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This meeting took place in 2006
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Structural Genomics (J5)
Organizer(s) Cheryl H. Arrowsmith, Christine A. Orengo, and Andrzej Joachimiak
January 29—February 3, 2006
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 29, 2005
Late Abstract Deadline: Oct 21, 2005
Scholarship Deadline: Sep 29, 2005
Early Registration Deadline: Nov 29, 2005
Joint Meeting:
Frontiers in Structural Biology (J6)
Summary of Meeting:
The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world.
View Scholarships/Awards
The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 29
MONDAY, JANUARY 30
TUESDAY, JANUARY 31
WEDNESDAY, FEBRUARY 1
THURSDAY, FEBRUARY 2
FRIDAY, FEBRUARY 3
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 29
19:30—20:30
Keynote Session (Joint)
Roger D. Kornberg,
Stanford University, USA
RNA Polymerase II Structure and Mechanism
RNA Polymerase II Structure and Mechanism
08:00—11:00
Protein Expression/Purification
Pär L. Nordlund,
Karolinska Institute, Sweden
Library Screening Methods for the Production of Human Proteins and Domains
Library Screening Methods for the Production of Human Proteins and Domains
Binesh Shrestha,
University of Oxford, UK
Short Talk: High Throughput Expression of Human Proteins in Insect Cells
Short Talk: High Throughput Expression of Human Proteins in Insect Cells
Ian E. Hunt,
Novartis Institutes for Biomedical Research, USA
Short Talk: From Gene to Protein: A Review of New and Enabling Technologies for Multi-Parallel Baculovirus Mediated Protein Expression
Short Talk: From Gene to Protein: A Review of New and Enabling Technologies for Multi-Parallel Baculovirus Mediated Protein Expression
Shigeyuki Yokoyama,
RIKEN, Japan
Cell Free Protein Expression
Cell Free Protein Expression
08:00—11:00
Membranes and Membrane Proteins
*
Daniel J. Leahy,
Johns Hopkins School of Medicine, USA
H. Ronald Kaback,
University of California, Los Angeles, USA
Structure and Mechanism of Lac Permease
Structure and Mechanism of Lac Permease
Pascal F. Egea,
University of California, San Francisco, USA
Targeting Proteins to Membranes: The Signal Recognition Particle
Targeting Proteins to Membranes: The Signal Recognition Particle
Elizabeth Reisinger Sprague,
California Institute of Technology, USA
Short Talk: Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging
Short Talk: Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging
Lukas K. Tamm,
University of Virginia, USA
Membrane Interactions of Influenza Hemagglutinin Fusion Proteins
Membrane Interactions of Influenza Hemagglutinin Fusion Proteins
Douglas C. Rees,
California Institute of Technology, USA
Structural Studies of ABC Transporters
Structural Studies of ABC Transporters
17:00—19:00
Bioinformatics
*
Christine A. Orengo,
University College London, UK
Target Selection that Samples Structure and Function Space
Target Selection that Samples Structure and Function Space
John Moult,
University of Maryland Biotechnology Institute, USA
Structural Bioinformatics for Target Selection, SNPs, and Alternative Splicing
Structural Bioinformatics for Target Selection, SNPs, and Alternative Splicing
Burkhard Rost,
Columbia University, USA
Structural Genomics Changes our Map of Protein Space
Structural Genomics Changes our Map of Protein Space
Olivier Lichtarge,
Baylor College of Medicine, USA
Short Talk: Evolutionary Importance Guides Functional Annotation of Proteins Based on Local Structural Similarity
Short Talk: Evolutionary Importance Guides Functional Annotation of Proteins Based on Local Structural Similarity
17:00—19:00
Macromolecular Interactions
*
Douglas C. Rees,
California Institute of Technology, USA
Stephen C. Blacklow,
Harvard Medical School, USA
Structural Basis for Recruitment of Mastermind Co-activators to Notch1 Transcription Complexes
Structural Basis for Recruitment of Mastermind Co-activators to Notch1 Transcription Complexes
Karin C. Felderer,
Max-Planck-Institute of Biochemistry, Germany
Short Talk: The 20s Proteasome: Mechanism of Substrate Translocation
Short Talk: The 20s Proteasome: Mechanism of Substrate Translocation
Daniel J. Leahy,
Johns Hopkins School of Medicine, USA
Ihog, a New Co-receptor for Hedgehog
Ihog, a New Co-receptor for Hedgehog
Gerhard Wagner,
Harvard Medical School, USA
Probing Macromolecular Interactions of Gene Expression with NMR
Probing Macromolecular Interactions of Gene Expression with NMR
19:30—22:00
Poster Session 1: Bioinformatics and Structural Genomics: Project Overviews/Summaries
08:00—11:15
Pushing Limits of Structural Biology (Joint)
X. Sunney Xie,
Peking University, China
Single Molecule Approach to Biochemistry: From in vitro to in vivo Studies
Single Molecule Approach to Biochemistry: From in vitro to in vivo Studies
Lewis E. Kay,
University of Toronto, Canada
NMR Spectroscopy of Supra- Molecular Machines making the new invisible...visible. NMR Studies of Excited Protein States Seeing the Invisible
NMR Spectroscopy of Supra- Molecular Machines making the new invisible...visible. NMR Studies of Excited Protein States Seeing the Invisible
Venki Ramakrishnan,
MRC Laboratory of Molecular Biology, UK
Crystal structures of functional states of the ribosome
Crystal structures of functional states of the ribosome
Joachim Frank,
Columbia University, USA
Application of Cryo-EM to Image Ribosome Dynamics
Application of Cryo-EM to Image Ribosome Dynamics
17:00—19:00
Crystallization and NMR Sample Production
Naomi Chayen,
Imperial College London, UK
Protein Crystallization: The Current Challenge
Protein Crystallization: The Current Challenge
Gaetano Thomas Montelione,
Rutgers University, USA
Protein Sample Production Technologies for Large-Scale Structural Proteomics
Protein Sample Production Technologies for Large-Scale Structural Proteomics
Zygmunt S. Derewenda,
University of Virginia, USA
Protein crystallization: from art to science
Protein crystallization: from art to science
Alexander Shekhtman,
University at Albany, State University of New York, USA
Short Talk: Mapping STructural INTeractions in Vivo Using in-cell NMR (STINT-NMR)
Short Talk: Mapping STructural INTeractions in Vivo Using in-cell NMR (STINT-NMR)
17:00—19:00
Experiment and Theory in Macromolecular Dynamics
Arthur G. Palmer, III,
Columbia University, USA
NMR Studies of Protein Dynamics
NMR Studies of Protein Dynamics
Mari L. DeMarco,
Washington University, USA
Mapping the Early Steps in Conversion of the Prion Protein
Mapping the Early Steps in Conversion of the Prion Protein
Zimei Bu,
Fox Chase Cancer Center, USA
Short Talk: Coupled Protein Domain Motion in Taq Polymerase Revealed by Neutron Spin Echo Spectroscopy
Short Talk: Coupled Protein Domain Motion in Taq Polymerase Revealed by Neutron Spin Echo Spectroscopy
Philip Anfinrud,
National Institutes of Health, USA
Time-Resolved X-ray Crystallography: Watching Proteins Function in Real Time
Time-Resolved X-ray Crystallography: Watching Proteins Function in Real Time
08:00—11:00
Data Collection and Analysis. Session sponsored by Bruker AXS and Bruker Biospin Corporation
Andrzej Joachimiak,
Argonne National Laboratory, USA
Application of Structural Genomics Pipeline to Expand Protein Fold Space and Discover Protein Function
Application of Structural Genomics Pipeline to Expand Protein Fold Space and Discover Protein Function
Thomas Szyperski,
SUNY at Buffalo, USA
GFT NMR-Based Structural Genomics
GFT NMR-Based Structural Genomics
Ad Bax,
NIDDK, National Institutes of Health, USA
Weak alignment offers shortcuts in NMR structure determination
Weak alignment offers shortcuts in NMR structure determination
Thomas C. Terwilliger,
Los Alamos National Laboratory, USA
PHENIX: New methods for automated structure solution, model-building, ligand-fitting and refinement
PHENIX: New methods for automated structure solution, model-building, ligand-fitting and refinement
Wladek Minor,
University of Virginia, USA
Short Talk: The Integration of Data Reduction and Structure Solution - From Diffraction Images to an Initial Model in Minutes
Short Talk: The Integration of Data Reduction and Structure Solution - From Diffraction Images to an Initial Model in Minutes
08:00—11:00
Protein-Nucleic Acid Interactions
Dale B. Wigley,
Institute of Cancer Research, UK
Structure and Mechanism of RecBCD: A Machine for Processing DNA Breaks
Structure and Mechanism of RecBCD: A Machine for Processing DNA Breaks
Hong Li,
Florida State University, USA
Short Talk: Co-Crystal Structure of the Splicing Endonuclease and its RNA Substrate
Short Talk: Co-Crystal Structure of the Splicing Endonuclease and its RNA Substrate
Juli Feigon,
University of California, Los Angeles, USA
Structural and Functional Studies of Human Telomerase and Yeast RNase III
Structural and Functional Studies of Human Telomerase and Yeast RNase III
17:00—19:00
Late Breaking Developments in Structural Genomics
*
Cheryl Arrowsmith,
University of Toronto, Canada
William C. Nierman,
Institute for Genomic Research, USA
Genomic Sequencing: What Can We Expect in the Next Five Years
Genomic Sequencing: What Can We Expect in the Next Five Years
John C. Norvell,
NIGMS, National Institutes of Health, USA
Protein Structure Imitative: Progress and Plans
Protein Structure Imitative: Progress and Plans
James E. Bradner,
Novartis Institutes for BioMedical Research, USA
Chemical Biology Tools to Complement Structural Genomics
Chemical Biology Tools to Complement Structural Genomics
17:00—19:00
Enzyme Mechanism
*
Arthur G. Palmer, III,
Columbia University, USA
Dorothee Kern,
Brandeis University, HHMI, USA
Short Talk: Intrinsic Motions along the Enzymatic Reaction Trajectory Observed by Crystallography, NMR and Computation
Short Talk: Intrinsic Motions along the Enzymatic Reaction Trajectory Observed by Crystallography, NMR and Computation
Peter E. Wright,
The Scripps Research Institute, USA
Protein Dynamics and Enzyme Function: An NMR View of Dihydrofolate Reductase
Protein Dynamics and Enzyme Function: An NMR View of Dihydrofolate Reductase
Cynthia Wolberger,
Johns Hopkins University School of Medicine, USA
Structural Insights into the Unusual Chemistry of Sir2 Deacetylases
Structural Insights into the Unusual Chemistry of Sir2 Deacetylases
19:30—22:00
Poster Session 3: Structures, Structural and Functional Analysis and Applications of Structural Genomics
08:00—11:00
Biological/Biochemical Insights from Structural Genomics
Cheryl Arrowsmith,
University of Toronto, Canada
Structural Proteomics as a Tool for Genome Annotation
Structural Proteomics as a Tool for Genome Annotation
Udo Oppermann,
University of Oxford, UK
An Integrated Structural and Functional Genomics Approach towards the Human SDR Family
An Integrated Structural and Functional Genomics Approach towards the Human SDR Family
Susan S. Taylor,
University of California, San Diego, USA
Evolution and Diversity of the Protein Kinase Superfamily
Evolution and Diversity of the Protein Kinase Superfamily
Andrew Robinson,
University of Groningen, Netherlands
Short Talk: Structural Genomics of the Mobile Metagenome
Short Talk: Structural Genomics of the Mobile Metagenome
08:00—11:00
Protein Folding and Design
Kevin W. Plaxco,
University of California, Santa Barbara, USA
From Playing with Toys to Predicting Protein Folding Fates
From Playing with Toys to Predicting Protein Folding Fates
Stephen L. Mayo,
California Institute of Technology, USA
Modulation and De Novo Design of Protein-Protein Interactions
Modulation and De Novo Design of Protein-Protein Interactions
Maxim S. Pometun,
University of Pennsylvania, USA
Short Talk: Cold-Induced Unfolding of Encapsulated Proteins
Short Talk: Cold-Induced Unfolding of Encapsulated Proteins
Jonathan S. Weissman,
University of California, San Francisco, USA
Structural Biology of Protein Aggrogation Diseases
Structural Biology of Protein Aggrogation Diseases
David Eisenberg,
University of California, Los Angeles, USA
Structural Studies of Amyloid
Structural Studies of Amyloid
17:00—19:00
Applications of Structural Genomics to Drug Discovery
Tom L. Blundell,
University of Cambridge, UK
High-Throughput Crystallography, Structural Bioinformatics and Fragment-Based Drug Discovery
High-Throughput Crystallography, Structural Bioinformatics and Fragment-Based Drug Discovery
*
Michael Sundström,
Karolinska University Hospital and Karolinska Institutet, Sweden
Structural Chemistry of Human Protein Families
Structural Chemistry of Human Protein Families
17:00—19:00
Macromolecular Interactions
*
Peter E. Wright,
The Scripps Research Institute, USA
Brenda A. Schulman,
Max Planck Institute of Biochemistry, Germany
Specificity in a Multi-enzyme Signaling Cascade
Specificity in a Multi-enzyme Signaling Cascade
Ethan C. Settembre,
Novartis Vaccines, USA
Short Talk: Assembly of the Rotavirus Internal Core Particle
Short Talk: Assembly of the Rotavirus Internal Core Particle
Timothy A. Springer,
Immune Disease Institute, Harvard University, USA
Signaling by Receptors with Two Transmembrane Domains
Signaling by Receptors with Two Transmembrane Domains
*Session Chair †Invited, not yet responded.
We gratefully acknowledge the generous grant for this conference provided by:
We gratefully acknowledge additional support for this conference from:
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Spectra Gases, Inc. Stable Isotopes Group |
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