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This meeting took place in 2006
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Nuclear Receptors: Orphan Brothers (X3)
Organizer(s) Vincent Giguère, David D. Moore and Anastasia Kralli
March 18—23, 2006
Fairmont Banff Springs • Banff, AB Canada
Abstract Deadline: Nov 17, 2005
Late Abstract Deadline: Dec 12, 2005
Scholarship Deadline: Nov 17, 2005
Early Registration Deadline: Jan 18, 2006
Supported by The Director's Fund
Joint Meeting:
Nuclear Receptors: Steroid Sisters (X4)
Summary of Meeting:
Nuclear receptors constitute a large family of transcription factors that control development and homeostasis of complex organisms, and play fundamental roles in human diseases. In contrast to classic steroid and thyroid hormone receptors, orphan nuclear receptors were originally identified without any prior knowledge of their association with natural or synthetic ligands. Studies of orphan nuclear receptors has not only led to the discovery of new hormone response systems and regulatory pathways controlling cell fate, organogenesis and vital metabolic functions, but also helped in uncovering molecular mechanisms common to the action of all members of the nuclear receptor family. This meeting will demonstrate the importance of orphan nuclear receptors in health and diseases, their potential as targets for drug discovery and the distinction and likeness in the molecular mechanisms of action used by orphan and steroid nuclear receptors.
View Scholarships/Awards
Nuclear receptors constitute a large family of transcription factors that control development and homeostasis of complex organisms, and play fundamental roles in human diseases. In contrast to classic steroid and thyroid hormone receptors, orphan nuclear receptors were originally identified without any prior knowledge of their association with natural or synthetic ligands. Studies of orphan nuclear receptors has not only led to the discovery of new hormone response systems and regulatory pathways controlling cell fate, organogenesis and vital metabolic functions, but also helped in uncovering molecular mechanisms common to the action of all members of the nuclear receptor family. This meeting will demonstrate the importance of orphan nuclear receptors in health and diseases, their potential as targets for drug discovery and the distinction and likeness in the molecular mechanisms of action used by orphan and steroid nuclear receptors.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SATURDAY, MARCH 18
SUNDAY, MARCH 19
MONDAY, MARCH 20
TUESDAY, MARCH 21
WEDNESDAY, MARCH 22
THURSDAY, MARCH 23
Conference Program Print | View meeting in 12 hr (am/pm) time
SATURDAY, MARCH 18
19:30—20:30
Keynote Address (Joint)
Elaine V. Fuchs,
Rockefeller University, USA
Transcriptional Control of Stem Cells and Their Lineages
Transcriptional Control of Stem Cells and Their Lineages
08:00—11:00
Development and Differentiation
Thomas Perlmann,
Karolinska Institutet, Ludwig Institute for Cancer Research, Sweden
Nurr1 and Other Factors in the Development and Stem Cell Engineering of Dopamine Neurons
Nurr1 and Other Factors in the Development and Stem Cell Engineering of Dopamine Neurons
*
Malcolm G. Parker,
Imperial College London, UK
The Ups and Downs of Nuclear Receptor Action in Fat and Fertility
The Ups and Downs of Nuclear Receptor Action in Fat and Fertility
Henry M. Krause,
University of Toronto, Canada
Live Animal Screening for Nuclear Receptor Ligands
Live Animal Screening for Nuclear Receptor Ligands
Austin J. Cooney,
Baylor College of Medicine, USA
Short Talk: Epigenetic Regulation of ES Cell Gene Repression by GCNF
Short Talk: Epigenetic Regulation of ES Cell Gene Repression by GCNF
08:00—11:00
Steroid Receptors and Disease
Carol A. Lange,
University of Minnesota, USA
Integration of Progesterone Receptor and MAP Kinase Signaling in Breast Cancer Cell Models
Integration of Progesterone Receptor and MAP Kinase Signaling in Breast Cancer Cell Models
*
Benita S. Katzenellenbogen,
University of Illinois, USA
Novel Modulators of Estrogen Receptor Function
Novel Modulators of Estrogen Receptor Function
Martin L. Privalsky,
University of California, Davis, USA
Aberrant Thyroid Hormone Receptors: Mutations, Isoforms and Disease
Aberrant Thyroid Hormone Receptors: Mutations, Isoforms and Disease
Kenneth S. Korach,
NIEHS, National Institutes of Health, USA
Differential Physiological Gene Responsiveness in ERKO Mice
Differential Physiological Gene Responsiveness in ERKO Mice
Karen E. Knudsen,
Thomas Jefferson University, Kimmel Cancer Center, USA
Short Talk: BRM ATPase Function in the Prostate: AR Regulation and Proliferative Control
Short Talk: BRM ATPase Function in the Prostate: AR Regulation and Proliferative Control
15:30—16:30
Hot Topics 1
Robert B. Beckstead,
Howard Hughes Medical Institute, University of Utah, USA
Regulation of DHR78 Activity through a SAM-Domain Containing Corepressor, Moses
Regulation of DHR78 Activity through a SAM-Domain Containing Corepressor, Moses
William A. Alaynick,
University of California, San Diego, The Salk Institute, USA
Loss of ERR3 Results in Cardiac Conduction Defects in Mouse
Loss of ERR3 Results in Cardiac Conduction Defects in Mouse
Daniel Malenfant,
Centre de Recherche en Cancérologie de l'Université Laval, Canada
Genome-Wide Location Analysis of FTF/LRH-1 in Mouse Liver and Human Hepatoma Cells
Genome-Wide Location Analysis of FTF/LRH-1 in Mouse Liver and Human Hepatoma Cells
15:30—16:30
Hot Topics 1
*
Nancy Lynn Weigel,
Baylor College of Medicine, USA
Mariam H. Al-Dhaheri,
Medical University of Ohio, USA
Protein Kinase A (PKA)-Induced Ligand Independent Activity of Estrogen Receptor in Breast Cancer Cells is Accompanied by Decreased Estradiol Binding, Increased Association of ERalpha with HSP90 and Loss of Cell Viability
Protein Kinase A (PKA)-Induced Ligand Independent Activity of Estrogen Receptor in Breast Cancer Cells is Accompanied by Decreased Estradiol Binding, Increased Association of ERalpha with HSP90 and Loss of Cell Viability
James Thompson,
University of Helsinki, Finland
Small Carboxyl-Terminal Domain Phosphatase 2 Knock-Down Increases RNA Polymerase II Phosphorylation and Androgen-Dependent Transcription in Prostate Cancer Cells
Small Carboxyl-Terminal Domain Phosphatase 2 Knock-Down Increases RNA Polymerase II Phosphorylation and Androgen-Dependent Transcription in Prostate Cancer Cells
Kirsten C. Fertuck,
Dana Farber Cancer Institute, USA
Coactivation by AIB1 Contributes to Long-Range Association Between Proximal and Distal Estrogen Receptor Binding Sites in Breast Cancer Cells
Coactivation by AIB1 Contributes to Long-Range Association Between Proximal and Distal Estrogen Receptor Binding Sites in Breast Cancer Cells
Frederic D. Flamant,
Ecole Normale Superieure, France
Inducible Expression of a TRalpha Receptor with a AF2 Domain Mutation to Identify the Cell Autonomous Effects of Thyroid Hormone in Mouse Development and Homeostasis
Inducible Expression of a TRalpha Receptor with a AF2 Domain Mutation to Identify the Cell Autonomous Effects of Thyroid Hormone in Mouse Development and Homeostasis
17:00—19:00
Coregulators and Chromatin (Joint)
*
Ronald M. Evans,
HHMI/The Salk Institute, USA
W. Lee Kraus,
University of Texas Southwestern Medical Center, USA
Estrogen Signaling in the Nucleus: Role of Receptors, Coactivators, and Chromatin
Estrogen Signaling in the Nucleus: Role of Receptors, Coactivators, and Chromatin
Bert W. O'Malley,
Baylor College of Medicine, USA
Birth to Death: Story of the SRC-3 Coactivator Complex
Birth to Death: Story of the SRC-3 Coactivator Complex
Michael G. Rosenfeld,
University of California, San Diego, USA
Coregulatory Strategies Linking Nuclear Receptor Gene Activation Events and DNA Damage/Repair
Coregulatory Strategies Linking Nuclear Receptor Gene Activation Events and DNA Damage/Repair
08:00—11:00
Metabolic Regulators and New Ligands
*
David D. Moore,
Baylor College of Medicine, USA
Vincent Giguère,
McGill University, Canada
Identification of ER and ERR-Driven Transcriptional Regulatory Networks: A Functional Genomic Approach to Uncover Nuclear Receptor Function in Physiology and Disease
Identification of ER and ERR-Driven Transcriptional Regulatory Networks: A Functional Genomic Approach to Uncover Nuclear Receptor Function in Physiology and Disease
Anastasia Kralli,
Johns Hopkins Medical School, USA
ERRa, A Regulator of Mitochondrial Function and Other PGC-1 Controlled Metabolic Pathways
ERRa, A Regulator of Mitochondrial Function and Other PGC-1 Controlled Metabolic Pathways
Beatrice Desvergne,
University of Lausanne, Switzerland
Endocrine Disruptors Modulate PPAR Actions: A Live Study in the Living Cells
Endocrine Disruptors Modulate PPAR Actions: A Live Study in the Living Cells
Holly A. Ingraham,
University of California, San Francisco, USA
NR5A Receptors in Neuroendocrine Physiology and in Female Reproductive Disease
NR5A Receptors in Neuroendocrine Physiology and in Female Reproductive Disease
Janice Marie Huss,
Beckman Research Institute at the City of Hope National Medical Center, USA
Short Talk: The Estrogen-Related Receptor alpha (ERRalpha) is Essential for Adaptive Cardiac Remodeling in Pressure Overload Models of Heart Failure
Short Talk: The Estrogen-Related Receptor alpha (ERRalpha) is Essential for Adaptive Cardiac Remodeling in Pressure Overload Models of Heart Failure
08:00—11:00
Molecular Pharmacology of Steroid Receptors
Geoffrey L. Greene,
University of Chicago, USA
Structural Basis for Differential Responses of ERα and ERβ to Diverse Ligands
Structural Basis for Differential Responses of ERα and ERβ to Diverse Ligands
Dean P. Edwards,
Baylor College of Medicine, USA
Transcriptional and Extra-nuclear Signaling Activities of the Progesterone Receptor Mediated by the Amino-terminal Domain.
Transcriptional and Extra-nuclear Signaling Activities of the Progesterone Receptor Mediated by the Amino-terminal Domain.
Nancy Lynn Weigel,
Baylor College of Medicine, USA
Regulation of Progesterone Receptor Action by Cycline Dependent Kinases
Regulation of Progesterone Receptor Action by Cycline Dependent Kinases
Michael A. Mancini,
Baylor College of Medicine, USA
Short Talk: Visualizing Nuclear Receptor Function at the Single Cell Level
Short Talk: Visualizing Nuclear Receptor Function at the Single Cell Level
15:30—16:30
Hot Topics 2
Marie Lagouge,
Centre de recherche des Cordeliers U1138, France
The SIRT-1 Activator, Resveratrol, Induces Weight Loss through Increasing Basal Energy Expenditure
The SIRT-1 Activator, Resveratrol, Induces Weight Loss through Increasing Basal Energy Expenditure
Junichiro Sonoda,
Regeneron Pharmaceuticals, Inc., USA
Metabolic Activation of Macrophage Function by ERRalpha
Metabolic Activation of Macrophage Function by ERRalpha
Y. Lynn Wang,
Weill Medical College of Cornell University, USA
PPARgamma Promotes Cell Survival through Its Actions on Cellular Metabolic Activities
PPARgamma Promotes Cell Survival through Its Actions on Cellular Metabolic Activities
Mercedes Ricote,
Centro Nacional de Investigaciones Cardiovasculares, Spain
Macrophage Specific PPAR-gamma Gene Deletion Causes Whole Body Insulin Resistance and Glucose Intolerance
Macrophage Specific PPAR-gamma Gene Deletion Causes Whole Body Insulin Resistance and Glucose Intolerance
15:30—16:30
Hot Topics 2
Wen Cai,
Karolinska Institute, Sweden
Crosstalk between Circadian System and Nuclear Receptors
Crosstalk between Circadian System and Nuclear Receptors
Eliot Michael Bourk,
University of California, San Diego, USA
An Evolutionarily Conserved Nuclear Receptor Sensor System Mediates Inflammatory Control of Estrogen-Repressed Genes
An Evolutionarily Conserved Nuclear Receptor Sensor System Mediates Inflammatory Control of Estrogen-Repressed Genes
Daniel B. Hardy,
Children's Health Research Institute, Lawson Health Research Institute, Canada
The Anti-Inflammatory Actions of the Progesterone Receptor (PR) May Exert a Protective Role in Breast Cancer
The Anti-Inflammatory Actions of the Progesterone Receptor (PR) May Exert a Protective Role in Breast Cancer
Atish Mukherjee,
Baylor College of Medicine, USA
Ablation of SRC2 Coactivator Function in Murine Cell Lineages that Express the Progesterone Receptor Results in Severe Defects in the Female Reproductive System and Mammary Gland
Ablation of SRC2 Coactivator Function in Murine Cell Lineages that Express the Progesterone Receptor Results in Severe Defects in the Female Reproductive System and Mammary Gland
17:00—19:00
Nuclear Receptors and Metabolism (Joint)
David J. Mangelsdorf,
University of Texas Southwestern Medical Center, USA
Ligand-dependent Regulation of Metabolism and Reproduction: Evolution of the Nuclear Receptor Paradigm
Ligand-dependent Regulation of Metabolism and Reproduction: Evolution of the Nuclear Receptor Paradigm
Ronald M. Evans,
HHMI/The Salk Institute, USA
PPARd at the Crossroads of Inflammation and Metabolism
PPARd at the Crossroads of Inflammation and Metabolism
Bruce M. Spiegelman,
Harvard Medical School, USA
PGC-1 Coactivators and the Control of Energy Homeostasis
PGC-1 Coactivators and the Control of Energy Homeostasis
08:00—11:00
Immune System
Xiao-Kun Zhang,
Sanford-Burnham Medical Research Institute, USA
The Nur77-Bcl-2 apoptotic pathway in cancer cells.
The Nur77-Bcl-2 apoptotic pathway in cancer cells.
Dan R. Littman,
HHMI/New York University School of Medicine, USA
Role of ROR?t in Development and Homeostasis of the Immune System
Role of ROR?t in Development and Homeostasis of the Immune System
Peter Tontonoz,
University of California, Los Angeles, USA
Nuclear Receptors, Metabolism and Inflammation
Nuclear Receptors, Metabolism and Inflammation
Timothy M. Willson†,
GlaxoSmithKline, USA
Structure-Guided Design of Anti-Inflammatory LXR Modulators
Structure-Guided Design of Anti-Inflammatory LXR Modulators
Ajay Chawla,
Merck and University of California, San Francisco, USA
Short Talk: Transcriptional Crosstalk between Metabolism and Inflammation
Short Talk: Transcriptional Crosstalk between Metabolism and Inflammation
08:00—11:00
Steroid Receptors and Chromatin
*
Michael R. Stallcup,
University of Southern California, USA
The p160 Coactivator Signaling Pathway: Roles of Secondary Coactivators and Protein Methylation in Transcriptional Regulation
The p160 Coactivator Signaling Pathway: Roles of Secondary Coactivators and Protein Methylation in Transcriptional Regulation
Jiemin Wong,
Baylor College of Medicine, USA
Function of Androgen Receptor in Chromatin
Function of Androgen Receptor in Chromatin
Catherine C. Thompson,
Pfizer, USA
Linking Corepressor Action and Wnt Signaling: Epithelial Stem Cell Differentiation
Linking Corepressor Action and Wnt Signaling: Epithelial Stem Cell Differentiation
Carolyn L. Smith,
Baylor College of Medicine, USA
Short Talk: Corepressor Contribution to Activation of Estrogen Receptor-a-Dependent Gene Expression
Short Talk: Corepressor Contribution to Activation of Estrogen Receptor-a-Dependent Gene Expression
15:30—16:30
Hot Topics 3
Kendall W. Nettles,
The Scripps Research Institute, USA
Structural Features of the Phantom Ligand Effect in RXR Heterodimers
Structural Features of the Phantom Ligand Effect in RXR Heterodimers
Ines Pineda-Torra,
University College London, UK
Phosphorylation of LXRalpha Reprograms Target Gene Expression in Macrophages
Phosphorylation of LXRalpha Reprograms Target Gene Expression in Macrophages
*
Frances M. Sladek,
University of California, Riverside, USA
Phosphorylation of a Conserved Serine in the Nuclear Receptor DNA Binding Domain Stimulates Nuclear Export
Phosphorylation of a Conserved Serine in the Nuclear Receptor DNA Binding Domain Stimulates Nuclear Export
Susanne Mandrup,
University of Southern Denmark, Denmark
PPAR Subtype Specific Activation of Genomic Target Genes in Hepatocytes upon Adenoviral Transgene Delivery
PPAR Subtype Specific Activation of Genomic Target Genes in Hepatocytes upon Adenoviral Transgene Delivery
15:30—16:30
Hot Topics 3
*
Carolyn L. Smith,
Baylor College of Medicine, USA
Didier Auboeuf,
Institut Universitaire d'hématologie/ Hôpital Saint Louis, France
Control of the Synthesis and the Fate of Gene Transcripts by Transcriptional Coregulators
Control of the Synthesis and the Fate of Gene Transcripts by Transcriptional Coregulators
Sung Hee Baek,
Seoul National University, South Korea
Roles of Nuclear Receptor Coregulators and their Modification Codes in Regulation of a Metastasis Suppressor Gene
Roles of Nuclear Receptor Coregulators and their Modification Codes in Regulation of a Metastasis Suppressor Gene
Suzanne E. Wardell,
Duke University Medical Center, USA
Circumventing Glucocorticoid Resistance in Multiple Myeloma Using Histone Deacetylase Inhibitors to Down-Regulate Growth Factor Receptor Expression
Circumventing Glucocorticoid Resistance in Multiple Myeloma Using Histone Deacetylase Inhibitors to Down-Regulate Growth Factor Receptor Expression
Shane M. Colley,
Western Australian Institute for Medical Research, Australia
Characterization of Four Novel SRA-Binding Coregulators that Modulate Nuclear Receptor Signaling in Cancer
Characterization of Four Novel SRA-Binding Coregulators that Modulate Nuclear Receptor Signaling in Cancer
17:00—19:00
Transcriptional Control Mechanisms (Joint)
*
Bert W. O'Malley,
Baylor College of Medicine, USA
Christopher K. Glass,
University of California, San Diego, USA
Mechanisms Mediating Anti-Inflammatory Activities of Nuclear Receptors
Mechanisms Mediating Anti-Inflammatory Activities of Nuclear Receptors
Pierre H. Chambon,
Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), France
Genetic and pharmacological dissection of the (patho)physiological function of RXR/Nuclear Receptor heterodimers in epidermal keratinocytes of the mouse skin
Genetic and pharmacological dissection of the (patho)physiological function of RXR/Nuclear Receptor heterodimers in epidermal keratinocytes of the mouse skin
Mitchell A. Lazar,
Perelman School of Medicine, University of Pennsylvania, USA
The Ups and Downs of Repression
The Ups and Downs of Repression
08:00—11:00
Physiology and Cancer
Carlie J. M. de Vries,
University of Amsterdam, Netherlands
Nur77-Like Nuclear Receptors in Atherosclerosis
Nur77-Like Nuclear Receptors in Atherosclerosis
David D. Moore,
Baylor College of Medicine, USA
Nuclear Receptors and Liver Regeneration
Nuclear Receptors and Liver Regeneration
Joyce J. Repa,
University of Texas Southwestern Medical Center, USA
LXR-mediated Regulation of Glucose and Lipid Metabolism.
LXR-mediated Regulation of Glucose and Lipid Metabolism.
Jacques Drouin,
Institut de Recherches Cliniques de Montréal, Canada
NGFIB and GR: Molecular Pathogenesis of Glucocorticoid Resistance in Cushing’s Disease
NGFIB and GR: Molecular Pathogenesis of Glucocorticoid Resistance in Cushing’s Disease
08:00—11:00
Steroid Receptor Biology
*
Keith R. Yamamoto,
University of California, San Francisco, USA
GR Ligands Differentially Modulate GR:GRE Occupancy or GR Regulatory Activity
GR Ligands Differentially Modulate GR:GRE Occupancy or GR Regulatory Activity
John A. Cidlowski,
NIEHS, National Institutes of Health, USA
The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-inflammatory Actions
The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms for Tissue Specific Anti-inflammatory Actions
Carole R. Mendelson,
University of Texas Southwestern Medical Center, USA
Mechanisms in the Decline of Progesterone Receptor Function Leading to Parturition
Mechanisms in the Decline of Progesterone Receptor Function Leading to Parturition
Inez Rogatsky,
Weill Medical College of Cornell University, USA
Short Talk: The GRIP1:IRF3 Interaction as a Target for Glucocorticoid Receptor-Mediated Immunosuppression
Short Talk: The GRIP1:IRF3 Interaction as a Target for Glucocorticoid Receptor-Mediated Immunosuppression
15:30—16:30
Hot Topics 4
*
Ming-Jer Tsai,
Baylor College of Medicine, USA
Xin Xie,
Baylor College of Medicine, USA
The Orphan Nuclear Receptor COUP-TFII Plays an Important Role in Adipogenesis
The Orphan Nuclear Receptor COUP-TFII Plays an Important Role in Adipogenesis
Takeshi Inagaki,
University of Tokyo, Japan
Regulation of Mucosal Defense in Intestine by the Nuclear Bile Acid Receptor
Regulation of Mucosal Defense in Intestine by the Nuclear Bile Acid Receptor
Grace L. Guo,
Rutgers University, USA
Role of the Farnesoid X Receptor in Foam-Cell Formation and Atherosclerosis Development
Role of the Farnesoid X Receptor in Foam-Cell Formation and Atherosclerosis Development
Liming Pei,
Children's Hospital of Philadelphia/University of Pennsylvania, USA
NR4A Orphan Nuclear Receptors Regulate Hepatic Glucose Metabolism in Fasting and Diabetes
NR4A Orphan Nuclear Receptors Regulate Hepatic Glucose Metabolism in Fasting and Diabetes
15:30—16:30
Hot Topics 4
*
Kenneth S. Korach,
NIEHS, National Institutes of Health, USA
Kerstin W. Sinkevicius,
Children's Hospital Boston, USA
Estrogen Receptor Alpha G525L Knock-In Mice
Estrogen Receptor Alpha G525L Knock-In Mice
Jan P. Tuckermann,
Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany
Glucocorticoid induced Osteoporosis requires the Glucocorticoid Receptor in Osteoblasts and does not Depend on DNA Binding of the Receptor
Glucocorticoid induced Osteoporosis requires the Glucocorticoid Receptor in Osteoblasts and does not Depend on DNA Binding of the Receptor
Eriko Matsuura,
University of Tokyo, Japan
E2F Transcriptional Activation as a Potential Mechanism of Neurodegeneration of Polyglutamine Expansion Androgen Receptor Mutants
E2F Transcriptional Activation as a Potential Mechanism of Neurodegeneration of Polyglutamine Expansion Androgen Receptor Mutants
17:00—19:00
Nuclear Receptors and Biological Function (Joint), Supported by Invitrogen Corporation
Donald P. McDonnell,
Duke University School of Medicine, USA
The Biological Consequences of Differential Receptor-Cofactor Interactions
The Biological Consequences of Differential Receptor-Cofactor Interactions
*Session Chair †Invited, not yet responded.
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