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This meeting took place in 2007
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Diabetes: Molecular Genetics, Signaling Pathways and Integrated Physiology (J1)
Organizer(s) Domenico Accili and Takashi Kadowaki
January 14—19, 2007
Keystone Resort • Keystone, CO USA
Abstract Deadline: Sep 14, 2006
Late Abstract Deadline: Oct 17, 2006
Scholarship Deadline: Sep 14, 2006
Early Registration Deadline: Nov 14, 2006
Sponsored by Biovitrum AB
Summary of Meeting:
Diabetes is a growing threat to public health worldwide. Type 2 diabetes results from insulin resistance and impaired beta cell function. Studies of insulin signaling and its interactions with nutrient and hormonal pathways remain central to ongoing research efforts to combat diabetes and its complications. The pace of discovery has been especially brisk in several areas: the mechanisms of inflammation-induced insulin resistance; the role of mitochondrial biogenesis and oxidative capacity in the susceptibility to the metabolic syndrome; the “endocrine” function of adipocytes by way of adipocytokine production; the mechanistic integration of beta cell failure and insulin resistance; the role of neural circuits in energy balance; and the mechanisms by which “non-canonical” insulin target tissues contribute to the onset of diabetes. The conference will act as a catalyst for further progress by bringing together leaders in the academic and pharmaceutical communities to present the latest developments in their research.
View Scholarships/Awards
Diabetes is a growing threat to public health worldwide. Type 2 diabetes results from insulin resistance and impaired beta cell function. Studies of insulin signaling and its interactions with nutrient and hormonal pathways remain central to ongoing research efforts to combat diabetes and its complications. The pace of discovery has been especially brisk in several areas: the mechanisms of inflammation-induced insulin resistance; the role of mitochondrial biogenesis and oxidative capacity in the susceptibility to the metabolic syndrome; the “endocrine” function of adipocytes by way of adipocytokine production; the mechanistic integration of beta cell failure and insulin resistance; the role of neural circuits in energy balance; and the mechanisms by which “non-canonical” insulin target tissues contribute to the onset of diabetes. The conference will act as a catalyst for further progress by bringing together leaders in the academic and pharmaceutical communities to present the latest developments in their research.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, JANUARY 14
MONDAY, JANUARY 15
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
TUESDAY, JANUARY 16
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
WEDNESDAY, JANUARY 17
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
THURSDAY, JANUARY 18
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
FRIDAY, JANUARY 19
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, JANUARY 14
19:30—21:30
Keynote Address (Joint)
*
Eleftheria Maratos-Flier,
Beth Israel Deaconess Medical Center, USA
Bruce M. Spiegelman,
Harvard Medical School, USA
PGC-1 Coactivators and the Control of Energy Homeostasis
PGC-1 Coactivators and the Control of Energy Homeostasis
D. Grahame Hardie,
University of Dundee, UK
Sensing of Energy and Nutrients by the AMP-Activated Protein Kinase System
Sensing of Energy and Nutrients by the AMP-Activated Protein Kinase System
08:00—11:00
Regulation of Neuronal Growth and Signaling (Joint)
*
Marc L. Reitman,
NIDDK, National Institutes of Health, USA
Jeffrey M. Friedman,
Rockefeller University, USA
Leptin and Neural Networks
Leptin and Neural Networks
Jeffrey Flier,
Harvard University, USA
Alternative Approaches to the Central Regulation of Energy Balance: Neurogenesis
Alternative Approaches to the Central Regulation of Energy Balance: Neurogenesis
Richard B. Simerly,
Vanderbilt University, USA
Leptin Signaling and Hypothalamic Development
Leptin Signaling and Hypothalamic Development
Morris F. White,
Boston Children's Hospital, Harvard Medical School, USA
Brain Irs2 Signaling in Life-Span and Nutrient Homeostasis
Brain Irs2 Signaling in Life-Span and Nutrient Homeostasis
17:00—19:00
Adipokines
Takashi Kadowaki,
University of Tokyo, Japan
Adiponectin Receptors
Adiponectin Receptors
Rexford S. Ahima,
University of Pennsylvania, USA
Resistin
Resistin
Bente Klarlund Pedersen,
University of Copenhagen, Denmark
Cytokines, Metabolism and Exercise
Cytokines, Metabolism and Exercise
Zhen Y. Jiang,
Sanford-Burnham Medical Research Institute, USA
Short Talk: Rab3A is Required for Constitutive and Insulin-Stimulated Secretion of Adiponectin
Short Talk: Rab3A is Required for Constitutive and Insulin-Stimulated Secretion of Adiponectin
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
17:00—19:00
The Role of the Gut in Energy Balance
*
Matthias H. Tschöp,
Helmholtz Zentrum München and Technische Universität München, Germany
Daniele Piomelli,
University of California, Irvine, USA
Oleoylethanolamide: Links Dietry Fat Absorption to Satiety
Oleoylethanolamide: Links Dietry Fat Absorption to Satiety
Mark Friedman,
Monell Center, USA
Hepatic Control of Feeding Behavior: Low Liver Energy Status as a Stimulus for Overeating
Hepatic Control of Feeding Behavior: Low Liver Energy Status as a Stimulus for Overeating
Svetlana E. Nikoulina,
Amylin Pharmaceuticals Inc., USA
Short Talk: Characterization of Gene Expression and Peptide Secretion in Primary Explant Cultures Generated from Colonic Crypts of Adult Mice
Short Talk: Characterization of Gene Expression and Peptide Secretion in Primary Explant Cultures Generated from Colonic Crypts of Adult Mice
Haruka Okamoto,
Regeneron Pharmaceuticals, Inc., USA
Short Talk: Proglucagon Deficient (PGCG-/-) Mice Exhibit a Predominate Metabolic Phenotype; Increased Body Weight and Food Intake with Accompanied Decrease in Energy Expenditure
Short Talk: Proglucagon Deficient (PGCG-/-) Mice Exhibit a Predominate Metabolic Phenotype; Increased Body Weight and Food Intake with Accompanied Decrease in Energy Expenditure
Feifan Guo,
Institute for Nutritional Sciences, China
Short Talk: GCN2 eIF2alpa Kinase Regulates Fatty Acid Homeostasis in the Liver During Deprivation of an Essential Amino Acid
Short Talk: GCN2 eIF2alpa Kinase Regulates Fatty Acid Homeostasis in the Liver During Deprivation of an Essential Amino Acid
08:00—11:00
Nutrient Sensing (Joint)
Luciano Rossetti,
Merck Research Laboratories, USA
Hypothalamic Nutrient Sensing and Liver Glucose Metabolism
Hypothalamic Nutrient Sensing and Liver Glucose Metabolism
Bradford B. Lowell,
Beth Israel Deaconess Medical Center, USA
Glucose-Sensing in Beta-Cells and POMC Neurons: Defects in Obesity and Role of UCP2
Glucose-Sensing in Beta-Cells and POMC Neurons: Defects in Obesity and Role of UCP2
Bernard Thorens,
University of Lausanne, Switzerland
Central Glucose Sensing in the Control of Feeding and Energy Expenditure
Central Glucose Sensing in the Control of Feeding and Energy Expenditure
Randy J. Seeley,
University of Michigan, USA
The Role of mTOR in the Hypothalamic Control of Food Intake and Body Weight
The Role of mTOR in the Hypothalamic Control of Food Intake and Body Weight
Jeong Ho Kim,
The Salk Institute, USA
Short Talk: mTOR Mediates IL-6-induced Insulin Resistance by Regulating STAT3/SOCS3
Short Talk: mTOR Mediates IL-6-induced Insulin Resistance by Regulating STAT3/SOCS3
Sean H. Adams,
University of Arkansas for Medical Sciences, USA
Short Talk: Tusc5, a Temperature-Sensitive PPARgamma-Responsive Adipocyte Gene Co-Expressed in Somatosensory Neurons
Short Talk: Tusc5, a Temperature-Sensitive PPARgamma-Responsive Adipocyte Gene Co-Expressed in Somatosensory Neurons
17:00—19:00
Mechanisms of beta Cell Failure in Diabetes
*
Anna Krook,
Karolinska Institutet, Sweden
Daniel J. Drucker,
Lunenfeld-Tanenbaum Research Institute, Canada
Physiological Role and Therapeutic Potential of Incretins in Modulating Beta Cell Survival
Physiological Role and Therapeutic Potential of Incretins in Modulating Beta Cell Survival
Lori Sussel,
University of Colorado Anschutz Medical Campus, USA
Islet Cell Development
Islet Cell Development
Masato Kasuga,
National Center for Global Health and Medicine, Japan
Insulin Signaling in Pancreatic beta Cells
Insulin Signaling in Pancreatic beta Cells
Jun Ding,
Model Animal Research Center, China
Short Talk: Mutation of PAX6 Leads to Down-Regulation of GLP-1 Causing Insufficient Insulin Secretion and Islet Defect
Short Talk: Mutation of PAX6 Leads to Down-Regulation of GLP-1 Causing Insufficient Insulin Secretion and Islet Defect
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
17:00—19:15
Integration in the Central Nervous System
*
Deborah Clegg,
Cedars-Sinai Medical Center, USA
Joel K. Elmquist,
University of Texas Southwestern Medical Center, USA
CNS Pathways Regulating Body Weight and Glucose Homeostasis
CNS Pathways Regulating Body Weight and Glucose Homeostasis
Ronald M. Lechan,
Tufts-New England Medical Center, USA
Arcuate to Paraventricular Nucleus Signals and Control of the Hypothalamic-Pituitary-Thyroid Axis
Arcuate to Paraventricular Nucleus Signals and Control of the Hypothalamic-Pituitary-Thyroid Axis
Sharon L. Wardlaw,
Columbia University College of Physicians and Surgeons, USA
The Hypothalamic Melanocortin System: Regulation of Energy Balance and Neuroendocrine Function
The Hypothalamic Melanocortin System: Regulation of Energy Balance and Neuroendocrine Function
Hans Rudolf Berthoud,
Pennington Biomedical Research Center, USA
Short Talk: Food Reward and Obesity: Accumbens-Hypothalamic Pathway and Orexin Signaling Drive High-Fat Intake
Short Talk: Food Reward and Obesity: Accumbens-Hypothalamic Pathway and Orexin Signaling Drive High-Fat Intake
Pavlos Pissios,
NGM Bio, USA
Short Talk: Regulation of the Mesolimbic Dopamine System by Melanin-Concentrating Hormone
Short Talk: Regulation of the Mesolimbic Dopamine System by Melanin-Concentrating Hormone
08:00—11:00
Modulation of Gene Function / Gene Expression (Joint)
*
Takashi Kadowaki,
University of Tokyo, Japan
Barbara B. Kahn,
Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Retinol Binding Protein 4 and Insulin Resistance
Retinol Binding Protein 4 and Insulin Resistance
David D. Moore,
Baylor College of Medicine, USA
Diabetes, Drug Metabolism and Vice Versa
Diabetes, Drug Metabolism and Vice Versa
Catherine Postic,
INSERM Institut Cochin, France
Role of ChREBP in the Physiopathology of Obesity and Insulin Resistance
Role of ChREBP in the Physiopathology of Obesity and Insulin Resistance
Marc R. Montminy,
The Salk Institute for Biological Studies, USA
The TORC Family of CREB Coactivators: Regulators of Energy Balance
The TORC Family of CREB Coactivators: Regulators of Energy Balance
Michihiro Matsumoto,
Diabetes Research Center, National Center for Global Health and Medicine, Japan
Short Talk: Central Role of the Transcription Factor FoxO1 in Hepatic Glucose Metabolism
Short Talk: Central Role of the Transcription Factor FoxO1 in Hepatic Glucose Metabolism
Jean Francois Louet,
Centre Méditerranéen de Médecine Moléculaire-C3M, France
Short Talk: The Coactivator SRC-3 is a Critical Regulator of the White Adipogenic Program
Short Talk: The Coactivator SRC-3 is a Critical Regulator of the White Adipogenic Program
17:00—19:00
Atherosclerosis
Alan R. Tall,
Columbia University, USA
Insulin Resistance and Atherosclerosis in Insulin Receptor Deficient Mice
Insulin Resistance and Atherosclerosis in Insulin Receptor Deficient Mice
Karin E. Bornfeldt,
University of Washington School of Medicine, USA
Diabetes and Lesion Initiation and Progression in the LDL Receptor-Deficient Mouse
Diabetes and Lesion Initiation and Progression in the LDL Receptor-Deficient Mouse
Christopher K. Glass,
University of California, San Diego, USA
Anti-Inflammatory and Antidiabetic Roles of PPAR in Macrophages
Anti-Inflammatory and Antidiabetic Roles of PPAR in Macrophages
Bai Luo,
University of Utah, USA
Short Talk: Protein O-GlcNAc Modification Reduces Angiogenesis in Endothelial Cells
Short Talk: Protein O-GlcNAc Modification Reduces Angiogenesis in Endothelial Cells
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
17:00—19:00
Nutrient Sensing
*
Yoshihiro Ogawa,
Kyushu University, Japan
David M. Sabatini,
Whitehead Institute for Biomedical Research, USA
Signaling through the mTORC1 and mTORC2 Pathways
Signaling through the mTORC1 and mTORC2 Pathways
Pere Puigserver,
Dana-Farber Cancer Institute, Harvard Medical School, USA
Nutrient Restriction Response Controlled through PGC-1a/SIRT1 Transcriptional Complexes
Nutrient Restriction Response Controlled through PGC-1a/SIRT1 Transcriptional Complexes
Ralph DiLeone,
Yale University School of Medicine, USA
Short Talk: Leptin Regulates Food Intake via Action on Dopamine Neurons of the Ventral Tegmental Area
Short Talk: Leptin Regulates Food Intake via Action on Dopamine Neurons of the Ventral Tegmental Area
Gina M. Leinninger,
Michigan State University, USA
Short Talk: Leptin Activates a Novel Population of LRb-Expressing Lateral Hypothalamic Neurons that Innervate the Ventral Tegmental Area
Short Talk: Leptin Activates a Novel Population of LRb-Expressing Lateral Hypothalamic Neurons that Innervate the Ventral Tegmental Area
Kamal N. Bharucha,
University of California, Los Angeles, USA
Short Talk: Regulation of Energy Homeostasis by the Drosophila AKH Receptor
Short Talk: Regulation of Energy Homeostasis by the Drosophila AKH Receptor
08:00—11:15
Mitochondria (Joint)
Robert S. Garofalo,
, USA
Nutrient Regulation of Energy Metabolism in Drosophila
Nutrient Regulation of Energy Metabolism in Drosophila
Kitt F. Petersen,
Yale University School of Medicine, USA
Mitochondria in Aging and Diabetes
Mitochondria in Aging and Diabetes
Vamsi K. Mootha,
Massachusetts General Hospital, USA
Systems Analysis of Mitochondrial Dysfunction in Human Diabetes
Systems Analysis of Mitochondrial Dysfunction in Human Diabetes
Ruojing Yang,
Merck & Co. Inc., USA
Short Talk: Targeting Insulin Resistance with RNA Interference
Short Talk: Targeting Insulin Resistance with RNA Interference
Mathias Treier,
Max-Delbrueck-Center for Molecular Medicine, Germany
Short Talk: Identification of a Transcriptional Regulator Required for Locomotor Activity and Hyperphagia
Short Talk: Identification of a Transcriptional Regulator Required for Locomotor Activity and Hyperphagia
17:00—19:00
Insulin Action
C. Ronald Kahn,
Joslin Diabetes Center and Harvard Medical School, USA
Critical Nodes in Insulin Signaling and Insulin Resistance
Critical Nodes in Insulin Signaling and Insulin Resistance
Alan R. Saltiel,
University of California, San Diego, USA
G Proteins as Signal Integrators in the Regulation of Glucose Transport
G Proteins as Signal Integrators in the Regulation of Glucose Transport
*
Rudolph L. Leibel,
Columbia University, USA
Selected Shorts
Selected Shorts
William L. Holland,
University of Texas Southwestern Medical Center, USA
Short Talk: Ceramide Involvment in Saturated Fat and Glucocorticord Induced Insulin Resistance
Short Talk: Ceramide Involvment in Saturated Fat and Glucocorticord Induced Insulin Resistance
Following Session is for Obesity: Peripheral and Central Pathways Regulating Energy Homeostasis (J2)
17:00—19:00
Genes versus Diet
*
Eric Ravussin,
Louisiana State University, Pennington Biomedical Research Center, USA
Sadaf Farooqi,
University of Cambridge, UK
Insights from Genetic Disruption of the Leptin-Melanocortin Pathway in Humans
Insights from Genetic Disruption of the Leptin-Melanocortin Pathway in Humans
Donald J. Marsh,
Merck Research Laboratories, USA
Validating Central Obesity Targets
Validating Central Obesity Targets
John Speakman,
Institute of Genetics and Developmental Biology, CAS, China
The Evolutionary Context of the Modern Obesity Epidemic
The Evolutionary Context of the Modern Obesity Epidemic
*Session Chair †Invited, not yet responded.
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