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This meeting took place in 2007

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Stem Cells and Cancer (X2)

Organizer(s) Irving L. Weissman and Michael F. Clarke
March 2—7, 2007
Keystone Resort • Keystone, CO USA
Abstract Deadline: Nov 2, 2006
Late Abstract Deadline: Dec 1, 2006
Scholarship Deadline: Nov 2, 2006
Early Registration Deadline: Jan 2, 2007

Supported by the Director's Fund

Summary of Meeting:
Cancers arise in tissues in which short-lived mature cells are constantly replenished by a rare population of stem cells. It is becoming apparent that tumors are caricatures of the organ in which they arise. The cancer cells in a tumor are arranged in a hierarchy and contain a minority population of cancer stem cells that drive tumor growth while the majority of the cancer cells are unable to do so. Normal stem cells and cancer stem cells maintain themselves through a process called self-renewal. The cancer stem cells are responsible for the growth and spread of tumors. Expansion of normal stem cells is under genetic constraints. Cancer stem cells have escaped these limitations on expansion resulting in expansion of the self-renewing cell populations. The goals of this meeting are to understand and present the most current research into the cellular and molecular biology of cancer stem cells. Topics that will be explored in this meeting are the cancer stem cell niche, the cell of origin of cancer stem cells, the regulation of stem cell self-renewal in normal stem cells and cancer, and cancer stem cells as therapeutic targets.

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Conference Program    Print  |   View meeting in 12 hr (am/pm) time



Shavano Foyer

Longs Peak Foyer
Keynote Address (Joint)

Colorado Rockies Ballroom
Allan C. Spradling, HHMI/Carnegie Institute, USA
Analyzing Stem Cells Within Intact Drosophila Tissues



Grays/Longs Peak
Mechanisms Governing Normal and Malignant Stem Cells (Joint)

Colorado Rockies Ballroom
* Roeland Nusse, HHMI/Stanford University, USA
Wnt Signaling and Self-Renewal

Leonard I. Zon, HHMI/Boston Children's Hospital, USA
Prostaglandin E2 is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis

Haifan Lin, Yale University, USA
Stem Cells, Small RNAs, and Self-Renewal

Mary Armanios, Johns Hopkins University School of Medicine, USA
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis

Andreas Androutsellis-Theotokis, NINDS, National Institutes of Health, USA
Short Talk: STAT3-Ser727: Integrator of Stem Cell Niche Survival Signals

Coffee Break

Longs Peak Foyer
Poster Setup

Grays/Longs Peak
Poster Viewing

Grays/Longs Peak
Workshop 1: Stem Cells on Hematopoietic Malignancies

Crestone/Red Cloud
* Catriona H.M. Jamieson, University of California, San Diego, USA

* Michael W. Becker, University of Rochester School of Medicine, USA

Eric R. Lechman, University Health Network, Canada
Identification of a Leukemia Stem Cell Specific miRNA Profile and the Requirement of miR-155 for the Maintenance of the Leukemogenic State

Naoki Hosen, Osaka University Graduate School of Medicine, Japan
CD96 is a Candidate for Leukemic Stem Cell-Specific Therapeutic Target

Yosuke Minami, Kobe University Hospital, Japan
Leukemia Stem Cells Induced by BCR-ABL Display Innate Resistance to Imatinib

Aniruddha Deshpande, Memorial Sloan-Kettering Cancer Center, USA
Acute Myeloid Leukemia is Propagated by a Leukemic Stem Cell with Lymphoid Characteristics in a Mouse Model of CALM/AF10 Positive Leukemia

Silvia Buonamici, H3 Biomedicine, Inc., USA
Targeting the NF-kappaB Signaling Pathway in Notch1-Induced T Cell Leukemia

Coffee Available

Longs Peak Foyer
Hematopoietic and Model Microenvironments

Crestone/Red Cloud
Tannishtha Reya, University of California, San Diego, USA
Wnt Signaling in Stem Cells and Cancer

Linheng Li, Stowers Institute for Medical Research, USA
Regulation of Stem Cells in Hematopoietic and Intestinal Niches by BMP and PTEN Pathways

* John E. Dick, Princess Margaret Cancer Centre, Canada
AML Stem cells

Remaking Cell Fate through Cell Interaction

Gerd Hasenfuss, Georg-August-University of Göttingen, Germany
Pluripotency of Spermatogonial Stem Cells From Adult Mouse Testis

Erika Matunis, Johns Hopkins University School of Medicine, USA
Converting Differentiating Cells to Stem Cells in the Drosophila Testis

* Helen M. Blau, Stanford University, USA
Directing Behavior of Single Stem Cells in Bioengineered Arrayed Niches

Ian Chambers, University of Edinburgh, UK
Short Talk: Nanog Function in Pluripotency and Germ Cell Development

Social Hour with Lite Bites

Grays/Longs Peak
Poster Session 1

Grays/Longs Peak



Grays/Longs Peak
Cancer Microenvironment or Tumor Microenvironment and Blood Vessels (Joint)

Colorado Rockies Ballroom
* Patrick O. Brown, Impossible Foods, USA
Cancer Stroma

Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Metastasis Initiating Functions

Philip A. Beachy, HHMI/Stanford University, USA
Hedgehog Signaling in Stem Cells and Cancer

Napoleone Ferrara, University of California, San Diego, USA
VEGF and Angiogenesis

Louise E. Purton, St. Vincent's Institute of Medical Research, Australia
Short Talk: A Microenvironment-Induced Myeloproliferative Disease Caused by RARgamma Deficiency

Renee D. Read, Emory University School of Medicine, USA
Short Talk: Modeling Human Brain Cancer in Fruit Flies

Sophia W.M. Bruggeman, University Medical Center Groningen, Netherlands
Short Talk: Polycomb Group Proteins Control Neutral Stem Cells and Brain Development, and Contribute to Gliomagenesis in an Ink4a/Afr Independent Manner

Coffee Break

Longs Peak Foyer
Poster Setup

Grays/Longs Peak
Poster Viewing

Grays/Longs Peak
Workshop 2: Cancer Genes and Cancer Progressions

Crestone/Red Cloud
* Edison T. Liu, The Jackson Laboratory, USA

* Maarten Van Lohuizen, Netherlands Cancer Institute, Netherlands

Mark LaBarge, City of Hope, USA
Cell-Microenvironment Interactions Guide Human Mammary Progenitor Cell Fate

Xin-Hai Pei, University of North Carolina, USA
Functional Collaboration of p18Ink4c and Brca1 in Mammary Stem Cell Regulation and Tumor Suppression

Susanne Schlisio, Karolinska Institute, Ludwig Institute for Cancer Research, Sweden
Neuronal Apoptosis by Prolyl hydroxylase EglN3: O2- Sensing and Cancer

Danielle Christina Shing, European Institute of Oncology, Italy
The PR Domain-negative Isoform of PRDM16 Induces a Stem Cell Phenotype and is Leukaemogenic

David M. Langenau, Massachusetts General Hospital, USA
Identifying the Cancer Stem Cell in Transgenic Zebrafish Models of Embryonal Rhabdomyosarcoma

Robert B. Clarke, University of Manchester, UK
Primary Human Breast Ductal Carcinoma in situ (DCIS) Mammosphere Formation: Importance of the EGF and Notch Receptor Signalling Pathways

Workshop 1

* Haifan Lin, Yale University, USA

Maria Victoria Gómez-Gaviro, National Institute for Medical Research, UK
Role of the Vasculature in the Cytoarchitecture of the Neural Stem Niche

Laura A. Banaszynski, University of Texas Southwestern Medical Center, USA
Regulated Expression of Transcription Factors Involved in the Establishment and Maintenance of Pluripotency

Michaela Gruber, University of Pennsylvania, USA
HIF-2alpha‘s Role in Erythropoiesis and Adult Stem Cells

Matthias Kieslinger, Helmholtz Center - National Research Center for Environment and Health, Germany
Expression of EBF2 in Osteoblastic Cells is Required for Sustained Haematopoiesis

Drew L. Sellers, University of Washington, USA
Thrombin Acts as an Early Response Cue Within the Adult Neural Stem Niche to Direct Proliferation and Differentiation in Response to Traumatic Injury

Sharon Gerecht-Nir, , USA
Nanotopography Regulates Cytoskeletal Organization of Human Stem Cells

Coffee Available

Longs Peak Foyer
Normal and Neoplastic Stem Cells of Epithelial Tissues

Crestone/Red Cloud
* Owen N. Witte, HHMI/University of California, Los Angeles, USA
Prostate Stem Cells

Michael F. Clarke, Stanford University, USA
Epithelial Cancer Stem Cells

Peter Dirks, Hospital for Sick Children, Canada
Brain Tumor Stem Cells

Organization of Skin

* Elaine V. Fuchs, Rockefeller University, USA
From Stem Cells to Tissue: Signaling, Transcription and Cytoskeletal Dynamics in Skin Morphogenesis

Fiona M. Watt, King's College London School of Medicine, UK
Stem Cells and Lineage Selection in Mammalian Epidermis

Yann Barrandon, École Polytechnique Fédérale de Lausanne, Switzerland
Microenvironmental Changes and Stem Cell Behavior

Sergei Y. Sokol, Icahn School of Medicine at Mount Sinai, USA
Short Talk: Regulation of Epidermal and Neuronal Progenitor Differentiation by aPKC and PAR-1

Social Hour with Lite Bites

Longs Peak Foyer
Poster Session 2

Grays/Longs Peak



Grays/Longs Peak
Cancer Genome Immunological Approaches Applicable to Cancer Stem Cell Therapies

Crestone/Red Cloud
Mark M. Davis, Stanford University School of Medicine, USA
Title to be Determined

Philip D. Greenberg, University of Washington, USA
Isolating/Creating T Cells That Can Target and Eliminate Cancer Stem Cells

Jeffrey J. Molldrem, University of Texas MD Anderson Cancer Center, USA
Peptide Vaccination Against Proteases Reverses T Cell Tolerance and Eliminates Leukemia Stem Cells

James P. Allison, University of Texas MD Anderson Cancer Center, USA

Microenvironments of the Bone Marrow

* David T. Scadden, Massachusetts General Hospital and Harvard University, USA
Hematopoietic Stem Cells and their Niche(s)

Paul J. Simmons, University of Texas Health Science Center at Houston, USA
Phenotypic Dissection of Stem Cell Niches and Mesenchymal Stem Cell Interactions in Bone Marrow

Sean J. Morrison, University of Texas Southwestern Medical Center, USA
Identification of Hematopoietic Stem Cells and Their Niches

Toshio Suda, Keio University, Japan
Molecular Interactions at the Bone: Stem Cell Interface

Ivan Maillard, University of Michigan, USA
Short Talk: Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver Through Effects on the Stem Cell Microenvironment

Masataka Kasai, National Institutes of Health, Japan
Short Talk: Negative Regulation of Stem Cell Self-Renewal and Osteoblast Formation

Coffee Break

Longs Peak Foyer
Poster Setup

Grays/Longs Peak
Poster Viewing

Grays/Longs Peak
Workshop 3: Cancer Stem Cells

Crestone/Red Cloud
* Laurie Elizabeth Ailles, Stanford University, USA

* Mark E.P. Prince, University of Michigan, USA

Shideng Bao Bao, Duke University Medical Center, USA
Cancer Stem Cells Contribute to Glioblastoma Radioresistance through Preferential Activation of DNA Damage Checkpoint and Repair

Catherine A. O'Brien, University Health Network, Canada
Identification of a Human Colon Cancer Cell Capable of Initiating Tumor Growth

Scott J. Dylla, Stemcentrx, Inc., USA
Colorectal Cancer Stem Cells (CoCSC) are Enriched in Residual Tumors following Cyclophosphamide Administration

Kent L. Erickson, University of California, Davis, USA
Small Molecule Combinatorial Libraries to Identify New Mammary Stem Cell Markers

Sheila R. Alcantara, University of Texas Southwestern Medical Center at Dallas, USA
Isolation and Characterization of Cancer Stem Cells in a Glioma Mouse Model

Carol Ann Sartorius, University of Colorado Anschutz Medical Campus, USA
Rare CK5+ Cells in Experimental Human Breast Tumors Express a Panel of “Stem-like” Genes

Coffee Available

Longs Peak Foyer
High Throughput Analysis of Cancer Genes Applicable to Cancer Stem Cells

Crestone/Red Cloud
* Frederick W. Alt, Boston Children's Hospital, USA
NHEJ and the Double-Strand Break Response in IgH Class Switch Recombination and Suppression of Translocations and Lymphoma

Neural Stem Cell Microenvironments

Jeffrey D. Macklis, Harvard University-MGH-HMS, USA
Molecular Development and Repair of Corticospinal Motor Neuron and Other Forebrain Projection Neuron Circuitry

* Charles Ffrench-Constant, University of Edinburgh, UK
Regulation of Neural Stem Cells by Extracellular Matrix Molecules of the Ventricular Zone Niche

Chay T. Kuo, Duke University School of Medicine, USA
Short Talk: Postnatal Deletion of Numb/Numblike Reveals Remodeling Capacity in Neurogenic Niche

Genetic and Epigenetic Alterations in Cancers & Epigenetic Regulation of Cancer Stem Cells

Crestone/Red Cloud
Tim C.P. Somervaille, Stanford University School of Medicine, USA
Transformation of Myeloid Progenitors to Leukemia Stem Cells by MLL Oncogenes

Tian Xu, Yale University School of Medicine, USA
Deciphering Genetic Basis of Tumor Progression and Metastasis

Social Hour with Lite Bites

Longs Peak Foyer
Poster Session 3

Grays/Longs Peak



Grays/Longs Peak
Finding Therapeutic Targets in Cancer Stem Cells

Crestone/Red Cloud
* Tessa L. Holyoake, University of Glasgow, UK
Characterisation of Cancer Stem Cells in CML

Thomas Thomas Look, Dana-Farber Cancer Institute, USA
Gamma Secretase Inhibitors for the Treatment of ALL

D. Gary Gilliland, Merck & Co., Inc., USA
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Gregory L. Verdine, Harvard University, USA
Drugging the Undruggable

Germ Cell Niche

Margaret T. Fuller, Stanford University, USA
Stromal-Stem Cell Interactions in the Fruit Fly Set Up an Oriented Mitotic Spindle for Asymmetric Stem Cell Division

Judith E. Kimble, University of Wisconsin, Madison, USA
Controls of Germline Stem Cells in C. elegans

Ting Xie, Stowers Institute for Medical Research, USA
Interactions Between Germline Stem Cells and Their Niche in the Drosophila Ovary

* Takashi Shinohara, Kyoto University, Japan
Culture and Genetic Modification of Mouse Germline Stem (GS) Cells

Niels Geijsen, Massachusetts General Hospital, USA
Short Talk: “Humanized” Murine Embryonic Stem Cells

Paul S. Cooke, University of Illinois at Urbana-Champaign, USA
Short Talk: Ets-Related Molecule (ERM) and Spermatogonial Stem Cell Self-Renewal

Coffee Break

Longs Peak Foyer
Workshop 4: Novel Cancer Therapies

Crestone/Red Cloud
* Austin Gurney, Napa Biotechnology Consulting, USA
Prognostic Role of Cancer Stem Cell Gene Signatures and Strategies to Target Tumorigenic Cell Populations

Chris Alan Joseph Folkins, Sunnybrook Health Sciences Centre, Canada
Therapies Combining Cytotoxic and Anti-angiogenic Effects Reduce the Fraction of Tumor Sphere Forming Cells in Glioma Xenograft Tumors

Christine E. Brown, Beckman Research Institute, City of Hope, USA
Targeted Elimination of Brain Tumor Initiating Cells with Adoptively Transferred T Cells

Xing Fan, Johns Hopkins University School of Medicine, USA
Depleting Cancer Stem Cells in Glioblastoma by Notch Pathway Blockade

Jie Zheng, St. Jude Children's Research Hospital, USA
Structure-based Investigation of Wnt Signaling Inhibitors

Craig Gedye, Melbourne Center for Clinical Science, Australia
Melanoma Stem-like Cells can be Eliminated by Targeting Cancer/Testis Antigens

Workshop 2

* Allan C. Spradling, HHMI/Carnegie Institute, USA

Arianna DellaValle, San Raffaele Scientific Institute, Italy
Pericytes of Human Post-Natal Skeletal Muscle are Myogenic Precursors, Distinct From Satellite Cells, and Efficiently Repair Dystrophic Muscle

Xudong Shi, University of Wisconsin, Madison, USA
Anchorage Independent Culture Maintains a Population of Prostate Progenitor Cells In Vitro

David R. Whikehart, University of Alabama at Birmingham, USA
Stem Cells in the Human Ocular Limbus Are Contained in a Niche Defined by Schwalbe’s Line

Indira U. Mysorekar, Washington University School of Medicine, USA
Molecular Regulation of the Bladder Epithelial Stem Cell Niche

John Yu, Institute of Stem Cell and Translational Cancer Research, Taiwan
Characterization of Pulmonary Stem Cells as Model for SARS and H5N1 Virus Infections

Coffee Available

Longs Peak Foyer
Normal and Neoplastic Stem Cells

Crestone/Red Cloud
Nobuko Uchida, StemCells, Inc., USA
Biology of Human Neural Stem Cells

* Irving L. Weissman, Stanford University, USA
Normal and Leukemic Stem Cells

Jeremy Naftali Rich, Cleveland Clinic, USA
Glioma Cancer Stem Cells Promote Tumor Radioresistance and Angiogenesis

Diane M. Simeone, University of Michigan, USA
Short Talk: Identification of Pancreatic Cancer Stem Cells

Designer Niches: Modeling and Making Microenvironments

* Donald E. Ingber, Wyss Institute for Biologically Inspired Engineering at Harvard, USA
Mechanical Control of Cell Fate Switching

David J. Mooney, Harvard University, USA
Constructing Tissue Microenvironments

Geeta Mehta, University of Michigan, USA
Short Talk: Creating Ex Vivo Niches for Hematopoeitic Stem Cells

Seth A. Townsend, Massachusetts Institute of Technology, USA
Short Talk: Novel Three-Dimensional Environments for in Vitro Growth of Stem Cells

Social Hour with Lite Bites

Grays/Longs Peak

Grays/Longs Peak



*Session Chair †Invited, not yet responded.

We gratefully acknowledge support for this conference from:

Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

Click here to view all of the donors who support the Directors' Fund.

We gratefully acknowledge additional support for this conference from:

Cell Signaling Technology, Inc. Educational donation provided by Amgen
Merck Research Laboratories

We gratefully acknowledge additional in-kind support for this conference from those foregoing speaker expense reimbursements:

OncoMed Pharmaceuticals, Inc.

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