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This meeting took place in 2007
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Autophagy in Health and Disease (Z3)
Organizer(s) Beth Levine, Daniel J. Klionsky and Noboru Mizushima
April 15—20, 2007
Portola Hotel & Spa • Monterey, California USA
Abstract Deadline: Dec 15, 2006
Late Abstract Deadline: Jan 18, 2007
Scholarship Deadline: Dec 15, 2006
Early Registration Deadline: Feb 15, 2007
Supported by the Director's Fund
Joint Meeting:
Apoptotic and Non-Apoptotic Cell Death Pathways (Z4)
Summary of Meeting:
Autophagy is the major pathway that eukaryotic cells use to degrade and recycle cytoplasmic contents during development, tissue homeostasis, and environmental stress. In recent years, there has been an explosion of knowledge about the molecular mechanisms of autophagy and its roles in organelle turnover, cell death regulation, cancer cell biology, innate immunity, aging, and neurodegenerative disorders. This meeting will focus on advances made in these areas, with the goal of understanding the molecular and cellular mechanisms by which autophagy and the deregulation of autophagy contributes to health and disease. In addition, the meeting will focus on how the autophagy pathway can be exploited as a therapeutic target in cancer, infectious diseases, aging and neurodegeneration.
View Scholarships/Awards
Autophagy is the major pathway that eukaryotic cells use to degrade and recycle cytoplasmic contents during development, tissue homeostasis, and environmental stress. In recent years, there has been an explosion of knowledge about the molecular mechanisms of autophagy and its roles in organelle turnover, cell death regulation, cancer cell biology, innate immunity, aging, and neurodegenerative disorders. This meeting will focus on advances made in these areas, with the goal of understanding the molecular and cellular mechanisms by which autophagy and the deregulation of autophagy contributes to health and disease. In addition, the meeting will focus on how the autophagy pathway can be exploited as a therapeutic target in cancer, infectious diseases, aging and neurodegeneration.
View Scholarships/Awards
No registration fees are used to fund entertainment or alcohol at this conference
SUNDAY, APRIL 15
MONDAY, APRIL 16
TUESDAY, APRIL 17
WEDNESDAY, APRIL 18
THURSDAY, APRIL 19
FRIDAY, APRIL 20
Conference Program Print | View meeting in 12 hr (am/pm) time
SUNDAY, APRIL 15
19:30—22:00
Keynote Session (Joint)
Richard A. Lockshin,
St. John's University, USA
Apoptosis, Autophagy, and More
Apoptosis, Autophagy, and More
Yoshinori Ohsumi,
Tokyo Institute of Technology, Japan
Molecular Mechanism of Membrane Dynamics during Autophagy
Molecular Mechanism of Membrane Dynamics during Autophagy
Craig B. Thompson,
Memorial Sloan Kettering Cancer Center, USA
Autophagy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress
Autophagy and Apoptosis Represent Alternative Cellular Responses to Bioenergetic Stress
08:00—11:00
Membrane Dynamics of Autophagy
Tamotsu Yoshimori,
Osaka University, Japan
New Insights into Molecular Mechanisms of the Canonical and Specialized Autophagy
New Insights into Molecular Mechanisms of the Canonical and Specialized Autophagy
Zvulun Elazar,
Weizmann Institute of Science, Israel
Regulation of Autophagy in Yeast and Mammals
Regulation of Autophagy in Yeast and Mammals
Sheila M. Thomas,
Harvard Medical School, USA
Short Talk: Teaching an Old Dog New Tricks: Role for Paxillin in Autophagy
Short Talk: Teaching an Old Dog New Tricks: Role for Paxillin in Autophagy
08:00—11:15
Multiple Cell Death Mechanisms in Mammalian Cells
*
Dale E. Bredesen,
Buck Institute for Research on Aging, USA
Toward a Mechanistic Taxonomy of Cell Death
Toward a Mechanistic Taxonomy of Cell Death
Yoshihide Tsujimoto,
Osaka University Medical School, Japan
Multiple Mechanisms of Cell Death and their Regulation by Bcl-2
Multiple Mechanisms of Cell Death and their Regulation by Bcl-2
Judy Lieberman,
Harvard University, USA
Many Ways to Die: The Caspase-Independent Granzyme A Pathway
Many Ways to Die: The Caspase-Independent Granzyme A Pathway
Douglas R. Green,
St. Jude Children's Research Hospital, USA
Life after Cytochrome c Release
Life after Cytochrome c Release
14:00—16:00
Workshop 1: Molecular Mechanisms and Regulation of Autophagy
Dale W. Hailey,
National Institutes of Health, USA
Using Photoactivatable GFP Fusions to Monitor Autophagosome Lifetime
Using Photoactivatable GFP Fusions to Monitor Autophagosome Lifetime
Claudine Kraft,
University of Freiburg, Germany
Ribophagy: Regulated Ribosome Turnover by Autophagy
Ribophagy: Regulated Ribosome Turnover by Autophagy
Amandine Bugnicourt,
Institut Jacques Monod, France
Irs4p/Tax4p: Two Yeast EH Domain Proteins Involved in Autophagy
Irs4p/Tax4p: Two Yeast EH Domain Proteins Involved in Autophagy
Yasuyoshi Sakai,
Graduate School of Agriculture, Kyoto University, Japan
Roles of Atg26 in Methanol-Induced Autophagy and Plant Pathogenicity
Roles of Atg26 in Methanol-Induced Autophagy and Plant Pathogenicity
Yu-Yun Chang,
University of Minnesota, USA
The Regulation and Function of Drosophila Atg1 in Autophagy
The Regulation and Function of Drosophila Atg1 in Autophagy
Jessica P. Monserrate,
University of California, Irvine, USA
Determining the Role of the Drosophila Bcl-2 Protein, Buffy, in Mediating Autophagy
Determining the Role of the Drosophila Bcl-2 Protein, Buffy, in Mediating Autophagy
Julian J. Lum,
British Columbia Cancer Agency, Canada
HIF-1alpha is a Hypoxia-Dependent Regulator of Autophagy
HIF-1alpha is a Hypoxia-Dependent Regulator of Autophagy
14:00—16:00
Workshop 1: Signal Transduction to Cell Death
*
Roya Khosravi-Far,
Harvard Medical School, Beth Israel Deaconess Medical Center, USA
Evasion from Apoptosis: A Hallmark of Cancer
Evasion from Apoptosis: A Hallmark of Cancer
Jonathan L. Coloff,
University of Illinois at Chicago, USA
Active Akt Requires Pentose Phosphate Pathway Activity to Maintain Mcl-1 Levels and Prevent Cell Death Upon Cytokine Withdrawal
Active Akt Requires Pentose Phosphate Pathway Activity to Maintain Mcl-1 Levels and Prevent Cell Death Upon Cytokine Withdrawal
Elizabeth Yang,
Vanderbilt University School of Medicine, USA
PP2A Regulates the Pro-Apoptotic Activity of FOXO1
PP2A Regulates the Pro-Apoptotic Activity of FOXO1
Eli Arama,
Weizmann Institute of Science, Israel
A Ubiquitin Ligase Complex Regulates Caspase Activation during Sperm Differentiation in Drosophila
A Ubiquitin Ligase Complex Regulates Caspase Activation during Sperm Differentiation in Drosophila
Ameeta Kelekar,
University of Minnesota, USA
Phosphorylation Regulates the Function and Intacellular Localization OF BH3 Only Protein NOXA in Human Leukemias
Phosphorylation Regulates the Function and Intacellular Localization OF BH3 Only Protein NOXA in Human Leukemias
Ashish Banerjee,
Monash University, Australia
Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival
Non-Transcriptional Role of NF-kappaB in Regulating B Cell Survival
Bingnan N. Kang,
Johns Hopkins University, USA
Death-Associated Protein Kinase Regulated by DANGER, an IP3 Receptor Binding Protein
Death-Associated Protein Kinase Regulated by DANGER, an IP3 Receptor Binding Protein
16:30—18:30
Regulation and Physiology of Autophagy
Patrice Codogno,
INSERM, France
Regulation of Macroautophagy by Sphingolipids
Regulation of Macroautophagy by Sphingolipids
Thomas P. Neufeld,
University of Minnesota, USA
TOR Signaling Pathway and Control of Autophagy in Drosophila
TOR Signaling Pathway and Control of Autophagy in Drosophila
Noboru Mizushima,
University of Tokyo, Japan
Physiological Role of Autophagy in Protein Metabolism in Mice
Physiological Role of Autophagy in Protein Metabolism in Mice
Jinghui Zhao,
AbbVie, USA
Short Talk: FoxO3 Stimulates Macroautophagy in Muscle Cells
Short Talk: FoxO3 Stimulates Macroautophagy in Muscle Cells
16:30—18:30
Apoptotic and Non-Apoptotic Cell Death in Invertebrates
*
Masayuki Miura,
University of Tokyo, Japan
Non-Apoptotic Function of Caspase Signaling in Drosophila
Non-Apoptotic Function of Caspase Signaling in Drosophila
Barbara Conradt,
Ludwig-Maximilians-Universitat, Germany
DRP-1-Mediated Mitochondrial Fragmentation during EGL-1-Induced Apoptosis in C. elegans
DRP-1-Mediated Mitochondrial Fragmentation during EGL-1-Induced Apoptosis in C. elegans
Monica Driscoll,
Rutgers University, USA
Dying by Injury Rather Than by Design: Deciphering Necrotic-like Neuronal Death Mechanisms in C. elegans
Dying by Injury Rather Than by Design: Deciphering Necrotic-like Neuronal Death Mechanisms in C. elegans
A. Louise McCormick,
Emory University, USA
Short Talk: Human Cytomegalovirus Subverts Caspase-Independent Death
Short Talk: Human Cytomegalovirus Subverts Caspase-Independent Death
08:00—11:00
Specific Autophagy and Organelle Degradation
*
Zvulun Elazar,
Weizmann Institute of Science, Israel
Suresh Subramani,
University of California, San Diego, USA
Role of ATG30 in Selective Peroxisome Turnover in Pichia pastoris
Role of ATG30 in Selective Peroxisome Turnover in Pichia pastoris
John J. Lemasters,
Medical University of South Carolina, USA
Mitochondrial Autophagy (Mitophagy) in Living Hepatocytes
Mitochondrial Autophagy (Mitophagy) in Living Hepatocytes
Ron R. Kopito,
Stanford University, USA
Role of Autophagy in the Degradation of Polyglutamine Aggregates
Role of Autophagy in the Degradation of Polyglutamine Aggregates
Sebastian Schuck,
HHMI/University of California, San Francisco, USA
Short Talk: Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
Short Talk: Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response
08:00—11:00
Apoptosis and Nonapoptosis in Cancer Cells
*
Marja Jäättelä,
Danish Cancer Society Research Center, Denmark
Lysosomal Control of Tumor Cell Death
Lysosomal Control of Tumor Cell Death
Joan S. Brugge,
Harvard Medical School, USA
Multiple Mechanisms Mediate Cell Death Associated with Loss of Extracellular Matrix Attachment
Multiple Mechanisms Mediate Cell Death Associated with Loss of Extracellular Matrix Attachment
Jean H. Overmeyer,
University of Toledo College of Medicine, USA
Short Talk: Activated Ras Induces a Unique Form of Type-II Death in Glioblastoma Cells by Mechanisms Distinct from Macroautophagy
Short Talk: Activated Ras Induces a Unique Form of Type-II Death in Glioblastoma Cells by Mechanisms Distinct from Macroautophagy
Kristin M. Tracy,
University of Chicago, USA
Short Talk: The RB Tumor Suppressor Blocks Non-Apoptotic Cell Death and Represses Expression of the Autophagy Regulator BNip3
Short Talk: The RB Tumor Suppressor Blocks Non-Apoptotic Cell Death and Represses Expression of the Autophagy Regulator BNip3
14:00—16:00
Workshop 2 (Joint): Technique Discussion: How to Differentiate Apoptosis vs. Necrosis vs. Autophagic Death Experimentally
*
Zahra F. Zakeri,
Queens College of City University of New York, USA
Noboru Mizushima,
University of Tokyo, Japan
Biochemical and Light Microscopic Detection of Autophagosome Formation and Autophagic Degradation
Biochemical and Light Microscopic Detection of Autophagosome Formation and Autophagic Degradation
Patrice Codogno,
INSERM, France
Autophagic Cell Death: Does Autophagy have a License to Kill?
Autophagic Cell Death: Does Autophagy have a License to Kill?
Henrick N. Horita,
University of Colorado at Denver & HSC, USA
So Many Ways to Die: Elucidating the Mechanism by Which DT-IL3 Kills Acute Myelogenous Leukemia Cells
So Many Ways to Die: Elucidating the Mechanism by Which DT-IL3 Kills Acute Myelogenous Leukemia Cells
Bahrad A. Sokhansanj,
Drexel University, USA
Systems Approach to Quantifying Cell Death Mechanism in Stress Response
Systems Approach to Quantifying Cell Death Mechanism in Stress Response
Einat Zalckvar,
Weizmann Institute of Science, Israel
System Level Analysis of the Cell Death Network by Single and Double RNAi–Mediated Perturbations
System Level Analysis of the Cell Death Network by Single and Double RNAi–Mediated Perturbations
16:30—18:30
Interaction of Apoptosis and Autophagy Pathways (Joint)
*
Michael J. Lenardo,
NIAID, National Institutes of Health, USA
Role of Autophagy in Caspase-Independent Cell Death
Role of Autophagy in Caspase-Independent Cell Death
Adi Kimchi,
Weizmann Institute of Science, Israel
System Level Analysis of Programmed Cell Death: Switching between Apoptosis, Autophagy and Necrosis
System Level Analysis of Programmed Cell Death: Switching between Apoptosis, Autophagy and Necrosis
Guido Kroemer,
Cordeliers Research Center, France
The Intricate Interplay between Apoptosis and Autophagy
The Intricate Interplay between Apoptosis and Autophagy
Adam Oberstein,
Princeton University, USA
Short Talk: Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex: Beclin 1 is a Novel BH3-Only Protein
Short Talk: Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex: Beclin 1 is a Novel BH3-Only Protein
08:00—11:00
Autophagy in Immunity and Infection
*
Beth Levine,
University of Texas Southwestern Medical Center, USA
Bcl-2 Anti-Apoptotic Proteins Function as Anti-Autophagy Proteins
Bcl-2 Anti-Apoptotic Proteins Function as Anti-Autophagy Proteins
Christian Münz,
University of Zurich, Switzerland
Role of Autophagy in Viral Antigen Presentation by Class II MHC Molecules
Role of Autophagy in Viral Antigen Presentation by Class II MHC Molecules
Vojo Deretic,
University of New Mexico Health Sciences Center, USA
Autophagy as an Immune Effector in Tuberculosis and HIV
Autophagy as an Immune Effector in Tuberculosis and HIV
Karla A. Kirkegaard,
Stanford University School of Medicine, USA
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
Subversion of Cellular Autophagosomal Machinery by RNA Viruses
Martine Biard-Piechaczyk,
Le Centre de Pharmacologie et Biotechnologie pour la Santé, France
Short Talk: Autophagy is Involved in CD4 T Cell Apoptosis Triggered by HIV-1 Envelope Proteins
Short Talk: Autophagy is Involved in CD4 T Cell Apoptosis Triggered by HIV-1 Envelope Proteins
Luc English,
University of Montreal, Canada
Short Talk: Contribution of the Auto/Phagolysosomal Compartment in the Presentation of Endogenous HSV-1 Viral Antigens on MHC Class I Molecules
Short Talk: Contribution of the Auto/Phagolysosomal Compartment in the Presentation of Endogenous HSV-1 Viral Antigens on MHC Class I Molecules
08:00—11:00
Apoptotic and Nonapoptotic Neuronal Cell Death
*
J. Marie Hardwick,
Johns Hopkins University Schools of Public Health and Medicine, USA
Regulation of Mitochondrial Function by Bcl-2 family Proteins
Regulation of Mitochondrial Function by Bcl-2 family Proteins
Valina L. Dawson,
Johns Hopkins University School of Medicine, USA
Parthanatos is a Key Regulator of Cell Death: PARP-1 and AIF Signaling
Parthanatos is a Key Regulator of Cell Death: PARP-1 and AIF Signaling
Claudio Soto,
University of Texas Medical School at Houston, USA
Mechanisms of Prion Neurotoxicity
Mechanisms of Prion Neurotoxicity
Axel Niemann,
ETH Zürich, Switzerland
Short Talk: Charcot-Marie-Tooth Disease Type 4A: A Human Disorder Caused by Mutations in the Gene Encoding GDAP1, a Mitochondrial Fission Factor
Short Talk: Charcot-Marie-Tooth Disease Type 4A: A Human Disorder Caused by Mutations in the Gene Encoding GDAP1, a Mitochondrial Fission Factor
Daniel Tondera,
Dana-Faber Cancer Institute, USA
Short Talk: Acute Mitochondrial Hyperfusion is a Stress-Induced Survival Mechanism
Short Talk: Acute Mitochondrial Hyperfusion is a Stress-Induced Survival Mechanism
Claudio A. Hetz,
University of Chile, Chile
Short Talk: The Pro-Apoptotic BCL-2 Family Member BIM Mediates Motoneuron Loss in a Model of Amyotrophic Lateral Sclerosis
Short Talk: The Pro-Apoptotic BCL-2 Family Member BIM Mediates Motoneuron Loss in a Model of Amyotrophic Lateral Sclerosis
16:30—18:30
Autophagy as a Target in Cancer Therapy
*
Adi Kimchi,
Weizmann Institute of Science, Israel
Seiji Kondo,
Sakura Home Clinic, Japan
Treatment of Malignant Gliomas with Manipulation of Autophagy
Treatment of Malignant Gliomas with Manipulation of Autophagy
Jae U. Jung,
Keck School of Medicine of University of Southern California, USA
UVRAG, Autophagy and Cancer
UVRAG, Autophagy and Cancer
Yoshinori Takahashi,
Pennsylvania State College of Medicine, USA
Short Talk: Regulation of Autophagy-Dependent Cell Death and Tumorigenesis by Endophilin B1/Bif-1
Short Talk: Regulation of Autophagy-Dependent Cell Death and Tumorigenesis by Endophilin B1/Bif-1
16:30—18:30
Models of Apoptotic and Nonapoptotic Cell Death
*
Sally A. Kornbluth,
Duke University Medical Center, USA
Metabolic Regulation of Caspase 2
Metabolic Regulation of Caspase 2
Zahra F. Zakeri,
Queens College of City University of New York, USA
Viral Infection Induces Multiple Cell Death Pathways
Viral Infection Induces Multiple Cell Death Pathways
Pierre Golstein,
Centre d'Immunologie de Marseille-Luminy, France
A Necrotic Cell Death Model
A Necrotic Cell Death Model
Thomas Rudel,
University of Würzburg, Germany
Short Talk: Control of cFLIP Expression by microRNAs to Confer Apoptosis Resistance of Infected Cells
Short Talk: Control of cFLIP Expression by microRNAs to Confer Apoptosis Resistance of Infected Cells
08:00—11:00
Autophagy in Cell Survival and Cell Death (Joint)
*
Eileen P. White,
Rutgers University, USA
Role of Autophagy in Cancer
Role of Autophagy in Cancer
Beth Levine,
University of Texas Southwestern Medical Center, USA
Novel Connections between Autophagy and Apoptosis
Novel Connections between Autophagy and Apoptosis
Eric H. Baehrecke,
University of Massachusetts Medical School, USA
Autophagic Cell Death in Drosophila
Autophagic Cell Death in Drosophila
Virginie M. Betin,
University of Bristol, UK
Short Talk: Functional Characterization of Human Atg4D: Processing of Atg8 Homologues and Regulation by Caspases
Short Talk: Functional Characterization of Human Atg4D: Processing of Atg8 Homologues and Regulation by Caspases
Cindy K. Miranti,
Van Andel Research Institute, USA
Short Talk: Inhibition of Integrin-Mediated Crosstalk with EGFR/Erk or Src Signaling Pathways in Autophagic Prostate Epithelial Cells Induces Caspase-Independent Death
Short Talk: Inhibition of Integrin-Mediated Crosstalk with EGFR/Erk or Src Signaling Pathways in Autophagic Prostate Epithelial Cells Induces Caspase-Independent Death
Francesco Cecconi,
University of Rome Tor Vergata, Italy
Short Talk: Ambra-1 Regulates Autophagy and Nervous System Development
Short Talk: Ambra-1 Regulates Autophagy and Nervous System Development
14:00—16:00
Workshop 3: Autophagy in Cell Death and Disease
*
Guido Kroemer,
Cordeliers Research Center, France
Claire Ying Chen Hou,
Genome Sciences Centre, Canada
Common Regulators of Apoptosis and Autophagy – An analysis of Known Cell Death Genes in Starvation-Induced Autophagy
Common Regulators of Apoptosis and Autophagy – An analysis of Known Cell Death Genes in Starvation-Induced Autophagy
Tri M. Bui Nguyen,
University of Minnesota, USA
Kringle 5 of Human Plasminogen, an Angiogenesis Inhibitor, Induces Both Autophagy and Apoptotic Death in Endothelial Cells
Kringle 5 of Human Plasminogen, an Angiogenesis Inhibitor, Induces Both Autophagy and Apoptotic Death in Endothelial Cells
John Hunter Brumell,
Hospital for Sick Children, Canada
Ubiquitinated-Protein Aggregates Form in Pancreatic beta-Cells During Diabetes-Induced Oxidative Stress and are Regulated by Autophagy
Ubiquitinated-Protein Aggregates Form in Pancreatic beta-Cells During Diabetes-Induced Oxidative Stress and are Regulated by Autophagy
Masaaki Komatsu,
Juntendo University School of Medicine, Japan
Selective Autophagy Regulates Formation of Intracytoplamic Inclusions
Selective Autophagy Regulates Formation of Intracytoplamic Inclusions
Paul Tannous,
University of Texas Southwestern Medical Center, USA
Cardiomyocyte Autophagy Attenuates Desmin-Related Cardiomyopathy
Cardiomyocyte Autophagy Attenuates Desmin-Related Cardiomyopathy
Gutian Xiao,
University of Pittsburgh Medical Center, USA
Autophagy Kisses NF-kappaB to Death without Hsp90 Chaperoning
Autophagy Kisses NF-kappaB to Death without Hsp90 Chaperoning
Heather Hartig Pua,
Duke University Medical Center, USA
A Critical Role for the Autophagy Gene Atg5 in T Cell Survival and Proliferation
A Critical Role for the Autophagy Gene Atg5 in T Cell Survival and Proliferation
Monica Andrea Delgado Vargas,
Lovelace Respiratory Research Institute, USA
TLR Ligands Control Induction of Autophagy in Macrophages
TLR Ligands Control Induction of Autophagy in Macrophages
14:00—16:00
Workshop 3: Execution Mechanisms of Cell Death
Ernst-Jan A.J. Geutjes,
Netherlands Cancer Institute, Netherlands
A High Throughput DUB siRNA Screen for Novel Regulators of the Pro-Apoptotic TNFR Pathway
A High Throughput DUB siRNA Screen for Novel Regulators of the Pro-Apoptotic TNFR Pathway
Lydia Lartigue,
La Jolla Institute for Allergy and Immunology, USA
Consequences of Mitochondrial Outer Membrane Permeabilization in the Absence of Caspase Activation
Consequences of Mitochondrial Outer Membrane Permeabilization in the Absence of Caspase Activation
Yongqiang Chen,
Manitoba Institute of Cell Biology, Canada
Reactive Oxygen Species Induce Autophagic Cell Death in Transformed and Cancer Cells
Reactive Oxygen Species Induce Autophagic Cell Death in Transformed and Cancer Cells
Anath Shalev,
University of Alabama at Birmingham, USA
Glucose-Induced Apoptosis of Pancreatic Beta Cells is Mediated by Thioredoxin-Interacting Protein
Glucose-Induced Apoptosis of Pancreatic Beta Cells is Mediated by Thioredoxin-Interacting Protein
Yolanda Huang,
University of North Carolina, Chapel Hill, USA
Therapeutic Strategy for Inducing Apoptosis in Brain Tumors without Affecting Primary Neurons
Therapeutic Strategy for Inducing Apoptosis in Brain Tumors without Affecting Primary Neurons
Karin Nowikovsky,
Max F. Perutz Laboratories, Vienna University, Austria
Loss of Mitochondrial K+/H+ Exchange Activity Causes Osmotic Swelling and Microautophagy
Loss of Mitochondrial K+/H+ Exchange Activity Causes Osmotic Swelling and Microautophagy
Jerry E. Chipuk,
St. Jude Children's Research Hospital, USA
Mitochondrial Outer Membrane Permeabilization Requires Endoplasmic Reticulum-Derived Sphingolipid Metabolism
Mitochondrial Outer Membrane Permeabilization Requires Endoplasmic Reticulum-Derived Sphingolipid Metabolism
16:30—18:30
Autophagy as a Therapeutic Target in Neurodegenerative Diseases
David C. Rubinsztein,
Cambridge Institute for Medical Research, UK
Autophagic Clearance of Aggregate-Prone Proteins: Therapeutic Implications
Autophagic Clearance of Aggregate-Prone Proteins: Therapeutic Implications
Tony Wyss-Coray,
Stanford University School of Medicine, USA
Autophagy Deficiency in Alzheimer’s Disease and Neurodegeneration
Autophagy Deficiency in Alzheimer’s Disease and Neurodegeneration
Ralph A. Nixon,
New York University, Langone Medical Center, USA
Macroautophagy Failure in Alzheimer's Disease: Genetic Factors and Pathological Consequences
Macroautophagy Failure in Alzheimer's Disease: Genetic Factors and Pathological Consequences
Maria L. Florez-McClure,
Martek Biosciences Corp., USA
Short Talk: Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of beta-Amyloid Peptide in C. elegans
Short Talk: Decreased Insulin-Receptor Signaling Promotes the Autophagic Degradation of beta-Amyloid Peptide in C. elegans
16:30—18:30
Small Molecule Regulators of Apoptosis and Necrosis
Shaomeng Wang,
University of Michigan, USA
Insights into the Mechanism of Action of Apoptosis Induction by Ultra-Potent Small-Molecule Smac Mimetics
Insights into the Mechanism of Action of Apoptosis Induction by Ultra-Potent Small-Molecule Smac Mimetics
Stephen W. Fesik,
Vanderbilt University School of Medicine, USA
Bcl-2 Family Inhibitors for the Treatment of Cancer
Bcl-2 Family Inhibitors for the Treatment of Cancer
*
Junying Yuan,
Harvard Medical School, USA
Studying Mechanisms of Cell Death: From Apoptosis to Necrosis
Studying Mechanisms of Cell Death: From Apoptosis to Necrosis
*Session Chair †Invited, not yet responded.
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