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This meeting took place in 2006

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Chemokines and Chemokine Receptors (A4)

Organizer(s) Andrew Luster and Philip Murphy
January 15—20, 2006
Snowbird Resort • Snowbird, UT USA
Abstract Deadline: Sep 15, 2005
Late Abstract Deadline: Oct 6, 2005
Scholarship Deadline: Sep 15, 2005
Early Registration Deadline: Nov 15, 2005

Supported by The Director's Fund

Summary of Meeting:
Chemokines are chemotactic cytokines that induce the directed migration of cells by activating specific G protein-coupled receptors. This system of ~50 cytokines and ~20 receptors plays a particularly prominent role in development, homeostasis and activation of leukocytes in the mammalian immune system. Chemokines determine the nature of the tissue inflammatory response in a wide range of human diseases and represent attractive new therapeutic targets. Chemokines may also attract and stimulate non-immune cells, such as tumor cells, neurons and blood vessels. This meeting will address major unanswered questions in the chemokine field including how chemokines regulate lymphoid development, how cells sense chemokine gradients, the nature of the chemokine signaling pathway, how chemokines amplify immunologically-mediated disease, and whether disrupting chemokine signaling can treat or prevent disease. A systems biology approach to chemokine function in vivo will be highlighted and will extend to the regulation and interrelationship of the chemokine system with other regulatory systems in vivo.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time



Ballroom Lobby

Ballroom Mezzanine & Lobby
Keynote Address

Ballroom 2-3
Eugene C. Butcher, Stanford University, USA
Leukocyte-Endothelial Cell Recognition: Toward a General Model of Leukocyte Trafficking



Golden Cliff, Wasatch, Superior Lobby
Chemokine Control of Leukocyte Trafficking in the Adaptive Immune Response

Ballroom 2-3
* Martin Lipp, Max-Delbrueck-Center, MDC, Germany

Ulrich H. Von Andrian, Harvard Medical School, USA
T Cell and DC Trafficking in the Lymph Node

Reinhold Förster, Hannover Medical School, Germany
DC Migraton in Tolerance and Immunity

Hans-Christian Reinecker, Massachusetts General Hospital, USA
Short Talk: Chemokine Receptors Regulate Intestinal DC Subsets in Mucosal Defense

Federica Sallusto, Università della Svizzera Italiana & ETH Zurich, Switzerland
Leukocyte Trafficking to the Inflamed Lymph Node

Joshua M. Farber, NIAID, National Institutes of Health, USA
Chemokines in CD4+ T Cell Memory

Thomas B. Issekutz, Dalhousie University, Canada
Short Talk: Migration of CCR4+ Memory CD4 T Cells to Dermal Inflammation is Mediated by CXCR3

Hanna Stenstad, Sahlgrenska Academy, Sweden
Short Talk: Gut Associated Lymphoid Tissue Primed CD4+ T Cells Display CCR9 Dependent and Independent Homing to the Murine Small Intestine

Coffee Break

Ballroom Mezzanine & Lobby
Poster Setup

Superior/Superior Lobby/Maybird
Poster Viewing

Superior/Superior Lobby/Maybird
Workshop 1: Novel Chemokine Biology

Ballroom 2-3
* Osamu Yoshie, Kinki University, Japan

* Joost J. Oppenheim, National Institutes of Health, USA
Alarmins are Non-Cognate Chemokine Receptor Ligands and Activators of Dendritic Cells

Brigitte Gomperts, University of California, Los Angeles, USA
Circulating Progenitor Epithelial Cells Traffic via CXCR4/CXCL12 in Response to Airway Injury

Yang Hu, Weill Graduate School of Medical Sciences of Cornell University, USA
Costimulation of Chemokine Receptor Signaling by MMP-9 Mediates Enhanced Migration of IFNá-DCs

George Ed Rainger, University of Birmingham, UK
A Multi-Cellular in Vitro Model of Chronic Inflammatory Joint Disease Identifies Novel Routes of Chemokine Expression Presentation and Function

Ewan A. Ross, University of Glasgow, UK
Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 Modulates Sdf-1alpha/Cxcr4 Responses of Hematopoietic Stem Cells

Marcus Svensson, Lund University, Sweden
Role of CCR9 in Thymic T Cell Development

Raffaella Bonecchi, Istituto Clinico Humanitas, Italy
The Chemokine Decoy Receptor D6 Protects the Fetus from Inflammation Acting as an Inflammatory CC Chemokine Scavenger at the Fetal-Maternal Interface

Gabriele S.V. Campanella, Massachusetts General Hospital, USA
IP-10 (CXCL10) Oligomerization is Important for its in Vivo Activity

Jana Barlic, National Institutes of Health, USA
Oxidized LDL Metabolites Upregulate Expression and Function of Monocyte CX3CR1 through a PPARgamma-dependent Pathway

Coffee Available

Ballroom Mezzanine & Lobby
Chemokines in Immune System Homeostasis

Ballroom 2-3
* Bernhard Moser, Cardiff University School of Medicine, UK
Steady-State T Cell Traffick in Human Skin

Mehrdad Matloubian, University of California, San Francisco, USA
Regulation of Lymphocyte Exit from Lymphoid Organs

Hugh Rosen, ActivX Biosciences, USA
S1P1 Control of Lymphocyte Trafficking

Shannon Bromley, Massachusetts General Hospital, USA
Short Talk: CCR7 Guides T Cell Exit from Peripheral Tissues and Entry into Afferent Lymphatic

Ariel Achtman, Max-Delbrück-Centrum für Molekulare Medizin, Germany
Short Talk: CCR7 Deficiency Leads to Disturbed Lymphocyte Recirculation through Non-Lymphoid Tissues and Causes Hypertrophic Gastropathy

Shahin Rafii, Weill Cornell Medical College, USA
Chemokine-Mediated Interaction of Hematopoietic Progenitors with the Bone Marrow Vascular Niche

Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
Poster Session 1

Superior/Superior Lobby/Maybird



Golden Cliff, Wasatch, Superior Lobby
Chemoattractant Signal Transduction

Ballroom 2-3
* Ann Richmond, Vanderbilt University School of Medicine, USA
Localiztion of Signaling Events in Chemotaxing

Ronen Alon, Weizmann Institute of Science, Israel
Chemokine Regulation of Lymphocyte Adhesion and Migration

Tatsuo Kinashi, Kansai Medical School, Japan
Roles of Rap1-RAPL in Chemokine-Mediated Immune Cell Migration

Dianqing Dan Wu, Yale University School of Medicine, USA
Genetic Study of Chemoattractant Signaling

Antonella Viola, University of Milan, Italy
Orchestration of Leukocyte Chemotaxis by Mitochondrial Dynamics

Jens V. Stein, University of Bern, Switzerland
Short Talk: A Central Role for DOCK2 During Interstitial T and B Lymphocyte Migration and Lymph Node Egress

Barbara Walzog, Ludwig-Maximilians-Universität, Germany
Short Talk: The Vav Binding Site of the Non-Receptor Tyrosine Kinase Syk at Tyr 348 Is Critical for Beta2 Integrin (CD11/CD18)-Mediated Leukocyte Polarization and Migration

Coffee Break

Ballroom Mezzanine & Lobby
Poster Setup

Superior/Superior Lobby/Maybird
Poster Viewing

Superior/Superior Lobby/Maybird
Coffee Available

Ballroom Mezzanine & Lobby
Regulation of Chemokine Action

Ballroom 2-3
* Gerry J. Graham, University of Glasgow, UK
The Chemokine Decoy Receptor, D6, Regulates the Inflammatory Response in vivo

Frances E. Lund, University of Alabama at Birmingham, USA
Regulation of Cell Trafficking under Homeostatic and Inflammatory Conditions: Roles for CD38, cADPR and Galphaq

Christopher M. Overall, University of British Columbia, Canada
Dynamic Regulation of the Chemokine Web by Matrix Metalloproteinases

Ifor Williams, Science Immunology, USA
Short Talk: Developmental Regulation of Sulfation of N-Terminal Tyrosine of Mouse CCR9 by Tyrsoylprotein Sulfotransferase-2

Andrea Meiser, Imperial College, Faculty of Medicine, UK
Short Talk: The Chemokine Receptor CXCR3 is Replenished at the Cell Surface by de novo Synthesis of Receptor and not by Receptor Recycling

Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
Poster Session 2

Superior/Superior Lobby/Maybird


Chemokines in Immunologically-Mediated Disease I

Ballroom 2-3
* Richard M. Ransohoff, Third Rock Ventures, USA
EAE in D6-/- Mice

Klaus Ley, La Jolla Institute for Allergy and Immunology, USA
Arrest Chemokines in Atherosclerosis: Specialized Receptors and Signaling Pathways

Seema S. Ahuja, University of Texas Health Science Center, USA
Chemokines and Chemokine Receptors in Rheumatoid Arthritis

Thomas J. Schall, ChemoCentryx, Inc., USA
Novel Chemokines and Chemokine Receptors in Development and Disease

Israel F. Charo, ChemoCentryx, Inc., USA
Chemokines and the Metabolic Syndrome

Robert E. Gerszten, Beth Israel Deaconess Medical Center, USA
Short Talk: The T Cell Chemokine CXCL10 (IP-10) Modulates Atherogenesis via the Local Balance of the Effector and Regulatory Arms of the Immune System

Nikolaos G. Frangogiannis, Baylor College of Medicine, USA
Short Talk: Role of the C-C Chemokines in Myocardial Infarction

Amnon Peled, Hebrew University, Israel
Role of Chemokine Receptors in NK Cell Mobilization and Trafficking

Toshihiro Nanki, Teikyo University, Japan
Short Talk: Pathogenic Role of CXCL16-CXCR6 Pathway in Rheumatoid Arthritis


Golden Cliff, Wasatch, Superior Lobby
Coffee Break

Ballroom Mezzanine & Lobby
Poster Setup

Superior/Superior Lobby/Maybird
Poster Viewing

Superior/Superior Lobby/Maybird
Coffee Available

Ballroom Mezzanine & Lobby
Chemokines in Immunologically-Mediated Disease II

Ballroom 2-3
* Craig Gerard, Children's Hospital Harvard University, USA

Nicholas W. Lukacs, University of Michigan, USA
Chemokine Receptors and Chronic Airway Disease

Dan R. Littman, HHMI/New York University School of Medicine, USA
Chemokines in Myeloid and T Cell Function

Richard M. Ransohoff, Third Rock Ventures, USA

Joseph El Khoury, Massachusetts General Hospital, USA
Short Talk: Chemokine Regulation of Microglial Recruitment in Alzheimer's Disease

Jesús Rivera-Nieves, Inflammatory Bowel Disease Center, USA
Short Talk: Role of CCR9/CCL25 in Chronic Murine Ileitis

Julie A. DeMartino, EMD Serono Research & Development Institute, Inc., USA
Updates and Future Directions of Anti-Chemokine Therapeutics

Social Hour with Lite Bites

Superior/Superior Lobby/Maybird
Poster Session 3

Superior/Superior Lobby/Maybird



Golden Cliff, Wasatch, Superior Lobby
Chemokines and Infectious Disease

Ballroom 2-3
* Steven L. Kunkel, University of Michigan Medical School, USA

Antonio Alcami, Centro de Biologia Molecular Severo Ochoa, Spain
Viral Chemokine Binding Proteins

Eric G. Pamer, University of Chicago, USA
Regulation of Leukocyte Trafficking during Infection

Kouji Matsushima, University of Tokyo School of Medicine, Japan
Chemokine-Regulated Subsets of DCs in Anti-Viral Immunity

Michael J. Holtzman, Washington University in St. Louis, USA
Chemokine Protection from Virus-Induced Cell Death

Jean K. Lim, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Chemokine Receptor CCR5 Mediates Resistance to West Nile Virus Infection in Mouse and Man

Fang Liao, Academia Sinica, Taiwan
Short Talk: Both CXCR3 and CXCL10/IP-10 are Required for Resistance to Primary Infection by Dengue Virus

Kathleen Kelly, University of California Los Angeles, USA
Short Talk: CXCL13 is Induced within Human Fallopian Tubes Following Infection with Chlamydia and Alters Oviduct Pathology

Coffee Break

Ballroom Mezzanine & Lobby
Workshop 2: Preclinical and Clinical Development of Anti-Chemokine Therapy for Disease

Ballroom 2-3
* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre, Switzerland

* Albert Zlotnik, University of California Irvine, USA
Diagnostic and Therapeutic Uses of Chemokines

Andreas J. Kungl, ProtAffin Biotechnologie AG, Austria
Developing Receptor-Deficient Chemokine Mutants Towards Glycosaminoglycan Antagonists: The CellJammer Anti-Inflammatory Approach

Andrea Martin, Eli Lilly and Company, USA
The Chemokine Binding Protein M3 Prevents Inflammatory and Autoimmune Diabetes

Christina Anne Bursill, Heart Reserach Institute, Australia
Membrane-Bound CC-Chemokine Inhibitor ‘M35K’ Provides Localised Inhibition of CC-Chemokine Activity in Vitro and in Vivo

Jen Alexander-Brett, Washington University, USA
Promiscuous Chemokine Sequestration By a Herpesvirus Decoy Receptor

R. William Hipkin, Schering-Plough Research Institute, USA
The Affinity and Intrinsic Activity of Chemokines at hCXCR1 and hCSCR2: CXCL8 is Functionally CXCR1-Selective

Kathleen A. Sullivan, Merck & Co., Inc., USA
In Vivo Consequences of CXCR3 Blockade with Small Molecule Antagonists

Kenneth R. Cooke, Johns Hopkins, USA
CCR1:CCL5 (RANTES) Receptor:Ligand Interactions Modulate Allogeneic T Cell Responses Following Allogeneic Bone Marrow Transplantation

Oliver Dewald, Klinikum Oldenburg, Germany
CCL2/MCP-1 Deficiency Prevents Development of Ischemic Cardiomyopathy Decreasing Interstitial Fibrosis

Coffee Available

Ballroom Mezzanine & Lobby
Chemokines in Cancer and Development

Ballroom 2-3
* Robert M. Strieter, University of Virginia School of Medicine, USA
Chemokines and Cancer

Fabienne Mackay, Monash University, Australia
CXCR7 Deficient Mice Reveal a Key Role for this Receptor in Cardiac Development and Splenic Marginal Zone B Cell Formation

Tyler J. Curiel, University of Texas Health, USA
Chemokines in Cancer Pathogenesis

Sergio A. Lira, Mount Sinai School of Medicine, USA
Tumorigenesis Induced by the HHV8-Encoded Chemokine Receptor

Gwendal Lazennec, INSERM, France
Short Talk: IL-8 is a Novel Marker for Breast Cancer

Hiroshi Miyazaki, Philips Institute-Virginia Commonwealth University, USA
Short Talk: Regulation of Squamous Cell Carcinoma Proliferation and Invasion by CXCL5

Social Hour with Lite Bites

Golden Cliff, Eagles Nest, Superior Lobby

Golden Cliff, Eagles Nest, Superior Lobby



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health

Grant No. 1 R13 AI066862-01

We gratefully acknowledge additional support for this conference from:

Educational donation provided by Amgen Novartis Institutes for BioMedical Research

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

EMD Serono, Inc.

Merck Research Laboratories

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