linköping University, Sweden
Islet Amyloid and Beta Cell Destruction in Diabetes

Marina Ramirez-Alvarado, Mayo Clinic College of Medicine, USA
Light Chain Amyloidosis-When Elevated Amounts of Protein, Multiple Mutations, Proteolytic Cleavage, and Loss of Associations Come Together

Matthew J. Trifilo, The Scripps Research Institute, USA
Short Talk: Conversion of PrPsen to PrPres and Extraneural Disease Associated with Amyloidogenic PrPres Deposits Occur in the Absence of PrP’s GPI Anchor

09:20—09:40
Coffee Break

Foyer
09:50—11:00
Organismal Models of Protein Misfolding Diseases

Peak 5
* Marie-Francoise Chesselet, University of California, Los Angeles, USA
Mouse Models of Parkinson’s and Huntington’s Disease

Don W. Cleveland, University of California, San Diego, USA
From Charcot to Lou Gehrig: The Unfolding Story in Mechanism and Treatment of ALS

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Therapeutics and Imaging

Peaks 1 - 4
* Charles G. Glabe, University of California, Irvine, USA

Edward Koo, University of California, San Diego, USA
APP Function and Effects of NSAIDs

Christoph Hock, University of Zurich, Switzerland
Biomarkers for Alzheimer's Disease

Chester Mathis, UPMC Presbyterian Hospital, USA
Imaging beta-Amyloid in vivo

Ward Pedersen, Creighton University Medical Center, USA
Short Talk: Rosiglitazone Attenuates Glucocorticoid-Induced Learning and Memory Deficits in Tg2576 Alzheimer Mice

17:00—19:00
Emerging Topics Session: Short Talks Selected from Abstracts

Peak 5
* Matthew J. Trifilo, The Scripps Research Institute, USA

Abraham Grossman, Q-RNA.com, USA
Small RNA Chaperones Facilitate Amyloid Protein Transformation in vitro and Lead to Aggregate Formation and Behavior Abnormalities in Drosophila

Christopher D. Link, University of Colorado, USA
Cellular Toxicity of Aggregating Proteins

Soumya S. Ray, Schrödinger, USA
Designing Aggregation Inhibitors of Superoxide Dismutase Mutants Linked to ALS

Leila M. Luheshi, University of Cambridge, UK
Can we Predict the in Vivo Aggregation and Toxicity of AB 1-42 Mutants From their Intrinsic Aggregation Propensities?

Shohei Koide, New York University Langone Health, USA
Short Talk: High Resolution Structures of Peptide Self-Assemblers

Rajaraman Krishnan, Proclara Biosciences, USA
Short Talk: Structural Insights on a Yeast Prion Illuminate Necleation and Strain Diversity

Jessie Chu, The Scripps Research Institute, USA
Short Talk: A Novel E3 Ubiquitin Ligase Involvd in Neurodegeneration

19:00—20:00
Social Hour with Lite Bites

Peaks 14-17
20:00—23:00
Entertainment

Peaks 14-17

SUNDAY, FEBRUARY 26

 
Departure


*Session Chair †Invited, not yet responded.


We gratefully acknowledge the generous grant for this conference provided by:


National Institutes of Health

Grant No. 1 R13 AG026970-01



We gratefully acknowledge additional support for this conference from:

Novartis Institutes for BioMedical Research
Alzheimer's Association

rPeptide, LLC
 

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